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The map label for this gene is metR [C]

Identifier: 145300016

GI number: 145300016

Start: 3364460

End: 3365344

Strand: Direct

Name: metR [C]

Synonym: ASA_3115

Alternate gene names: 145300016

Gene position: 3364460-3365344 (Clockwise)

Preceding gene: 145300015

Following gene: 145300018

Centisome position: 71.55

GC content: 61.92

Gene sequence:

>885_bases
ATGTTTCGTCCCAAGAGCACGTTTGAGCAATGGCGGATCTTTCAGGCCGTGGTGGACTGCGGCGGTTATGCCCAGGCCGC
CGAGGCGCTGAACAAGAGCCAATCCTCTCTCAATCATGCGGTGGCCAAGCTGCAGCAGAGTCTGGGAGTCCCCCTGCTGG
AAGTGAGGGGGCGCAAGGCGGTATTGACGCCGGCAGGGGAGATCTTCCTCAAGCGGGCCCGTCAGCTCAGCCAGCAGGTG
GAAGAGCTGGAAAATCTGGCCAACAACCTGGAGCGGCAGTGGGAGCCGCAGATCAATCTCTATGTTTCCGTGCTGCAACC
GCGGGAGCGTCTCTATCGGGCACTGGCCAACTTCTATCCCCGCAGCCGGGGCTGCCGCGTCAATCTGCACGAACGCATTC
ACTGCCACTTCAATGCATTGCAGGTAGGGGATCTCATGCTGTCCGAACACCTGCCCCAGGATCGCACCGGCCTGCCGCTG
GACGAAGTGTGCCTGCTGCCGCTCTGCTCGGCCGAACATCCCCTCGCTGCCCTGACGGGAGCCGTCTCAACCGAGGAGCT
CGCCAGCCATAACCAGATAAGCTTGCATCCCCCCATCCACCGCTCGGTGGACTGGAACGATGCGGACGACACCGGCTGGA
AGGCGACCCACTATCACGAAGCCATCGCCATGCTCAAACTCGGCCTTGGCTATGCCTGGTTGCCCCGCCATCTGGTGCAG
GAGGAGCTGGGCAGCGGCGCCCTGGTGCCACTGGATCTGGAGAGCGGCAACGAGCGCCATCTCTATACCTATCTGCTCAC
CCCGTCAGCCGATACCCTGGGTCCGGCCACCGAACTGCTGCTGCGCTGTCTTCGCAACGAATATCAGACCGATAACGACA
AGTAA

Upstream 100 bases:

>100_bases
ATAACCGGAACCCTGCACCGCATGGGGTTAAATTCAATAGGGTGTCGTCGGCACCCTGTCGAAGGCCTTTATCAGATCCG
ATCCCTTATCAGGTTGAGAT

Downstream 100 bases:

>100_bases
CCTCGGTAAGCGACAGCGATACTGATATCTCAGCTCACGCCATCAACGGCCGATACCCTGGGTCCGGCCACCGAACTGCT
GCTGCGCTGTCTGCGCAACG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MFRPKSTFEQWRIFQAVVDCGGYAQAAEALNKSQSSLNHAVAKLQQSLGVPLLEVRGRKAVLTPAGEIFLKRARQLSQQV
EELENLANNLERQWEPQINLYVSVLQPRERLYRALANFYPRSRGCRVNLHERIHCHFNALQVGDLMLSEHLPQDRTGLPL
DEVCLLPLCSAEHPLAALTGAVSTEELASHNQISLHPPIHRSVDWNDADDTGWKATHYHEAIAMLKLGLGYAWLPRHLVQ
EELGSGALVPLDLESGNERHLYTYLLTPSADTLGPATELLLRCLRNEYQTDNDK

Sequences:

>Translated_294_residues
MFRPKSTFEQWRIFQAVVDCGGYAQAAEALNKSQSSLNHAVAKLQQSLGVPLLEVRGRKAVLTPAGEIFLKRARQLSQQV
EELENLANNLERQWEPQINLYVSVLQPRERLYRALANFYPRSRGCRVNLHERIHCHFNALQVGDLMLSEHLPQDRTGLPL
DEVCLLPLCSAEHPLAALTGAVSTEELASHNQISLHPPIHRSVDWNDADDTGWKATHYHEAIAMLKLGLGYAWLPRHLVQ
EELGSGALVPLDLESGNERHLYTYLLTPSADTLGPATELLLRCLRNEYQTDNDK
>Mature_294_residues
MFRPKSTFEQWRIFQAVVDCGGYAQAAEALNKSQSSLNHAVAKLQQSLGVPLLEVRGRKAVLTPAGEIFLKRARQLSQQV
EELENLANNLERQWEPQINLYVSVLQPRERLYRALANFYPRSRGCRVNLHERIHCHFNALQVGDLMLSEHLPQDRTGLPL
DEVCLLPLCSAEHPLAALTGAVSTEELASHNQISLHPPIHRSVDWNDADDTGWKATHYHEAIAMLKLGLGYAWLPRHLVQ
EELGSGALVPLDLESGNERHLYTYLLTPSADTLGPATELLLRCLRNEYQTDNDK

Specific function: Control Of The Last Step In Methionine Biosynthesis; Metr Is A Positive Activator Of The Meta, Mete And Meth Genes. Metr Is Also A Negative Regulator Of Its Own Expression. Binds Homocysteine As An Inducer. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=295, Percent_Identity=28.4745762711864, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33148; Mature: 33148

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPKSTFEQWRIFQAVVDCGGYAQAAEALNKSQSSLNHAVAKLQQSLGVPLLEVRGRKA
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEE
VLTPAGEIFLKRARQLSQQVEELENLANNLERQWEPQINLYVSVLQPRERLYRALANFYP
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCC
RSRGCRVNLHERIHCHFNALQVGDLMLSEHLPQDRTGLPLDEVCLLPLCSAEHPLAALTG
CCCCCEEEHHHEEEEEECHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
AVSTEELASHNQISLHPPIHRSVDWNDADDTGWKATHYHEAIAMLKLGLGYAWLPRHLVQ
CCCHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
EELGSGALVPLDLESGNERHLYTYLLTPSADTLGPATELLLRCLRNEYQTDNDK
HHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFRPKSTFEQWRIFQAVVDCGGYAQAAEALNKSQSSLNHAVAKLQQSLGVPLLEVRGRKA
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEE
VLTPAGEIFLKRARQLSQQVEELENLANNLERQWEPQINLYVSVLQPRERLYRALANFYP
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCC
RSRGCRVNLHERIHCHFNALQVGDLMLSEHLPQDRTGLPLDEVCLLPLCSAEHPLAALTG
CCCCCEEEHHHEEEEEECHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
AVSTEELASHNQISLHPPIHRSVDWNDADDTGWKATHYHEAIAMLKLGLGYAWLPRHLVQ
CCCHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
EELGSGALVPLDLESGNERHLYTYLLTPSADTLGPATELLLRCLRNEYQTDNDK
HHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]