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The map label for this gene is chb [H]

Identifier: 145300008

GI number: 145300008

Start: 3353503

End: 3355368

Strand: Direct

Name: chb [H]

Synonym: ASA_3107

Alternate gene names: 145300008

Gene position: 3353503-3355368 (Clockwise)

Preceding gene: 145300007

Following gene: 145300009

Centisome position: 71.31

GC content: 64.47

Gene sequence:

>1866_bases
ATGTCTACACCCCTGATCCACACCCAGGTTGACCGACGCGATGGCGAGGACGTCTGGTTCCGATTCAGCCTGAGCCAGTT
GCCGGCAGCCCCCTGGAAACTTCACTTCTGCCTGGCACGCCACATAGATCCCGCCTCCCTCGAAGGTGCCAGACTGGAGC
GCCAGAGCGGCAGCTACAAGGTGCTGATCCCGGCCGAGGGGCAAAGCGAGCTGCGTTTTTGCTGTCGCAACACCCCCATC
AAGCGATTGTCTGACATGCCGCAGGGCTTCTTCCTGAGCCTGCCCGAGGCGAGCACGGGCACCCAGCTGATGCCGGTCAC
CTTGGTGGAACAAGAGCTGGGCCTGCCGCCAAGCGGGCCCGGCGCCCCGGATCTGCCAGAGGTCGAGCCCCTCACCGGCA
TAGTGCCCCAGCCAGATCAGCTGGTGCTGCTGGAGGGCAACTTCCGGCTGGCGGAGCGGGCTCATGTCAGCGGGCCCGGG
TCGCTGACCGGCCTGCTGGCCCATTTCAACGAGCTGACTGGGCTAGCGCTGGAGCAGGATCATGATGCCGAGATCCGGCT
GTTCGAGGCCCCCCTGGCTGCCGAAGCCTATCGCCTCACCATCACGCCTGAGGGGGTGACCATAGCCGCAGCTGGCGAGG
CTGGCTGGCGCCACGGCCTGACAAGCCTGGCCCAGTGGGCTCTGCAGCACGGAGAGAGCCTGCCCTGCATCGAGCTGGTC
GATGCCCCCCGCTTCGGTTTTCGCGGCATCTTCCTCGACTGCGCCCGCCACTTTCACCCCGTCGCTAACCTCAAGCGCCT
GCTCAAACTGATGAGCCTCTACAAGTTCAACCGCTTCCACTGGCATCTGACCGATGACGAGGGGTGGCGGCTCGAGATCA
AGGCTTTCCCGCAACTGACAGAAATCGCCGCCTGGCGTGGCCACGATCTGCCAGTGGGGCCCCAGCTCAGTGGCGGCCCC
GAACCCTATGGCGGCTACTACACCCAAAGCGAGGTACGCGAGCTGGTGGCTTATGCCAGCGAGCTCGGTATTACCGTCAT
CCCCGAGATCGACATCCCGGGCCACTGCCACGCCGCCATCAAGGCGCTGCCCGGGCTACTGATCGAGGAAGCGGATCGCT
CCCGCTACCTGTCGGTGCAATATTTCGACGACAACGTGCTCAACCCGGCCCTGCCCGGCACCTATCAGTTCCTGGAGGCG
GTAATCGACGAGGTGTGCGAGCTGTTCCCGGGCCCCTTGGTACACATGGGGGGGGACGAGGTACCGACCGGAGTATGGAC
CGACAGCCCGGCCTGCCAGCAGTTGATGCAACGGCAGGGATATCAGGATTACCGCGAGCTGCAGGGCCACCTGCTGCGCC
ACTGCCAACAGTATCTGGCCAGCAAGGGCAAGCAGATGCTGGGTTGGGAGGAGATATTGCACGGCGACAAGGTAAGCCGG
GATGCCACCATCTTCGCCTGGACCAGCTTCCAGGCAGGGCTGGATGCCGCGGCTGCGGGCTATCCCGTTGTGATGGCACC
GGCCCAGCACCTCTATCTGGATCTGGCCTGGAGCCAGGATCCCCGAGAACCCGGCCTCTACTGGGCGGGCACCCTCAATC
TGGAGCAGGTCTATCGATGTGATCCTGCCCCGGCCGATTTCCATGCCAACGATAACATCCTGGGGGTGCTGAGCCCCTTA
TGGTCGGAACTGGTTACCTCTCGTGACCGTCTCGACTATATGTTGTTCCCGCGCATGCTGGCCACCGCCGAGGTGGCCTG
GAGCGACGCCACCCGCAAGGCGTGGGATCACTTCGCCGCCCGCCTGCCGGGCCAGCTGCAGATCCTCGACCAGCTACAGG
TGCGTTATCGGGTGCCACAGAGGTAG

Upstream 100 bases:

>100_bases
GAATACCCATGCCTGCACTTTGGATCCCTCCCCGGGTTGACCAGTACCACAAGGAGATGATCGCCCTGTTTGTTCCCTTA
ACTCCATCAGAGGAATTTTC

Downstream 100 bases:

>100_bases
TGTTATCTTTCTGTCTGGCGACCTTTGGGTCGCCTTTTTTTACCATCCACCAACAAAAAACCAACTTTCCCCTACCATTC
ATCCGCCATTGTTGGCAAAA

Product: N-acetyl-beta-hexosaminidase

Products: NA

Alternate protein names: Beta-N-acetylhexosaminidase; N-acetyl-beta-glucosaminidase [H]

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MSTPLIHTQVDRRDGEDVWFRFSLSQLPAAPWKLHFCLARHIDPASLEGARLERQSGSYKVLIPAEGQSELRFCCRNTPI
KRLSDMPQGFFLSLPEASTGTQLMPVTLVEQELGLPPSGPGAPDLPEVEPLTGIVPQPDQLVLLEGNFRLAERAHVSGPG
SLTGLLAHFNELTGLALEQDHDAEIRLFEAPLAAEAYRLTITPEGVTIAAAGEAGWRHGLTSLAQWALQHGESLPCIELV
DAPRFGFRGIFLDCARHFHPVANLKRLLKLMSLYKFNRFHWHLTDDEGWRLEIKAFPQLTEIAAWRGHDLPVGPQLSGGP
EPYGGYYTQSEVRELVAYASELGITVIPEIDIPGHCHAAIKALPGLLIEEADRSRYLSVQYFDDNVLNPALPGTYQFLEA
VIDEVCELFPGPLVHMGGDEVPTGVWTDSPACQQLMQRQGYQDYRELQGHLLRHCQQYLASKGKQMLGWEEILHGDKVSR
DATIFAWTSFQAGLDAAAAGYPVVMAPAQHLYLDLAWSQDPREPGLYWAGTLNLEQVYRCDPAPADFHANDNILGVLSPL
WSELVTSRDRLDYMLFPRMLATAEVAWSDATRKAWDHFAARLPGQLQILDQLQVRYRVPQR

Sequences:

>Translated_621_residues
MSTPLIHTQVDRRDGEDVWFRFSLSQLPAAPWKLHFCLARHIDPASLEGARLERQSGSYKVLIPAEGQSELRFCCRNTPI
KRLSDMPQGFFLSLPEASTGTQLMPVTLVEQELGLPPSGPGAPDLPEVEPLTGIVPQPDQLVLLEGNFRLAERAHVSGPG
SLTGLLAHFNELTGLALEQDHDAEIRLFEAPLAAEAYRLTITPEGVTIAAAGEAGWRHGLTSLAQWALQHGESLPCIELV
DAPRFGFRGIFLDCARHFHPVANLKRLLKLMSLYKFNRFHWHLTDDEGWRLEIKAFPQLTEIAAWRGHDLPVGPQLSGGP
EPYGGYYTQSEVRELVAYASELGITVIPEIDIPGHCHAAIKALPGLLIEEADRSRYLSVQYFDDNVLNPALPGTYQFLEA
VIDEVCELFPGPLVHMGGDEVPTGVWTDSPACQQLMQRQGYQDYRELQGHLLRHCQQYLASKGKQMLGWEEILHGDKVSR
DATIFAWTSFQAGLDAAAAGYPVVMAPAQHLYLDLAWSQDPREPGLYWAGTLNLEQVYRCDPAPADFHANDNILGVLSPL
WSELVTSRDRLDYMLFPRMLATAEVAWSDATRKAWDHFAARLPGQLQILDQLQVRYRVPQR
>Mature_620_residues
STPLIHTQVDRRDGEDVWFRFSLSQLPAAPWKLHFCLARHIDPASLEGARLERQSGSYKVLIPAEGQSELRFCCRNTPIK
RLSDMPQGFFLSLPEASTGTQLMPVTLVEQELGLPPSGPGAPDLPEVEPLTGIVPQPDQLVLLEGNFRLAERAHVSGPGS
LTGLLAHFNELTGLALEQDHDAEIRLFEAPLAAEAYRLTITPEGVTIAAAGEAGWRHGLTSLAQWALQHGESLPCIELVD
APRFGFRGIFLDCARHFHPVANLKRLLKLMSLYKFNRFHWHLTDDEGWRLEIKAFPQLTEIAAWRGHDLPVGPQLSGGPE
PYGGYYTQSEVRELVAYASELGITVIPEIDIPGHCHAAIKALPGLLIEEADRSRYLSVQYFDDNVLNPALPGTYQFLEAV
IDEVCELFPGPLVHMGGDEVPTGVWTDSPACQQLMQRQGYQDYRELQGHLLRHCQQYLASKGKQMLGWEEILHGDKVSRD
ATIFAWTSFQAGLDAAAAGYPVVMAPAQHLYLDLAWSQDPREPGLYWAGTLNLEQVYRCDPAPADFHANDNILGVLSPLW
SELVTSRDRLDYMLFPRMLATAEVAWSDATRKAWDHFAARLPGQLQILDQLQVRYRVPQR

Specific function: Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc, and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc), aryl-beta-GalNAc a

COG id: COG3525

COG function: function code G; N-acetyl-beta-hexosaminidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 20 family [H]

Homologues:

Organism=Homo sapiens, GI4504373, Length=443, Percent_Identity=27.313769751693, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI189181666, Length=300, Percent_Identity=30.3333333333333, Blast_Score=149, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17569815, Length=422, Percent_Identity=25.8293838862559, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24657468, Length=493, Percent_Identity=26.1663286004057, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17647501, Length=493, Percent_Identity=26.1663286004057, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281365639, Length=493, Percent_Identity=26.1663286004057, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24657474, Length=493, Percent_Identity=26.1663286004057, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24653074, Length=424, Percent_Identity=28.0660377358491, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551090, Length=424, Percent_Identity=28.0660377358491, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17933586, Length=438, Percent_Identity=26.2557077625571, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR001540
- InterPro:   IPR015883
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00728 Glyco_hydro_20; PF02838 Glyco_hydro_20b [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 69331; Mature: 69199

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPLIHTQVDRRDGEDVWFRFSLSQLPAAPWKLHFCLARHIDPASLEGARLERQSGSYK
CCCCCEEEECCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCEE
VLIPAEGQSELRFCCRNTPIKRLSDMPQGFFLSLPEASTGTQLMPVTLVEQELGLPPSGP
EEEECCCCHHHHHHHCCCCHHHHHCCCCCEEEECCCCCCCCEEEEEEEEHHHCCCCCCCC
GAPDLPEVEPLTGIVPQPDQLVLLEGNFRLAERAHVSGPGSLTGLLAHFNELTGLALEQD
CCCCCCCCCCCCCCCCCCCCEEEEECCEEEEHHCCCCCCHHHHHHHHHHHHHHCCEECCC
HDAEIRLFEAPLAAEAYRLTITPEGVTIAAAGEAGWRHGLTSLAQWALQHGESLPCIELV
CCCEEEEEECCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
DAPRFGFRGIFLDCARHFHPVANLKRLLKLMSLYKFNRFHWHLTDDEGWRLEIKAFPQLT
CCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCHH
EIAAWRGHDLPVGPQLSGGPEPYGGYYTQSEVRELVAYASELGITVIPEIDIPGHCHAAI
HHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHH
KALPGLLIEEADRSRYLSVQYFDDNVLNPALPGTYQFLEAVIDEVCELFPGPLVHMGGDE
HHCCCHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
VPTGVWTDSPACQQLMQRQGYQDYRELQGHLLRHCQQYLASKGKQMLGWEEILHGDKVSR
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHCCCCCCC
DATIFAWTSFQAGLDAAAAGYPVVMAPAQHLYLDLAWSQDPREPGLYWAGTLNLEQVYRC
CCEEEEEECCCCCCCHHHCCCCEEECCCCEEEEEEEECCCCCCCCEEEEEECCHHHHHCC
DPAPADFHANDNILGVLSPLWSELVTSRDRLDYMLFPRMLATAEVAWSDATRKAWDHFAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
RLPGQLQILDQLQVRYRVPQR
HCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STPLIHTQVDRRDGEDVWFRFSLSQLPAAPWKLHFCLARHIDPASLEGARLERQSGSYK
CCCCEEEECCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCEE
VLIPAEGQSELRFCCRNTPIKRLSDMPQGFFLSLPEASTGTQLMPVTLVEQELGLPPSGP
EEEECCCCHHHHHHHCCCCHHHHHCCCCCEEEECCCCCCCCEEEEEEEEHHHCCCCCCCC
GAPDLPEVEPLTGIVPQPDQLVLLEGNFRLAERAHVSGPGSLTGLLAHFNELTGLALEQD
CCCCCCCCCCCCCCCCCCCCEEEEECCEEEEHHCCCCCCHHHHHHHHHHHHHHCCEECCC
HDAEIRLFEAPLAAEAYRLTITPEGVTIAAAGEAGWRHGLTSLAQWALQHGESLPCIELV
CCCEEEEEECCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
DAPRFGFRGIFLDCARHFHPVANLKRLLKLMSLYKFNRFHWHLTDDEGWRLEIKAFPQLT
CCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCHH
EIAAWRGHDLPVGPQLSGGPEPYGGYYTQSEVRELVAYASELGITVIPEIDIPGHCHAAI
HHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHH
KALPGLLIEEADRSRYLSVQYFDDNVLNPALPGTYQFLEAVIDEVCELFPGPLVHMGGDE
HHCCCHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
VPTGVWTDSPACQQLMQRQGYQDYRELQGHLLRHCQQYLASKGKQMLGWEEILHGDKVSR
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHCCCCCCC
DATIFAWTSFQAGLDAAAAGYPVVMAPAQHLYLDLAWSQDPREPGLYWAGTLNLEQVYRC
CCEEEEEECCCCCCCHHHCCCCEEECCCCEEEEEEEECCCCCCCCEEEEEECCHHHHHCC
DPAPADFHANDNILGVLSPLWSELVTSRDRLDYMLFPRMLATAEVAWSDATRKAWDHFAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
RLPGQLQILDQLQVRYRVPQR
HCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969205 [H]