Click here to switch to the map view.

The map label for this gene is hemC

Identifier: 145294537

GI number: 145294537

Start: 545006

End: 545914

Strand: Direct

Name: hemC

Synonym: cgR_0489

Alternate gene names: 145294537

Gene position: 545006-545914 (Clockwise)

Preceding gene: 145294536

Following gene: 145294538

Centisome position: 16.44

GC content: 61.61

Gene sequence:

>909_bases
ATGACCTTAAAAATTGGTACCCGAGGATCCAAACTTGCCACCACCCAAGCTGGCACCATCCGCGACCAGCTGAAATACTT
CGGACGCGACGCCGAACTGCACATTGTGACCACCCCCGGTGATGTCAATATGTCCCCAGTTGAGCGCATTGGCGTCGGCG
TGTTCACCCAGGCGCTGCGTGATGTGCTGCATGCTGGTGAATGCGATGTGGCTGTGCACTCCATGAAGGATCTGCCGACC
GCCGCCGATCCTCGATTCCACCTGGTCGTGCCAACTCGTGCGGACTCCCGCGAGGCCCTTATCGCCCGCGACGGCCTGAC
TCTGGCTGAGCTTCCAGAAGGCGCAAAGGTGGGAACTTCCGCTCCTCGACGTATCTCTCAACTCAAGGCAATCCGTCCTG
ACCTGGAGATTCTCCCACTGCGCGGAAATATCGACACCCGCATGGGTAAAGTTACCTCCGGTGAACTCGATGCCGTGATG
CTCGCCTACGCGGGTCTTACTCGCGTCGGCATGCAGGACCGCGCAACGGAAGTTTTCGACGCCGACATCATCATGCCCGC
CCCCGCACAGGGCGCACTTGCGATCGAATGCCGCGCCGACGACACCGAAACCGTCCGCGCGCTCAACATGCTGATGCATG
CCGACACGTTTGTCTCCGCGGTTGCAGAACGCACCGTGCTCAACCGCCTCGAAGCTGGCTGCACCGCGCCTGTCGCAGCG
CACGCCACCTTGGACGGCTACTCCGGCGACACCATGACTCTTACCGCCGGCGTTTACGCACTTGACGGCTCTGACCAGCT
GGTATTCTCCGCCGAAGGTGACGGCGCCCGCCCAGAAGAGCTCGGCGAGCTCGTTGCACAACAGCTTATCGACGCCGGAG
CCGCCAATTTGCTCGGCGACCGCAGCTAA

Upstream 100 bases:

>100_bases
GCGGCACCGGCAACCACGTCCGTCAACGCGTCAGAACTGCCGGATGCGGGTATCGTCGCATTCGTGAACGCACCTTCTGC
CACACAAACGAGGGAGTAAC

Downstream 100 bases:

>100_bases
TTAGGGCCCGAAATTTCCACATTGAGAGCGTAGCGAAAGAATGTGCGAATATCCACCACAAATGGCTGATTAGGGGGCGG
TTTGTGGTGGATTTTTGCAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTLKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDVLHAGECDVAVHSMKDLPT
AADPRFHLVVPTRADSREALIARDGLTLAELPEGAKVGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVM
LAYAGLTRVGMQDRATEVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAA
HATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAANLLGDRS

Sequences:

>Translated_302_residues
MTLKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDVLHAGECDVAVHSMKDLPT
AADPRFHLVVPTRADSREALIARDGLTLAELPEGAKVGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVM
LAYAGLTRVGMQDRATEVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAA
HATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAANLLGDRS
>Mature_301_residues
TLKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDVLHAGECDVAVHSMKDLPTA
ADPRFHLVVPTRADSREALIARDGLTLAELPEGAKVGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVML
AYAGLTRVGMQDRATEVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAAH
ATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAANLLGDRS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=275, Percent_Identity=37.4545454545455, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI66933009, Length=275, Percent_Identity=37.4545454545455, Blast_Score=163, Evalue=2e-40,
Organism=Escherichia coli, GI48994974, Length=305, Percent_Identity=39.344262295082, Blast_Score=181, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6319996, Length=317, Percent_Identity=31.5457413249211, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI20130425, Length=282, Percent_Identity=37.2340425531915, Blast_Score=167, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_CORGB (A4QB59)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137358.1
- ProteinModelPortal:   A4QB59
- STRING:   A4QB59
- GeneID:   4992828
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0489
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   RATEVFD
- ProtClustDB:   PRK00072
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 31974; Mature: 31843

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALR
CEEEECCCCCEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
DVLHAGECDVAVHSMKDLPTAADPRFHLVVPTRADSREALIARDGLTLAELPEGAKVGTS
HHHHCCCCCEEHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHCCCCCCCCCC
APRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFD
CHHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHC
ADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAA
CCEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
HATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAANLLGD
EEEECCCCCCEEEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHCCC
RS
CC
>Mature Secondary Structure 
TLKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALR
EEEECCCCCEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
DVLHAGECDVAVHSMKDLPTAADPRFHLVVPTRADSREALIARDGLTLAELPEGAKVGTS
HHHHCCCCCEEHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHCCCCCCCCCC
APRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFD
CHHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHC
ADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAA
CCEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
HATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAANLLGD
EEEECCCCCCEEEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHCCC
RS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA