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The map label for this gene is pdxK [H]

Identifier: 146284537

GI number: 146284537

Start: 21502

End: 22362

Strand: Reverse

Name: pdxK [H]

Synonym: Ent638_4211

Alternate gene names: 146284537

Gene position: 22362-21502 (Counterclockwise)

Preceding gene: 146284538

Following gene: 146284535

Centisome position: 14.18

GC content: 47.39

Gene sequence:

>861_bases
TTGATATCCCGAGTTACCCAGGCACAGGGGCTAGCCCGTACTGCCGACATCATTTCCATTCAGTCTCAGGTTGTTTATGG
GAGCGTAGGTAATAGTATCGCTCTGCCTGCACTTATAAAGCATGGATGGCACACACTTGCAGTACCGACTTTCCTACTCA
GCAACACACCCGATAATCAAGGCTGCTATGGCGGCGAGATTTCCGATGCGTGGTTTTGCGGTTTCCTTCAGAGCATTCAG
GAGCGTAGACAAGATACCCAGCTGCGTGCAGTCATAACGGGTTATTTAGGTAGCACATCAAAAGCAGAACGTGTTTTCGC
ATGGCTCAACCAAATAGCCACTCAAAACCCTGGGATACTTATTGTTGTGGATCCGGTCATGGGAGACGACGACACGGGAT
ATTACGTCGATCCGGATCTCACTTTCTGGTATCGCAATCATCTTTTACCACTCGCAACAGGTCTGACGCCTAACCGCTTT
GAACTAGAGTGCCTGATGGGTAAAACGCTGATTACCGAACAAGAGATCATCTCGGCTGCTCTTACTTTCCTCAACGATAA
AACACAATGGGTTGTCGTGACCAGCGCCTCACATACCGAGAATAGCCAGATGCTTAAAATCATCTGCGTCTCTGCCAGTA
TCGTGCACATCGTAGAACATGCAGCACTTCCAAATGCGCCAAAAGGCACTGGTGATCTTTTTACAGCAGAACTGACGGCA
GGTTTATTACGTGGTTTTTCGCTTGAAAATGCTGTTAAAACAGCCTCTGAACTGACTCGAGTTTGTGTGATGAACTCGCT
AATTGACGGTACGGACATGCTTGACATTCAGAGACTAGAATCAGGAGAACTTAAATGCTAA

Upstream 100 bases:

>100_bases
GCTATTGAAGAAGGTGCCAATATCGTGCGCGTTGGTCAGGCGATCTTTGGTGCTCGTTCGCTTCCTGATGAATATTTCTG
GCCGAAAGGAGAATAAGCTC

Downstream 100 bases:

>100_bases
AAACTCACCGCCTTAGCGTGTACTTCAATGAAATCCTCATCGGCAACCTGGACTGCGAAAGCTGTCAGGCTGAAACGCTC
ATCAGAAAACTACAGAATGT

Product: phosphomethylpyrimidine kinase type-1

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MISRVTQAQGLARTADIISIQSQVVYGSVGNSIALPALIKHGWHTLAVPTFLLSNTPDNQGCYGGEISDAWFCGFLQSIQ
ERRQDTQLRAVITGYLGSTSKAERVFAWLNQIATQNPGILIVVDPVMGDDDTGYYVDPDLTFWYRNHLLPLATGLTPNRF
ELECLMGKTLITEQEIISAALTFLNDKTQWVVVTSASHTENSQMLKIICVSASIVHIVEHAALPNAPKGTGDLFTAELTA
GLLRGFSLENAVKTASELTRVCVMNSLIDGTDMLDIQRLESGELKC

Sequences:

>Translated_286_residues
MISRVTQAQGLARTADIISIQSQVVYGSVGNSIALPALIKHGWHTLAVPTFLLSNTPDNQGCYGGEISDAWFCGFLQSIQ
ERRQDTQLRAVITGYLGSTSKAERVFAWLNQIATQNPGILIVVDPVMGDDDTGYYVDPDLTFWYRNHLLPLATGLTPNRF
ELECLMGKTLITEQEIISAALTFLNDKTQWVVVTSASHTENSQMLKIICVSASIVHIVEHAALPNAPKGTGDLFTAELTA
GLLRGFSLENAVKTASELTRVCVMNSLIDGTDMLDIQRLESGELKC
>Mature_286_residues
MISRVTQAQGLARTADIISIQSQVVYGSVGNSIALPALIKHGWHTLAVPTFLLSNTPDNQGCYGGEISDAWFCGFLQSIQ
ERRQDTQLRAVITGYLGSTSKAERVFAWLNQIATQNPGILIVVDPVMGDDDTGYYVDPDLTFWYRNHLLPLATGLTPNRF
ELECLMGKTLITEQEIISAALTFLNDKTQWVVVTSASHTENSQMLKIICVSASIVHIVEHAALPNAPKGTGDLFTAELTA
GLLRGFSLENAVKTASELTRVCVMNSLIDGTDMLDIQRLESGELKC

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=186, Percent_Identity=30.6451612903226, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788758, Length=244, Percent_Identity=51.2295081967213, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1787924, Length=245, Percent_Identity=27.7551020408163, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17507759, Length=232, Percent_Identity=28.8793103448276, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17507757, Length=242, Percent_Identity=28.099173553719, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324354, Length=246, Percent_Identity=27.6422764227642, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45553007, Length=188, Percent_Identity=31.3829787234043, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 31217; Mature: 31217

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRVTQAQGLARTADIISIQSQVVYGSVGNSIALPALIKHGWHTLAVPTFLLSNTPDNQ
CCCCHHHHHCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCC
GCYGGEISDAWFCGFLQSIQERRQDTQLRAVITGYLGSTSKAERVFAWLNQIATQNPGIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEE
IVVDPVMGDDDTGYYVDPDLTFWYRNHLLPLATGLTPNRFELECLMGKTLITEQEIISAA
EEECCCCCCCCCCEEECCCEEEEHHHCCHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHH
LTFLNDKTQWVVVTSASHTENSQMLKIICVSASIVHIVEHAALPNAPKGTGDLFTAELTA
HHHHCCCCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHH
GLLRGFSLENAVKTASELTRVCVMNSLIDGTDMLDIQRLESGELKC
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MISRVTQAQGLARTADIISIQSQVVYGSVGNSIALPALIKHGWHTLAVPTFLLSNTPDNQ
CCCCHHHHHCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCC
GCYGGEISDAWFCGFLQSIQERRQDTQLRAVITGYLGSTSKAERVFAWLNQIATQNPGIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEE
IVVDPVMGDDDTGYYVDPDLTFWYRNHLLPLATGLTPNRFELECLMGKTLITEQEIISAA
EEECCCCCCCCCCEEECCCEEEEHHHCCHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHH
LTFLNDKTQWVVVTSASHTENSQMLKIICVSASIVHIVEHAALPNAPKGTGDLFTAELTA
HHHHCCCCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHH
GLLRGFSLENAVKTASELTRVCVMNSLIDGTDMLDIQRLESGELKC
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA