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The map label for this gene is serA [H]

Identifier: 146300216

GI number: 146300216

Start: 2945587

End: 2946537

Strand: Reverse

Name: serA [H]

Synonym: Fjoh_2461

Alternate gene names: 146300216

Gene position: 2946537-2945587 (Counterclockwise)

Preceding gene: 146300217

Following gene: 146300215

Centisome position: 48.33

GC content: 36.49

Gene sequence:

>951_bases
ATGAAAGTATTAGCAAATGACGGAATTTCTAAAAGTGGAATTCTAGCCTTAGAAAAAGGCGGATTTGAAGTTATAACTAC
AAAAGTAGCTCAGGAACAAGTAGCTAACTTTATTAATGAAAATAATGTAGACGTAATTTTAGTGCGCAGTGCGACTAAAG
TTCGTAAAGATATTATCGACGCTTGTCCTGGTATCAAAATCATCGGACGTGGTGGTGTTGGTATGGATAACATCGATGTT
GATTATGCTAAAAGCAAAGGAATTCATGTAATTAATACTCCAGCTTCATCTTCAGAATCTGTTGCTGAATTGGTATTTGG
ACACTTATTTTCTGGTGTTCGTTTCTTACATGATTCAAACAGAAATATGCCTCTTGAAGGAGATTCTAACTTTGACGGTT
TGAAAAAAGCGTATGCAAACGGAGTTGAATTAAGAGGAAAAACTCTTGGTATTGTTGGTATTGGACGTATCGGACAAGCT
ACTGCAAAAATGGCGCTTGGTCTTGGTATGAAAGTTATCGCTGCAGACAGCTTTATTCCTCAGGTAGACATAAAAGTTGA
ATTTTTCGACGGACAGTCTATCACGACTACAATCGTTTCTCAATCATTAGAATCTTTATTTAAAGAAGCTGATTTCATTA
CATTACACGTTCCTGCACAAGATGGTTACATCATTGGAGAAAAAGAACTTGCAATCATGAAAGATGGTATTGGAATTGTA
AACTGTGCTCGCGGCGGTGTTATTGATGAAGTAGCTTTAGTAAAAGCTTTAGATTCAGGAAAAGTAGCTTTCGCTGGTTT
AGACGTTTTTGAAAGTGAGCCAAAACCAGAAATGGCAATCTTAATGCATTCTAAAATCTCTTTAACTCCTCACATTGGAG
CTGCGACAGGAGAAGCACAAGACAGAATTGGTACTGAATTAGCTTCACAAATTATTACTTTGTTGAGTTAA

Upstream 100 bases:

>100_bases
AAATCAAAAAAAAATATAATACTTGGTTCATCGATTAAACAATTAAACGAATAAACAGTTAAACTTTTATACGATTAACC
AAATAAACAATAAACACACA

Downstream 100 bases:

>100_bases
ATATCAAAAAAAAACAAATAAATCTATTAAAGGGATTTACTGCTTATTTGCAGTAAATCCCTTTCTTTTTAATTAGTTTT
GACGCACAATCTTGTAATTA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKVLANDGISKSGILALEKGGFEVITTKVAQEQVANFINENNVDVILVRSATKVRKDIIDACPGIKIIGRGGVGMDNIDV
DYAKSKGIHVINTPASSSESVAELVFGHLFSGVRFLHDSNRNMPLEGDSNFDGLKKAYANGVELRGKTLGIVGIGRIGQA
TAKMALGLGMKVIAADSFIPQVDIKVEFFDGQSITTTIVSQSLESLFKEADFITLHVPAQDGYIIGEKELAIMKDGIGIV
NCARGGVIDEVALVKALDSGKVAFAGLDVFESEPKPEMAILMHSKISLTPHIGAATGEAQDRIGTELASQIITLLS

Sequences:

>Translated_316_residues
MKVLANDGISKSGILALEKGGFEVITTKVAQEQVANFINENNVDVILVRSATKVRKDIIDACPGIKIIGRGGVGMDNIDV
DYAKSKGIHVINTPASSSESVAELVFGHLFSGVRFLHDSNRNMPLEGDSNFDGLKKAYANGVELRGKTLGIVGIGRIGQA
TAKMALGLGMKVIAADSFIPQVDIKVEFFDGQSITTTIVSQSLESLFKEADFITLHVPAQDGYIIGEKELAIMKDGIGIV
NCARGGVIDEVALVKALDSGKVAFAGLDVFESEPKPEMAILMHSKISLTPHIGAATGEAQDRIGTELASQIITLLS
>Mature_316_residues
MKVLANDGISKSGILALEKGGFEVITTKVAQEQVANFINENNVDVILVRSATKVRKDIIDACPGIKIIGRGGVGMDNIDV
DYAKSKGIHVINTPASSSESVAELVFGHLFSGVRFLHDSNRNMPLEGDSNFDGLKKAYANGVELRGKTLGIVGIGRIGQA
TAKMALGLGMKVIAADSFIPQVDIKVEFFDGQSITTTIVSQSLESLFKEADFITLHVPAQDGYIIGEKELAIMKDGIGIV
NCARGGVIDEVALVKALDSGKVAFAGLDVFESEPKPEMAILMHSKISLTPHIGAATGEAQDRIGTELASQIITLLS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=319, Percent_Identity=37.3040752351097, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI4557497, Length=252, Percent_Identity=34.5238095238095, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI61743967, Length=252, Percent_Identity=34.5238095238095, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=30.5019305019305, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580578, Length=253, Percent_Identity=31.2252964426877, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4557499, Length=253, Percent_Identity=31.2252964426877, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI6912396, Length=264, Percent_Identity=30.3030303030303, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1789279, Length=322, Percent_Identity=32.9192546583851, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787645, Length=273, Percent_Identity=31.5018315018315, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87082289, Length=259, Percent_Identity=31.2741312741313, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788660, Length=274, Percent_Identity=29.1970802919708, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=314, Percent_Identity=35.9872611464968, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25147481, Length=284, Percent_Identity=27.8169014084507, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=328, Percent_Identity=32.0121951219512, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=326, Percent_Identity=32.2085889570552, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324055, Length=234, Percent_Identity=32.4786324786325, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=305, Percent_Identity=24.5901639344262, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=95, Percent_Identity=44.2105263157895, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=282, Percent_Identity=26.5957446808511, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=320, Percent_Identity=36.5625, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24646446, Length=273, Percent_Identity=32.6007326007326, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24646448, Length=273, Percent_Identity=32.6007326007326, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24646452, Length=273, Percent_Identity=32.6007326007326, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24646450, Length=273, Percent_Identity=32.6007326007326, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI62472511, Length=273, Percent_Identity=32.6007326007326, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574286, Length=296, Percent_Identity=28.3783783783784, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45552429, Length=275, Percent_Identity=26.5454545454545, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574284, Length=275, Percent_Identity=26.5454545454545, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585514, Length=275, Percent_Identity=26.5454545454545, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574282, Length=275, Percent_Identity=26.5454545454545, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551003, Length=275, Percent_Identity=26.5454545454545, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571528, Length=283, Percent_Identity=27.5618374558304, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585516, Length=274, Percent_Identity=25.9124087591241, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33465; Mature: 33465

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLANDGISKSGILALEKGGFEVITTKVAQEQVANFINENNVDVILVRSATKVRKDIID
CEEECCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
ACPGIKIIGRGGVGMDNIDVDYAKSKGIHVINTPASSSESVAELVFGHLFSGVRFLHDSN
HCCCEEEEECCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCC
RNMPLEGDSNFDGLKKAYANGVELRGKTLGIVGIGRIGQATAKMALGLGMKVIAADSFIP
CCCCCCCCCCCHHHHHHHCCCEEECCCEEEEEEECCCCHHHHHHHHHCCEEEEECCCCCC
QVDIKVEFFDGQSITTTIVSQSLESLFKEADFITLHVPAQDGYIIGEKELAIMKDGIGIV
EEEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCEEEEECCCCEE
NCARGGVIDEVALVKALDSGKVAFAGLDVFESEPKPEMAILMHSKISLTPHIGAATGEAQ
EECCCCCHHHHHHHHHHCCCCEEEEECHHHCCCCCCCEEEEEECCEEECCCCCCCCCCHH
DRIGTELASQIITLLS
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVLANDGISKSGILALEKGGFEVITTKVAQEQVANFINENNVDVILVRSATKVRKDIID
CEEECCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
ACPGIKIIGRGGVGMDNIDVDYAKSKGIHVINTPASSSESVAELVFGHLFSGVRFLHDSN
HCCCEEEEECCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCC
RNMPLEGDSNFDGLKKAYANGVELRGKTLGIVGIGRIGQATAKMALGLGMKVIAADSFIP
CCCCCCCCCCCHHHHHHHCCCEEECCCEEEEEEECCCCHHHHHHHHHCCEEEEECCCCCC
QVDIKVEFFDGQSITTTIVSQSLESLFKEADFITLHVPAQDGYIIGEKELAIMKDGIGIV
EEEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCEEEEECCCCEE
NCARGGVIDEVALVKALDSGKVAFAGLDVFESEPKPEMAILMHSKISLTPHIGAATGEAQ
EECCCCCHHHHHHHHHHCCCCEEEEECHHHCCCCCCCEEEEEECCEEECCCCCCCCCCHH
DRIGTELASQIITLLS
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]