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The map label for this gene is cycA [H]

Identifier: 145294622

GI number: 145294622

Start: 631041

End: 632402

Strand: Direct

Name: cycA [H]

Synonym: cgR_0573

Alternate gene names: 145294622

Gene position: 631041-632402 (Clockwise)

Preceding gene: 145294621

Following gene: 145294623

Centisome position: 19.04

GC content: 53.45

Gene sequence:

>1362_bases
TTGAGCAATAGACACCTTCAGCTCATCGCCATCGGCGGAGCGATCGGTACGGGTCTGTTCATGGGGTCCGGCAAGACGAT
CTCCGTTGCGGGGCCATCAGTAATTTTGGTGTACGCCATTATTGGTTTCATGCTTTTCTTTGTCATGCGTGCCATGGGAG
AGCTGCTGCTAGCCAATCTGAATTACAAATCTTTGCGCGATGCGGTCTCTGATATTTTGGGACCTGGCGCAGGTTTTGTC
ACCGGCTGGACATATTGGTTCTGCTGGATTGCCACAGGCATGGCGGACATCGTGGCGATCACTGGATACGCCCAATACTG
GTGGCCTGAGATCCCATTGTGGCTTCCAGGTGTGCTCACCATTGCGTTGCTGTTTGCCCTGAACTTGGCTGCGGTACGAC
TGTTCGGTGAGATGGAGTTTTGGTTCGCCATCATCAAAATCGTGGCTATCGTGTCGTTGATCGTCGTGGGACTTTTCATG
GTGGTCACAGCCTTTGAATCACCTAATGGCACCACCGCGCAGTTCAACAACCTCATTGAGCATGGCGGATTTTTCCCCAA
CGGCATCACCGGTTTCTTGGCTGGTTTCCAGATCGCTATCTTTGCGTTCGTCGGGATTGAACTTGCCGGCACTGCAGCTG
CAGAGACTGAGAATCCCACCAAGACGCTTCCTCGGGCAATCAACTCCATTCCCATCCGCATCGTAGTGTTCTATGTTTTG
GCGTTGGCTGTTATCATGATGGTCACCCCATGGGATCAGGTCAGTGCTGACAACAGCCCATTCGTGCAGATGTTCGCGCT
GGCAGGAATCCCAGCGGCGGCAGGCATCATTAACTTTGTGGTCATCACTTCTGCAGCGTCGTCTGCCAACAGTGGTATTT
TCTCCACCTCCCGCATGTTGTATGGATTGTCTTTGGAAGGCGCAGCTCCGAAACGGTGGAGCCGGTTGTCCAAGAACTTG
GTGCCAGCCAGGGGATTGACTTTTTCTGTGATTTGCCTCATTCCAGCGGTGGGTTTGCTGTACGCTGGCGGCACTGTCAT
CGAGGCATTCACACTGATCACCACGGTTTCTTCGGTGTTGTTCATGGTGGTGTGGTCCTACATTTTGGTGGCTTATATCG
TCTACCGCCGCAACAGCCCGGAATTACACAAAAAGTCGATTTTCAAAATGCCTGGCGGCGTGGTCATGGCAGTTGTGGTG
TTGGTGTTCTTCGCAGTGATGTTGGTGGTGCTGTCCCTGGAGCCGGATACCCGTGCAGCGCTCATCGCGACGCCAGTGTG
GTTCATCATTTTGGGTATCGGTTGGTTGTCCGTCGGTGGAGCTAAGGGCGCTAAGCGTCGCAGCCAAATAGCCTCCCACT
AA

Upstream 100 bases:

>100_bases
TTAGCGCCCATTAACGCTTCACATCCTTATATTCCCAAGGAGCACGACCATTTCTGATTCAGCAGTCCAGGAGAATCACG
AACCGCACCTCAAGCGCGGT

Downstream 100 bases:

>100_bases
AGCTCCTGGGTTAGACTCGAACGCGTGGCTAAAGCAGATTTAGACAAGGACCCCTTCGACGTAGCGTCAATGTTCGATGA
CGTCGGAAAGAACTACGATC

Product: hypothetical protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANLNYKSLRDAVSDILGPGAGFV
TGWTYWFCWIATGMADIVAITGYAQYWWPEIPLWLPGVLTIALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFM
VVTAFESPNGTTAQFNNLIEHGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVL
ALAVIMMVTPWDQVSADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRMLYGLSLEGAAPKRWSRLSKNL
VPARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVLFMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVV
LVFFAVMLVVLSLEPDTRAALIATPVWFIILGIGWLSVGGAKGAKRRSQIASH

Sequences:

>Translated_453_residues
MSNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANLNYKSLRDAVSDILGPGAGFV
TGWTYWFCWIATGMADIVAITGYAQYWWPEIPLWLPGVLTIALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFM
VVTAFESPNGTTAQFNNLIEHGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVL
ALAVIMMVTPWDQVSADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRMLYGLSLEGAAPKRWSRLSKNL
VPARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVLFMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVV
LVFFAVMLVVLSLEPDTRAALIATPVWFIILGIGWLSVGGAKGAKRRSQIASH
>Mature_452_residues
SNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANLNYKSLRDAVSDILGPGAGFVT
GWTYWFCWIATGMADIVAITGYAQYWWPEIPLWLPGVLTIALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFMV
VTAFESPNGTTAQFNNLIEHGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVLA
LAVIMMVTPWDQVSADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRMLYGLSLEGAAPKRWSRLSKNLV
PARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVLFMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVVL
VFFAVMLVVLSLEPDTRAALIATPVWFIILGIGWLSVGGAKGAKRRSQIASH

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=329, Percent_Identity=24.0121580547112, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790653, Length=448, Percent_Identity=65.8482142857143, Blast_Score=611, Evalue=1e-176,
Organism=Escherichia coli, GI1786302, Length=436, Percent_Identity=39.2201834862385, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI48994972, Length=425, Percent_Identity=40.4705882352941, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI1786602, Length=437, Percent_Identity=39.3592677345538, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1786789, Length=436, Percent_Identity=36.4678899082569, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI87081915, Length=456, Percent_Identity=36.4035087719298, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=33.1887201735358, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1788480, Length=440, Percent_Identity=32.2727272727273, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1789017, Length=326, Percent_Identity=33.7423312883436, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17531343, Length=143, Percent_Identity=27.972027972028, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324924, Length=407, Percent_Identity=30.958230958231, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6324061, Length=400, Percent_Identity=31.5, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=397, Percent_Identity=31.4861460957179, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6320772, Length=343, Percent_Identity=32.0699708454811, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=383, Percent_Identity=29.242819843342, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322892, Length=414, Percent_Identity=27.2946859903382, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=438, Percent_Identity=25.7990867579909, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321629, Length=419, Percent_Identity=26.9689737470167, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319543, Length=448, Percent_Identity=25.6696428571429, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324059, Length=339, Percent_Identity=31.2684365781711, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319824, Length=389, Percent_Identity=26.9922879177378, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320251, Length=404, Percent_Identity=26.980198019802, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319542, Length=397, Percent_Identity=25.6926952141058, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320717, Length=396, Percent_Identity=25.2525252525253, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321053, Length=430, Percent_Identity=28.1395348837209, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6322967, Length=416, Percent_Identity=25.2403846153846, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324981, Length=423, Percent_Identity=26.7139479905437, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320364, Length=462, Percent_Identity=25.1082251082251, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161077963, Length=213, Percent_Identity=25.3521126760563, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48595; Mature: 48464

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANL
CCCCEEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NYKSLRDAVSDILGPGAGFVTGWTYWFCWIATGMADIVAITGYAQYWWPEIPLWLPGVLT
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
IALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFMVVTAFESPNGTTAQFNNLIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVL
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
ALAVIMMVTPWDQVSADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRML
HHHHHHHHCCCHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YGLSLEGAAPKRWSRLSKNLVPARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVL
EEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVVLVFFAVMLVVLSLEPDTRAA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LIATPVWFIILGIGWLSVGGAKGAKRRSQIASH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
SNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANL
CCCEEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NYKSLRDAVSDILGPGAGFVTGWTYWFCWIATGMADIVAITGYAQYWWPEIPLWLPGVLT
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
IALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFMVVTAFESPNGTTAQFNNLIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVL
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
ALAVIMMVTPWDQVSADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRML
HHHHHHHHCCCHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YGLSLEGAAPKRWSRLSKNLVPARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVL
EEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVVLVFFAVMLVVLSLEPDTRAA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LIATPVWFIILGIGWLSVGGAKGAKRRSQIASH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]