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The map label for this gene is lysA [C]

Identifier: 145296096

GI number: 145296096

Start: 2219738

End: 2222392

Strand: Reverse

Name: lysA [C]

Synonym: cgR_2017

Alternate gene names: 145296096

Gene position: 2222392-2219738 (Counterclockwise)

Preceding gene: 145296097

Following gene: 145296095

Centisome position: 67.06

GC content: 49.72

Gene sequence:

>2655_bases
ATGGGTGGAGGAAAACCTTTGTTCAAGGTAGCTATCATTGGTGGCGGACCGCGCGGGTTGTGGGCTGCTGAAGAATTACT
AGCTCTTGCTAGGGAGAGAGGAGCCAGCATTGATCTTCATGTTTTTAATGATGGTCTCGGTGTGGCATATCAACCTGATC
AGCCTGAAGAATGGCTGATAAATGTACGATCTTCCACGATTACTACACAGTTCAGCGACTTCAGTCAATGGCTACGAAAA
CGCAATGTAGATTCATCTTTCCCACCTCGACGATTAGTAGGGGAGTTCCTGGAAGAATCTTGGGATGCGCTTCTTGAATA
TGTACCTCAGGGGTGTTCTCTTACGATGCACACTAAACATGTAGACACAATCAAACCCTGCGGTAAAAAGAGTGAACGTT
GGTTAGTGCAGGAACAAGAGTTTGATGAAATTCTTTTAGCTACTGGACATGCACACGATTGGCCTGGATCCTTATCGCAA
GAAGATTTCCCTGAGTCAGTACGCCTGATCGCATCTCCTTATCCTGCTAATAATCTAGACGGGATCAAGTCCACAGACAG
AGTGTTAGTGCGTGGGGCAGCTCTCACTTTCATCGACATCACTCGAGTATGCTCACCGGCCGTATTCATTCCAATAACCC
GCACAGGGAAACTAATGATACCGAAGCCCGACGTGACTGACTTATATTTAGAGGACCTCTTAAATGAGGGTTCGGAAAAT
ATTCGGTCCGCCAAGGATCTTTCCGAACTTAGGACAGTTCTAAAAGAGGTTTCCTCCCAAATTCAGGAACGAGCTGGGAA
AAAAGATGAAGAATGGGGAATGGGGGCTACTTGGCGGGAGCTGTACCCAAGCATCGTGGAACGCGCTTCATACGAAGGGC
GTGACAGCTTGAAGGGGTTTGATCACTTAGCCCGGGAAATGGAAAGACTAGCCTTCGGCCCACCACCCGAAAGTTTTAAC
TACCTCCAAGAACTCGTAAAATCCGGAGTGGTAGACATCACTCACCTGCATCGTGGCCGGGAACCACTGGCAGATTTGGT
TCGTGAACTTGAAATAACTGTGGTGATAGACGCAGTTATTCCCCCACCGGGAGTAGTGCCAGGCACATTGGTGCACAATT
TGGTAAAAGAGGGATATGCCAGAATCCGTCCTGGGACTCGGGGGTTAGATGTAGCGGCTGACGGCACCGTTCAAGGGCAG
CAACATTTGGCTGCAGTCGGACGGATGACGGAAGATGTGGTTTTGGGTAATGACACATTGTCGCGGTCATTGCATGACAT
AATCCCGAAGTGGGCTCGGCGAGTTGTCCGCGACGCGAGTACGTATCCCAATAGGGTGCATGGTATTCCACCGCTTCCGG
CACGGTTGGAACCCTGGGCGGAAAAGCTCACTTCAGATCCGGCCACATGCCGCCACCTGATTGAAGAATTCGGGAGTCCT
GTGAATGTACTCCATTCAGGTTCTATGCCTCGTAATATAAATGAGTTGGTTGACGCCGGCATTGAGATGGGGGTGGATAC
TCGAATATTTTTTGCCCGTAAAGCGAATAAGGGTCTTACCTTCGTCGATGCCGTTAAAGACACCGGTCATGGTGTAGATG
TAGCCAGTGAACGAGAGTTATCTCAGGTGCTTAATCGTGGAGTCCCAGGAGAGCGGATCATTCTATCCGCAGCTATCAAA
CCGGACAGACTATTAGCATTAGCGATCGAAAATGGCGTGATCATCTCTGTGGATTCGCGTGATGAATTAGATCGCATTTC
GGCTTTGGTTGGCGACCGCGTTGCACGAGTTGCGCCTAGAGTAGCTCCAGATCCTGCAGTCTTACCTCCAACTAGATTTG
GTGAGCGAGCCGCAGACTGGGGTAATCGGCTTACCGAGGTGATACCCGGCGTGGATATTGTGGGTCTTCACGTTCACCTT
CATGGCTATGCTGCAAAAGACCGTGCTCTAGCTCTACAGGAATGTTGCCAACTCGTCGATTCTCTCAGAGAATGCGGGCA
TTCCCCACAGTTTATTGACCTTGGAGGAGGGGTACCTATGAGCTACATTGAATCTGAGGAAGATTGGATCCGTTATCAAT
CCGCTAAATCTGCGACTTCAGCCGGGTATGCCGAATCCTTTACGTGGAAAGACGATCCGTTATCTAATACGTACCCGTTC
TATCAGACCCCAGTGCGCGGTAATTGGTTGAAAGATGTGCTTTCTAAGGGGGTAGCCCAGATGCTCATTGACCGGGGATT
GCGGTTACACCTAGAGCCTGGTCGAAGTTTACTAGATGGGTGTGGCGTCACTCTTGCCGAAGTTGCTTTTGTGAAAACCC
GAAGTGACGGGTTGCCTCTAGTGGGACTGGCTATGAACCGAACGCAGTGCCGGACTACATCCGATGATTTTCTCATTGAT
CCCCTGCATATCACTGACGGTGATGTAGGTGAGGAAATCGAAGCATATCTAGTGGGTGCCTACTGCATCGAAGATGAGCT
GATTTTACGCCGGCGAATCCGCTTCCCGAGAGGAATCAAACCAGGAGATATCATCGGAATTCCTAACACCGCAGGATACT
TCATGCATATCTTGGAAAGTGCATCGCACCAAATCCCGTTGGCGAAAAATGTAGTGTGGCCGGAGGGGCAGTTAGACGAT
ATCGATGCGGATTAA

Upstream 100 bases:

>100_bases
CTATGGAGATATTACGCCCCGACATCCCTGCGGGTAGCAATGTAGTAGTAATTCTTCATGATGACGGAAATAAGTATTTA
GATACGATTTATAACGACGA

Downstream 100 bases:

>100_bases
GACATAACCATTCGCTAATCTTTCGACGCCCCTTCTGAGGTGGGGATTTCTTTTCATCCCCTTTAATTATTTTCGGAAAT
TTAAACAACAATCCTCGAAA

Product: hypothetical protein

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 884; Mature: 883

Protein sequence:

>884_residues
MGGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLINVRSSTITTQFSDFSQWLRK
RNVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKHVDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQ
EDFPESVRLIASPYPANNLDGIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEN
IRSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLKGFDHLAREMERLAFGPPPESFN
YLQELVKSGVVDITHLHRGREPLADLVRELEITVVIDAVIPPPGVVPGTLVHNLVKEGYARIRPGTRGLDVAADGTVQGQ
QHLAAVGRMTEDVVLGNDTLSRSLHDIIPKWARRVVRDASTYPNRVHGIPPLPARLEPWAEKLTSDPATCRHLIEEFGSP
VNVLHSGSMPRNINELVDAGIEMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASERELSQVLNRGVPGERIILSAAIK
PDRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPRVAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHL
HGYAAKDRALALQECCQLVDSLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPF
YQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPLVGLAMNRTQCRTTSDDFLID
PLHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGIKPGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDD
IDAD

Sequences:

>Translated_884_residues
MGGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLINVRSSTITTQFSDFSQWLRK
RNVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKHVDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQ
EDFPESVRLIASPYPANNLDGIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEN
IRSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLKGFDHLAREMERLAFGPPPESFN
YLQELVKSGVVDITHLHRGREPLADLVRELEITVVIDAVIPPPGVVPGTLVHNLVKEGYARIRPGTRGLDVAADGTVQGQ
QHLAAVGRMTEDVVLGNDTLSRSLHDIIPKWARRVVRDASTYPNRVHGIPPLPARLEPWAEKLTSDPATCRHLIEEFGSP
VNVLHSGSMPRNINELVDAGIEMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASERELSQVLNRGVPGERIILSAAIK
PDRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPRVAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHL
HGYAAKDRALALQECCQLVDSLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPF
YQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPLVGLAMNRTQCRTTSDDFLID
PLHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGIKPGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDD
IDAD
>Mature_883_residues
GGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLINVRSSTITTQFSDFSQWLRKR
NVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKHVDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQE
DFPESVRLIASPYPANNLDGIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSENI
RSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLKGFDHLAREMERLAFGPPPESFNY
LQELVKSGVVDITHLHRGREPLADLVRELEITVVIDAVIPPPGVVPGTLVHNLVKEGYARIRPGTRGLDVAADGTVQGQQ
HLAAVGRMTEDVVLGNDTLSRSLHDIIPKWARRVVRDASTYPNRVHGIPPLPARLEPWAEKLTSDPATCRHLIEEFGSPV
NVLHSGSMPRNINELVDAGIEMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASERELSQVLNRGVPGERIILSAAIKP
DRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPRVAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHLH
GYAAKDRALALQECCQLVDSLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPFY
QTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPLVGLAMNRTQCRTTSDDFLIDP
LHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGIKPGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDDI
DAD

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG4529

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 97613; Mature: 97482

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLI
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEECCCCCHHHHE
NVRSSTITTQFSDFSQWLRKRNVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKH
EECCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
VDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQEDFPESVRLIASPYPANNLD
CCHHCCCCCCCHHCCCCHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCC
GIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEN
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCHHHHHHHHHHHCCHHH
IRSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLKGF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
DHLAREMERLAFGPPPESFNYLQELVKSGVVDITHLHRGREPLADLVRELEITVVIDAVI
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEHHHHHCCCHHHHHHHHHCEEEEEEEECC
PPPGVVPGTLVHNLVKEGYARIRPGTRGLDVAADGTVQGQQHLAAVGRMTEDVVLGNDTL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCEEECCHHH
SRSLHDIIPKWARRVVRDASTYPNRVHGIPPLPARLEPWAEKLTSDPATCRHLIEEFGSP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCC
VNVLHSGSMPRNINELVDAGIEMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASEREL
EEEHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEHHHCCCCCCCCCCHHHH
SQVLNRGVPGERIILSAAIKPDRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPR
HHHHHCCCCCCEEEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
VAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHLHGYAAKDRALALQECCQLVD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHH
SLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPF
HHHHHCCCCCEEECCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
YQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPL
EECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCHHHHHHHHHEECCCCCCE
VGLAMNRTQCRTTSDDFLIDPLHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGIK
EEEECCCCCCCCCCCCEEEECEECCCCCCCHHHHHHEEEHHHHHHHHHHHHHHCCCCCCC
PGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDDIDAD
CCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLI
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEECCCCCHHHHE
NVRSSTITTQFSDFSQWLRKRNVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKH
EECCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
VDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQEDFPESVRLIASPYPANNLD
CCHHCCCCCCCHHCCCCHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCC
GIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEN
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCHHHHHHHHHHHCCHHH
IRSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLKGF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
DHLAREMERLAFGPPPESFNYLQELVKSGVVDITHLHRGREPLADLVRELEITVVIDAVI
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEHHHHHCCCHHHHHHHHHCEEEEEEEECC
PPPGVVPGTLVHNLVKEGYARIRPGTRGLDVAADGTVQGQQHLAAVGRMTEDVVLGNDTL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCEEECCHHH
SRSLHDIIPKWARRVVRDASTYPNRVHGIPPLPARLEPWAEKLTSDPATCRHLIEEFGSP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCC
VNVLHSGSMPRNINELVDAGIEMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASEREL
EEEHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEHHHCCCCCCCCCCHHHH
SQVLNRGVPGERIILSAAIKPDRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPR
HHHHHCCCCCCEEEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
VAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHLHGYAAKDRALALQECCQLVD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHH
SLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPF
HHHHHCCCCCEEECCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
YQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPL
EECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCHHHHHHHHHEECCCCCCE
VGLAMNRTQCRTTSDDFLIDPLHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGIK
EEEECCCCCCCCCCCCEEEECEECCCCCCCHHHHHHEEEHHHHHHHHHHHHHHCCCCCCC
PGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDDIDAD
CCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]