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The map label for this gene is aer [H]

Identifier: 145300009

GI number: 145300009

Start: 3355583

End: 3357115

Strand: Direct

Name: aer [H]

Synonym: ASA_3108

Alternate gene names: 145300009

Gene position: 3355583-3357115 (Clockwise)

Preceding gene: 145300008

Following gene: 145300010

Centisome position: 71.36

GC content: 63.27

Gene sequence:

>1533_bases
ATGGCTCGCAGAGACGTCCATACCCTGGACAGCGAAGTGGAGTTTCCTGCCGACGAACAACTCGTTTCCACCACCGACCT
GCGCGGAGTGATCACCTACGCCAACCCCGCCTTCTGCCGCATCGCCGGCTACCCCGTTGAAGAGCTGGTCGGTCACAACC
ACAACCTGGTGCGCCACCCCGACATGCCCAAGGCCGCCTTTGCCGATCTGTGGGCCCGCCTCAAGGAGGGCAAGCCCTGG
CGCGGCATGGTGAAGAACCGCTGCAAGGATGGCCGTTACTACTGGGTCGACGCCTATGTGACCCCCATCTACGAGGGGGG
CAGGATCAGCGGCTACCAGTCAGTGCGCTGCAAACCGGAACCTCAGCTCAAGCGCGTCGCCAGCCAGACCTATCAGGCCC
TGCTCAAGGCTGAGCGGGGCTCGGCCAGCAGCCTTCCCTCTTTCAACCGCGTGCGCCTGCCGGTGCTGGGCTTGCTGTTG
CTCGGCCTGCTCGGCTGGGCCTTTCTCAGCAAGGGCGCCATGACAGCCCTGCTGATGCTGCTGCCCCTGGTGCTCATCGG
TGGCGCCTACTGGCGGGAAATATTCTCCCTGCCCCTCTACCTGCAGCAGCTCGGCCGGGAGTATGACAGCCTGACCCGGC
TGGTTTATTCGGGTGACGGCCCGGGCGCCATCGCCGATTTTCACATCAAGATGCTGCAGGCCCGCATCCGTACCGTGCTG
GGCCGGATCAACGATGCGACCCATCCCCTGCAAACCCTGGCCACCAACCTGAAACAGGCGTCCCATCAGGCCTGTCTCGA
CATCAACGAGCAGGATGCACAGACCCAGCAGATGGCTGCCGCCATGACCCAGATGGCCAGCACGGCTCATGAGATTGCCC
ATAACATTCAGGACTCCAACGGTCAGGTCAACGAGGCACGCAGCCGCTGCGAGCACACCAACAAACAGCTGAGCCAGACC
GAACAGCGCATCGAGCAGCTCGCTAAACAGGCTGAACTGGCGTTCAACTCTGCGGTAGAACTTGCCAGCGAGTCGGAGCG
GATCGGCAGCGTCATGGGCGAAATTCAGGGCATAGCCGATCAGACCAACCTGCTGGCCCTCAACGCCGCCATCGAGGCGG
CGCGGGCCGGTGAGCAGGGCCGCGGCTTTGCGGTGGTGGCCGACGAGGTGCGTACCCTGTCGACCCGCACCCACAAGGCG
ACCGAGCAGATCCAGGGCAGCATACAGCAGATCCAGCACACACTGGGACGCTGGAAGGGGATGATGCAGGAGAACCTGCA
ACAGACCCGCCAGGGCGCCAGCAGCCTGCATTCCGTACTGGAAGAGATAGAGCTGGTCACTGAGCACTCCACCCAGATCG
CCGCCGCCGCCGAGCAGCAACAGGCGGTGGTGGAGGAGATCAGCCGCAGCATCAACCAGATATCCCAGTACTCCCAGGCC
AATAGCCAGAAGATGCAGGAGGTCGACGACTCGAGTCAGGAGCTGCTGGAGCGCGCCAGGCAACTCAAGGGGCTCAGTCA
GACCTTTGGTTGA

Upstream 100 bases:

>100_bases
AAGCCGACTCGGCGCGCCTTGGCAATCACCTGCAACCACGCCCGGATCTGCCACAATAACAACGACAAAACTATCAACAA
GAACATCGGAGCCTATTCCT

Downstream 100 bases:

>100_bases
CACAGGTTGCCACCCCCACGACAGAAGCGCCACAATGGCGCTTCTGTCGTTTCTGGAGAGTCATGACCCATGAGAATGGA
GCCAGCCCCTGCCCCCCTGA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MARRDVHTLDSEVEFPADEQLVSTTDLRGVITYANPAFCRIAGYPVEELVGHNHNLVRHPDMPKAAFADLWARLKEGKPW
RGMVKNRCKDGRYYWVDAYVTPIYEGGRISGYQSVRCKPEPQLKRVASQTYQALLKAERGSASSLPSFNRVRLPVLGLLL
LGLLGWAFLSKGAMTALLMLLPLVLIGGAYWREIFSLPLYLQQLGREYDSLTRLVYSGDGPGAIADFHIKMLQARIRTVL
GRINDATHPLQTLATNLKQASHQACLDINEQDAQTQQMAAAMTQMASTAHEIAHNIQDSNGQVNEARSRCEHTNKQLSQT
EQRIEQLAKQAELAFNSAVELASESERIGSVMGEIQGIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLSTRTHKA
TEQIQGSIQQIQHTLGRWKGMMQENLQQTRQGASSLHSVLEEIELVTEHSTQIAAAAEQQQAVVEEISRSINQISQYSQA
NSQKMQEVDDSSQELLERARQLKGLSQTFG

Sequences:

>Translated_510_residues
MARRDVHTLDSEVEFPADEQLVSTTDLRGVITYANPAFCRIAGYPVEELVGHNHNLVRHPDMPKAAFADLWARLKEGKPW
RGMVKNRCKDGRYYWVDAYVTPIYEGGRISGYQSVRCKPEPQLKRVASQTYQALLKAERGSASSLPSFNRVRLPVLGLLL
LGLLGWAFLSKGAMTALLMLLPLVLIGGAYWREIFSLPLYLQQLGREYDSLTRLVYSGDGPGAIADFHIKMLQARIRTVL
GRINDATHPLQTLATNLKQASHQACLDINEQDAQTQQMAAAMTQMASTAHEIAHNIQDSNGQVNEARSRCEHTNKQLSQT
EQRIEQLAKQAELAFNSAVELASESERIGSVMGEIQGIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLSTRTHKA
TEQIQGSIQQIQHTLGRWKGMMQENLQQTRQGASSLHSVLEEIELVTEHSTQIAAAAEQQQAVVEEISRSINQISQYSQA
NSQKMQEVDDSSQELLERARQLKGLSQTFG
>Mature_509_residues
ARRDVHTLDSEVEFPADEQLVSTTDLRGVITYANPAFCRIAGYPVEELVGHNHNLVRHPDMPKAAFADLWARLKEGKPWR
GMVKNRCKDGRYYWVDAYVTPIYEGGRISGYQSVRCKPEPQLKRVASQTYQALLKAERGSASSLPSFNRVRLPVLGLLLL
GLLGWAFLSKGAMTALLMLLPLVLIGGAYWREIFSLPLYLQQLGREYDSLTRLVYSGDGPGAIADFHIKMLQARIRTVLG
RINDATHPLQTLATNLKQASHQACLDINEQDAQTQQMAAAMTQMASTAHEIAHNIQDSNGQVNEARSRCEHTNKQLSQTE
QRIEQLAKQAELAFNSAVELASESERIGSVMGEIQGIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRTLSTRTHKAT
EQIQGSIQQIQHTLGRWKGMMQENLQQTRQGASSLHSVLEEIELVTEHSTQIAAAAEQQQAVVEEISRSINQISQYSQAN
SQKMQEVDDSSQELLERARQLKGLSQTFG

Specific function: Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a r

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=514, Percent_Identity=31.7120622568093, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1788194, Length=348, Percent_Identity=26.7241379310345, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1787690, Length=356, Percent_Identity=25.561797752809, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788195, Length=213, Percent_Identity=28.169014084507, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI2367378, Length=260, Percent_Identity=26.5384615384615, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF08447 PAS_3 [H]

EC number: NA

Molecular weight: Translated: 56583; Mature: 56452

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50112 PAS ; PS00142 ZINC_PROTEASE ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRDVHTLDSEVEFPADEQLVSTTDLRGVITYANPAFCRIAGYPVEELVGHNHNLVRHP
CCCCCCHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCEEEECCCCHHHHCCCCCCCCCCC
DMPKAAFADLWARLKEGKPWRGMVKNRCKDGRYYWVDAYVTPIYEGGRISGYQSVRCKPE
CCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCC
PQLKRVASQTYQALLKAERGSASSLPSFNRVRLPVLGLLLLGLLGWAFLSKGAMTALLML
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLVLIGGAYWREIFSLPLYLQQLGREYDSLTRLVYSGDGPGAIADFHIKMLQARIRTVL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
GRINDATHPLQTLATNLKQASHQACLDINEQDAQTQQMAAAMTQMASTAHEIAHNIQDSN
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQVNEARSRCEHTNKQLSQTEQRIEQLAKQAELAFNSAVELASESERIGSVMGEIQGIAD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QTNLLALNAAIEAARAGEQGRGFAVVADEVRTLSTRTHKATEQIQGSIQQIQHTLGRWKG
CHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MMQENLQQTRQGASSLHSVLEEIELVTEHSTQIAAAAEQQQAVVEEISRSINQISQYSQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSQKMQEVDDSSQELLERARQLKGLSQTFG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARRDVHTLDSEVEFPADEQLVSTTDLRGVITYANPAFCRIAGYPVEELVGHNHNLVRHP
CCCCCHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCEEEECCCCHHHHCCCCCCCCCCC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HHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9190831; 9380671 [H]