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The map label for this gene is hemA2

Identifier: 146301493

GI number: 146301493

Start: 4450052

End: 4451356

Strand: Reverse

Name: hemA2

Synonym: Fjoh_3752

Alternate gene names: 146301493

Gene position: 4451356-4450052 (Counterclockwise)

Preceding gene: 146301494

Following gene: 146301492

Centisome position: 73.01

GC content: 36.17

Gene sequence:

>1305_bases
ATGGAAAATTTTAATATGCCCAGATCTACGACTTTTTACGCATTAGGATTAAGTTACAAGAAAGCAGATGCAGTTATAAG
AGGAAAATTTAGTTTAGATGCCCAGGCACAATCTGATTTATTGCTGCAGGCTAAGGCAGAAGGCATAGAATCATTGGTTG
TTACCTCTACCTGCAATAGAACTGAAATTTATGGTTTTGCCCATCATCCTTATGAACTTATCAAACTGCTTTGCGAAAAC
AGCAATGGCTCCATAGAAGAATTTCAGCAGGCTGCTTATATATATAAGAATGAAGAAGCTGTCAGCCATATGTTCCGGGT
AGGAACAGGTTTGGACAGTCAGATTTTGGGTGATTTTGAAATCATCAGCCAGATTAAAACCGCTTTTAACAATAGTAAAC
AGGAAGGCTTGGTCAATACATTTCTGGACCGGTTGGTAAATACAGTTATTCAAGCCAGCAAAAAAGTTAAAACTGAGACG
AAAATTTCTTCCGGGGCAACGTCAGTTTCTTTTGCATCAGTGCAGTATATAATCCGAAATGTGGCAGATATTGGAAGCAA
AAATATTTTGTTATTCGGAACAGGGAAAATAGGAAGAAATACGTGCGAAAACTTAGTAAAACATACTAAAAACAGTCATA
TTACTCTTATAAACAGAACAAAAAACAAAGCCGAATTATTGGCTGGCAAGCTGAATGTTATTGTAAAAGATTATGCTGAT
TTAAAACAAGAACTGCACCAAGCCGATGTGCTGGTTGTAGCTACAGGAGCACAAAATCCGACTATTGACAAAGCATCGCT
TGCTTTACAGAAACCCTTATTGATTCTGGATTTATCCATCCCGCGCAATGTAGATGCCAATGTAGAAGAAATACCCGGTG
TAACTTTAATACATCTGGATGCATTATCTCAAATTACGGATGACACGCTGGAAAGAAGAAAACAGCATATACCTGCTGCA
GAAGCCATTATTGATGATATGAAATTAGAACTGAATACCTGGGTAAACGGCCGAAAATGTGCTCCGACTATTCATGCATT
AAAATCCAAGCTAAATGATATTGTATCTGCCGAATTTGCTTTTCAAAAAAAGAAAATAACCCATTTTGATGATGCTCAGA
TGGATTTAATAAGTTCCAGAATTATTCAAAAATTGACAAACCATTTTGCCAGCCATTTAAAAAATGAAAACACTTCAGTG
GATCAAAGTATTGAATTTATTGAAAAAATATTTCAGATCGGACAGCTTGCACCCAATAAGACTTCTTCACCAATAGCTGA
TAAATACAAAATCAATCTCTCATAA

Upstream 100 bases:

>100_bases
GTTTAAATCCATTTATCCCATAGTGATCAAAAAGCACTTCCGGCGCTGTTATATAAATCTGCAGTTACTAATTTTTGAAC
TTTTTAAGGAAACCATAAAT

Downstream 100 bases:

>100_bases
ATACATAATTTACTATTAAATCGGAATAGTAAGTCCAGATATGATGAATTACGTTTTTTGAGTGGGCACAAAATAAAAAA
TGAATTTCGGAATATGGAAA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR 2

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MENFNMPRSTTFYALGLSYKKADAVIRGKFSLDAQAQSDLLLQAKAEGIESLVVTSTCNRTEIYGFAHHPYELIKLLCEN
SNGSIEEFQQAAYIYKNEEAVSHMFRVGTGLDSQILGDFEIISQIKTAFNNSKQEGLVNTFLDRLVNTVIQASKKVKTET
KISSGATSVSFASVQYIIRNVADIGSKNILLFGTGKIGRNTCENLVKHTKNSHITLINRTKNKAELLAGKLNVIVKDYAD
LKQELHQADVLVVATGAQNPTIDKASLALQKPLLILDLSIPRNVDANVEEIPGVTLIHLDALSQITDDTLERRKQHIPAA
EAIIDDMKLELNTWVNGRKCAPTIHALKSKLNDIVSAEFAFQKKKITHFDDAQMDLISSRIIQKLTNHFASHLKNENTSV
DQSIEFIEKIFQIGQLAPNKTSSPIADKYKINLS

Sequences:

>Translated_434_residues
MENFNMPRSTTFYALGLSYKKADAVIRGKFSLDAQAQSDLLLQAKAEGIESLVVTSTCNRTEIYGFAHHPYELIKLLCEN
SNGSIEEFQQAAYIYKNEEAVSHMFRVGTGLDSQILGDFEIISQIKTAFNNSKQEGLVNTFLDRLVNTVIQASKKVKTET
KISSGATSVSFASVQYIIRNVADIGSKNILLFGTGKIGRNTCENLVKHTKNSHITLINRTKNKAELLAGKLNVIVKDYAD
LKQELHQADVLVVATGAQNPTIDKASLALQKPLLILDLSIPRNVDANVEEIPGVTLIHLDALSQITDDTLERRKQHIPAA
EAIIDDMKLELNTWVNGRKCAPTIHALKSKLNDIVSAEFAFQKKKITHFDDAQMDLISSRIIQKLTNHFASHLKNENTSV
DQSIEFIEKIFQIGQLAPNKTSSPIADKYKINLS
>Mature_434_residues
MENFNMPRSTTFYALGLSYKKADAVIRGKFSLDAQAQSDLLLQAKAEGIESLVVTSTCNRTEIYGFAHHPYELIKLLCEN
SNGSIEEFQQAAYIYKNEEAVSHMFRVGTGLDSQILGDFEIISQIKTAFNNSKQEGLVNTFLDRLVNTVIQASKKVKTET
KISSGATSVSFASVQYIIRNVADIGSKNILLFGTGKIGRNTCENLVKHTKNSHITLINRTKNKAELLAGKLNVIVKDYAD
LKQELHQADVLVVATGAQNPTIDKASLALQKPLLILDLSIPRNVDANVEEIPGVTLIHLDALSQITDDTLERRKQHIPAA
EAIIDDMKLELNTWVNGRKCAPTIHALKSKLNDIVSAEFAFQKKKITHFDDAQMDLISSRIIQKLTNHFASHLKNENTSV
DQSIEFIEKIFQIGQLAPNKTSSPIADKYKINLS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=393, Percent_Identity=29.7709923664122, Blast_Score=159, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM12_FLAJ1 (A5FDF9)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001196084.1
- ProteinModelPortal:   A5FDF9
- SMR:   A5FDF9
- STRING:   A5FDF9
- GeneID:   5089786
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_3752
- eggNOG:   COG0373
- HOGENOM:   HBG479062
- OMA:   EVRPEHF
- ProtClustDB:   CLSK851822
- BioCyc:   FJOH376686:FJOH_3752-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48168; Mature: 48168

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 58-58 BINDING 113-113 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFNMPRSTTFYALGLSYKKADAVIRGKFSLDAQAQSDLLLQAKAEGIESLVVTSTCNR
CCCCCCCCCCEEEEEECCHHHHCCEEEECCCCCCCCCHHHHHHHHHHCHHEEEEECCCCC
TEIYGFAHHPYELIKLLCENSNGSIEEFQQAAYIYKNEEAVSHMFRVGTGLDSQILGDFE
CEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHH
IISQIKTAFNNSKQEGLVNTFLDRLVNTVIQASKKVKTETKISSGATSVSFASVQYIIRN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VADIGSKNILLFGTGKIGRNTCENLVKHTKNSHITLINRTKNKAELLAGKLNVIVKDYAD
HHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
LKQELHQADVLVVATGAQNPTIDKASLALQKPLLILDLSIPRNVDANVEEIPGVTLIHLD
HHHHHHHCCEEEEEECCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCHHHCCCEEEEEHH
ALSQITDDTLERRKQHIPAAEAIIDDMKLELNTWVNGRKCAPTIHALKSKLNDIVSAEFA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FQKKKITHFDDAQMDLISSRIIQKLTNHFASHLKNENTSVDQSIEFIEKIFQIGQLAPNK
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
TSSPIADKYKINLS
CCCCCCCCEEEECC
>Mature Secondary Structure
MENFNMPRSTTFYALGLSYKKADAVIRGKFSLDAQAQSDLLLQAKAEGIESLVVTSTCNR
CCCCCCCCCCEEEEEECCHHHHCCEEEECCCCCCCCCHHHHHHHHHHCHHEEEEECCCCC
TEIYGFAHHPYELIKLLCENSNGSIEEFQQAAYIYKNEEAVSHMFRVGTGLDSQILGDFE
CEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHH
IISQIKTAFNNSKQEGLVNTFLDRLVNTVIQASKKVKTETKISSGATSVSFASVQYIIRN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VADIGSKNILLFGTGKIGRNTCENLVKHTKNSHITLINRTKNKAELLAGKLNVIVKDYAD
HHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
LKQELHQADVLVVATGAQNPTIDKASLALQKPLLILDLSIPRNVDANVEEIPGVTLIHLD
HHHHHHHCCEEEEEECCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCHHHCCCEEEEEHH
ALSQITDDTLERRKQHIPAAEAIIDDMKLELNTWVNGRKCAPTIHALKSKLNDIVSAEFA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FQKKKITHFDDAQMDLISSRIIQKLTNHFASHLKNENTSVDQSIEFIEKIFQIGQLAPNK
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
TSSPIADKYKINLS
CCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA