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The map label for this gene is adhC [C]

Identifier: 145294448

GI number: 145294448

Start: 439737

End: 440843

Strand: Direct

Name: adhC [C]

Synonym: cgR_0403

Alternate gene names: 145294448

Gene position: 439737-440843 (Clockwise)

Preceding gene: 145294447

Following gene: 145294449

Centisome position: 13.27

GC content: 56.64

Gene sequence:

>1107_bases
ATGAGCACTGTCGTGCCTGGAATTGTCGCCCTGTCCAAGGGTGCACCGGTAGAAAAAGTAAACGTTGTTGTCCCTGATCC
AGGTGCTAACGATGTCATCGTCAAAATTCAGGCCTGCGGTGTGTGCCACACCGACTTGGCCTACCGCGATGGCGATATTT
CAGATGAGTTCCCTTACCTCCTCGGCCACGAGGCAGCAGGCATTGTTGAGGAGGTAGGCGAGTCCGTCACCCACGTTGAG
GTCGGCGATTTCGTCATCTTGAACTGGCGTGCAGTGTGCGGCGAGTGCCGTGCATGTAAGAAGGGTGAGCCCAAGTACTG
CTTTAACACCCACAACGCCTCTAAGAAGATGACCCTGGAAGACGGCACCGAGCTGTCCCCAGCACTGGGTATTGGCGCGT
TCTTGGAAAAGACCCTGGTCCACGAAGGCCAGTGCACCAAGGTTAACCCTGAGGAAGATCCAGCAGCAGCTGGCCTTCTG
GGTTGTGGCATCATGGCAGGCCTTGGCGCTGCGGTGAACACCGGTGATATTAAGCGTGGCGAGTCCGTAGCAGTCTTCGG
CCTGGGCGGCGTAGGCATGGCAGCTATTGCTGGTGCCAAGCTTGCAGGTGCATCGAAGATTATTGCTGTCGATATTGATG
CCAGGAAGCTGGAGTGGGCGAAGGAATTCGGCGCGACCCACACCATTGATTCCTCTGGTCTTGGTGGCGAAGGCGATGCC
TCTGAGGTCGTGGCGAAGGTTCGTGAGCTCACCGATGGTTTCGGCACCGATGTCTCCATCGACGCGGTAGGCATCATGCC
GACCTGGCAGCAGGCGTTTTACTCCCGTGACCATGCAGGCCGCATGGTGATGGTGGGCGTTCCAAACCTGACGTCTCGCG
TAGATATTCCTGCGATTGATTTCTACGGTCGCGGTGGCTCCGTGCGCCCTGCATGGTACGGCGACTGCCTGCCTGAGCGT
GATTTCCCAACTTATGTGGATCTGCACCTGCAGGGTCGTTTCCCACTGGATAAGTTTGTTTCTGAGCGTATTGGTCTTGA
TGATGTTGAAGAGGCTTTCAACACCATGAAGGCTGGCGACGTGCTGCGTTCTGTGGTGGAGATCTAA

Upstream 100 bases:

>100_bases
GACTCCGCAGGGATGGCCTACAAGTACGGTCACGGACTTAATTTCTAGATTGTAGGTAGTCTCGTGGGCACAACTGAAAT
CTTATTGAAAAGGAGTGTCC

Downstream 100 bases:

>100_bases
ATGGCTCACGACGGATTGCGCGTAGAAAACATTGTCACCTCAGGCATCTTTGCCCTTGATGGTGGCGAATGGGAAGTCGA
CAACAACATCTGGGTTGTGG

Product: hypothetical protein

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSTVVPGIVALSKGAPVEKVNVVVPDPGANDVIVKIQACGVCHTDLAYRDGDISDEFPYLLGHEAAGIVEEVGESVTHVE
VGDFVILNWRAVCGECRACKKGEPKYCFNTHNASKKMTLEDGTELSPALGIGAFLEKTLVHEGQCTKVNPEEDPAAAGLL
GCGIMAGLGAAVNTGDIKRGESVAVFGLGGVGMAAIAGAKLAGASKIIAVDIDARKLEWAKEFGATHTIDSSGLGGEGDA
SEVVAKVRELTDGFGTDVSIDAVGIMPTWQQAFYSRDHAGRMVMVGVPNLTSRVDIPAIDFYGRGGSVRPAWYGDCLPER
DFPTYVDLHLQGRFPLDKFVSERIGLDDVEEAFNTMKAGDVLRSVVEI

Sequences:

>Translated_368_residues
MSTVVPGIVALSKGAPVEKVNVVVPDPGANDVIVKIQACGVCHTDLAYRDGDISDEFPYLLGHEAAGIVEEVGESVTHVE
VGDFVILNWRAVCGECRACKKGEPKYCFNTHNASKKMTLEDGTELSPALGIGAFLEKTLVHEGQCTKVNPEEDPAAAGLL
GCGIMAGLGAAVNTGDIKRGESVAVFGLGGVGMAAIAGAKLAGASKIIAVDIDARKLEWAKEFGATHTIDSSGLGGEGDA
SEVVAKVRELTDGFGTDVSIDAVGIMPTWQQAFYSRDHAGRMVMVGVPNLTSRVDIPAIDFYGRGGSVRPAWYGDCLPER
DFPTYVDLHLQGRFPLDKFVSERIGLDDVEEAFNTMKAGDVLRSVVEI
>Mature_367_residues
STVVPGIVALSKGAPVEKVNVVVPDPGANDVIVKIQACGVCHTDLAYRDGDISDEFPYLLGHEAAGIVEEVGESVTHVEV
GDFVILNWRAVCGECRACKKGEPKYCFNTHNASKKMTLEDGTELSPALGIGAFLEKTLVHEGQCTKVNPEEDPAAAGLLG
CGIMAGLGAAVNTGDIKRGESVAVFGLGGVGMAAIAGAKLAGASKIIAVDIDARKLEWAKEFGATHTIDSSGLGGEGDAS
EVVAKVRELTDGFGTDVSIDAVGIMPTWQQAFYSRDHAGRMVMVGVPNLTSRVDIPAIDFYGRGGSVRPAWYGDCLPERD
FPTYVDLHLQGRFPLDKFVSERIGLDDVEEAFNTMKAGDVLRSVVEI

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=362, Percent_Identity=35.9116022099448, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=34.3324250681199, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=35.3099730458221, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=36.6576819407008, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=31.7934782608696, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=31.7934782608696, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=32.2314049586777, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4501939, Length=356, Percent_Identity=32.5842696629214, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=32.171581769437, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI156627571, Length=368, Percent_Identity=25.2717391304348, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=34.3243243243243, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=27.4725274725275, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788073, Length=353, Percent_Identity=25.2124645892351, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081918, Length=270, Percent_Identity=30.7407407407407, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786825, Length=258, Percent_Identity=31.0077519379845, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082125, Length=369, Percent_Identity=25.2032520325203, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788075, Length=340, Percent_Identity=26.4705882352941, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787863, Length=342, Percent_Identity=24.5614035087719, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786518, Length=284, Percent_Identity=28.169014084507, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=24.702380952381, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790718, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=25.2252252252252, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=370, Percent_Identity=35.1351351351351, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71997431, Length=372, Percent_Identity=34.9462365591398, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17565904, Length=339, Percent_Identity=33.3333333333333, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17562876, Length=356, Percent_Identity=28.3707865168539, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562878, Length=380, Percent_Identity=26.8421052631579, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562584, Length=361, Percent_Identity=26.8698060941828, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=361, Percent_Identity=26.3157894736842, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=360, Percent_Identity=25.2777777777778, Blast_Score=81, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=32.258064516129, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6319955, Length=360, Percent_Identity=29.1666666666667, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=360, Percent_Identity=29.1666666666667, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=287, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=377, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=369, Percent_Identity=24.390243902439, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=367, Percent_Identity=24.7956403269755, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=287, Percent_Identity=26.8292682926829, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=369, Percent_Identity=24.6612466124661, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17737897, Length=359, Percent_Identity=25.9052924791086, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17137530, Length=357, Percent_Identity=24.0896358543417, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551930, Length=331, Percent_Identity=25.3776435045317, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45550770, Length=331, Percent_Identity=25.3776435045317, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221457811, Length=331, Percent_Identity=25.3776435045317, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 38854; Mature: 38722

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVVPGIVALSKGAPVEKVNVVVPDPGANDVIVKIQACGVCHTDLAYRDGDISDEFPYL
CCCCCCCCEEECCCCCCEEEEEEECCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCHH
LGHEAAGIVEEVGESVTHVEVGDFVILNWRAVCGECRACKKGEPKYCFNTHNASKKMTLE
HCCCHHHHHHHHCCCEEEEEECCEEEEEHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEC
DGTELSPALGIGAFLEKTLVHEGQCTKVNPEEDPAAAGLLGCGIMAGLGAAVNTGDIKRG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
ESVAVFGLGGVGMAAIAGAKLAGASKIIAVDIDARKLEWAKEFGATHTIDSSGLGGEGDA
CEEEEEEECCHHHHHHHCCHHCCCCEEEEEECCHHHHHHHHHCCCEEEECCCCCCCCCCH
SEVVAKVRELTDGFGTDVSIDAVGIMPTWQQAFYSRDHAGRMVMVGVPNLTSRVDIPAID
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEE
FYGRGGSVRPAWYGDCLPERDFPTYVDLHLQGRFPLDKFVSERIGLDDVEEAFNTMKAGD
EECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHH
VLRSVVEI
HHHHHHCC
>Mature Secondary Structure 
STVVPGIVALSKGAPVEKVNVVVPDPGANDVIVKIQACGVCHTDLAYRDGDISDEFPYL
CCCCCCCEEECCCCCCEEEEEEECCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCHH
LGHEAAGIVEEVGESVTHVEVGDFVILNWRAVCGECRACKKGEPKYCFNTHNASKKMTLE
HCCCHHHHHHHHCCCEEEEEECCEEEEEHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEC
DGTELSPALGIGAFLEKTLVHEGQCTKVNPEEDPAAAGLLGCGIMAGLGAAVNTGDIKRG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
ESVAVFGLGGVGMAAIAGAKLAGASKIIAVDIDARKLEWAKEFGATHTIDSSGLGGEGDA
CEEEEEEECCHHHHHHHCCHHCCCCEEEEEECCHHHHHHHHHCCCEEEECCCCCCCCCCH
SEVVAKVRELTDGFGTDVSIDAVGIMPTWQQAFYSRDHAGRMVMVGVPNLTSRVDIPAID
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEE
FYGRGGSVRPAWYGDCLPERDFPTYVDLHLQGRFPLDKFVSERIGLDDVEEAFNTMKAGD
EECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHH
VLRSVVEI
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]