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The map label for this gene is gcvT [H]

Identifier: 146300317

GI number: 146300317

Start: 3048321

End: 3049403

Strand: Reverse

Name: gcvT [H]

Synonym: Fjoh_2562

Alternate gene names: 146300317

Gene position: 3049403-3048321 (Counterclockwise)

Preceding gene: 146300321

Following gene: 146300316

Centisome position: 50.02

GC content: 37.21

Gene sequence:

>1083_bases
ATGAAAAATACTGCGCTTACGCACATACATGAGAGTCTGGGAGCGAAAATGCTGCCTTTTGCAGGTTATAACATGCCTAT
TACATACGAAGGTGTAAATGCTGAACATGAAACGGTTCGTAATGGTGTGGGAGTTTTTGATGTTTCGCACATGGGAGAAT
TTTTGCTGACTGGTCCTAATGCATTGGCATTGATTCAAAAAGTAACTTCAAATGATGCTTCGACGTTGACAATTGGAAGA
GCGCAATATTCTTGTCTGCCAAATAATGAAGGCGGAATCGTTGACGATTTGATTATTTATAAAATGAAAGAAGAGCAGTA
TTTGCTAGTTGTAAATGCTTCGAATATTGAAAAAGACTGGAACTGGATTTCTTCTTATAATGATTTGGGAGTTGAAATGA
GAAATCTTTCTGATGACTATTCTTTATTGGCAATTCAGGGACCAAAAGCAGTTGAAGCTATGCAGGCTTTAACTTCTGTA
GACTTGTCTGCAATTACGTATTACCATTTTGAGGTAGGCGATTTTGCCGGAATCGAACATGTAATTATTTCTGCTACAGG
TTATACTGGTTCTGGCGGATTTGAAATTTACTGTAAAAACAACGAAGTAGAACAAATCTGGAATAAAGTTTTTGAAGCTG
GAGCTGCTTACGGAATCAAACCTATTGGTCTTGCGGCACGTGACACTTTGCGTCTTGAAATGGGATTCTGTTTATACGGA
AATGATATTAACGATACTACTTCTCCACTTGAAGCTGGTCTAGGATGGATTACTAAATTCACCAAAGATTTTACAAACTC
TGAAGCTCTTAAAAAACAAAAAGAAGCTGGTGTTGCCAGAAAATTAATTGCTTTTGAAATGCAGGAGCGTGCGGTGCCAA
GACACGATTATGAAATTGTAGACGGTGAAGGAAATGTTATAGGAATTGTAACTTCTGGAACTATGTCGCCTTCTATGAAT
AAAGGGATTGGTTTAGGATATGTAACGGTGGCAAACAGTGCTGTTGACAGCGATATTTTTATTAGAATCAGAAAAAATGA
TGTTCCTGCTAAAGTGGTAAAATTACCTTTTTACAAGAAATAA

Upstream 100 bases:

>100_bases
GCAGGAAATAGCTCCTAATTATTGCGAAATTTATAATTTAAGGCATTCTAATTAGATATTTTTTGAATAGATTTGCAAAA
CAATTTTATAAAACAACACA

Downstream 100 bases:

>100_bases
TTTTTTAAACATATAATTTTCATAATGCATTACAAGTCAAATTGTAATGCATTTTTTTATGGCAGATTAATTCATTTTAA
AGTTAATTCTTTACATATTT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKNTALTHIHESLGAKMLPFAGYNMPITYEGVNAEHETVRNGVGVFDVSHMGEFLLTGPNALALIQKVTSNDASTLTIGR
AQYSCLPNNEGGIVDDLIIYKMKEEQYLLVVNASNIEKDWNWISSYNDLGVEMRNLSDDYSLLAIQGPKAVEAMQALTSV
DLSAITYYHFEVGDFAGIEHVIISATGYTGSGGFEIYCKNNEVEQIWNKVFEAGAAYGIKPIGLAARDTLRLEMGFCLYG
NDINDTTSPLEAGLGWITKFTKDFTNSEALKKQKEAGVARKLIAFEMQERAVPRHDYEIVDGEGNVIGIVTSGTMSPSMN
KGIGLGYVTVANSAVDSDIFIRIRKNDVPAKVVKLPFYKK

Sequences:

>Translated_360_residues
MKNTALTHIHESLGAKMLPFAGYNMPITYEGVNAEHETVRNGVGVFDVSHMGEFLLTGPNALALIQKVTSNDASTLTIGR
AQYSCLPNNEGGIVDDLIIYKMKEEQYLLVVNASNIEKDWNWISSYNDLGVEMRNLSDDYSLLAIQGPKAVEAMQALTSV
DLSAITYYHFEVGDFAGIEHVIISATGYTGSGGFEIYCKNNEVEQIWNKVFEAGAAYGIKPIGLAARDTLRLEMGFCLYG
NDINDTTSPLEAGLGWITKFTKDFTNSEALKKQKEAGVARKLIAFEMQERAVPRHDYEIVDGEGNVIGIVTSGTMSPSMN
KGIGLGYVTVANSAVDSDIFIRIRKNDVPAKVVKLPFYKK
>Mature_360_residues
MKNTALTHIHESLGAKMLPFAGYNMPITYEGVNAEHETVRNGVGVFDVSHMGEFLLTGPNALALIQKVTSNDASTLTIGR
AQYSCLPNNEGGIVDDLIIYKMKEEQYLLVVNASNIEKDWNWISSYNDLGVEMRNLSDDYSLLAIQGPKAVEAMQALTSV
DLSAITYYHFEVGDFAGIEHVIISATGYTGSGGFEIYCKNNEVEQIWNKVFEAGAAYGIKPIGLAARDTLRLEMGFCLYG
NDINDTTSPLEAGLGWITKFTKDFTNSEALKKQKEAGVARKLIAFEMQERAVPRHDYEIVDGEGNVIGIVTSGTMSPSMN
KGIGLGYVTVANSAVDSDIFIRIRKNDVPAKVVKLPFYKK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=370, Percent_Identity=32.1621621621622, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI257796258, Length=356, Percent_Identity=31.7415730337079, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI257796254, Length=362, Percent_Identity=29.8342541436464, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI257796256, Length=314, Percent_Identity=31.8471337579618, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=28.2738095238095, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI197927446, Length=327, Percent_Identity=26.2996941896024, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI21361378, Length=327, Percent_Identity=26.2996941896024, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI194306651, Length=318, Percent_Identity=27.0440251572327, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1789272, Length=371, Percent_Identity=36.6576819407008, Blast_Score=225, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17560118, Length=372, Percent_Identity=35.4838709677419, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32563613, Length=320, Percent_Identity=25, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71994045, Length=311, Percent_Identity=25.7234726688103, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71994052, Length=311, Percent_Identity=25.7234726688103, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320222, Length=384, Percent_Identity=32.8125, Blast_Score=193, Evalue=4e-50,
Organism=Drosophila melanogaster, GI20129441, Length=375, Percent_Identity=32.5333333333333, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI28571104, Length=328, Percent_Identity=25.9146341463415, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI20130091, Length=333, Percent_Identity=23.4234234234234, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39494; Mature: 39494

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTALTHIHESLGAKMLPFAGYNMPITYEGVNAEHETVRNGVGVFDVSHMGEFLLTGPN
CCCCHHHHHHHHHCCEECCCCCCCCCEEECCCCCHHHHHHCCCCEEEHHHCCCEEEECCC
ALALIQKVTSNDASTLTIGRAQYSCLPNNEGGIVDDLIIYKMKEEQYLLVVNASNIEKDW
HHHHHHHHHCCCCCEEEEECEEEEECCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCH
NWISSYNDLGVEMRNLSDDYSLLAIQGPKAVEAMQALTSVDLSAITYYHFEVGDFAGIEH
HHHHCCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEEEEECCCCCCCEE
VIISATGYTGSGGFEIYCKNNEVEQIWNKVFEAGAAYGIKPIGLAARDTLRLEMGFCLYG
EEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEEC
NDINDTTSPLEAGLGWITKFTKDFTNSEALKKQKEAGVARKLIAFEMQERAVPRHDYEIV
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
DGEGNVIGIVTSGTMSPSMNKGIGLGYVTVANSAVDSDIFIRIRKNDVPAKVVKLPFYKK
CCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEECCCCCC
>Mature Secondary Structure
MKNTALTHIHESLGAKMLPFAGYNMPITYEGVNAEHETVRNGVGVFDVSHMGEFLLTGPN
CCCCHHHHHHHHHCCEECCCCCCCCCEEECCCCCHHHHHHCCCCEEEHHHCCCEEEECCC
ALALIQKVTSNDASTLTIGRAQYSCLPNNEGGIVDDLIIYKMKEEQYLLVVNASNIEKDW
HHHHHHHHHCCCCCEEEEECEEEEECCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCH
NWISSYNDLGVEMRNLSDDYSLLAIQGPKAVEAMQALTSVDLSAITYYHFEVGDFAGIEH
HHHHCCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEEEEECCCCCCCEE
VIISATGYTGSGGFEIYCKNNEVEQIWNKVFEAGAAYGIKPIGLAARDTLRLEMGFCLYG
EEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEEC
NDINDTTSPLEAGLGWITKFTKDFTNSEALKKQKEAGVARKLIAFEMQERAVPRHDYEIV
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
DGEGNVIGIVTSGTMSPSMNKGIGLGYVTVANSAVDSDIFIRIRKNDVPAKVVKLPFYKK
CCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA