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The map label for this gene is prpD2 [H]

Identifier: 145294830

GI number: 145294830

Start: 859713

End: 861227

Strand: Direct

Name: prpD2 [H]

Synonym: cgR_0777

Alternate gene names: 145294830

Gene position: 859713-861227 (Clockwise)

Preceding gene: 145294829

Following gene: 145294831

Centisome position: 25.94

GC content: 55.58

Gene sequence:

>1515_bases
ATGATTAACCACGAAGTGCGCACCCACCGTTCTGCGGAAGAGTTCCCGTACGAGGAGCACCTGGCTCACAAGATCGCTCG
CGTTGCAGCCGACCCAGTTGAGGTTGCTGCGGACACTCAGGAAATGATCATCAACCGCATCATCGACAATGCATCGGTGC
AGGCAGCTTCCGTGTTGCGTCGACCAGTTAGCTCTGCCCGTGCGATGGCACAGGTCAGGCCAGTTACCGATGGTCGGGGT
GCATCTGTTTTCGGTTTGCCAGGACGTTATGCTGCGGAATGGGCTGCGCTTGCTAACGGCACTGCGGTGCGTGAGCTTGA
TTTCCATGACACGTTCCTCGCTGCGGAATACTCCCACCCAGGAGATAACATTCCTCCGATTCTGGCTGCAGCACAGCAGG
CTGGAAAAGGTGGCAAGGATCTGATCCGTGGCATCGCTACTGGATATGAGATTCAGGTGAACTTGGTGCGTGGAATGTGC
TTGCATGAGCACAAGATTGATCACGTTGCTCACCTTGGACCATCAGCTGCTGCTGGCATTGGAACCTTGCTGAACCTGGA
TGTGGACACCATCTACCAGGCAATTGGTCAGGCATTGCACACCACCACGGCGACGAGGCAGTCCCGTAAAGGTGCGATTT
CTTCATGGAAGGCATTTGCCCCTGCGTTTGCAGGCAAGATGTCCATCGAGGCCGTTGATCGTGCAATGCGCGGTGAGGGC
GCGCCGTCACCAATCTGGGAAGGCGAAGACGGCGTAATTGCATGGCTGCTGTCCGGTCCCGATCACATTTACACCATTCC
TTTGCCTGCAGAAGGTGAAGCCAAGCGAGCAATCTTGGATACCTACACCAAGGAACATTCGGCTGAATACCAGTCACAGG
CACCGATCGACTTGGCGCGCAGCATGGGGGAGAAGCTGGCAGCACAGGGCTTGGACCTGCGTGATGTGGAATCCATTGTG
TTGCACACCTCCCACCACACTCACTACGTGATCGGCACCGGATCTAATGATCCACAGAAGTTCGATCCTGATGCGTCGCG
TGAAACCCTTGATCACTCCATCATGTACATTTTTGCTGTCGCACTGGAGGATCGCGCGTGGCACCACGAGCGTTCCTATG
CTCCTGAGCGTGCCCACCGCCCAGAGACCATTGAGCTGTGGAACAAGATTTCCACGGTGGAGGATCCTGAGTGGACCAGG
CGTTATCACTCCGTTGATCCTGCTGAGAAGGCCTTCGGCGCACGCGCAGTGATCACCTTCAAGGATGGAACCGTCGTGGA
AGATGAACTGGCTGTGGCGGATGCGCATCCTCTGGGAGCACGGCCTTTCGCTAGGGAGCAGTACATTCAGAAATTCCGCA
CCTTGGCTGAAGGTGTTGTGTCCGAAAAGGAACAGGATCGCTTCTTGGATGCGGCACAGCGTACGCACGAGCTTGAGGAT
CTTTCAGAACTCAACATTGAATTGGATGCCGATATTTTGGCCAAGGCTCCTGTGATTCCGGAAGGACTGTTCTGA

Upstream 100 bases:

>100_bases
GTCACAAAATTACACAACTTTTACAGTGACCTAGATCGCTTTTTAAAGAATTAGCGTGGTGTGCAACATCAGTTCGTTGA
GAAGGAGTCACATTCCAGCC

Downstream 100 bases:

>100_bases
TGGCGGGTTTGTTTTCCTCTGCTGTTGCACCAACGGAGCGTCGAAAAGCATTACGCGCAGCACTGGCTGCGCCTGAAATT
GCCCGCATGCCTGGTGCATT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLRRPVSSARAMAQVRPVTDGRG
ASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHPGDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMC
LHEHKIDHVAHLGPSAAAGIGTLLNLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
APSPIWEGEDGVIAWLLSGPDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLARSMGEKLAAQGLDLRDVESIV
LHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAVALEDRAWHHERSYAPERAHRPETIELWNKISTVEDPEWTR
RYHSVDPAEKAFGARAVITFKDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
LSELNIELDADILAKAPVIPEGLF

Sequences:

>Translated_504_residues
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLRRPVSSARAMAQVRPVTDGRG
ASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHPGDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMC
LHEHKIDHVAHLGPSAAAGIGTLLNLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
APSPIWEGEDGVIAWLLSGPDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLARSMGEKLAAQGLDLRDVESIV
LHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAVALEDRAWHHERSYAPERAHRPETIELWNKISTVEDPEWTR
RYHSVDPAEKAFGARAVITFKDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
LSELNIELDADILAKAPVIPEGLF
>Mature_504_residues
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLRRPVSSARAMAQVRPVTDGRG
ASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHPGDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMC
LHEHKIDHVAHLGPSAAAGIGTLLNLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
APSPIWEGEDGVIAWLLSGPDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLARSMGEKLAAQGLDLRDVESIV
LHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAVALEDRAWHHERSYAPERAHRPETIELWNKISTVEDPEWTR
RYHSVDPAEKAFGARAVITFKDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
LSELNIELDADILAKAPVIPEGLF

Specific function: Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate [H]

COG id: COG2079

COG function: function code R; Uncharacterized protein involved in propionate catabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpD family [H]

Homologues:

Organism=Escherichia coli, GI1786528, Length=414, Percent_Identity=24.6376811594203, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325258, Length=452, Percent_Identity=26.3274336283186, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005656 [H]

Pfam domain/function: PF03972 MmgE_PrpD [H]

EC number: =4.2.1.79 [H]

Molecular weight: Translated: 55335; Mature: 55335

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLR
CCCCCHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
RPVSSARAMAQVRPVTDGRGASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHP
HHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCCCEEEEECCCCCEEEEECCCC
GDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMCLHEHKIDHVAHLGPSAAAGI
CCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHH
GTLLNLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
HHHEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC
APSPIWEGEDGVIAWLLSGPDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLAR
CCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
SMGEKLAAQGLDLRDVESIVLHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAV
HHHHHHHHCCCCHHHHHHHHEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ALEDRAWHHERSYAPERAHRPETIELWNKISTVEDPEWTRRYHSVDPAEKAFGARAVITF
HHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCEEEEEE
KDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
CCCCEECHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LSELNIELDADILAKAPVIPEGLF
HHHCCEEECCHHHHCCCCCCCCCC
>Mature Secondary Structure
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLR
CCCCCHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
RPVSSARAMAQVRPVTDGRGASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHP
HHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCCCEEEEECCCCCEEEEECCCC
GDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMCLHEHKIDHVAHLGPSAAAGI
CCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHH
GTLLNLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
HHHEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC
APSPIWEGEDGVIAWLLSGPDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLAR
CCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
SMGEKLAAQGLDLRDVESIVLHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAV
HHHHHHHHCCCCHHHHHHHHEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ALEDRAWHHERSYAPERAHRPETIELWNKISTVEDPEWTRRYHSVDPAEKAFGARAVITF
HHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCEEEEEE
KDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
CCCCEECHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LSELNIELDADILAKAPVIPEGLF
HHHCCEEECCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11976302; 12948626 [H]