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The map label for this gene is hisD [H]

Identifier: 145296064

GI number: 145296064

Start: 2183270

End: 2184598

Strand: Reverse

Name: hisD [H]

Synonym: cgR_1986

Alternate gene names: 145296064

Gene position: 2184598-2183270 (Counterclockwise)

Preceding gene: 145296066

Following gene: 145296063

Centisome position: 65.92

GC content: 57.11

Gene sequence:

>1329_bases
ATGTTGAATGTCACTGACCTGCGAGGTCAAACACCATCCAAGAGCGACATCCGACGTGCTTTGCCACGTGGTGGCACTGA
CGTGTGGTCTGTGCTTCCCATAGTGCAGCCTGTTGTAGAAGATGTCCAAAACCGCGGCGCTGAAGCTGCTTTGGATTACG
GCGAGAAGTTCGACCATATTCGCCCCGCCTCGGTGCGGGTGCCAGCTGAGGTTATTGCTGCAGCAGAAAACACCTTAGAT
CCGTTGGTGCGTGAATCGATTGAAGAGTCGATTCGTCGCGTCCGCAAGGTTCACGCTGAGCAAAAGCCAGCCGAGCACAC
CACTGAACTTTCACCAGGTGGCACCGTCACTGAGCGTTTCATGCCGATTGATCGCGTGGGACTGTACGTTCCAGGCGGCA
ATGCGGTGTACCCATCAAGCGTGATTATGAATACTGTCCCAGCTCAAGAGGCTGGTGTGAACTCCCTTGTGGTTGCGTCG
CCTCCTCAGGCTGAGCACGGTGGCTGGCCTCACCCCACCATTTTGGCGGCGTGTTCCATCTTGGGTGTTGATGAGGTGTG
GGCTGTCGGCGGCGGTCAGGCCGTGGCGTTGCTGGCTTATGGTGATGACGCTGCAGGTCTCGAGCCTGTGGATATGATCA
CTGGACCTGGCAATATCTTTGTCACCGCTGCGAAGCGCCTGGTCAGAGGAGTGGTAGGTACTGATTCTGAGGCTGGCCCT
ACAGAAATCGCTGTGCTTGCTGATGCCTCTGCCAACGCCGTCAACGTTGCCTACGATCTGATCAGCCAAGCAGAACACGA
TGTCATGGCTGCGTCCGTGCTCATCACTGACTCCGAGCAGCTTGCCAAGGACGTAAACAGGGAAATCGAGGCGCGTTACT
CAATCACGCGCAACGCCGAACGCGTCGCAGAAGCTTTGCGCGGGGCCCAGAGTGGCATCGTGCTTGTCGACGACATTTCC
GTGGGTATCCAAGTAGCCGATCAATACGCAGCGGAACACCTGGAAATCCACACTGAGAGCGCGCGCGCCGTAGCAGAGCA
GATCACCAACGCGGGTGCGATCTTCGTGGGCGATTTCTCACCAGTACCACTGGGTGATTACTCCGCAGGATCCAACCACG
TGCTGCCAACCTCTGGATCCGCTCGTTTCTCCGCAGGTCTATCCACGCACACGTTCCTTCGCCCAGTCAACCTCATTGAA
TACGATGAGGCTGCTCTGAAGGACGTCTCGCAGGTTGTCATCAACTTTGCCAACGCCGAAGATCTTCCAGCGCACGGCGA
AGCAATCCGTGCACGCTTTGAAAACCTCCCCACCACCGACGAGGCCTAA

Upstream 100 bases:

>100_bases
GGTAAACATGCGGGCTTAAGAACTTGTGTTGAGGCCGCTTGGATTCGGGCACCGAGCTCGAAGAATTTCGATTCAACCTT
TTAAGGGAGAACTTTTCGCC

Downstream 100 bases:

>100_bases
GAAAAATGACCAAAATTACTTTGAGCGATTTGCCATTGCGTGAAGAACTGCGCGGTGAGCACGCTTACGGCGCACCCCAG
CTCAACGTTGATATTCGCCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHIRPASVRVPAEVIAAAENTLD
PLVRESIEESIRRVRKVHAEQKPAEHTTELSPGGTVTERFMPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVAS
PPQAEHGGWPHPTILAACSILGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAERVAEALRGAQSGIVLVDDIS
VGIQVADQYAAEHLEIHTESARAVAEQITNAGAIFVGDFSPVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIE
YDEAALKDVSQVVINFANAEDLPAHGEAIRARFENLPTTDEA

Sequences:

>Translated_442_residues
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHIRPASVRVPAEVIAAAENTLD
PLVRESIEESIRRVRKVHAEQKPAEHTTELSPGGTVTERFMPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVAS
PPQAEHGGWPHPTILAACSILGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAERVAEALRGAQSGIVLVDDIS
VGIQVADQYAAEHLEIHTESARAVAEQITNAGAIFVGDFSPVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIE
YDEAALKDVSQVVINFANAEDLPAHGEAIRARFENLPTTDEA
>Mature_442_residues
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHIRPASVRVPAEVIAAAENTLD
PLVRESIEESIRRVRKVHAEQKPAEHTTELSPGGTVTERFMPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVAS
PPQAEHGGWPHPTILAACSILGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAERVAEALRGAQSGIVLVDDIS
VGIQVADQYAAEHLEIHTESARAVAEQITNAGAIFVGDFSPVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIE
YDEAALKDVSQVVINFANAEDLPAHGEAIRARFENLPTTDEA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=410, Percent_Identity=35.1219512195122, Blast_Score=235, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6319819, Length=430, Percent_Identity=34.6511627906977, Blast_Score=242, Evalue=8e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46729; Mature: 46729

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHI
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
RPASVRVPAEVIAAAENTLDPLVRESIEESIRRVRKVHAEQKPAEHTTELSPGGTVTERF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHC
MPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVASPPQAEHGGWPHPTILAACSI
CCHHHEEEEECCCCCCCCCHHHHCCCCCHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
LGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
CCCHHHHCCCCCCEEEEEEECCCCCCCCCHHEEECCCCEEHHHHHHHHHHHCCCCCCCCC
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAE
CEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEEECHHHHHHHHHHHHHHHHHHHCCHH
RVAEALRGAQSGIVLVDDISVGIQVADQYAAEHLEIHTESARAVAEQITNAGAIFVGDFS
HHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCEEEEECCC
PVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIEYDEAALKDVSQVVINFANAE
CCCCCCCCCCCCCEECCCCCCCEECCCCHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCC
DLPAHGEAIRARFENLPTTDEA
CCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLNVTDLRGQTPSKSDIRRALPRGGTDVWSVLPIVQPVVEDVQNRGAEAALDYGEKFDHI
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
RPASVRVPAEVIAAAENTLDPLVRESIEESIRRVRKVHAEQKPAEHTTELSPGGTVTERF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHC
MPIDRVGLYVPGGNAVYPSSVIMNTVPAQEAGVNSLVVASPPQAEHGGWPHPTILAACSI
CCHHHEEEEECCCCCCCCCHHHHCCCCCHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
LGVDEVWAVGGGQAVALLAYGDDAAGLEPVDMITGPGNIFVTAAKRLVRGVVGTDSEAGP
CCCHHHHCCCCCCEEEEEEECCCCCCCCCHHEEECCCCEEHHHHHHHHHHHCCCCCCCCC
TEIAVLADASANAVNVAYDLISQAEHDVMAASVLITDSEQLAKDVNREIEARYSITRNAE
CEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEEECHHHHHHHHHHHHHHHHHHHCCHH
RVAEALRGAQSGIVLVDDISVGIQVADQYAAEHLEIHTESARAVAEQITNAGAIFVGDFS
HHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCEEEEECCC
PVPLGDYSAGSNHVLPTSGSARFSAGLSTHTFLRPVNLIEYDEAALKDVSQVVINFANAE
CCCCCCCCCCCCCEECCCCCCCEECCCCHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCC
DLPAHGEAIRARFENLPTTDEA
CCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]