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The map label for this gene is hemL

Identifier: 145294556

GI number: 145294556

Start: 567846

End: 569159

Strand: Direct

Name: hemL

Synonym: cgR_0507

Alternate gene names: 145294556

Gene position: 567846-569159 (Clockwise)

Preceding gene: 145294555

Following gene: 145294557

Centisome position: 17.13

GC content: 57.61

Gene sequence:

>1314_bases
ATGACGCACATGACATCGTCCAATACGGCTCGATCCGCAGAGTGGTTTGAAAAGGCTCAGAAGCTCACCCCTGGTGGTGT
GAATTCTCCTGTTCGCGCTTTCGGTTCAGTTGGCGGACAAGCCCGTTTCATCGAAAAAGCTCACGGTTCAACGCTGATCG
ATGTGGACGGAAATGAATACGTTGACCTGGTCTGTTCTTGGGGCCCCATGCTGATGGGTCACGCTCACCCAGCAGTAGTC
GAGGCTGTGCAGAAGGCCGTCGTGGATGGTCTTTCTTTCGGCGCTCCCACCATCGGTGAGGTTGAGTTAGCCCAAGATAT
CGTCAAGCGCACTTCTGTGGAGGAAGTCCGCCTGGTCAACTCCGGCACTGAGGCCACCATGTCGGCGGTTCGCCTGGCGC
GCGGTTACACTCAGCGTTCCAAGATTTTGAAGTTTGAGGGCTGCTACCACGGCCACGTCGATGCGCTGCTCGCATCTGCT
GGTTCTGGTGTCGCAACTTTCGCTCTGCCTGATTCCCCAGGCATCACCGGCGCTCAGACTTCTGACACCATTGTTGTTCC
TTACAACGACATTGAAGCCGTGCGCAACGCTTTTGCGGAGTACCCAGGCGAGATCGCCTGCATCATCGCAGAGGCAGCCG
GTGGCAACATGGGCACCGTCGCTCCAAAGGACAACTTTAACGACAAGCTTCTCGCGATCGCTCACGCAGACGGCGCGCTG
CTGATCCTCGATGAGGTCATGACTGGTTTCCGCACCTCATACCGCGGCTGGTTCGGCATCGACAAGGTTGCCGCTGACCT
GGTCACCTTCGGCAAAGTCGTCTCCGGTGGCCTGCCTGCCGCAGCGTTCGGCGGCAAGGCTGAAATCATGAACATGCTGG
CCCCACAGGGCCCCGTCTACCAAGCAGGCACACTGTCCGGCAACCCGGTTGCGGTCGCAGCTGGTCGGGCATCGCTTAAG
CTTGCCGACGAATCCCTCTACACAACCATCAACGCCAACGCAGATCGTCTCCACGGTTTGATCTCTGATGCCTTAACCCA
CGAAGGCGTAGCCCACCACATTCAGCGTGCCTCAAACATGCTGTCTATCCGTTTTGCAGAAGGTGAGGGCCACAACTTCT
CTGATATGAAGGCAGCCGACACCTTCCGCTTCGCACCGTTCTTCCACACTTTGCTGGACAACGGCGTCTACGCACCACCA
AGCGTTTTCGAAACCTGGTTTGTGTCTTCCGCTCTCACGGACGATGATTTCTCCAAGATCGAGCAGGCACTCAAGCCCGC
CGCACGTGCAGCAGCAGAAGCGAAGGCATCATGA

Upstream 100 bases:

>100_bases
AAGCACCCAAAAACACTATTGAACACCCCAATCGCTGTTGAGAGTTTGTAAAGTTCGACTGTCAACGAGCTGGATTGGCT
TCACAGATTGAATTAATACA

Downstream 100 bases:

>100_bases
CGCAAACCATTGTCCATCTAGTTCGCCACGGCGAAGTCCACAACCCAGAGAAAATCCTGTACGGACGCATGCCCGGATAC
AGGTTGTCTTCCCGTGGACG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTHMTSSNTARSAEWFEKAQKLTPGGVNSPVRAFGSVGGQARFIEKAHGSTLIDVDGNEYVDLVCSWGPMLMGHAHPAVV
EAVQKAVVDGLSFGAPTIGEVELAQDIVKRTSVEEVRLVNSGTEATMSAVRLARGYTQRSKILKFEGCYHGHVDALLASA
GSGVATFALPDSPGITGAQTSDTIVVPYNDIEAVRNAFAEYPGEIACIIAEAAGGNMGTVAPKDNFNDKLLAIAHADGAL
LILDEVMTGFRTSYRGWFGIDKVAADLVTFGKVVSGGLPAAAFGGKAEIMNMLAPQGPVYQAGTLSGNPVAVAAGRASLK
LADESLYTTINANADRLHGLISDALTHEGVAHHIQRASNMLSIRFAEGEGHNFSDMKAADTFRFAPFFHTLLDNGVYAPP
SVFETWFVSSALTDDDFSKIEQALKPAARAAAEAKAS

Sequences:

>Translated_437_residues
MTHMTSSNTARSAEWFEKAQKLTPGGVNSPVRAFGSVGGQARFIEKAHGSTLIDVDGNEYVDLVCSWGPMLMGHAHPAVV
EAVQKAVVDGLSFGAPTIGEVELAQDIVKRTSVEEVRLVNSGTEATMSAVRLARGYTQRSKILKFEGCYHGHVDALLASA
GSGVATFALPDSPGITGAQTSDTIVVPYNDIEAVRNAFAEYPGEIACIIAEAAGGNMGTVAPKDNFNDKLLAIAHADGAL
LILDEVMTGFRTSYRGWFGIDKVAADLVTFGKVVSGGLPAAAFGGKAEIMNMLAPQGPVYQAGTLSGNPVAVAAGRASLK
LADESLYTTINANADRLHGLISDALTHEGVAHHIQRASNMLSIRFAEGEGHNFSDMKAADTFRFAPFFHTLLDNGVYAPP
SVFETWFVSSALTDDDFSKIEQALKPAARAAAEAKAS
>Mature_436_residues
THMTSSNTARSAEWFEKAQKLTPGGVNSPVRAFGSVGGQARFIEKAHGSTLIDVDGNEYVDLVCSWGPMLMGHAHPAVVE
AVQKAVVDGLSFGAPTIGEVELAQDIVKRTSVEEVRLVNSGTEATMSAVRLARGYTQRSKILKFEGCYHGHVDALLASAG
SGVATFALPDSPGITGAQTSDTIVVPYNDIEAVRNAFAEYPGEIACIIAEAAGGNMGTVAPKDNFNDKLLAIAHADGALL
ILDEVMTGFRTSYRGWFGIDKVAADLVTFGKVVSGGLPAAAFGGKAEIMNMLAPQGPVYQAGTLSGNPVAVAAGRASLKL
ADESLYTTINANADRLHGLISDALTHEGVAHHIQRASNMLSIRFAEGEGHNFSDMKAADTFRFAPFFHTLLDNGVYAPPS
VFETWFVSSALTDDDFSKIEQALKPAARAAAEAKAS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=319, Percent_Identity=28.8401253918495, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI13994255, Length=316, Percent_Identity=26.5822784810127, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI37574042, Length=333, Percent_Identity=27.3273273273273, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226442709, Length=305, Percent_Identity=27.8688524590164, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI24119277, Length=337, Percent_Identity=25.8160237388724, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI226442705, Length=332, Percent_Identity=25.9036144578313, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI284507298, Length=239, Percent_Identity=27.6150627615063, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786349, Length=413, Percent_Identity=49.3946731234867, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1789016, Length=419, Percent_Identity=31.2649164677804, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693181, Length=388, Percent_Identity=28.3505154639175, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789759, Length=293, Percent_Identity=29.3515358361775, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1787560, Length=349, Percent_Identity=30.3724928366762, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788044, Length=289, Percent_Identity=28.3737024221453, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786991, Length=251, Percent_Identity=28.2868525896414, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992977, Length=376, Percent_Identity=28.4574468085106, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=293, Percent_Identity=26.962457337884, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=300, Percent_Identity=27.3333333333333, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=314, Percent_Identity=24.5222929936306, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_CORGB (A4QB78)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137377.1
- ProteinModelPortal:   A4QB78
- SMR:   A4QB78
- STRING:   A4QB78
- GeneID:   4991646
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0507
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- ProtClustDB:   PRK00062
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46019; Mature: 45888

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHMTSSNTARSAEWFEKAQKLTPGGVNSPVRAFGSVGGQARFIEKAHGSTLIDVDGNEY
CCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHCCCCEEEEECCCCE
VDLVCSWGPMLMGHAHPAVVEAVQKAVVDGLSFGAPTIGEVELAQDIVKRTSVEEVRLVN
EEEEECCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHEEC
SGTEATMSAVRLARGYTQRSKILKFEGCYHGHVDALLASAGSGVATFALPDSPGITGAQT
CCHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCC
SDTIVVPYNDIEAVRNAFAEYPGEIACIIAEAAGGNMGTVAPKDNFNDKLLAIAHADGAL
CCEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCE
LILDEVMTGFRTSYRGWFGIDKVAADLVTFGKVVSGGLPAAAFGGKAEIMNMLAPQGPVY
EEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCCCE
QAGTLSGNPVAVAAGRASLKLADESLYTTINANADRLHGLISDALTHEGVAHHIQRASNM
ECCCCCCCCEEEEECCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCE
LSIRFAEGEGHNFSDMKAADTFRFAPFFHTLLDNGVYAPPSVFETWFVSSALTDDDFSKI
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHH
EQALKPAARAAAEAKAS
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
THMTSSNTARSAEWFEKAQKLTPGGVNSPVRAFGSVGGQARFIEKAHGSTLIDVDGNEY
CCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHCCCCEEEEECCCCE
VDLVCSWGPMLMGHAHPAVVEAVQKAVVDGLSFGAPTIGEVELAQDIVKRTSVEEVRLVN
EEEEECCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHEEC
SGTEATMSAVRLARGYTQRSKILKFEGCYHGHVDALLASAGSGVATFALPDSPGITGAQT
CCHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCC
SDTIVVPYNDIEAVRNAFAEYPGEIACIIAEAAGGNMGTVAPKDNFNDKLLAIAHADGAL
CCEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCE
LILDEVMTGFRTSYRGWFGIDKVAADLVTFGKVVSGGLPAAAFGGKAEIMNMLAPQGPVY
EEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCCCE
QAGTLSGNPVAVAAGRASLKLADESLYTTINANADRLHGLISDALTHEGVAHHIQRASNM
ECCCCCCCCEEEEECCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCE
LSIRFAEGEGHNFSDMKAADTFRFAPFFHTLLDNGVYAPPSVFETWFVSSALTDDDFSKI
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHH
EQALKPAARAAAEAKAS
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA