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The map label for this gene is aroP [H]

Identifier: 146300892

GI number: 146300892

Start: 3740919

End: 3742343

Strand: Reverse

Name: aroP [H]

Synonym: Fjoh_3147

Alternate gene names: 146300892

Gene position: 3742343-3740919 (Counterclockwise)

Preceding gene: 146300914

Following gene: 146300891

Centisome position: 61.38

GC content: 36.07

Gene sequence:

>1425_bases
GTGAAAAAAAATCATGATGCCGTAGAAGAAACTCAGCTTAAACGCGGGCTGACTAACCGACACATTCAGTTAATTGCCTT
AGGCGGATCTATAGGAACAGGTCTTTTCCTGGGCATTGGTCCGGCGGCCGTATTGGCAGGACCTTCGGTTATTTTAGGAT
ATGCTATTGCCGGAATTATCGCTTTCTTTATTATGAGACAGCTTGGCGAAATGGTTGTCGAAGAACCTGTATCTGGAAGT
TTTAGTTATTTTGCCTATAAATACTGCGGTTCTTTTGCGGGTTTTGCATCGGGTTGGAATTATTGGATTTTGTATATTCT
TGTTAGTATGGCCGAACTAACAGCCATTGGGGTTTATGTACAGTTTTGGTGGCCCGAAATTCCGCTTTGGGCATCCAGTT
TGTTTTTCTTTTTGGTTATTAATGCTTTAAATTTTGCCTCGGTAAAAGTGTACGGAGAAACAGAATTTTGGTTCTCAATT
ATAAAAGTTGTCGCCATTATTGCCATGATTCTTTTTGGTACTTATTTATTAATAAGCGGTACAGGAGGAGAGCACGCCAG
TATTCATAATTTGTATAATGATGGAGGTTTTTTTCCAAAAGGAGTTTTTGAAAAAACAGCAGCAGGGGATTTTCAGGGAT
TATTGTCGGCAATGGCTTTGATTATGTTTTCTTTTGGCGGTTTAGAACTTATTGGAATTACCGCTGCAGAAGCAGAAAAT
CCAGAAAAAAACATTCCAAAAGCAACCAATCAGGTTATTTACAGAATCCTTATATTTTATGTTGGTGCATTGGTTATTTT
GTTTGCTTTGTCGCCGTGGAGACAAATTACAACAGACAGCAGTCCGTTTGTAATGGTTTTTCAAAACTTAAACGGAATGG
AGTTTGAACTTTTTGGAAACAAAATATTTTTTACAAGCCTTATCGCAAATGTCCTTAACTTAATTGTATTAACTGCCGCT
TTATCTGTATACAACAGCAGTGTGTACAGCAACTCCAGAATGTTATTTGGTTTAGCAGATCAGGGCAGTGCTCCTAAGTT
TTTAAAGAAGCTGAACAAACAATCAGTGCCGGTTAATGCTATTTTAGTTTCTTCATGCTTTGCGGCTGTTTGTATTTTAA
TAAATAAAGTAATTCCAGAAGAAGCTTTTAGTATTTTAATGTCTTTAGTAGTGTCTTGTTTGGTTATTAACTGGGTTATG
ATTTCGTATACGCACCTGCAGTTTAGACGTGCCAAAGACAAGGAAAACACAAAAACAAAATTTGCTTCTATATTTTATCC
GGTAAGTAATTATATCTGTTTCATATTTTTATTGGGAATTTTATCCATCATGTGGATGACGAATATGAAGATATCTGTAG
AATTAATTCCTATTTGGCTGTTGATTCTTTTTGTGTTTTATAAGGTTTTTAAAAAGAAGGAATAG

Upstream 100 bases:

>100_bases
GACAGATGAGACAGAAAGAAGTTTGTACGATTCCTTTTTTAACTTATCTTCGCTGTTTATACATTTTTTGAATACATTTA
AATACCTTAAAATCTAATCT

Downstream 100 bases:

>100_bases
TTATAACGTTTTTAACCATAAACCAACAGTGAAAGAATTTATCAAAAGAATATTCAGAAAATCAACATCAGAAAAACTTC
CAAATATTAAAATCGAATTA

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKKNHDAVEETQLKRGLTNRHIQLIALGGSIGTGLFLGIGPAAVLAGPSVILGYAIAGIIAFFIMRQLGEMVVEEPVSGS
FSYFAYKYCGSFAGFASGWNYWILYILVSMAELTAIGVYVQFWWPEIPLWASSLFFFLVINALNFASVKVYGETEFWFSI
IKVVAIIAMILFGTYLLISGTGGEHASIHNLYNDGGFFPKGVFEKTAAGDFQGLLSAMALIMFSFGGLELIGITAAEAEN
PEKNIPKATNQVIYRILIFYVGALVILFALSPWRQITTDSSPFVMVFQNLNGMEFELFGNKIFFTSLIANVLNLIVLTAA
LSVYNSSVYSNSRMLFGLADQGSAPKFLKKLNKQSVPVNAILVSSCFAAVCILINKVIPEEAFSILMSLVVSCLVINWVM
ISYTHLQFRRAKDKENTKTKFASIFYPVSNYICFIFLLGILSIMWMTNMKISVELIPIWLLILFVFYKVFKKKE

Sequences:

>Translated_474_residues
MKKNHDAVEETQLKRGLTNRHIQLIALGGSIGTGLFLGIGPAAVLAGPSVILGYAIAGIIAFFIMRQLGEMVVEEPVSGS
FSYFAYKYCGSFAGFASGWNYWILYILVSMAELTAIGVYVQFWWPEIPLWASSLFFFLVINALNFASVKVYGETEFWFSI
IKVVAIIAMILFGTYLLISGTGGEHASIHNLYNDGGFFPKGVFEKTAAGDFQGLLSAMALIMFSFGGLELIGITAAEAEN
PEKNIPKATNQVIYRILIFYVGALVILFALSPWRQITTDSSPFVMVFQNLNGMEFELFGNKIFFTSLIANVLNLIVLTAA
LSVYNSSVYSNSRMLFGLADQGSAPKFLKKLNKQSVPVNAILVSSCFAAVCILINKVIPEEAFSILMSLVVSCLVINWVM
ISYTHLQFRRAKDKENTKTKFASIFYPVSNYICFIFLLGILSIMWMTNMKISVELIPIWLLILFVFYKVFKKKE
>Mature_474_residues
MKKNHDAVEETQLKRGLTNRHIQLIALGGSIGTGLFLGIGPAAVLAGPSVILGYAIAGIIAFFIMRQLGEMVVEEPVSGS
FSYFAYKYCGSFAGFASGWNYWILYILVSMAELTAIGVYVQFWWPEIPLWASSLFFFLVINALNFASVKVYGETEFWFSI
IKVVAIIAMILFGTYLLISGTGGEHASIHNLYNDGGFFPKGVFEKTAAGDFQGLLSAMALIMFSFGGLELIGITAAEAEN
PEKNIPKATNQVIYRILIFYVGALVILFALSPWRQITTDSSPFVMVFQNLNGMEFELFGNKIFFTSLIANVLNLIVLTAA
LSVYNSSVYSNSRMLFGLADQGSAPKFLKKLNKQSVPVNAILVSSCFAAVCILINKVIPEEAFSILMSLVVSCLVINWVM
ISYTHLQFRRAKDKENTKTKFASIFYPVSNYICFIFLLGILSIMWMTNMKISVELIPIWLLILFVFYKVFKKKE

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=304, Percent_Identity=25.3289473684211, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI258645169, Length=451, Percent_Identity=22.3946784922395, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI258614005, Length=452, Percent_Identity=22.3451327433628, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI258614003, Length=452, Percent_Identity=22.3451327433628, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786302, Length=463, Percent_Identity=62.2030237580993, Blast_Score=589, Evalue=1e-169,
Organism=Escherichia coli, GI1786789, Length=466, Percent_Identity=56.2231759656652, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI48994972, Length=469, Percent_Identity=39.6588486140725, Blast_Score=330, Evalue=9e-92,
Organism=Escherichia coli, GI1786602, Length=472, Percent_Identity=40.0423728813559, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1790653, Length=483, Percent_Identity=36.4389233954451, Blast_Score=318, Evalue=7e-88,
Organism=Escherichia coli, GI87081915, Length=428, Percent_Identity=35.0467289719626, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788480, Length=450, Percent_Identity=34.8888888888889, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1789017, Length=439, Percent_Identity=34.1685649202733, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=31.9634703196347, Blast_Score=240, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17540018, Length=419, Percent_Identity=23.8663484486874, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17533459, Length=448, Percent_Identity=24.5535714285714, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=419, Percent_Identity=33.4128878281623, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6324061, Length=411, Percent_Identity=32.360097323601, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324059, Length=432, Percent_Identity=33.3333333333333, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6322892, Length=413, Percent_Identity=31.4769975786925, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=434, Percent_Identity=32.258064516129, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321053, Length=422, Percent_Identity=29.6208530805687, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324924, Length=423, Percent_Identity=31.2056737588652, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319824, Length=491, Percent_Identity=27.9022403258656, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=424, Percent_Identity=29.4811320754717, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=428, Percent_Identity=30.607476635514, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320717, Length=504, Percent_Identity=26.1904761904762, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6319608, Length=422, Percent_Identity=29.6208530805687, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320251, Length=421, Percent_Identity=28.5035629453682, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=421, Percent_Identity=27.3159144893112, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=421, Percent_Identity=26.603325415677, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322967, Length=418, Percent_Identity=27.2727272727273, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=427, Percent_Identity=28.8056206088993, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=503, Percent_Identity=26.2425447316103, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24666159, Length=443, Percent_Identity=21.2189616252822, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221512776, Length=443, Percent_Identity=21.2189616252822, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24668806, Length=455, Percent_Identity=21.978021978022, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356285, Length=455, Percent_Identity=21.978021978022, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668802, Length=455, Percent_Identity=21.978021978022, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667468, Length=395, Percent_Identity=24.0506329113924, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52703; Mature: 52703

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNHDAVEETQLKRGLTNRHIQLIALGGSIGTGLFLGIGPAAVLAGPSVILGYAIAGII
CCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCHHHHHCCHHHHHHHHHHHHH
AFFIMRQLGEMVVEEPVSGSFSYFAYKYCGSFAGFASGWNYWILYILVSMAELTAIGVYV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEE
QFWWPEIPLWASSLFFFLVINALNFASVKVYGETEFWFSIIKVVAIIAMILFGTYLLISG
EEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEC
TGGEHASIHNLYNDGGFFPKGVFEKTAAGDFQGLLSAMALIMFSFGGLELIGITAAEAEN
CCCCCCHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
PEKNIPKATNQVIYRILIFYVGALVILFALSPWRQITTDSSPFVMVFQNLNGMEFELFGN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEECCCCCEEEEECC
KIFFTSLIANVLNLIVLTAALSVYNSSVYSNSRMLFGLADQGSAPKFLKKLNKQSVPVNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCHHH
ILVSSCFAAVCILINKVIPEEAFSILMSLVVSCLVINWVMISYTHLQFRRAKDKENTKTK
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
FASIFYPVSNYICFIFLLGILSIMWMTNMKISVELIPIWLLILFVFYKVFKKKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKNHDAVEETQLKRGLTNRHIQLIALGGSIGTGLFLGIGPAAVLAGPSVILGYAIAGII
CCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCHHHHHCCHHHHHHHHHHHHH
AFFIMRQLGEMVVEEPVSGSFSYFAYKYCGSFAGFASGWNYWILYILVSMAELTAIGVYV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEE
QFWWPEIPLWASSLFFFLVINALNFASVKVYGETEFWFSIIKVVAIIAMILFGTYLLISG
EEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEC
TGGEHASIHNLYNDGGFFPKGVFEKTAAGDFQGLLSAMALIMFSFGGLELIGITAAEAEN
CCCCCCHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
PEKNIPKATNQVIYRILIFYVGALVILFALSPWRQITTDSSPFVMVFQNLNGMEFELFGN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEECCCCCEEEEECC
KIFFTSLIANVLNLIVLTAALSVYNSSVYSNSRMLFGLADQGSAPKFLKKLNKQSVPVNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCHHH
ILVSSCFAAVCILINKVIPEEAFSILMSLVVSCLVINWVMISYTHLQFRRAKDKENTKTK
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
FASIFYPVSNYICFIFLLGILSIMWMTNMKISVELIPIWLLILFVFYKVFKKKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]