Click here to switch to the map view.

The map label for this gene is serC

Identifier: 146300217

GI number: 146300217

Start: 2946783

End: 2947853

Strand: Reverse

Name: serC

Synonym: Fjoh_2462

Alternate gene names: 146300217

Gene position: 2947853-2946783 (Counterclockwise)

Preceding gene: 146300218

Following gene: 146300216

Centisome position: 48.35

GC content: 35.76

Gene sequence:

>1071_bases
ATGAAAAAACACAACTACAGCGCAGGACCTAGTATTTTACCTCAGGAAGTTTTTGAAAAAGCATCAAAAGCAGTTTTAAA
TTTTAATGATTCAGGATTATCTATTCTTGAAATTTCGCACCGAAGCAAAGATTTTGTGGCTGTTATGGATGAAGCTCGTT
CGCTGGCTTTAGAATTATTAGGACTTCAGGGAAAAGGATATCAGGCTTTGTTTTTACAAGGTGGTGCAAGTACTGCATTC
TTGATGGCTCCTTATAACTTAATGAAAGAAAACGGAAAAGCAGCTTATTTAGATTCAGGAACGTGGGCAACTGCGGCTAT
TAAAGAAGCTAAACTTTTTGGAGAAACTGTTATCGTAGGCTCTTCAAAAGATGACAATTATACTTATATTCCAAAAGGTT
ACGAAATACCAGCCGATGCTGATTATTTTCACTGTACAAGCAACAATACTATTTTTGGAACTCAAATACAGGAATTCCCA
TCGACTAACATTCCAGTAGTGTGCGATATGAGTTCTGATATTTTCTCTCGTGAATTGGATTTTTCTAAATTCGATTTAAT
CTATGCCGGAGCTCAAAAAAATATGGGACCTGCAGGAACAACTCTTGTTGTAGTTAAAGAAGAAATCTTAGGCAAAAACG
GAAGAACAATTCCTAGTATGTTAGATTATGCTAAGCATATCAAAGCAGAAAGTATGTACAATACTCCTTCTGTATTTGCT
GTATATGTTTCATTACTGACATTACAATGGATTAAAGCTAAAGGCGGAATTGCAGCTGTTGAAAAATTAAACAATGCAAA
AGCAGATTTACTTTATGCTGAAATTGACAGAAACCCATTATTTAAAGGTGCTGCTAATGTAGAAGATCGTTCTAAAATGA
ACGTTACTTTCTTATTAAACAACCCTGAGCATACTGAAACTTTTGACGCTTTATGGAAAGCTGCAGGAATTTCTGGATTG
CCGGGACACCGTTCTGTTGGTGGTTACAGAGCTTCTATTTACAACGCTATGCCTATCGAAAGTGTTCAGGTTTTAGTTGA
TGTAATGAAAGCATTGGAATCTAAAGTTTAG

Upstream 100 bases:

>100_bases
TGTTTAATTATTTCGAATTATTTATCGCTTTTTCAGCTCCTATTACCGAAATTTGCATCTTTAAATTTTTCGACAAATTT
TTCGACTATTAACAACAACC

Downstream 100 bases:

>100_bases
TTTTCAGTTTTCAGTCTCAGTTTTCAGCAAACTGAGACTGAAAACTGAGACTGAGTACTAACCTAGCCCCGATAGAAGTA
GAAATCCTTTTTTGTTTTTT

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKKHNYSAGPSILPQEVFEKASKAVLNFNDSGLSILEISHRSKDFVAVMDEARSLALELLGLQGKGYQALFLQGGASTAF
LMAPYNLMKENGKAAYLDSGTWATAAIKEAKLFGETVIVGSSKDDNYTYIPKGYEIPADADYFHCTSNNTIFGTQIQEFP
STNIPVVCDMSSDIFSRELDFSKFDLIYAGAQKNMGPAGTTLVVVKEEILGKNGRTIPSMLDYAKHIKAESMYNTPSVFA
VYVSLLTLQWIKAKGGIAAVEKLNNAKADLLYAEIDRNPLFKGAANVEDRSKMNVTFLLNNPEHTETFDALWKAAGISGL
PGHRSVGGYRASIYNAMPIESVQVLVDVMKALESKV

Sequences:

>Translated_356_residues
MKKHNYSAGPSILPQEVFEKASKAVLNFNDSGLSILEISHRSKDFVAVMDEARSLALELLGLQGKGYQALFLQGGASTAF
LMAPYNLMKENGKAAYLDSGTWATAAIKEAKLFGETVIVGSSKDDNYTYIPKGYEIPADADYFHCTSNNTIFGTQIQEFP
STNIPVVCDMSSDIFSRELDFSKFDLIYAGAQKNMGPAGTTLVVVKEEILGKNGRTIPSMLDYAKHIKAESMYNTPSVFA
VYVSLLTLQWIKAKGGIAAVEKLNNAKADLLYAEIDRNPLFKGAANVEDRSKMNVTFLLNNPEHTETFDALWKAAGISGL
PGHRSVGGYRASIYNAMPIESVQVLVDVMKALESKV
>Mature_356_residues
MKKHNYSAGPSILPQEVFEKASKAVLNFNDSGLSILEISHRSKDFVAVMDEARSLALELLGLQGKGYQALFLQGGASTAF
LMAPYNLMKENGKAAYLDSGTWATAAIKEAKLFGETVIVGSSKDDNYTYIPKGYEIPADADYFHCTSNNTIFGTQIQEFP
STNIPVVCDMSSDIFSRELDFSKFDLIYAGAQKNMGPAGTTLVVVKEEILGKNGRTIPSMLDYAKHIKAESMYNTPSVFA
VYVSLLTLQWIKAKGGIAAVEKLNNAKADLLYAEIDRNPLFKGAANVEDRSKMNVTFLLNNPEHTETFDALWKAAGISGL
PGHRSVGGYRASIYNAMPIESVQVLVDVMKALESKV

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=356, Percent_Identity=40.4494382022472, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI10863955, Length=351, Percent_Identity=37.3219373219373, Blast_Score=215, Evalue=5e-56,
Organism=Escherichia coli, GI1787136, Length=356, Percent_Identity=41.0112359550562, Blast_Score=271, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17506897, Length=362, Percent_Identity=36.7403314917127, Blast_Score=233, Evalue=9e-62,
Organism=Saccharomyces cerevisiae, GI6324758, Length=389, Percent_Identity=37.0179948586118, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI21356589, Length=357, Percent_Identity=37.8151260504202, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_FLAJ1 (A5FH28)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001194808.1
- ProteinModelPortal:   A5FH28
- SMR:   A5FH28
- STRING:   A5FH28
- GeneID:   5090319
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_2462
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   FJOH376686:FJOH_2462-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 38872; Mature: 38872

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 41-41 BINDING 102-102 BINDING 150-150 BINDING 169-169 BINDING 192-192

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHNYSAGPSILPQEVFEKASKAVLNFNDSGLSILEISHRSKDFVAVMDEARSLALELL
CCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
GLQGKGYQALFLQGGASTAFLMAPYNLMKENGKAAYLDSGTWATAAIKEAKLFGETVIVG
CCCCCCEEEEEEECCCCEEEEECCHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
SSKDDNYTYIPKGYEIPADADYFHCTSNNTIFGTQIQEFPSTNIPVVCDMSSDIFSRELD
CCCCCCEEECCCCCCCCCCCCEEEECCCCEEEECCHHHCCCCCCCEEEECCCHHHHHCCC
FSKFDLIYAGAQKNMGPAGTTLVVVKEEILGKNGRTIPSMLDYAKHIKAESMYNTPSVFA
CCCEEEEEECCCCCCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
VYVSLLTLQWIKAKGGIAAVEKLNNAKADLLYAEIDRNPLFKGAANVEDRSKMNVTFLLN
HHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEC
NPEHTETFDALWKAAGISGLPGHRSVGGYRASIYNAMPIESVQVLVDVMKALESKV
CCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKHNYSAGPSILPQEVFEKASKAVLNFNDSGLSILEISHRSKDFVAVMDEARSLALELL
CCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
GLQGKGYQALFLQGGASTAFLMAPYNLMKENGKAAYLDSGTWATAAIKEAKLFGETVIVG
CCCCCCEEEEEEECCCCEEEEECCHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
SSKDDNYTYIPKGYEIPADADYFHCTSNNTIFGTQIQEFPSTNIPVVCDMSSDIFSRELD
CCCCCCEEECCCCCCCCCCCCEEEECCCCEEEECCHHHCCCCCCCEEEECCCHHHHHCCC
FSKFDLIYAGAQKNMGPAGTTLVVVKEEILGKNGRTIPSMLDYAKHIKAESMYNTPSVFA
CCCEEEEEECCCCCCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
VYVSLLTLQWIKAKGGIAAVEKLNNAKADLLYAEIDRNPLFKGAANVEDRSKMNVTFLLN
HHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEC
NPEHTETFDALWKAAGISGLPGHRSVGGYRASIYNAMPIESVQVLVDVMKALESKV
CCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA