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The map label for this gene is yccK [H]

Identifier: 146284547

GI number: 146284547

Start: 31444

End: 32616

Strand: Direct

Name: yccK [H]

Synonym: Ent638_4221

Alternate gene names: 146284547

Gene position: 31444-32616 (Clockwise)

Preceding gene: 146284546

Following gene: 146284548

Centisome position: 19.93

GC content: 50.64

Gene sequence:

>1173_bases
ATGAGTCAGCCAAAAACCCGTCCTGCACAACGCACTGAAAGCATAAGCGCTTTCAGCCGACGCAACTTTCTGTCTTCTTC
TGCCTTAATGGGGGCAGGGTTGATTATGGGGAGTTTACCTGACAGGGCGCATGCAACGTCATCAGAGCCGACAGCAAAAC
CGGCACAGGCCAGACAAGGTTCACAGACAATGCCGACGCGAAAACTTGGATCTATGGTGGTTTCCGCACTGGGTGCCGGA
TGTATGAGTATCAGCGCTAACTACGGGGCGGCAGCGGATAAATCCCAGGGGATAAGAACGATACGCGAGGCACACGCCAG
AGGCGTCACGCTATTCGATACCGCCGAAGTTTATGGACCTTATACCAATGAAGAACTGGTTGGCGAGGCGCTTGCTCCTG
TTCGTAACCAGGTCTTTATTGCCAGCAAATTTGGATTTGATATTCAACATGGCGGGCTGAACAGTCAGCCAAAACATATC
CGAAAAGTGCTGGAGGCCTCTCTCAGGCGTTTACGCACTGACCGTATCGATCTGTATTATCAGCATCGCGTTGATCCCGG
TGTTCCCATAGAGGACGTAGCCGGGACTATCCAGGATTTGATTAAAGAAGGCAAGGTTCTACATTTTGGTCTTTCTGAAG
CAAGTCCTTCTACCATCCATCAGGCTCATGCGATCCAGCCTGTCACCGCAGTACAGACGGAATATTCTGTCATGAACCGC
GATCCGGAACATAATGGTGTGCTGGATACCTGCGAGGAGCTGGGAATTGGTTTCGTCCCCTGGGGGCCGATAGGCATGGG
GTATCTGACCGGAACGGTGAGCGTTAACACTCATTTTGATCCCAAAACCGACTTACGCTCCACTTTTGAACGTTTTACGC
CTGAAAATTTAGCGAATAACTGGCCCTTTGTGGAAAAGCTGAAAGCTATCGCTGACAGTAAGGGCGCGACACCGTCTCAG
ATCGCGCTTGCATGGCTTCTGGCCAAAAAAACCTGGATTGTTCCTATTCCCGGGACACGAAATATCAACCATCTCCGTGA
AAACCATGGTGCTTTAGAGATCCAGTTAACCACTACTGAGTTAAGCGAAATGGATAAAGCTATGTCCGGGCTTCGCGTCT
ATGGTGGTCGCATGAATAGTGCCCAGATGGACCTCGTTGAGCCCAAAGCTTAA

Upstream 100 bases:

>100_bases
TCCGAATGACCATAACAGGTTGCGTCGTCCCGGCCACGTAACCGGCCCTCACCAGGGGTACCCGTCCTGATAGTAAAACC
TTTATTAAGCGGAGAACGAT

Downstream 100 bases:

>100_bases
TTCCCGCCTGAGGGTAGGCTTAAACTATTGGAAGAAATTTTATGAATATTGAGAAGAAAAAAAGAGTCGCTGTTGTTACC
GGAGCATCCTCTGGTATAGG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSQPKTRPAQRTESISAFSRRNFLSSSALMGAGLIMGSLPDRAHATSSEPTAKPAQARQGSQTMPTRKLGSMVVSALGAG
CMSISANYGAAADKSQGIRTIREAHARGVTLFDTAEVYGPYTNEELVGEALAPVRNQVFIASKFGFDIQHGGLNSQPKHI
RKVLEASLRRLRTDRIDLYYQHRVDPGVPIEDVAGTIQDLIKEGKVLHFGLSEASPSTIHQAHAIQPVTAVQTEYSVMNR
DPEHNGVLDTCEELGIGFVPWGPIGMGYLTGTVSVNTHFDPKTDLRSTFERFTPENLANNWPFVEKLKAIADSKGATPSQ
IALAWLLAKKTWIVPIPGTRNINHLRENHGALEIQLTTTELSEMDKAMSGLRVYGGRMNSAQMDLVEPKA

Sequences:

>Translated_390_residues
MSQPKTRPAQRTESISAFSRRNFLSSSALMGAGLIMGSLPDRAHATSSEPTAKPAQARQGSQTMPTRKLGSMVVSALGAG
CMSISANYGAAADKSQGIRTIREAHARGVTLFDTAEVYGPYTNEELVGEALAPVRNQVFIASKFGFDIQHGGLNSQPKHI
RKVLEASLRRLRTDRIDLYYQHRVDPGVPIEDVAGTIQDLIKEGKVLHFGLSEASPSTIHQAHAIQPVTAVQTEYSVMNR
DPEHNGVLDTCEELGIGFVPWGPIGMGYLTGTVSVNTHFDPKTDLRSTFERFTPENLANNWPFVEKLKAIADSKGATPSQ
IALAWLLAKKTWIVPIPGTRNINHLRENHGALEIQLTTTELSEMDKAMSGLRVYGGRMNSAQMDLVEPKA
>Mature_389_residues
SQPKTRPAQRTESISAFSRRNFLSSSALMGAGLIMGSLPDRAHATSSEPTAKPAQARQGSQTMPTRKLGSMVVSALGAGC
MSISANYGAAADKSQGIRTIREAHARGVTLFDTAEVYGPYTNEELVGEALAPVRNQVFIASKFGFDIQHGGLNSQPKHIR
KVLEASLRRLRTDRIDLYYQHRVDPGVPIEDVAGTIQDLIKEGKVLHFGLSEASPSTIHQAHAIQPVTAVQTEYSVMNRD
PEHNGVLDTCEELGIGFVPWGPIGMGYLTGTVSVNTHFDPKTDLRSTFERFTPENLANNWPFVEKLKAIADSKGATPSQI
ALAWLLAKKTWIVPIPGTRNINHLRENHGALEIQLTTTELSEMDKAMSGLRVYGGRMNSAQMDLVEPKA

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=344, Percent_Identity=25.8720930232558, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI27436966, Length=324, Percent_Identity=26.2345679012346, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI27436964, Length=353, Percent_Identity=26.0623229461756, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI4504825, Length=321, Percent_Identity=25.8566978193146, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI27436962, Length=346, Percent_Identity=26.0115606936416, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI27436971, Length=321, Percent_Identity=26.1682242990654, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1787674, Length=314, Percent_Identity=30.5732484076433, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081735, Length=307, Percent_Identity=29.9674267100977, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789375, Length=285, Percent_Identity=29.4736842105263, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788070, Length=319, Percent_Identity=29.153605015674, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788081, Length=301, Percent_Identity=25.2491694352159, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI48994888, Length=290, Percent_Identity=28.9655172413793, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789199, Length=333, Percent_Identity=26.1261261261261, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323998, Length=338, Percent_Identity=28.1065088757396, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319958, Length=291, Percent_Identity=27.8350515463918, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322615, Length=248, Percent_Identity=29.4354838709677, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6325384, Length=314, Percent_Identity=27.3885350318471, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325169, Length=325, Percent_Identity=24.6153846153846, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319951, Length=333, Percent_Identity=24.9249249249249, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640980, Length=348, Percent_Identity=22.9885057471264, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI45549126, Length=348, Percent_Identity=22.7011494252874, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646155, Length=167, Percent_Identity=31.7365269461078, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 42484; Mature: 42353

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPKTRPAQRTESISAFSRRNFLSSSALMGAGLIMGSLPDRAHATSSEPTAKPAQARQG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
SQTMPTRKLGSMVVSALGAGCMSISANYGAAADKSQGIRTIREAHARGVTLFDTAEVYGP
CCCCCHHHHHHHHHHHHCCCHHEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHCCC
YTNEELVGEALAPVRNQVFIASKFGFDIQHGGLNSQPKHIRKVLEASLRRLRTDRIDLYY
CCCHHHHHHHHHHHHHCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEE
QHRVDPGVPIEDVAGTIQDLIKEGKVLHFGLSEASPSTIHQAHAIQPVTAVQTEYSVMNR
EECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCC
DPEHNGVLDTCEELGIGFVPWGPIGMGYLTGTVSVNTHFDPKTDLRSTFERFTPENLANN
CCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCHHHHCCC
WPFVEKLKAIADSKGATPSQIALAWLLAKKTWIVPIPGTRNINHLRENHGALEIQLTTTE
CCHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCEEEEEEEHHH
LSEMDKAMSGLRVYGGRMNSAQMDLVEPKA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQPKTRPAQRTESISAFSRRNFLSSSALMGAGLIMGSLPDRAHATSSEPTAKPAQARQG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
SQTMPTRKLGSMVVSALGAGCMSISANYGAAADKSQGIRTIREAHARGVTLFDTAEVYGP
CCCCCHHHHHHHHHHHHCCCHHEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHCCC
YTNEELVGEALAPVRNQVFIASKFGFDIQHGGLNSQPKHIRKVLEASLRRLRTDRIDLYY
CCCHHHHHHHHHHHHHCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEE
QHRVDPGVPIEDVAGTIQDLIKEGKVLHFGLSEASPSTIHQAHAIQPVTAVQTEYSVMNR
EECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCC
DPEHNGVLDTCEELGIGFVPWGPIGMGYLTGTVSVNTHFDPKTDLRSTFERFTPENLANN
CCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCHHHHCCC
WPFVEKLKAIADSKGATPSQIALAWLLAKKTWIVPIPGTRNINHLRENHGALEIQLTTTE
CCHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCEEEEEEEHHH
LSEMDKAMSGLRVYGGRMNSAQMDLVEPKA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]