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The map label for this gene is mutM [H]

Identifier: 146337247

GI number: 146337247

Start: 83514

End: 84395

Strand: Reverse

Name: mutM [H]

Synonym: BRADO0074

Alternate gene names: 146337247

Gene position: 84395-83514 (Counterclockwise)

Preceding gene: 146337260

Following gene: 146337246

Centisome position: 1.13

GC content: 66.21

Gene sequence:

>882_bases
ATGCCTGAACTGCCCGAAGTCGAGACCGTCCGGCGCGGGCTGCAGCCGGTCATGGAGGGAGCCAAGATCGTGACCGCGGA
GGCGCGGCGCGGCGACTTGCGGTTTCCGTTTCAACCCGATTTTGTGAAGCGCTTGCAGGGGCAGACCGTCAGAGGGCTCG
GCCGCCGCGCCAAATATCTGCTGGCCGATCTCGGCTCCGGCGACGTGCTGCTGATGCATCTGGGCATGTCCGGCTCGTTC
CGGGTGATCAAGCCCGAGCACGAGGAAACCCCGGGCGAGTTTCACTATCCGCGCGGCAAGGACAGCGTCCACGACCATGT
CGTGTTTCACATGTCTTCCGGCGCCGACATCGTTTTCAACGACCCGCGCCGCTTCGGCTTCATGAAGATCATCGGCCGCG
GCGAGATCGAGACCGAGCCGCACCTCAAGGACCTCGGGCCGGAGCCGCTCGGCAACGAATTCGATGCCGCCATGCTGGCG
CGCGCCTGTGCCGGCAAGAAGACCAGCCTCAAGGCCGCGTTGCTCGACCAGCGCGTGGTCGCCGGGCTCGGCAACATCTA
TGTCTGCGAGGCGCTGTTCCGCGCGCATCTGTCGCCGCGCCGTCTGGCCGCGACGCTGGCGACCAGGAAGGGCGAGCCGA
CGGACCATGCAAAGCGGCTGGTTGAGGCGATCCACACCGTGCTCAACGAGGCGATCCGCGCCGGCGGCTCGTCGCTGCGC
GATCACCGCCAGACCACTGGCGAGCTCGGCTATTTCCAGCACTCGTTCCAGGTCTATGACCGAGAGGGCGAGCCGTGCCG
CACGGATGGCTGCGAGGGCGTCGTCAAGCGCTTCGTGCAGAACGGACGATCGACGTTCTGGTGCCCGAAGTGTCAGAGAT
GA

Upstream 100 bases:

>100_bases
TACTCCGATACGGCACCATAGCGCCGGTGCGGCCAAGGCGCTATCACGTCGGCCGGACAAGGTGAATGGTCGCAGGACGC
AAAAGGTGAAATGAACGGAC

Downstream 100 bases:

>100_bases
GCGAACGGCGCTCCGCCCGGGTCTGCTTGTGACGGCCGGGCTCGGGCGTATACTGCCGTTATGGCTGTCAGCTCGCCCGA
CCTGAAAGCATTTCTGCTCG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPELPEVETVRRGLQPVMEGAKIVTAEARRGDLRFPFQPDFVKRLQGQTVRGLGRRAKYLLADLGSGDVLLMHLGMSGSF
RVIKPEHEETPGEFHYPRGKDSVHDHVVFHMSSGADIVFNDPRRFGFMKIIGRGEIETEPHLKDLGPEPLGNEFDAAMLA
RACAGKKTSLKAALLDQRVVAGLGNIYVCEALFRAHLSPRRLAATLATRKGEPTDHAKRLVEAIHTVLNEAIRAGGSSLR
DHRQTTGELGYFQHSFQVYDREGEPCRTDGCEGVVKRFVQNGRSTFWCPKCQR

Sequences:

>Translated_293_residues
MPELPEVETVRRGLQPVMEGAKIVTAEARRGDLRFPFQPDFVKRLQGQTVRGLGRRAKYLLADLGSGDVLLMHLGMSGSF
RVIKPEHEETPGEFHYPRGKDSVHDHVVFHMSSGADIVFNDPRRFGFMKIIGRGEIETEPHLKDLGPEPLGNEFDAAMLA
RACAGKKTSLKAALLDQRVVAGLGNIYVCEALFRAHLSPRRLAATLATRKGEPTDHAKRLVEAIHTVLNEAIRAGGSSLR
DHRQTTGELGYFQHSFQVYDREGEPCRTDGCEGVVKRFVQNGRSTFWCPKCQR
>Mature_292_residues
PELPEVETVRRGLQPVMEGAKIVTAEARRGDLRFPFQPDFVKRLQGQTVRGLGRRAKYLLADLGSGDVLLMHLGMSGSFR
VIKPEHEETPGEFHYPRGKDSVHDHVVFHMSSGADIVFNDPRRFGFMKIIGRGEIETEPHLKDLGPEPLGNEFDAAMLAR
ACAGKKTSLKAALLDQRVVAGLGNIYVCEALFRAHLSPRRLAATLATRKGEPTDHAKRLVEAIHTVLNEAIRAGGSSLRD
HRQTTGELGYFQHSFQVYDREGEPCRTDGCEGVVKRFVQNGRSTFWCPKCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=293, Percent_Identity=43.3447098976109, Blast_Score=217, Evalue=7e-58,
Organism=Escherichia coli, GI1786932, Length=295, Percent_Identity=25.0847457627119, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 32670; Mature: 32539

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLQPVMEGAKIVTAEARRGDLRFPFQPDFVKRLQGQTVRGLGRRAKYL
CCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHH
LADLGSGDVLLMHLGMSGSFRVIKPEHEETPGEFHYPRGKDSVHDHVVFHMSSGADIVFN
HHCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEC
DPRRFGFMKIIGRGEIETEPHLKDLGPEPLGNEFDAAMLARACAGKKTSLKAALLDQRVV
CCCHHCHHHEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AGLGNIYVCEALFRAHLSPRRLAATLATRKGEPTDHAKRLVEAIHTVLNEAIRAGGSSLR
HHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
DHRQTTGELGYFQHSFQVYDREGEPCRTDGCEGVVKRFVQNGRSTFWCPKCQR
HHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLQPVMEGAKIVTAEARRGDLRFPFQPDFVKRLQGQTVRGLGRRAKYL
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHH
LADLGSGDVLLMHLGMSGSFRVIKPEHEETPGEFHYPRGKDSVHDHVVFHMSSGADIVFN
HHCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEC
DPRRFGFMKIIGRGEIETEPHLKDLGPEPLGNEFDAAMLARACAGKKTSLKAALLDQRVV
CCCHHCHHHEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AGLGNIYVCEALFRAHLSPRRLAATLATRKGEPTDHAKRLVEAIHTVLNEAIRAGGSSLR
HHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
DHRQTTGELGYFQHSFQVYDREGEPCRTDGCEGVVKRFVQNGRSTFWCPKCQR
HHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA