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The map label for this gene is fkpA [H]

Identifier: 145299933

GI number: 145299933

Start: 3260805

End: 3261275

Strand: Direct

Name: fkpA [H]

Synonym: ASA_3025

Alternate gene names: 145299933

Gene position: 3260805-3261275 (Clockwise)

Preceding gene: 145299932

Following gene: 145299934

Centisome position: 69.34

GC content: 56.9

Gene sequence:

>471_bases
ATGAAATTCATTCTGATCGCGCTGCTGATTGCCGGTGTCGCCTACTACTTCTACTCCAGCAGCAACAACAAAAAACAAGC
GGTGGAAAATGTGCGCAAGGGCGCCGAGTTCCTCGCCAGCAACAAAGACAAACCTCTGGTGACCACCACTGCCTCCGGTC
TGCAATACGAAGTGCTGACACCGGGCACAGGCACGGTTCACCCCACCTCCACCAGCAAGGTGAAGGTGCACTACGAGGGC
AAGCTGCTGGACGGCACAGTGTTCGACAGCTCGGTCGCCCGTGGCGAGCCCATCGAGTTTGGCCTCAATCAGGTGATAGC
TGGCTGGACCGAAGGGGTACAGCTGATGGTGGAAGGTGAGAAGACCCGCTTCTACATCTCCGCCAATCTGGCCTATGGCG
ACCGTGCCGCAGGCAAGATACCGCCGGGATCAGTGCTGATCTTTGACGTTGAGCTGCTGGGTATTCAATAA

Upstream 100 bases:

>100_bases
CTGTCAGATCCTGCGGCGTCCCGGCTCGCCCTCTCTGGCTGGCTGGGATATGATGCCGCTCTCATTGCACTCTTTATATG
TGAGGGAATAGGGATAAACG

Downstream 100 bases:

>100_bases
GCAGGTTTATGCCAATCGCGCCGCTGGCAAGATCCCACTGAGCCCCCGTGCTGATCTTCGACGTTGAGCTGCTGGGTATC
CAATAAGCAGGCTTATGCCA

Product: peptidyl-prolyl cis-trans isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKFILIALLIAGVAYYFYSSSNNKKQAVENVRKGAEFLASNKDKPLVTTTASGLQYEVLTPGTGTVHPTSTSKVKVHYEG
KLLDGTVFDSSVARGEPIEFGLNQVIAGWTEGVQLMVEGEKTRFYISANLAYGDRAAGKIPPGSVLIFDVELLGIQ

Sequences:

>Translated_156_residues
MKFILIALLIAGVAYYFYSSSNNKKQAVENVRKGAEFLASNKDKPLVTTTASGLQYEVLTPGTGTVHPTSTSKVKVHYEG
KLLDGTVFDSSVARGEPIEFGLNQVIAGWTEGVQLMVEGEKTRFYISANLAYGDRAAGKIPPGSVLIFDVELLGIQ
>Mature_156_residues
MKFILIALLIAGVAYYFYSSSNNKKQAVENVRKGAEFLASNKDKPLVTTTASGLQYEVLTPGTGTVHPTSTSKVKVHYEG
KLLDGTVFDSSVARGEPIEFGLNQVIAGWTEGVQLMVEGEKTRFYISANLAYGDRAAGKIPPGSVLIFDVELLGIQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=43.9252336448598, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=43.9252336448598, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI206725530, Length=86, Percent_Identity=50, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI17149844, Length=86, Percent_Identity=50, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI17149842, Length=86, Percent_Identity=50, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=39.2523364485981, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4503727, Length=165, Percent_Identity=30.9090909090909, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI224809329, Length=142, Percent_Identity=35.9154929577465, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI224809327, Length=142, Percent_Identity=35.9154929577465, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4758384, Length=142, Percent_Identity=35.9154929577465, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI224809331, Length=142, Percent_Identity=36.6197183098592, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI8923659, Length=86, Percent_Identity=44.1860465116279, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI4503729, Length=97, Percent_Identity=43.298969072165, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI33469985, Length=82, Percent_Identity=40.2439024390244, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI192448443, Length=105, Percent_Identity=37.1428571428571, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI87082390, Length=124, Percent_Identity=54.0322580645161, Blast_Score=127, Evalue=3e-31,
Organism=Escherichia coli, GI1789745, Length=133, Percent_Identity=42.1052631578947, Blast_Score=100, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17561782, Length=95, Percent_Identity=48.4210526315789, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=40.5660377358491, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=87, Percent_Identity=49.4252873563218, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=54.5454545454545, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=106, Percent_Identity=43.3962264150943, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323482, Length=118, Percent_Identity=38.135593220339, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=45.7943925233645, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=46.7289719626168, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281363946, Length=110, Percent_Identity=42.7272727272727, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17352457, Length=110, Percent_Identity=42.7272727272727, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356629, Length=87, Percent_Identity=48.2758620689655, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16832; Mature: 16832

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFILIALLIAGVAYYFYSSSNNKKQAVENVRKGAEFLASNKDKPLVTTTASGLQYEVLT
CHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEC
PGTGTVHPTSTSKVKVHYEGKLLDGTVFDSSVARGEPIEFGLNQVIAGWTEGVQLMVEGE
CCCCEECCCCCCEEEEEECCEEEECEEECCCCCCCCCHHHCHHHHHHCCCCCEEEEEECC
KTRFYISANLAYGDRAAGKIPPGSVLIFDVELLGIQ
CEEEEEEEEEEECCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MKFILIALLIAGVAYYFYSSSNNKKQAVENVRKGAEFLASNKDKPLVTTTASGLQYEVLT
CHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEC
PGTGTVHPTSTSKVKVHYEGKLLDGTVFDSSVARGEPIEFGLNQVIAGWTEGVQLMVEGE
CCCCEECCCCCCEEEEEECCEEEECEEECCCCCCCCCHHHCHHHHHHCCCCCEEEEEECC
KTRFYISANLAYGDRAAGKIPPGSVLIFDVELLGIQ
CEEEEEEEEEEECCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]