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The map label for this gene is aslA [H]

Identifier: 146300887

GI number: 146300887

Start: 3731528

End: 3733102

Strand: Reverse

Name: aslA [H]

Synonym: Fjoh_3142

Alternate gene names: 146300887

Gene position: 3733102-3731528 (Counterclockwise)

Preceding gene: 146300888

Following gene: 146300884

Centisome position: 61.23

GC content: 38.48

Gene sequence:

>1575_bases
ATGAGAAAGTATATTGTTTTATTAGCTTTAGCTTTAGTTGCTGAAATGAGCGCACAGCAAAACTATTTTAACCCAACGGT
TAAAGTAAAAGACTATTTAGAGCCTGCAATTCCGCATCCAGATCAGGATAAAGAAATGAAGGATAAATTGAGCAAATTAA
AGAAGAAACCGAATATCCTGATTATTCTTATTGATGATATGGGTTACGGAGATATTGGTGTTTATGGCGGAGGCGTCGCG
ATTGGTGCGCCAACTCCAAACATGGATAAACTGGCTCATGAAGGTTTACAGCTTACTTCAACCTATGCACAGCCAACTTG
TACACCAAGCCGTGCAGCAATTATGACGGGAAGAATTCCGGCAAGATCAGGTTTGACAAGACCAACACTTACAGGTGAAA
ATCCGAAAGTAAATCCGTGGGCTTCAGAAAATACAACGGCTAAAATACTTTCTCAAAACGGTTATAAATCGGCTATTTCA
GGTAAATGGCATTTGGGCGAAAGTAAAGGAAGTCTGCCAAACGAAGTTGGTTATGATGAATGGCTGGGATTTGGTTCTGT
TCAGTCAGAATACGCACAGTTTGTTAATGAGTGGATTTATCCAGATTTAATCAATAAACCAGATCGATTGGCTGCAGTGA
AAAAAATGGTAGACCAAAATATCTTAACTGGTGTAAAGGGAGGAGAAAACAAGGTTGTACAGCCTATATCAAATATTGAA
GAACTTTCTAAAGTCGATCAGGTTTTTGCAAACTACAGCGAAGATTTCATCAAACGTTCGGTAAAAGAAAATAAGCCTTT
CTATTTAATTCATTCTTTTTCTAAAGTGCATAATGACAACTATGTATCTGAAGGTTATAAAGGAAAAAGCCCTGCAGCAA
TTCCGTATAAAGATGCTATTGTTGAAGTAGATGACATTGTGGGCAGACTGATGAAACTTTTGCAGGACTTAAAAATTGAC
GACAATACATTAGTATTCCTTACTTCTGACAACGGTCCAAATGAAGATGTTTGGCCAGATGGCGGTTATACACCCTTTAG
AGGAGGAAAAGGCACAACTTGGGAAGGTGGAGTTAGAGTTCCGGGAATTGCTTACTGGAAAGGCATGATAGCTCCGGGAC
GTATAAGCGATGGTTTGTTTGATATTTGCGATATGTTTAATACTTCTCTTTCGGCAGCAGGAGTTTTAGATAAAATTCCT
TCAAGTAATTATATTGATGGAGTAGATCAGTTATCGTTTTTCTTGTCAGACAAAGGAGTGTCGAATCGAAATGCCGTTTT
TATGTATTCAGAAACCAAATTTATGGCTATTCGCTGGCAGGAATACAAAGTACACATGAATGTTTTTAATACTTCGGCGA
CAAGAAGAAATCTGGACCAATCGACTATTCAAAGTATTGGGATGAGTCCGTGGGTATACAATATTTACGCAGACCCAAAA
GAACAATTGAGTCAGGGACACCGTTATTTTGAGTGGGGAATCCCAGGCGTAATGGGACTTATTGCAGCTCACTTAGCTAC
TTATCAAAAATATCCAATGAAAGATATTGGTTTGAAAAAACCGGGTGCTGAGTAA

Upstream 100 bases:

>100_bases
TTCGTATAAGCTTCCATTTAAGTTTACGGGAATTATTGATAAGGTCGAGATTGACTTGAAATAATTGTGAATTAAAAATT
TTAGCATAAATCAAAGAATT

Downstream 100 bases:

>100_bases
TGATTTATAAAATTATTTAGTAAGTATGAAAACAGAAAACTCCTTTTTATACAGGGCAGTTTTCTGTTTTTATTTTGAAT
GGCTATCTCTTTTAGTTATA

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MRKYIVLLALALVAEMSAQQNYFNPTVKVKDYLEPAIPHPDQDKEMKDKLSKLKKKPNILIILIDDMGYGDIGVYGGGVA
IGAPTPNMDKLAHEGLQLTSTYAQPTCTPSRAAIMTGRIPARSGLTRPTLTGENPKVNPWASENTTAKILSQNGYKSAIS
GKWHLGESKGSLPNEVGYDEWLGFGSVQSEYAQFVNEWIYPDLINKPDRLAAVKKMVDQNILTGVKGGENKVVQPISNIE
ELSKVDQVFANYSEDFIKRSVKENKPFYLIHSFSKVHNDNYVSEGYKGKSPAAIPYKDAIVEVDDIVGRLMKLLQDLKID
DNTLVFLTSDNGPNEDVWPDGGYTPFRGGKGTTWEGGVRVPGIAYWKGMIAPGRISDGLFDICDMFNTSLSAAGVLDKIP
SSNYIDGVDQLSFFLSDKGVSNRNAVFMYSETKFMAIRWQEYKVHMNVFNTSATRRNLDQSTIQSIGMSPWVYNIYADPK
EQLSQGHRYFEWGIPGVMGLIAAHLATYQKYPMKDIGLKKPGAE

Sequences:

>Translated_524_residues
MRKYIVLLALALVAEMSAQQNYFNPTVKVKDYLEPAIPHPDQDKEMKDKLSKLKKKPNILIILIDDMGYGDIGVYGGGVA
IGAPTPNMDKLAHEGLQLTSTYAQPTCTPSRAAIMTGRIPARSGLTRPTLTGENPKVNPWASENTTAKILSQNGYKSAIS
GKWHLGESKGSLPNEVGYDEWLGFGSVQSEYAQFVNEWIYPDLINKPDRLAAVKKMVDQNILTGVKGGENKVVQPISNIE
ELSKVDQVFANYSEDFIKRSVKENKPFYLIHSFSKVHNDNYVSEGYKGKSPAAIPYKDAIVEVDDIVGRLMKLLQDLKID
DNTLVFLTSDNGPNEDVWPDGGYTPFRGGKGTTWEGGVRVPGIAYWKGMIAPGRISDGLFDICDMFNTSLSAAGVLDKIP
SSNYIDGVDQLSFFLSDKGVSNRNAVFMYSETKFMAIRWQEYKVHMNVFNTSATRRNLDQSTIQSIGMSPWVYNIYADPK
EQLSQGHRYFEWGIPGVMGLIAAHLATYQKYPMKDIGLKKPGAE
>Mature_524_residues
MRKYIVLLALALVAEMSAQQNYFNPTVKVKDYLEPAIPHPDQDKEMKDKLSKLKKKPNILIILIDDMGYGDIGVYGGGVA
IGAPTPNMDKLAHEGLQLTSTYAQPTCTPSRAAIMTGRIPARSGLTRPTLTGENPKVNPWASENTTAKILSQNGYKSAIS
GKWHLGESKGSLPNEVGYDEWLGFGSVQSEYAQFVNEWIYPDLINKPDRLAAVKKMVDQNILTGVKGGENKVVQPISNIE
ELSKVDQVFANYSEDFIKRSVKENKPFYLIHSFSKVHNDNYVSEGYKGKSPAAIPYKDAIVEVDDIVGRLMKLLQDLKID
DNTLVFLTSDNGPNEDVWPDGGYTPFRGGKGTTWEGGVRVPGIAYWKGMIAPGRISDGLFDICDMFNTSLSAAGVLDKIP
SSNYIDGVDQLSFFLSDKGVSNRNAVFMYSETKFMAIRWQEYKVHMNVFNTSATRRNLDQSTIQSIGMSPWVYNIYADPK
EQLSQGHRYFEWGIPGVMGLIAAHLATYQKYPMKDIGLKKPGAE

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=456, Percent_Identity=33.7719298245614, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI146229331, Length=449, Percent_Identity=30.7349665924276, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI146229329, Length=449, Percent_Identity=30.7349665924276, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI6005990, Length=449, Percent_Identity=30.7349665924276, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI146229324, Length=449, Percent_Identity=30.7349665924276, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI45430057, Length=477, Percent_Identity=29.3501048218029, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI157266309, Length=512, Percent_Identity=27.9296875, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI146229327, Length=360, Percent_Identity=27.7777777777778, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI31742482, Length=513, Percent_Identity=25.5360623781676, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI71852584, Length=456, Percent_Identity=27.1929824561404, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI58743319, Length=444, Percent_Identity=27.9279279279279, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI59797060, Length=494, Percent_Identity=25.5060728744939, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI109389362, Length=522, Percent_Identity=24.7126436781609, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI38569407, Length=345, Percent_Identity=26.6666666666667, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI38569405, Length=311, Percent_Identity=27.3311897106109, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI53831991, Length=215, Percent_Identity=31.6279069767442, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI71852586, Length=143, Percent_Identity=40.5594405594406, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1790233, Length=508, Percent_Identity=38.7795275590551, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI87081924, Length=433, Percent_Identity=27.2517321016166, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790112, Length=230, Percent_Identity=25.2173913043478, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533416, Length=418, Percent_Identity=27.9904306220096, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI115533418, Length=410, Percent_Identity=27.3170731707317, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17559078, Length=275, Percent_Identity=29.4545454545455, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24666109, Length=382, Percent_Identity=29.5811518324607, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI281363223, Length=395, Percent_Identity=28.3544303797468, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24666175, Length=373, Percent_Identity=28.4182305630027, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI281366397, Length=354, Percent_Identity=27.4011299435028, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI281366395, Length=354, Percent_Identity=27.4011299435028, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24666163, Length=354, Percent_Identity=27.4011299435028, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 58201; Mature: 58201

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKYIVLLALALVAEMSAQQNYFNPTVKVKDYLEPAIPHPDQDKEMKDKLSKLKKKPNIL
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEE
IILIDDMGYGDIGVYGGGVAIGAPTPNMDKLAHEGLQLTSTYAQPTCTPSRAAIMTGRIP
EEEECCCCCCCEEEECCCEEECCCCCCHHHHHHCCCEEEECCCCCCCCCCCCEEEECCCC
ARSGLTRPTLTGENPKVNPWASENTTAKILSQNGYKSAISGKWHLGESKGSLPNEVGYDE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCCCEEECCCCCCCCCCCCHHH
WLGFGSVQSEYAQFVNEWIYPDLINKPDRLAAVKKMVDQNILTGVKGGENKVVQPISNIE
HHCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
ELSKVDQVFANYSEDFIKRSVKENKPFYLIHSFSKVHNDNYVSEGYKGKSPAAIPYKDAI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCHHCCCCCCCCCCCCHHHHH
VEVDDIVGRLMKLLQDLKIDDNTLVFLTSDNGPNEDVWPDGGYTPFRGGKGTTWEGGVRV
EEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGIAYWKGMIAPGRISDGLFDICDMFNTSLSAAGVLDKIPSSNYIDGVDQLSFFLSDKGV
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
SNRNAVFMYSETKFMAIRWQEYKVHMNVFNTSATRRNLDQSTIQSIGMSPWVYNIYADPK
CCCCEEEEEECCEEEEEEEEEEEEEEEEECCCHHHHCCCHHHHHHCCCCCEEEEEECCCH
EQLSQGHRYFEWGIPGVMGLIAAHLATYQKYPMKDIGLKKPGAE
HHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCC
>Mature Secondary Structure
MRKYIVLLALALVAEMSAQQNYFNPTVKVKDYLEPAIPHPDQDKEMKDKLSKLKKKPNIL
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEE
IILIDDMGYGDIGVYGGGVAIGAPTPNMDKLAHEGLQLTSTYAQPTCTPSRAAIMTGRIP
EEEECCCCCCCEEEECCCEEECCCCCCHHHHHHCCCEEEECCCCCCCCCCCCEEEECCCC
ARSGLTRPTLTGENPKVNPWASENTTAKILSQNGYKSAISGKWHLGESKGSLPNEVGYDE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCCCEEECCCCCCCCCCCCHHH
WLGFGSVQSEYAQFVNEWIYPDLINKPDRLAAVKKMVDQNILTGVKGGENKVVQPISNIE
HHCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
ELSKVDQVFANYSEDFIKRSVKENKPFYLIHSFSKVHNDNYVSEGYKGKSPAAIPYKDAI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCHHCCCCCCCCCCCCHHHHH
VEVDDIVGRLMKLLQDLKIDDNTLVFLTSDNGPNEDVWPDGGYTPFRGGKGTTWEGGVRV
EEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGIAYWKGMIAPGRISDGLFDICDMFNTSLSAAGVLDKIPSSNYIDGVDQLSFFLSDKGV
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
SNRNAVFMYSETKFMAIRWQEYKVHMNVFNTSATRRNLDQSTIQSIGMSPWVYNIYADPK
CCCCEEEEEECCEEEEEEEEEEEEEEEEECCCHHHHCCCHHHHHHCCCCCEEEEEECCCH
EQLSQGHRYFEWGIPGVMGLIAAHLATYQKYPMKDIGLKKPGAE
HHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]