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The map label for this gene is mip [H]

Identifier: 146301650

GI number: 146301650

Start: 4658339

End: 4658965

Strand: Direct

Name: mip [H]

Synonym: Fjoh_3911

Alternate gene names: 146301650

Gene position: 4658339-4658965 (Clockwise)

Preceding gene: 146301649

Following gene: 146301651

Centisome position: 76.41

GC content: 35.41

Gene sequence:

>627_bases
ATGGACATTTTAGAACTATTAGGACACATTGGTAAAACCGAAGAAAAAGATAAAATTTCGTATTCAGCTGGAGTTGTAAT
GGCTCTAAGTCTGAAAGATATTGGATTTGAAGAAATAAAATATGAAGATTATGTAGACGGAATGAAATCAGTTTTTGATA
AATCCGGAGAAAAAATTTCGCCAAAACGCTCTATTGATATTTTCAACAATTATGTGGCATTGCTGCAGGAAGAATTAAAA
GTTAAAAATGCCGAAATAGGAACTGCTTTTCTGGCTAAAAATGCCTCAAAAGAAGGTATTACTGTATTGTCAAGCGGTTT
GCAATATGAAGTTTTAACCGAAGGAAACGGCAGAAAACCAAAAATAACTGATACCGTAAATGTAATTTATGAAGGTTATT
TGATAAATAAAGATGTCTTTGATTCAACCAAAGATACAGGCCCTCAAAAAATGAGAGTATTGCAGACCATAAAAGGCTGG
CAGGAAGCACTGCAGTTAATGCCCGAAGGTTCGCGCTGGAAAATTTATATCCCGCATGATTTGGCTTACGCCGAAATGGG
AGCGCCGCCGATCATTCAGCCCAACTCTACTTTAGTATTCATTATAGAACTTTTAAATATCGTTTAA

Upstream 100 bases:

>100_bases
GCCAAATTACAAATTGCATTTTCATGAAACACTTTCTCCAAATGATGAAAATATTTCATTTGGACAACTCAATTATTATT
TACATCTAAAAAAATAAATT

Downstream 100 bases:

>100_bases
AATGAAATACCTGTCTGAATATCGAAATCCGGAACTGGTTAAACACTACATAAGTGAAATCCATAAAATAACCACAAAAC
CATGGAATATCATGGAAATT

Product: FKBP type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MDILELLGHIGKTEEKDKISYSAGVVMALSLKDIGFEEIKYEDYVDGMKSVFDKSGEKISPKRSIDIFNNYVALLQEELK
VKNAEIGTAFLAKNASKEGITVLSSGLQYEVLTEGNGRKPKITDTVNVIYEGYLINKDVFDSTKDTGPQKMRVLQTIKGW
QEALQLMPEGSRWKIYIPHDLAYAEMGAPPIIQPNSTLVFIIELLNIV

Sequences:

>Translated_208_residues
MDILELLGHIGKTEEKDKISYSAGVVMALSLKDIGFEEIKYEDYVDGMKSVFDKSGEKISPKRSIDIFNNYVALLQEELK
VKNAEIGTAFLAKNASKEGITVLSSGLQYEVLTEGNGRKPKITDTVNVIYEGYLINKDVFDSTKDTGPQKMRVLQTIKGW
QEALQLMPEGSRWKIYIPHDLAYAEMGAPPIIQPNSTLVFIIELLNIV
>Mature_208_residues
MDILELLGHIGKTEEKDKISYSAGVVMALSLKDIGFEEIKYEDYVDGMKSVFDKSGEKISPKRSIDIFNNYVALLQEELK
VKNAEIGTAFLAKNASKEGITVLSSGLQYEVLTEGNGRKPKITDTVNVIYEGYLINKDVFDSTKDTGPQKMRVLQTIKGW
QEALQLMPEGSRWKIYIPHDLAYAEMGAPPIIQPNSTLVFIIELLNIV

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=40.5660377358491, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=40.5660377358491, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=40.5660377358491, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI87082390, Length=200, Percent_Identity=38, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1789745, Length=126, Percent_Identity=41.2698412698413, Blast_Score=84, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=39.622641509434, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 23263; Mature: 23263

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILELLGHIGKTEEKDKISYSAGVVMALSLKDIGFEEIKYEDYVDGMKSVFDKSGEKIS
CCHHHHHHHCCCCCCHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PKRSIDIFNNYVALLQEELKVKNAEIGTAFLAKNASKEGITVLSSGLQYEVLTEGNGRKP
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHEECCCCEEEEEECCCCCCC
KITDTVNVIYEGYLINKDVFDSTKDTGPQKMRVLQTIKGWQEALQLMPEGSRWKIYIPHD
CHHHHHHHEEECEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
LAYAEMGAPPIIQPNSTLVFIIELLNIV
HHHHHCCCCCEECCCCHHHHHHHHHHHC
>Mature Secondary Structure
MDILELLGHIGKTEEKDKISYSAGVVMALSLKDIGFEEIKYEDYVDGMKSVFDKSGEKIS
CCHHHHHHHCCCCCCHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PKRSIDIFNNYVALLQEELKVKNAEIGTAFLAKNASKEGITVLSSGLQYEVLTEGNGRKP
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHEECCCCEEEEEECCCCCCC
KITDTVNVIYEGYLINKDVFDSTKDTGPQKMRVLQTIKGWQEALQLMPEGSRWKIYIPHD
CHHHHHHHEEECEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
LAYAEMGAPPIIQPNSTLVFIIELLNIV
HHHHHCCCCCEECCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7516906 [H]