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The map label for this gene is mhpC [C]

Identifier: 146300850

GI number: 146300850

Start: 3673586

End: 3674461

Strand: Direct

Name: mhpC [C]

Synonym: Fjoh_3105

Alternate gene names: 146300850

Gene position: 3673586-3674461 (Clockwise)

Preceding gene: 146300849

Following gene: 146300853

Centisome position: 60.25

GC content: 35.62

Gene sequence:

>876_bases
ATGAATCTTTACAACGACGAATCTTTAATACAGCAGATACCCGGTTTTAAAAATAACTATACTACAGTAAATGGAGTCAA
TTTGCACTATGTAACGGGAGGACAAGGCAGTCCATTAGTCTTAATTCCGGGATGGCCGCAAACTTGGTGGAGTTATCGTA
AAATTATGCCCATTTTAGCAGAAAAGCACAGCCTTATTGTTGTTGATTTACGAGGAATGGGTTCATCGGAAAAACCTTTA
GACGGCTACACTAAAAAAAATATGGCCCAGGATATTCAATTGTTAATTGCACATTTGGGATACAAAAAAATAAATATTGC
AGGTCATGATATTGGAGCTGCAGTTGCTTTTAGTTATGCTGCTAACTTTCCTGAAAATACAGATAAACTTATCATTTTAG
ATACTCCGCACCCCGACGAAAACATATACAAACTGCCAATGATGCCTATTGGAAATCCTGTATTTCCTTGGTGGCTTGCT
TTTAACCAAGTAAAACAACTACCCGAAGAATTGCTGGAAGGACGTTATGATATATTGCAAAATTATATCTTTAATCACCT
TTTGATTGACCCCGAAGCAATTAATGAGTTTGACAGAAAAGTCTATGCTGAGGCCTATAACAATAAAGATGCAATAAGAA
GCTCTAATGGCTGGTACCAAGCCTTTACTGAAGACATTCAGGATATCAAACAATACAAAAAAGTCCAAATCCCTGCCATA
GGAATTGGAAGTCAGGAAGGAGCAAAAATGCTTAGTTATTTCTTTTCTGTTTATCTTGAAAATTTTAGCATAGAAGAAAT
AGAAAATTCCGGTCACTTTATACATGAAGAAAAACCGGAGCTTACAGCGTTACTGATAAATAATTTTTTAATCTAA

Upstream 100 bases:

>100_bases
TGGATTTCTTTGAAAGGAGGTATTAGTTTAAATAGATAAGAACTGTAATTAAATCCAGACTTAATTTCTACGGATATAAC
GAATAAATAAAAAAGCAAAA

Downstream 100 bases:

>100_bases
AAATCTTAATCATCTAATGTCAAAACTATGCAAGCCCGCAGGAATAACATGTGGGCTTGCATAATCTACAATATTTGGTT
TAAAATCTGCTTCAAGTTAC

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: SEH; Cytosolic epoxide hydrolase; cEH; Epoxide hydratase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MNLYNDESLIQQIPGFKNNYTTVNGVNLHYVTGGQGSPLVLIPGWPQTWWSYRKIMPILAEKHSLIVVDLRGMGSSEKPL
DGYTKKNMAQDIQLLIAHLGYKKINIAGHDIGAAVAFSYAANFPENTDKLIILDTPHPDENIYKLPMMPIGNPVFPWWLA
FNQVKQLPEELLEGRYDILQNYIFNHLLIDPEAINEFDRKVYAEAYNNKDAIRSSNGWYQAFTEDIQDIKQYKKVQIPAI
GIGSQEGAKMLSYFFSVYLENFSIEEIENSGHFIHEEKPELTALLINNFLI

Sequences:

>Translated_291_residues
MNLYNDESLIQQIPGFKNNYTTVNGVNLHYVTGGQGSPLVLIPGWPQTWWSYRKIMPILAEKHSLIVVDLRGMGSSEKPL
DGYTKKNMAQDIQLLIAHLGYKKINIAGHDIGAAVAFSYAANFPENTDKLIILDTPHPDENIYKLPMMPIGNPVFPWWLA
FNQVKQLPEELLEGRYDILQNYIFNHLLIDPEAINEFDRKVYAEAYNNKDAIRSSNGWYQAFTEDIQDIKQYKKVQIPAI
GIGSQEGAKMLSYFFSVYLENFSIEEIENSGHFIHEEKPELTALLINNFLI
>Mature_291_residues
MNLYNDESLIQQIPGFKNNYTTVNGVNLHYVTGGQGSPLVLIPGWPQTWWSYRKIMPILAEKHSLIVVDLRGMGSSEKPL
DGYTKKNMAQDIQLLIAHLGYKKINIAGHDIGAAVAFSYAANFPENTDKLIILDTPHPDENIYKLPMMPIGNPVFPWWLA
FNQVKQLPEELLEGRYDILQNYIFNHLLIDPEAINEFDRKVYAEAYNNKDAIRSSNGWYQAFTEDIQDIKQYKKVQIPAI
GIGSQEGAKMLSYFFSVYLENFSIEEIENSGHFIHEEKPELTALLINNFLI

Specific function: Involved in catabolic degradation of epoxides. Shows highest activity towards C6 and C7 carbocyclic epoxides. Also active towards linear 1,2-epoxyalkanes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=282, Percent_Identity=23.758865248227, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI27597073, Length=305, Percent_Identity=23.6065573770492, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI218777840, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI13376164, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI18777795, Length=104, Percent_Identity=31.7307692307692, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17554012, Length=292, Percent_Identity=27.3972602739726, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562298, Length=290, Percent_Identity=18.9655172413793, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639
- InterPro:   IPR010497 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF06441 EHN [H]

EC number: =3.3.2.10 [H]

Molecular weight: Translated: 33271; Mature: 33271

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLYNDESLIQQIPGFKNNYTTVNGVNLHYVTGGQGSPLVLIPGWPQTWWSYRKIMPILA
CCCCCHHHHHHHCCCCCCCCEEECCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHH
EKHSLIVVDLRGMGSSEKPLDGYTKKNMAQDIQLLIAHLGYKKINIAGHDIGAAVAFSYA
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
ANFPENTDKLIILDTPHPDENIYKLPMMPIGNPVFPWWLAFNQVKQLPEELLEGRYDILQ
CCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NYIFNHLLIDPEAINEFDRKVYAEAYNNKDAIRSSNGWYQAFTEDIQDIKQYKKVQIPAI
HHHHHHHEECHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEE
GIGSQEGAKMLSYFFSVYLENFSIEEIENSGHFIHEEKPELTALLINNFLI
ECCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNLYNDESLIQQIPGFKNNYTTVNGVNLHYVTGGQGSPLVLIPGWPQTWWSYRKIMPILA
CCCCCHHHHHHHCCCCCCCCEEECCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHH
EKHSLIVVDLRGMGSSEKPLDGYTKKNMAQDIQLLIAHLGYKKINIAGHDIGAAVAFSYA
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
ANFPENTDKLIILDTPHPDENIYKLPMMPIGNPVFPWWLAFNQVKQLPEELLEGRYDILQ
CCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NYIFNHLLIDPEAINEFDRKVYAEAYNNKDAIRSSNGWYQAFTEDIQDIKQYKKVQIPAI
HHHHHHHEECHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEE
GIGSQEGAKMLSYFFSVYLENFSIEEIENSGHFIHEEKPELTALLINNFLI
ECCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9578475 [H]