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The map label for this gene is hemA [H]

Identifier: 145294536

GI number: 145294536

Start: 543610

End: 545004

Strand: Direct

Name: hemA [H]

Synonym: cgR_0488

Alternate gene names: 145294536

Gene position: 543610-545004 (Clockwise)

Preceding gene: 145294535

Following gene: 145294537

Centisome position: 16.4

GC content: 56.06

Gene sequence:

>1395_bases
ATGGTGAGTGTACTCATCGTAGGGATGTCGCACAGGTCTGCGCCTGTGTCGCTTCTTGAACGTCTGAGCATGGATGATTC
AGTACGTGGTGAAACAACTCAAGCACTCCTGGGTAGGGCGTCTTTAAGCGAGGCCCTCATTGTCTCTACGTGTAACCGCC
TGGAGGTCTACACCGTCACTAGCAGTTTCCATACTGGTGTTAATGATGTGGTGGAGGTTCTCCATGAGGCAAGTGGCGTA
GATATTGAAACTTTGCGCGGATATCTTTATGTCCGTTACGCCGATGCTGCTGCTGAACACATGTTGGTGGTGACTTCCGG
GTTGGATTCCATGGTGTTGGGTGAGCAGCAGATCATTGGTCAGGTGCGCACTGCGTACCAAGCAGCTAATGAATATGGGT
CTGTCGGTCCTGCTTTGCATTCACTTACCCAGACCGCGCTGCATACCGGCAAGCGCGTGCATTCGGAGACTGCCATTGAT
GATGCTGGTGCATCGATGGTGTCTTTCGCTGTGGATCGCGCGTTGGTGCAGATGGGTCTTGATTCGGAGGCAGAAGCCCC
ACTATCTGGCAAGACAGCCTTGGTGTTGGGCGCTGGCGCGATGAGTTCTCTTGCAGCCACTCACCTTGGTCGCGCTGGAA
TTTCCAAGTTGATCATGGCCAACCGCACTCTGGAACGTGCCGAAAGGCTTGCGGAGCATTCCCTAGAAGCCGGAGTTCCT
GCAGAGGTTGTGGAATACGATCAGCGAGCTTCCGCCTACAATCGCGTTGACCTGGTAGTTTCCGCCACGGGCGCGGATGA
TTTCACCGTGAAGCCTGAGGATATTCCAGAAGGTGCTTCGTTGATGTTGGTGGATTTGTCCATGCCACGAGACATCGATG
ATGCTTGTGCGGATCTGCCGGGCGTTGATTTGGTGAACATCGAACGCCTGCACAAGGCCTCCCGTGAGGGTGGATCGGGC
ATGGCGCCAAGCGAGGAAGAAGCTTTGGCGATTGTTCGGGAAGAGTTGGATTCTTTCACCTCTGAGCAGCGCATTCGCGA
TATCGTTCCGGCTGTGTCCGCGTTGCGCAGGCAGGCCGCGTCGGTGGGAAGCGATGAATTGGATCGACTCCGCCAACGTG
CCCCCGGGATTTCCGAGGTGGAATGGGGGGAAGTGGAGAAAACAGTGAGACGGGTCGTCGATAAGCTTCTTCATCAACCC
ACTGTGCGCGTCAAGGAACTGGCGGCCCGGTCCGGCAGCATCTCTTATGATTCAGCTCTGCAAGAGCTGTTCGGCTTGGA
GTCGCTGGCGAGCACCGCGGCACCGGCAACCACGTCCGTCAACGCGTCAGAACTGCCGGATGCGGGTATCGTCGCATTCG
TGAACGCACCTTCTGCCACACAAACGAGGGAGTAA

Upstream 100 bases:

>100_bases
AATGCTTTGTTGTGATGTCCGCGAATGAAAGCTACCGTATTTTAATCAACTAGGATTCATTCTTTTGGTGGATCAAAGGC
TCCGTTGAAAGTCGGGTGGA

Downstream 100 bases:

>100_bases
CATGACCTTAAAAATTGGTACCCGAGGATCCAAACTTGCCACCACCCAAGCTGGCACCATCCGCGACCAGCTGAAATACT
TCGGACGCGACGCCGAACTG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MVSVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTSSFHTGVNDVVEVLHEASGV
DIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQVRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAID
DAGASMVSFAVDRALVQMGLDSEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISKLIMANRTLERAERLAEHSLEAGVP
AEVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLPGVDLVNIERLHKASREGGSG
MAPSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAASVGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHQP
TVRVKELAARSGSISYDSALQELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE

Sequences:

>Translated_464_residues
MVSVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTSSFHTGVNDVVEVLHEASGV
DIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQVRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAID
DAGASMVSFAVDRALVQMGLDSEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISKLIMANRTLERAERLAEHSLEAGVP
AEVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLPGVDLVNIERLHKASREGGSG
MAPSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAASVGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHQP
TVRVKELAARSGSISYDSALQELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE
>Mature_464_residues
MVSVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTSSFHTGVNDVVEVLHEASGV
DIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQVRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAID
DAGASMVSFAVDRALVQMGLDSEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISKLIMANRTLERAERLAEHSLEAGVP
AEVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLPGVDLVNIERLHKASREGGSG
MAPSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAASVGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHQP
TVRVKELAARSGSISYDSALQELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=438, Percent_Identity=28.7671232876712, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 49329; Mature: 49329

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVT
CEEEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
SSFHTGVNDVVEVLHEASGVDIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIG
CCHHCCHHHHHHHHHHHCCCCHHHHCCEEEEEEECHHHCEEEEEECCCCHHHHHHHHHHH
QVRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAIDDAGASMVSFAVDRALVQMGL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
DSEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISKLIMANRTLERAERLAEHSLEAGVP
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AEVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLP
HHHHHHHHHHHHCCCEEEEEEECCCCCCEECCCCCCCCCCEEEEEECCCCCHHHHHHCCC
GVDLVNIERLHKASREGGSGMAPSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAA
CCCEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHQPTVRVKELAARSGSISYDSAL
HCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
QELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MVSVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVT
CEEEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
SSFHTGVNDVVEVLHEASGVDIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIG
CCHHCCHHHHHHHHHHHCCCCHHHHCCEEEEEEECHHHCEEEEEECCCCHHHHHHHHHHH
QVRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAIDDAGASMVSFAVDRALVQMGL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
DSEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISKLIMANRTLERAERLAEHSLEAGVP
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AEVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLP
HHHHHHHHHHHHCCCEEEEEEECCCCCCEECCCCCCCCCCEEEEEECCCCCHHHHHHCCC
GVDLVNIERLHKASREGGSGMAPSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAA
CCCEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHQPTVRVKELAARSGSISYDSAL
HCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
QELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA