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The map label for this gene is ipdC [H]

Identifier: 146301575

GI number: 146301575

Start: 4545089

End: 4546849

Strand: Direct

Name: ipdC [H]

Synonym: Fjoh_3836

Alternate gene names: 146301575

Gene position: 4545089-4546849 (Clockwise)

Preceding gene: 146301574

Following gene: 146301577

Centisome position: 74.55

GC content: 39.52

Gene sequence:

>1761_bases
ATGGGACAGAAAAAAATATCCGTTGCAAAATACCTGCAGATACGTCTTGAACAATTAGGATTAACACATTTATTTGGGAT
TGCAGGCAATTATACTGCACCCTTTTTAAATACAATTCACGAAGATAAAAATGCGAAAATTAAAATCGTTAACGACACAA
ATGAAATAAATGCCGGACACTGTACTGATGCCTATGCACGTCAAAACGGTTTCGCTGCAGTAGCGGTAACCTATGGCGTA
GGCGCATTTACACTGCTTAATTCAGTTGCAGGTTCTTATGTAGAGCATTGTCCCGTGCTTGTTATTAATGGAGGGCCTAC
CAACAAAGACCAGCAGCGAAGCCTGGTTCAGGGTATGCTGGCATCACATATGACGGGAGACATGTATAGTAATATCAATG
TTTTTCGAAACGTTACCGTTGCAGCAGAACAAATTACGGGTTCATCTGATGCTCCTTACAAAATTGATTCCGTACTGAAT
GCCTGTATTTTATATGGAAGACCGGTTTATCTAGAAGTTTTTGAAGATGCCTGGCGAATGGAATGCAATCCGCCTGACGC
TCCATTAGCAGAAAGAGAAGTATCTAAATGTCAATCAAGTGCACGCAAGGCTGCTAAAAGAGTAGCTGCAATGGCACAGG
GCAAAGAAATTATTTTCTGGGGAGGAATTGAGATCCAGCGCTATGGTATTCAAAAAGAATTTTTGGATTTGATTGAAACA
ACCGATACAGAATTTGTGACCTCAATACTTGGAAAATCAATTGTGTCGGAAAACCATCCTAAGTTCAAAGGCGTTTTTAA
CGGTAAGGCATCGCCAAAAGATGTCAAGGAAAAATTCGAAAAAGCCCAGCTTAAAATCGGCCTTGGCGTATGGACCACAG
GCAAAAACCTGGGTGGTTTTGATGTTTGGAAAGATGATACTGTACTTGCCAATCACAGCGGTGTAAGGATTGGCGCCTCT
TACATCGCCAATGTATCGTTGCGGGATTTTATGATATTTCTAAAAGAAGAACTTACTAAAGTTAAATTTAGTGCTTATGA
AATGTATGACGCAGAACAGCTGCCTGAATCATTTTTTGTAGCGGATCAAAGCATTAGAAAAAATGCGAAACCAACGCTTA
CTTATGATACCTTTTTCAAACGGATCAATACTTTTATTGACGAAAGGCATATAGTAGTGGCAGATGCCGGTTTTCCTTTA
TTGGGTGCACAGGGAATTCGTATTGCAGAACCAAATGGATTTGTAGCGCAGGCATCATGGCTTTCGATAGGTTATTCCGT
TCCCGCCGCCACCGGAATAAAATGTGCCAGACCAGATAAAAGACCCGTAGTATTTGTTGGAGACGGTGCTTTTCAGGAAA
CATGCCAAGCTATATCTACACAGAATAAACTAAAACACGATACGGTTGTATTTGTTTTGGATAATGGAATTTATGGTATT
GAACAAATGCTTGTTAATCCAAATCCTTTTCGCGGTGCAGAAAAGGTTGAATACAGCATTCCCGATCTAAACGATATTTA
TGATTACAACCAGATGCACCGTTGGAAATATGCAAAACTTGTTGATGTATTTGGAGGCAGAGGTTTTGAAGTCAGCACTC
TCGACGAACTTAACGAAGTTTTAAAACATCTTGAGAACATTAAAGAAAATACTATCGTTCATGTAAACATTCCTAAAACA
TCTATTCCTGAATCAATTGCTTATAAGACAGAGGAGCCTGGAGAAGATGAATTTCTGGATAAAGACTGGAGTTTATGTTA
A

Upstream 100 bases:

>100_bases
TCTCTGAAACATGCCTGGATTGAAGGTGCAATTGAATCTGGAATCCGCACCGCGCTTGAAGTCAACGAAAATACTGGTAA
CCTTAATAACCCGATTTAAG

Downstream 100 bases:

>100_bases
TTTCAAAATAGGCACATTTTAAAATTATTCAACCGGCAGAAACATACTTTTTACCGAATGAACTTAATACATTTTCTGCC
GCAAAAGCTAAGGCGAATTT

Product: thiamine pyrophosphate binding domain-containing protein

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MGQKKISVAKYLQIRLEQLGLTHLFGIAGNYTAPFLNTIHEDKNAKIKIVNDTNEINAGHCTDAYARQNGFAAVAVTYGV
GAFTLLNSVAGSYVEHCPVLVINGGPTNKDQQRSLVQGMLASHMTGDMYSNINVFRNVTVAAEQITGSSDAPYKIDSVLN
ACILYGRPVYLEVFEDAWRMECNPPDAPLAEREVSKCQSSARKAAKRVAAMAQGKEIIFWGGIEIQRYGIQKEFLDLIET
TDTEFVTSILGKSIVSENHPKFKGVFNGKASPKDVKEKFEKAQLKIGLGVWTTGKNLGGFDVWKDDTVLANHSGVRIGAS
YIANVSLRDFMIFLKEELTKVKFSAYEMYDAEQLPESFFVADQSIRKNAKPTLTYDTFFKRINTFIDERHIVVADAGFPL
LGAQGIRIAEPNGFVAQASWLSIGYSVPAATGIKCARPDKRPVVFVGDGAFQETCQAISTQNKLKHDTVVFVLDNGIYGI
EQMLVNPNPFRGAEKVEYSIPDLNDIYDYNQMHRWKYAKLVDVFGGRGFEVSTLDELNEVLKHLENIKENTIVHVNIPKT
SIPESIAYKTEEPGEDEFLDKDWSLC

Sequences:

>Translated_586_residues
MGQKKISVAKYLQIRLEQLGLTHLFGIAGNYTAPFLNTIHEDKNAKIKIVNDTNEINAGHCTDAYARQNGFAAVAVTYGV
GAFTLLNSVAGSYVEHCPVLVINGGPTNKDQQRSLVQGMLASHMTGDMYSNINVFRNVTVAAEQITGSSDAPYKIDSVLN
ACILYGRPVYLEVFEDAWRMECNPPDAPLAEREVSKCQSSARKAAKRVAAMAQGKEIIFWGGIEIQRYGIQKEFLDLIET
TDTEFVTSILGKSIVSENHPKFKGVFNGKASPKDVKEKFEKAQLKIGLGVWTTGKNLGGFDVWKDDTVLANHSGVRIGAS
YIANVSLRDFMIFLKEELTKVKFSAYEMYDAEQLPESFFVADQSIRKNAKPTLTYDTFFKRINTFIDERHIVVADAGFPL
LGAQGIRIAEPNGFVAQASWLSIGYSVPAATGIKCARPDKRPVVFVGDGAFQETCQAISTQNKLKHDTVVFVLDNGIYGI
EQMLVNPNPFRGAEKVEYSIPDLNDIYDYNQMHRWKYAKLVDVFGGRGFEVSTLDELNEVLKHLENIKENTIVHVNIPKT
SIPESIAYKTEEPGEDEFLDKDWSLC
>Mature_585_residues
GQKKISVAKYLQIRLEQLGLTHLFGIAGNYTAPFLNTIHEDKNAKIKIVNDTNEINAGHCTDAYARQNGFAAVAVTYGVG
AFTLLNSVAGSYVEHCPVLVINGGPTNKDQQRSLVQGMLASHMTGDMYSNINVFRNVTVAAEQITGSSDAPYKIDSVLNA
CILYGRPVYLEVFEDAWRMECNPPDAPLAEREVSKCQSSARKAAKRVAAMAQGKEIIFWGGIEIQRYGIQKEFLDLIETT
DTEFVTSILGKSIVSENHPKFKGVFNGKASPKDVKEKFEKAQLKIGLGVWTTGKNLGGFDVWKDDTVLANHSGVRIGASY
IANVSLRDFMIFLKEELTKVKFSAYEMYDAEQLPESFFVADQSIRKNAKPTLTYDTFFKRINTFIDERHIVVADAGFPLL
GAQGIRIAEPNGFVAQASWLSIGYSVPAATGIKCARPDKRPVVFVGDGAFQETCQAISTQNKLKHDTVVFVLDNGIYGIE
QMLVNPNPFRGAEKVEYSIPDLNDIYDYNQMHRWKYAKLVDVFGGRGFEVSTLDELNEVLKHLENIKENTIVHVNIPKTS
IPESIAYKTEEPGEDEFLDKDWSLC

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321524, Length=590, Percent_Identity=26.271186440678, Blast_Score=184, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6323163, Length=596, Percent_Identity=26.006711409396, Blast_Score=180, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6323073, Length=590, Percent_Identity=25.9322033898305, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6320123, Length=593, Percent_Identity=23.2715008431703, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320588, Length=571, Percent_Identity=23.9929947460595, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 65140; Mature: 65009

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQKKISVAKYLQIRLEQLGLTHLFGIAGNYTAPFLNTIHEDKNAKIKIVNDTNEINAGH
CCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCC
CTDAYARQNGFAAVAVTYGVGAFTLLNSVAGSYVEHCPVLVINGGPTNKDQQRSLVQGML
CCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
ASHMTGDMYSNINVFRNVTVAAEQITGSSDAPYKIDSVLNACILYGRPVYLEVFEDAWRM
HHHHCCHHHHCCHHHHEEEEEHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCC
ECNPPDAPLAEREVSKCQSSARKAAKRVAAMAQGKEIIFWGGIEIQRYGIQKEFLDLIET
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHHHHHHHC
TDTEFVTSILGKSIVSENHPKFKGVFNGKASPKDVKEKFEKAQLKIGLGVWTTGKNLGGF
CCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCC
DVWKDDTVLANHSGVRIGASYIANVSLRDFMIFLKEELTKVKFSAYEMYDAEQLPESFFV
CCCCCCEEEECCCCCEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHH
ADQSIRKNAKPTLTYDTFFKRINTFIDERHIVVADAGFPLLGAQGIRIAEPNGFVAQASW
CCHHHHCCCCCCEEHHHHHHHHHHHHCCCEEEEEECCCCEECCCCEEEECCCCCEEEEHH
LSIGYSVPAATGIKCARPDKRPVVFVGDGAFQETCQAISTQNKLKHDTVVFVLDNGIYGI
EEECCCCCCCCCCEECCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHH
EQMLVNPNPFRGAEKVEYSIPDLNDIYDYNQMHRWKYAKLVDVFGGRGFEVSTLDELNEV
HHHHCCCCCCCCCCEEEECCCCCHHHHCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
LKHLENIKENTIVHVNIPKTSIPESIAYKTEEPGEDEFLDKDWSLC
HHHHHHHHHCCEEEEECCCCCCCHHHCCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
GQKKISVAKYLQIRLEQLGLTHLFGIAGNYTAPFLNTIHEDKNAKIKIVNDTNEINAGH
CCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCC
CTDAYARQNGFAAVAVTYGVGAFTLLNSVAGSYVEHCPVLVINGGPTNKDQQRSLVQGML
CCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
ASHMTGDMYSNINVFRNVTVAAEQITGSSDAPYKIDSVLNACILYGRPVYLEVFEDAWRM
HHHHCCHHHHCCHHHHEEEEEHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCC
ECNPPDAPLAEREVSKCQSSARKAAKRVAAMAQGKEIIFWGGIEIQRYGIQKEFLDLIET
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHHHHHHHC
TDTEFVTSILGKSIVSENHPKFKGVFNGKASPKDVKEKFEKAQLKIGLGVWTTGKNLGGF
CCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCC
DVWKDDTVLANHSGVRIGASYIANVSLRDFMIFLKEELTKVKFSAYEMYDAEQLPESFFV
CCCCCCEEEECCCCCEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHH
ADQSIRKNAKPTLTYDTFFKRINTFIDERHIVVADAGFPLLGAQGIRIAEPNGFVAQASW
CCHHHHCCCCCCEEHHHHHHHHHHHHCCCEEEEEECCCCEECCCCEEEECCCCCEEEEHH
LSIGYSVPAATGIKCARPDKRPVVFVGDGAFQETCQAISTQNKLKHDTVVFVLDNGIYGI
EEECCCCCCCCCCEECCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHH
EQMLVNPNPFRGAEKVEYSIPDLNDIYDYNQMHRWKYAKLVDVFGGRGFEVSTLDELNEV
HHHHCCCCCCCCCCEEEECCCCCHHHHCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
LKHLENIKENTIVHVNIPKTSIPESIAYKTEEPGEDEFLDKDWSLC
HHHHHHHHHCCEEEEECCCCCCCHHHCCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]