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The map label for this gene is ung

Identifier: 146300661

GI number: 146300661

Start: 3454130

End: 3454795

Strand: Reverse

Name: ung

Synonym: Fjoh_2912

Alternate gene names: 146300661

Gene position: 3454795-3454130 (Counterclockwise)

Preceding gene: 146300665

Following gene: 146300654

Centisome position: 56.67

GC content: 34.53

Gene sequence:

>666_bases
ATGGACGTAAAAATGCATTCTTCTTGGAAACCAATTCTAAATGAAGAATTTCAAAAACCATATTTCAGCGAATTAATTTC
TTTTGTAAAATCAGAATATACCACTAAGGTTTGTTATCCAAAGGGAAATCAGATTTTTTCTGCTTTTGATCATTGTCATT
TTGATGAAGTAAAAGTGGTTATCATTGGGCAGGATCCTTATCACGGACCAAATCAGGCAAATGGTTTATGTTTTTCTGTA
AATGACGGAATTCCTTTTCCTCCTTCTTTGCATAATATTTTTAAAGAAATCGAAACTGATTTGGGTAAACCAATGCCGTC
AACCGGTAATCTTGAGCGCTGGGCAGATCAGGGTGTATTTCTTTTAAATGCAACTTTAACGGTTAGGCAGTCTGAAGCAG
GAAGTCACCAGGGAAAAGGCTGGGAAAAATTTACAGATGCTGTTATTAAACAAATTTCTGCCGAAAAAGAAAATGTTGTT
TTTCTTCTATGGGGTGGATTTGCTCAAAAGAAAGCTGCTTTGATTGATTCATCAAAACATCATATTTTAAAATCCGGACA
TCCTTCGCCTTTAAGTGCAAACAGAGGTTTTTGGTTTGGAAACAAACATTTCAGCCAGACAAATGATTTCTTGAAATCAA
AAGGATTAAAACAAATTGAATGGTAA

Upstream 100 bases:

>100_bases
AAAAACATAATGATTGAATTCTACTAGTTCGTGTCTAAATTTTGTTATGTGTAAATATGATTTTAACTTATAATTTCTGA
TATTCGCTAAAAAAAATGTT

Downstream 100 bases:

>100_bases
ATGATTAGAGGTTCTTTTTTATTCTAATAATTAAGGACCTCAAATTTTTCACCTGATACTCTAAAAATACTTGGGTCTAC
TGTGCAGTTTTGGAGGATTT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MDVKMHSSWKPILNEEFQKPYFSELISFVKSEYTTKVCYPKGNQIFSAFDHCHFDEVKVVIIGQDPYHGPNQANGLCFSV
NDGIPFPPSLHNIFKEIETDLGKPMPSTGNLERWADQGVFLLNATLTVRQSEAGSHQGKGWEKFTDAVIKQISAEKENVV
FLLWGGFAQKKAALIDSSKHHILKSGHPSPLSANRGFWFGNKHFSQTNDFLKSKGLKQIEW

Sequences:

>Translated_221_residues
MDVKMHSSWKPILNEEFQKPYFSELISFVKSEYTTKVCYPKGNQIFSAFDHCHFDEVKVVIIGQDPYHGPNQANGLCFSV
NDGIPFPPSLHNIFKEIETDLGKPMPSTGNLERWADQGVFLLNATLTVRQSEAGSHQGKGWEKFTDAVIKQISAEKENVV
FLLWGGFAQKKAALIDSSKHHILKSGHPSPLSANRGFWFGNKHFSQTNDFLKSKGLKQIEW
>Mature_221_residues
MDVKMHSSWKPILNEEFQKPYFSELISFVKSEYTTKVCYPKGNQIFSAFDHCHFDEVKVVIIGQDPYHGPNQANGLCFSV
NDGIPFPPSLHNIFKEIETDLGKPMPSTGNLERWADQGVFLLNATLTVRQSEAGSHQGKGWEKFTDAVIKQISAEKENVV
FLLWGGFAQKKAALIDSSKHHILKSGHPSPLSANRGFWFGNKHFSQTNDFLKSKGLKQIEW

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=222, Percent_Identity=52.2522522522522, Blast_Score=237, Evalue=6e-63,
Organism=Homo sapiens, GI6224979, Length=222, Percent_Identity=52.2522522522522, Blast_Score=236, Evalue=9e-63,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=52.7777777777778, Blast_Score=222, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=53.4562211981567, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=234, Percent_Identity=44.4444444444444, Blast_Score=177, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_FLAJ1 (A5FFT1)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001195252.1
- ProteinModelPortal:   A5FFT1
- SMR:   A5FFT1
- STRING:   A5FFT1
- GeneID:   5092732
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_2912
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   MLWGNYA
- ProtClustDB:   PRK05254
- BioCyc:   FJOH376686:FJOH_2912-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24985; Mature: 24985

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKMHSSWKPILNEEFQKPYFSELISFVKSEYTTKVCYPKGNQIFSAFDHCHFDEVKVV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCEEEE
IIGQDPYHGPNQANGLCFSVNDGIPFPPSLHNIFKEIETDLGKPMPSTGNLERWADQGVF
EECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEE
LLNATLTVRQSEAGSHQGKGWEKFTDAVIKQISAEKENVVFLLWGGFAQKKAALIDSSKH
EEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCH
HILKSGHPSPLSANRGFWFGNKHFSQTNDFLKSKGLKQIEW
HHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDVKMHSSWKPILNEEFQKPYFSELISFVKSEYTTKVCYPKGNQIFSAFDHCHFDEVKVV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCEEEE
IIGQDPYHGPNQANGLCFSVNDGIPFPPSLHNIFKEIETDLGKPMPSTGNLERWADQGVF
EECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEE
LLNATLTVRQSEAGSHQGKGWEKFTDAVIKQISAEKENVVFLLWGGFAQKKAALIDSSKH
EEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCH
HILKSGHPSPLSANRGFWFGNKHFSQTNDFLKSKGLKQIEW
HHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA