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The map label for this gene is sdhA [H]

Identifier: 146337399

GI number: 146337399

Start: 249130

End: 250968

Strand: Direct

Name: sdhA [H]

Synonym: BRADO0234

Alternate gene names: 146337399

Gene position: 249130-250968 (Clockwise)

Preceding gene: 146337398

Following gene: 146337400

Centisome position: 3.34

GC content: 66.18

Gene sequence:

>1839_bases
ATGGCCGGCGGAGCAAATGGCAGCGCGAACGGCGCGCCCGCGACGAACGGAAAAGCCTATCCGATCGAGGACCACACCTA
CGATGTCGTCGTGGTCGGCGCCGGCGGCGCGGGCTTGCGCGCCGTCGTCGGCTGCAGCGAAGCGGGCCTGCGCACGGCCT
GCATCACCAAGGTGTTCCCGACCCGCTCGCACACCGTGGCGGCGCAGGGCGGCATCTCGGCCTCGCTCGGCAACATGCAC
CAGGACGACTGGCGCTGGCACATGTACGACACCGTCAAGGGCTCCGACTGGCTCGGTGACCAGGACGCCATCGAATACAT
GGTCCGCAACGCGCCGGACGCCGTCTATGAGCTCGAGCATTGGGGCGTGCCGTTCTCGCGCACCGAGGACGGCAAGATCT
ACCAGCGCCCGTTCGGCGGCATGACCATGGACTACGGCAAGGGCCAGGCGCAGCGCACCTGCGCCGCGGCCGACCGGACC
GGTCACGCGATGCTTCACACGATGTATGGCCAGTCGCTGCGCCATGCCGCGGAGTTCTTCATCGAGTTCTTCGCCATCGA
CCTGATCATGGACGACCAGGGCACCTGCCGCGGCGTCATCGCGATCAAGCTCGACGACGGCACCCTGCACCGCTTCCGCG
CTCAGACCACCATCCTGGCGACCGGCGGCTACGGCCGCGCCTACGCCTCCTGCACCTCGGCGCATACCTGCACCGGCGAC
GGCGGCGGTATGGCGCTGCGCGCCGGCCTGCCGTTGCAGGACATGGAGTTCGTGCAGTTCCACCCGACCGGCATTTACGG
CTCGGGCTGTCTGGTCACCGAAGGCGCGCGCGGCGAAGGCGGCTACCTCGTCAATTCCGAGGGCGAGCGCTTCATGGAGC
GATATGCGCCCTCCGCCAAGGACCTCGCCTCGCGCGACGTCGTCTCGCGCGCGATGACCATCGAGATCCGCGAAGGCCGC
GGCGTCGGCAAGAAGAAGGATCACATCTTCCTGCATCTCGACCATCTCGATCCGAAGGTACTGGCCGAGCGTCTGCCCGG
CATTTCCGAATCGGCCAAGATCTTTGCCAATGTCGACGTCACTCGCGAGCCGATCCCGATCGTGCCGACGGTGCATTACA
ACATGGGCGGCATCCCGACGAACTATCACGCCGAGGTGCTGACCAAGAAGGACGGCGACGACAACGCGATCGTCCCGGGC
TTGATGGCGGTGGGCGAGGCGGCCTGCGTGTCCGTGCACGGCGCCAACCGGCTCGGCTCCAACTCGCTGATCGACCTCGT
GGTGTTCGGCCGCGCCGCCGCGCTGCGGCTGGCCGAGAAGCTGACGCCGAACGGCAAGCAGCCGGATCTGCCAAAGGACT
CGGCCGACAAGGCCCTCAGCCGGCTCGACCATTATCGCTACGCCTCCGGCGGCACGCCGACCGCGAAGCTGCGCGAGAGC
ATGCAGCACGTGATGCAGACCAACTGCGCCGTGTTCCGCACCGGCGAGGTGCTGCAGGAAGGTCATAACCTGATTCACAA
GGTGTATGGCGGCATCGGTGACATCGCCGTGTCGGACCGTTCGCTGGTGTGGAATTCGGACCTGATCGAGACCCTGGAGT
TCGACAACCTCATCGCGCAGGCGGTGGTGACGATGGACTCCGCGGTCAATCGCACCGAGAGCCGCGGCGCCCACGCCCGC
GAGGACTTCCCAGATCGCGACGACAAGAACTGGATGAAGCACACGCTGGCGTGGATCGACAACAAGGACGGCAAGACCAC
GATCGATTACCGCCCGGTGCACAATTACACCATGACCAACGACGTGCAGTATATTCCGCCGAAGGCACGCGTCTACTGA

Upstream 100 bases:

>100_bases
GCTCAAACTCATCGCGATCATGGGCAACAACTTCTTTGCCGTGACCGTGGCGATCGCCTCGATCTACGCCCTCATCAAAC
TGTCCACTGGAGTCTAGCGA

Downstream 100 bases:

>100_bases
TCGCGCGTGTGCCGAGCCCGTCCGTCAAAACCTGAGAAGGCCTATCGAAATGGCTGAGTTCGCACTTCCGAAGAATTCCC
AGATCACCGGCGGCAAGACC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MAGGANGSANGAPATNGKAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMH
QDDWRWHMYDTVKGSDWLGDQDAIEYMVRNAPDAVYELEHWGVPFSRTEDGKIYQRPFGGMTMDYGKGQAQRTCAAADRT
GHAMLHTMYGQSLRHAAEFFIEFFAIDLIMDDQGTCRGVIAIKLDDGTLHRFRAQTTILATGGYGRAYASCTSAHTCTGD
GGGMALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEIREGR
GVGKKKDHIFLHLDHLDPKVLAERLPGISESAKIFANVDVTREPIPIVPTVHYNMGGIPTNYHAEVLTKKDGDDNAIVPG
LMAVGEAACVSVHGANRLGSNSLIDLVVFGRAAALRLAEKLTPNGKQPDLPKDSADKALSRLDHYRYASGGTPTAKLRES
MQHVMQTNCAVFRTGEVLQEGHNLIHKVYGGIGDIAVSDRSLVWNSDLIETLEFDNLIAQAVVTMDSAVNRTESRGAHAR
EDFPDRDDKNWMKHTLAWIDNKDGKTTIDYRPVHNYTMTNDVQYIPPKARVY

Sequences:

>Translated_612_residues
MAGGANGSANGAPATNGKAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMH
QDDWRWHMYDTVKGSDWLGDQDAIEYMVRNAPDAVYELEHWGVPFSRTEDGKIYQRPFGGMTMDYGKGQAQRTCAAADRT
GHAMLHTMYGQSLRHAAEFFIEFFAIDLIMDDQGTCRGVIAIKLDDGTLHRFRAQTTILATGGYGRAYASCTSAHTCTGD
GGGMALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEIREGR
GVGKKKDHIFLHLDHLDPKVLAERLPGISESAKIFANVDVTREPIPIVPTVHYNMGGIPTNYHAEVLTKKDGDDNAIVPG
LMAVGEAACVSVHGANRLGSNSLIDLVVFGRAAALRLAEKLTPNGKQPDLPKDSADKALSRLDHYRYASGGTPTAKLRES
MQHVMQTNCAVFRTGEVLQEGHNLIHKVYGGIGDIAVSDRSLVWNSDLIETLEFDNLIAQAVVTMDSAVNRTESRGAHAR
EDFPDRDDKNWMKHTLAWIDNKDGKTTIDYRPVHNYTMTNDVQYIPPKARVY
>Mature_611_residues
AGGANGSANGAPATNGKAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMHQ
DDWRWHMYDTVKGSDWLGDQDAIEYMVRNAPDAVYELEHWGVPFSRTEDGKIYQRPFGGMTMDYGKGQAQRTCAAADRTG
HAMLHTMYGQSLRHAAEFFIEFFAIDLIMDDQGTCRGVIAIKLDDGTLHRFRAQTTILATGGYGRAYASCTSAHTCTGDG
GGMALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEIREGRG
VGKKKDHIFLHLDHLDPKVLAERLPGISESAKIFANVDVTREPIPIVPTVHYNMGGIPTNYHAEVLTKKDGDDNAIVPGL
MAVGEAACVSVHGANRLGSNSLIDLVVFGRAAALRLAEKLTPNGKQPDLPKDSADKALSRLDHYRYASGGTPTAKLRESM
QHVMQTNCAVFRTGEVLQEGHNLIHKVYGGIGDIAVSDRSLVWNSDLIETLEFDNLIAQAVVTMDSAVNRTESRGAHARE
DFPDRDDKNWMKHTLAWIDNKDGKTTIDYRPVHNYTMTNDVQYIPPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=612, Percent_Identity=61.9281045751634, Blast_Score=760, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=52.7210884353742, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1790597, Length=579, Percent_Identity=42.4870466321244, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=564, Percent_Identity=29.6099290780142, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17550100, Length=614, Percent_Identity=60.2605863192182, Blast_Score=739, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=613, Percent_Identity=58.4013050570963, Blast_Score=715, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=614, Percent_Identity=64.8208469055375, Blast_Score=800, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=64.1541038525963, Blast_Score=766, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=487, Percent_Identity=25.4620123203285, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17137288, Length=628, Percent_Identity=62.5796178343949, Blast_Score=791, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=628, Percent_Identity=62.5796178343949, Blast_Score=791, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=628, Percent_Identity=62.5796178343949, Blast_Score=791, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=619, Percent_Identity=54.281098546042, Blast_Score=682, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66579; Mature: 66448

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGANGSANGAPATNGKAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFP
CCCCCCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHCC
TRSHTVAAQGGISASLGNMHQDDWRWHMYDTVKGSDWLGDQDAIEYMVRNAPDAVYELEH
CCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHEEHHH
WGVPFSRTEDGKIYQRPFGGMTMDYGKGQAQRTCAAADRTGHAMLHTMYGQSLRHAAEFF
CCCCCCCCCCCCEEECCCCCCEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IEFFAIDLIMDDQGTCRGVIAIKLDDGTLHRFRAQTTILATGGYGRAYASCTSAHTCTGD
HHHHHEEEEECCCCCEEEEEEEEECCCCEEEEEEEEEEEEECCCCCHHHHCCCCCEECCC
GGGMALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAK
CCCEEEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHH
DLASRDVVSRAMTIEIREGRGVGKKKDHIFLHLDHLDPKVLAERLPGISESAKIFANVDV
HHHHHHHHHHEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCEEEEECCC
TREPIPIVPTVHYNMGGIPTNYHAEVLTKKDGDDNAIVPGLMAVGEAACVSVHGANRLGS
CCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCEEEEEEECCCCCCC
NSLIDLVVFGRAAALRLAEKLTPNGKQPDLPKDSADKALSRLDHYRYASGGTPTAKLRES
CCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHH
MQHVMQTNCAVFRTGEVLQEGHNLIHKVYGGIGDIAVSDRSLVWNSDLIETLEFDNLIAQ
HHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCHHHHHHHHHHHHHH
AVVTMDSAVNRTESRGAHAREDFPDRDDKNWMKHTLAWIDNKDGKTTIDYRPVHNYTMTN
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEEECCCCCEECC
DVQYIPPKARVY
CEEECCCCCCCC
>Mature Secondary Structure 
AGGANGSANGAPATNGKAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFP
CCCCCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHCC
TRSHTVAAQGGISASLGNMHQDDWRWHMYDTVKGSDWLGDQDAIEYMVRNAPDAVYELEH
CCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHEEHHH
WGVPFSRTEDGKIYQRPFGGMTMDYGKGQAQRTCAAADRTGHAMLHTMYGQSLRHAAEFF
CCCCCCCCCCCCEEECCCCCCEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IEFFAIDLIMDDQGTCRGVIAIKLDDGTLHRFRAQTTILATGGYGRAYASCTSAHTCTGD
HHHHHEEEEECCCCCEEEEEEEEECCCCEEEEEEEEEEEEECCCCCHHHHCCCCCEECCC
GGGMALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAK
CCCEEEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHH
DLASRDVVSRAMTIEIREGRGVGKKKDHIFLHLDHLDPKVLAERLPGISESAKIFANVDV
HHHHHHHHHHEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCEEEEECCC
TREPIPIVPTVHYNMGGIPTNYHAEVLTKKDGDDNAIVPGLMAVGEAACVSVHGANRLGS
CCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCEEEEEEECCCCCCC
NSLIDLVVFGRAAALRLAEKLTPNGKQPDLPKDSADKALSRLDHYRYASGGTPTAKLRES
CCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHH
MQHVMQTNCAVFRTGEVLQEGHNLIHKVYGGIGDIAVSDRSLVWNSDLIETLEFDNLIAQ
HHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCHHHHHHHHHHHHHH
AVVTMDSAVNRTESRGAHAREDFPDRDDKNWMKHTLAWIDNKDGKTTIDYRPVHNYTMTN
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEEECCCCCEECC
DVQYIPPKARVY
CEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA