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The map label for this gene is cobA [H]

Identifier: 145295902

GI number: 145295902

Start: 2029457

End: 2030209

Strand: Reverse

Name: cobA [H]

Synonym: cgR_1827

Alternate gene names: 145295902

Gene position: 2030209-2029457 (Counterclockwise)

Preceding gene: 145295904

Following gene: 145295901

Centisome position: 61.26

GC content: 52.19

Gene sequence:

>753_bases
ATGATGATTTCCCAAGAAAACCAACCAACAATCCAGCCAGTCTCCTTAATTGGTGGAGGTCCTGGTGCATGGGACTTAAT
TACGGTGCGTGGGATGAATCGCCTTCAGGAGGCTGATGTCATTTTGGCTGATCACTTGGGGCCCACTGATGAGTTGGAAA
AGTTGTGCGACATCAGCTCGAAGACTGTTGTTGATGTGTCCAAGCTTCCGTATGGGCGGCAGGTCACTCAGGAGCGTACT
AATGAGATGCTTGTTGAATACGCACAGCAGGGACTAAAGGTGGTGCGCCTTAAAGGTGGTGACCCTTATGTCTTCGGTCG
GGGTTTTGAAGAGTTGGAGTTTTTGGCCGAGCATGGAATTGAATCCGAGGTCATTCCGGGTGTGACCAGTGCGGTGTCCG
TTCCAGCCGCAGCGGGAATTCCAATTACCAATCGGGGAGTGGTGCATTCCTTTACCGTGGTGTCTGGACATTTGCCTCCA
GGACATCCGAAGTCACTGGTTGATTGGGCTGCGTTGGCCAAATCTGGTGGCACCTTGTCCATCATCATGGGTGTGAAAAA
TGCGGGTGCGATTGCCCAGGCGCTCATGGACGGCGGGCTTGATGCAGATACTCCAGCAGCTGTTATTCAGGAAGGCACTA
CTGATGCACAACGCTCAGTTCGGTGCACCTTGGGCACATTGGGTGTAGTCATGGTGGAGGAAGAAATTAAGCCTCCAGCG
GTGTATGTCATTGGACAAGTTGCTGGCCTCTAA

Upstream 100 bases:

>100_bases
GGGCTGATGCGAAATCAGCTTCGAGTTTGAAAGGTGCAGTATTCATGGTTCAAGCCTAGTGTTCGGGTTCCTGCAATTGT
TGGGACTAGGATTAAAGTCC

Downstream 100 bases:

>100_bases
GCAGATCGCCTAAGAATGGGGGTAGTTTCCTCCCTTTTATAGACACTTGTCCAGGGGTTTGTTGTTGGTTTTGTGAAAAA
CCTTAAGTTGGGTGGTTAAA

Product: hypothetical protein

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MMISQENQPTIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISSKTVVDVSKLPYGRQVTQERT
NEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLAEHGIESEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPP
GHPKSLVDWAALAKSGGTLSIIMGVKNAGAIAQALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGVVMVEEEIKPPA
VYVIGQVAGL

Sequences:

>Translated_250_residues
MMISQENQPTIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISSKTVVDVSKLPYGRQVTQERT
NEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLAEHGIESEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPP
GHPKSLVDWAALAKSGGTLSIIMGVKNAGAIAQALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGVVMVEEEIKPPA
VYVIGQVAGL
>Mature_250_residues
MMISQENQPTIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISSKTVVDVSKLPYGRQVTQERT
NEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLAEHGIESEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPP
GHPKSLVDWAALAKSGGTLSIIMGVKNAGAIAQALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGVVMVEEEIKPPA
VYVIGQVAGL

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=237, Percent_Identity=39.2405063291139, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=33.4763948497854, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 26271; Mature: 26271

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMISQENQPTIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISS
CCCCCCCCCCCCEEEEECCCCCCEEEEEECCHHHHHHHCEEEECCCCCHHHHHHHHCCCC
KTVVDVSKLPYGRQVTQERTNEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLAEHGI
CCEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHHCCC
ESEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPPGHPKSLVDWAALAKSGGTLS
CCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEE
IIMGVKNAGAIAQALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGVVMVEEEIKPPA
EEEECCCHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHEEEEECCCEEEEEECCCCCCE
VYVIGQVAGL
EEEEEECCCC
>Mature Secondary Structure
MMISQENQPTIQPVSLIGGGPGAWDLITVRGMNRLQEADVILADHLGPTDELEKLCDISS
CCCCCCCCCCCCEEEEECCCCCCEEEEEECCHHHHHHHCEEEECCCCCHHHHHHHHCCCC
KTVVDVSKLPYGRQVTQERTNEMLVEYAQQGLKVVRLKGGDPYVFGRGFEELEFLAEHGI
CCEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHHCCC
ESEVIPGVTSAVSVPAAAGIPITNRGVVHSFTVVSGHLPPGHPKSLVDWAALAKSGGTLS
CCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEE
IIMGVKNAGAIAQALMDGGLDADTPAAVIQEGTTDAQRSVRCTLGTLGVVMVEEEIKPPA
EEEECCCHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHEEEEECCCEEEEEECCCCCCE
VYVIGQVAGL
EEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]