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The map label for this gene is birA [C]

Identifier: 146300357

GI number: 146300357

Start: 3097172

End: 3097900

Strand: Direct

Name: birA [C]

Synonym: Fjoh_2602

Alternate gene names: 146300357

Gene position: 3097172-3097900 (Clockwise)

Preceding gene: 146300348

Following gene: 146300360

Centisome position: 50.8

GC content: 33.33

Gene sequence:

>729_bases
ATGAAACTAATCAAACTCGATGCCATAGATTCTACAAATGATTTCCTAAAATCAATGTCAAGTCAGGATGAACAGGAGAA
TTTTACAGTGGTAACGGCTGAAAATCAGACAAAAGGCAAGGGGCAAATGGGCGCTGTTTGGAAATCTGAAACCGGTAAAA
ACTTAATTATGAGTGTATTGGTAAAGGATTTTCTTTTTGATAATGAAAAGGTTTTTAACTTAAATATTATCGTTTCGTTA
TCTGTTTTAGAAGTTTTAAAATCTTTAAATATTCCTGATTTATGTATAAAATGGCCAAACGACATTATGTCATACAATAA
GAAAATTGGTGGCATACTTATAGAAAATACTCTAAAAAGTGATGGCAGAATCGTGTCAGTTGTCGGGATTGGGCTTAATG
TCAATCAAACCAATTATACTGAACTGCCAAATGCTTCTTCGCTGGCTGTAATTTCTGGGAAAACTTTTGATAAGAACGCT
TTGGTTGTTTCTATAGTTGAAAAAATGAAGGAAAAAATCGAATTATGGCAGACTAATACAGCAGCTTTTTGGGAAGATTA
TTTTAATTCACTTTTTAAAAAAGGAGTTCCAATGCCGTTTAAAAATCTCCAGAATACAAACTTTATGGGAATTATTCAGG
GCGTTTCTCCGGTAGGGAAACTGCAGGTTTTACTTGAAGATGATTCGGTTGCTGAGTTTGAGATTAAAGAGATTCAGATG
CTTTATTAA

Upstream 100 bases:

>100_bases
TTCGCCATGAATTATTTTATATGAATTTGTAAAGTTACCAAATTTTGTGATTATTTTTGAACCTTAACAAAATATTAAAT
TAAGATATTTAAATTATTTA

Downstream 100 bases:

>100_bases
GATGCTAAGGTTCTGAGATGCTAAGATTCTAAGGTGCTAAGGTTCTGAGTTTCTAAGATTCTAAGATTTTGAGTTTCTAA
GATGCTAAGGTTTCTACAGA

Product: biotin--acetyl-CoA-carboxylase ligase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MKLIKLDAIDSTNDFLKSMSSQDEQENFTVVTAENQTKGKGQMGAVWKSETGKNLIMSVLVKDFLFDNEKVFNLNIIVSL
SVLEVLKSLNIPDLCIKWPNDIMSYNKKIGGILIENTLKSDGRIVSVVGIGLNVNQTNYTELPNASSLAVISGKTFDKNA
LVVSIVEKMKEKIELWQTNTAAFWEDYFNSLFKKGVPMPFKNLQNTNFMGIIQGVSPVGKLQVLLEDDSVAEFEIKEIQM
LY

Sequences:

>Translated_242_residues
MKLIKLDAIDSTNDFLKSMSSQDEQENFTVVTAENQTKGKGQMGAVWKSETGKNLIMSVLVKDFLFDNEKVFNLNIIVSL
SVLEVLKSLNIPDLCIKWPNDIMSYNKKIGGILIENTLKSDGRIVSVVGIGLNVNQTNYTELPNASSLAVISGKTFDKNA
LVVSIVEKMKEKIELWQTNTAAFWEDYFNSLFKKGVPMPFKNLQNTNFMGIIQGVSPVGKLQVLLEDDSVAEFEIKEIQM
LY
>Mature_242_residues
MKLIKLDAIDSTNDFLKSMSSQDEQENFTVVTAENQTKGKGQMGAVWKSETGKNLIMSVLVKDFLFDNEKVFNLNIIVSL
SVLEVLKSLNIPDLCIKWPNDIMSYNKKIGGILIENTLKSDGRIVSVVGIGLNVNQTNYTELPNASSLAVISGKTFDKNA
LVVSIVEKMKEKIELWQTNTAAFWEDYFNSLFKKGVPMPFKNLQNTNFMGIIQGVSPVGKLQVLLEDDSVAEFEIKEIQM
LY

Specific function: Bira Acts Both As A Biotin-Operon Repressor And As The Enzyme That Synthesizes The Corepressor, Acetyl-CoA:Carbon- Dioxide Ligase. This Protein Also Activates Biotin To Form Biotinyl-5'-Adenylate And Transfers The Biotin Moiety To Biotin-Accepting Protei

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Homo sapiens, GI46255045, Length=139, Percent_Identity=33.0935251798561, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790408, Length=232, Percent_Identity=28.0172413793103, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004408
- InterPro:   IPR003142
- InterPro:   IPR004143 [H]

Pfam domain/function: PF02237 BPL_C; PF03099 BPL_LipA_LipB [H]

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 27100; Mature: 27100

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIKLDAIDSTNDFLKSMSSQDEQENFTVVTAENQTKGKGQMGAVWKSETGKNLIMSVL
CCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHH
VKDFLFDNEKVFNLNIIVSLSVLEVLKSLNIPDLCIKWPNDIMSYNKKIGGILIENTLKS
HHHHHCCCCEEEEEEEEEHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCEEEECCCCC
DGRIVSVVGIGLNVNQTNYTELPNASSLAVISGKTFDKNALVVSIVEKMKEKIELWQTNT
CCCEEEEEEECEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
AAFWEDYFNSLFKKGVPMPFKNLQNTNFMGIIQGVSPVGKLQVLLEDDSVAEFEIKEIQM
HHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEHEEEEE
LY
CC
>Mature Secondary Structure
MKLIKLDAIDSTNDFLKSMSSQDEQENFTVVTAENQTKGKGQMGAVWKSETGKNLIMSVL
CCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHH
VKDFLFDNEKVFNLNIIVSLSVLEVLKSLNIPDLCIKWPNDIMSYNKKIGGILIENTLKS
HHHHHCCCCEEEEEEEEEHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCEEEECCCCC
DGRIVSVVGIGLNVNQTNYTELPNASSLAVISGKTFDKNALVVSIVEKMKEKIELWQTNT
CCCEEEEEEECEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
AAFWEDYFNSLFKKGVPMPFKNLQNTNFMGIIQGVSPVGKLQVLLEDDSVAEFEIKEIQM
HHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEHEEEEE
LY
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]