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The map label for this gene is uxuB [H]

Identifier: 145296484

GI number: 145296484

Start: 2632172

End: 2633524

Strand: Direct

Name: uxuB [H]

Synonym: cgR_2395

Alternate gene names: 145296484

Gene position: 2632172-2633524 (Clockwise)

Preceding gene: 145296483

Following gene: 145296485

Centisome position: 79.42

GC content: 57.43

Gene sequence:

>1353_bases
ATGAGCACGCCGCTAAATCGCAAGAACGCTTCCTGCCCGGACGCGCCCCCTGTTCGCCTAGTTCACCTAGGCCTTGGCGC
TTTCCACCGCGCACACCAGGTCTGGTACACCCAAAAAGCTGATCCAACCTGGGGTTATGCATCCTTTACTGGCCGCAGTG
CCCGCATGTCTGATGCGTTAACTCCACAGGATGGCCTGTACACCTTGGTGACTCGTTCTGGTGAAGGCGATTCACCTGAA
CTAATTTCTTCCCTCGTTGAGGCCCAACCTGCAGCGAACGTGGAACGCCTCGTTGAGTTGATGGCAGATCCGCAGGTTGC
TGTGGTTACTTTGACCATCACTGAGGCTGGCTATCACTTGGCTGCAGATGGCTCTTTGGATGAAGCCCACGAAGATGTCG
CTTCTGACTTGGAAGCACTTGCGGGAGACTCTTTAGAGTTGAAGACCGCCGCTGGCAAGTTGGTCAAGGGCTTGGCTGCA
CGTAAGACTGCTGAAGCTGGCGGAATTGCCATCATGAGCTGCGACAACATTGCAGACAACGGTGCGCTAACCTCCGGTGC
AGTTCTTGGCCTTGCCGCAAAGGTCTCCCCTGAATTGGCAGCGTGGGTCAAGGACAACGTCACCTTCCCATCCACCTCCA
TCGACCGCATTACCCCAGCTACTGAGGATTCCTTGATCGCGGACGTGGAAGCCCAGACCGGTTTCCACGACAACGCCCCT
GTTGTCACCGAACCTTTCGCTTCTTGGATCATCGAAGGTGAATTCCCTGCTGGCCGCCCTAATTGGGAGAACGCTGGCGT
GGAATTCGTCTCCGATATTGAGCAGTTTGAGCGTCGCAAGCTGTGGCTCCTCAACGGCTCACACTCCCTGATGGCGTACT
TCGGCCAGCTGCGCGGACACGCAACCGTTGCCGATGCAATCAACGATTCTGTCGTGCGTTCCCACGTGGAAGCCCTCTGG
GATGAGGCAGCAAATCACCTCACAGCCGAAGGCCTCAACGTCCCTGGTTACCGCCAGAGCCTGATCGAGCGTTTCGAAAA
CCCTCGCATCGTGCACAACTTGGCGCAGATCGCCATCGACGGCGCAACCAAGCAGCGCATGCGCGCGGTCCCAATCCTCA
AGGCCGAACTCGCAGCCGGCCGCCCCGGAAACGGTGCCGCGCTGTCGATCGCGGCGTGGATCGCCTACGTCCTAGGCACC
GAGGAAGTCCGCGACACCCGCTCAGCGGAAATCAACGAGGCAAAATTGCTTGACGACGCGATCCTCGGCCTCATCACTGT
TCTCGACGAAGACCTCGCCACCAATGATGCAATCGTTACACACATTAAGAAAGTTGTTTCCGAACTTTCTTAG

Upstream 100 bases:

>100_bases
ACCTGGCACGTCTTGTTGCAGAGCACCGCATCACCGAAAGCCGCGCCGCTGAAATCATCGTGGATCTCATCGATGCTTCC
CCAAGAAGGGTCTTCAAACT

Downstream 100 bases:

>100_bases
AACCCATCAGTTTTAACAGTGCCACCTGCCGGCCAGCCTTTATTTGTTTAGTCTCCGGAACTTGGCACTAATTTAGATAC
CTGGAGATTTTTCGTGACTA

Product: hypothetical protein

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSTPLNRKNASCPDAPPVRLVHLGLGAFHRAHQVWYTQKADPTWGYASFTGRSARMSDALTPQDGLYTLVTRSGEGDSPE
LISSLVEAQPAANVERLVELMADPQVAVVTLTITEAGYHLAADGSLDEAHEDVASDLEALAGDSLELKTAAGKLVKGLAA
RKTAEAGGIAIMSCDNIADNGALTSGAVLGLAAKVSPELAAWVKDNVTFPSTSIDRITPATEDSLIADVEAQTGFHDNAP
VVTEPFASWIIEGEFPAGRPNWENAGVEFVSDIEQFERRKLWLLNGSHSLMAYFGQLRGHATVADAINDSVVRSHVEALW
DEAANHLTAEGLNVPGYRQSLIERFENPRIVHNLAQIAIDGATKQRMRAVPILKAELAAGRPGNGAALSIAAWIAYVLGT
EEVRDTRSAEINEAKLLDDAILGLITVLDEDLATNDAIVTHIKKVVSELS

Sequences:

>Translated_450_residues
MSTPLNRKNASCPDAPPVRLVHLGLGAFHRAHQVWYTQKADPTWGYASFTGRSARMSDALTPQDGLYTLVTRSGEGDSPE
LISSLVEAQPAANVERLVELMADPQVAVVTLTITEAGYHLAADGSLDEAHEDVASDLEALAGDSLELKTAAGKLVKGLAA
RKTAEAGGIAIMSCDNIADNGALTSGAVLGLAAKVSPELAAWVKDNVTFPSTSIDRITPATEDSLIADVEAQTGFHDNAP
VVTEPFASWIIEGEFPAGRPNWENAGVEFVSDIEQFERRKLWLLNGSHSLMAYFGQLRGHATVADAINDSVVRSHVEALW
DEAANHLTAEGLNVPGYRQSLIERFENPRIVHNLAQIAIDGATKQRMRAVPILKAELAAGRPGNGAALSIAAWIAYVLGT
EEVRDTRSAEINEAKLLDDAILGLITVLDEDLATNDAIVTHIKKVVSELS
>Mature_449_residues
STPLNRKNASCPDAPPVRLVHLGLGAFHRAHQVWYTQKADPTWGYASFTGRSARMSDALTPQDGLYTLVTRSGEGDSPEL
ISSLVEAQPAANVERLVELMADPQVAVVTLTITEAGYHLAADGSLDEAHEDVASDLEALAGDSLELKTAAGKLVKGLAAR
KTAEAGGIAIMSCDNIADNGALTSGAVLGLAAKVSPELAAWVKDNVTFPSTSIDRITPATEDSLIADVEAQTGFHDNAPV
VTEPFASWIIEGEFPAGRPNWENAGVEFVSDIEQFERRKLWLLNGSHSLMAYFGQLRGHATVADAINDSVVRSHVEALWD
EAANHLTAEGLNVPGYRQSLIERFENPRIVHNLAQIAIDGATKQRMRAVPILKAELAAGRPGNGAALSIAAWIAYVLGTE
EVRDTRSAEINEAKLLDDAILGLITVLDEDLATNDAIVTHIKKVVSELS

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=456, Percent_Identity=37.0614035087719, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1788497, Length=456, Percent_Identity=36.1842105263158, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1787823, Length=394, Percent_Identity=39.5939086294416, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI48994885, Length=423, Percent_Identity=28.3687943262411, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1790028, Length=231, Percent_Identity=29.8701298701299, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324401, Length=398, Percent_Identity=33.1658291457286, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320765, Length=398, Percent_Identity=33.1658291457286, Blast_Score=214, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 48059; Mature: 47928

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPLNRKNASCPDAPPVRLVHLGLGAFHRAHQVWYTQKADPTWGYASFTGRSARMSDAL
CCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHCCCC
TPQDGLYTLVTRSGEGDSPELISSLVEAQPAANVERLVELMADPQVAVVTLTITEAGYHL
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEECCCEEE
AADGSLDEAHEDVASDLEALAGDSLELKTAAGKLVKGLAARKTAEAGGIAIMSCDNIADN
EECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
GALTSGAVLGLAAKVSPELAAWVKDNVTFPSTSIDRITPATEDSLIADVEAQTGFHDNAP
CCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHCCCCCCCC
VVTEPFASWIIEGEFPAGRPNWENAGVEFVSDIEQFERRKLWLLNGSHSLMAYFGQLRGH
CEECCHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHCCC
ATVADAINDSVVRSHVEALWDEAANHLTAEGLNVPGYRQSLIERFENPRIVHNLAQIAID
CHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHC
GATKQRMRAVPILKAELAAGRPGNGAALSIAAWIAYVLGTEEVRDTRSAEINEAKLLDDA
CHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHH
ILGLITVLDEDLATNDAIVTHIKKVVSELS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STPLNRKNASCPDAPPVRLVHLGLGAFHRAHQVWYTQKADPTWGYASFTGRSARMSDAL
CCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHCCCC
TPQDGLYTLVTRSGEGDSPELISSLVEAQPAANVERLVELMADPQVAVVTLTITEAGYHL
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEECCCEEE
AADGSLDEAHEDVASDLEALAGDSLELKTAAGKLVKGLAARKTAEAGGIAIMSCDNIADN
EECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
GALTSGAVLGLAAKVSPELAAWVKDNVTFPSTSIDRITPATEDSLIADVEAQTGFHDNAP
CCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHCCCCCCCC
VVTEPFASWIIEGEFPAGRPNWENAGVEFVSDIEQFERRKLWLLNGSHSLMAYFGQLRGH
CEECCHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHCCC
ATVADAINDSVVRSHVEALWDEAANHLTAEGLNVPGYRQSLIERFENPRIVHNLAQIAID
CHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHC
GATKQRMRAVPILKAELAAGRPGNGAALSIAAWIAYVLGTEEVRDTRSAEINEAKLLDDA
CHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHH
ILGLITVLDEDLATNDAIVTHIKKVVSELS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]