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The map label for this gene is dnaX [H]

Identifier: 145294359

GI number: 145294359

Start: 342566

End: 344791

Strand: Direct

Name: dnaX [H]

Synonym: cgR_0314

Alternate gene names: 145294359

Gene position: 342566-344791 (Clockwise)

Preceding gene: 145294358

Following gene: 145294360

Centisome position: 10.34

GC content: 60.11

Gene sequence:

>2226_bases
GTGACTGATCCTCTGTCCGCTGCTTTGGATAGCGGGCGCATCAACCATGCGTACCTTTTTTCGGGTCCGCGTGGTTGTGG
CAAGACGTCGTCGGCACGCATCCTTGCCCGGTCCCTCAACTGCGTGGAAGGCCCAACTTCCACGCCGTGTGGGGTGTGTA
ATTCTTGCGTAGCGCTGGCCCCGGGTGGCCCTGGAACCCTTGATGTCACTGAGCTCGACGCCGCCAGTAACAATGGTGTC
GATGACATGCGTGAACTGCGCGAACGCGCGAACTACGCCCCGGCGGAATCTCGCTACCGCGTGTTCATCATTGACGAAGC
CCACATGATCAGTACCCAAGGCTTCAATGCCTTGCTGAAAATCGTTGAAGAGCCACCAGCGCACCTGATTTTCATCTTCG
CCACCACCGAGCCGGACAAAATGATCGGTACGATCCGTTCCCGCACGCACAATTACCCATTCCGCCTGCTCACCCCAGGC
GATATGCGCAAAGTGCTGAAAAATGCGGTCGATGGCGAAGGCGTCCACGTCGACGATTCCGTTTACCCACTGGTCATCCG
CGCCGGCGGCGGCAGCCCCCGCGACAGCCTCTCCATCCTCGACCAGCTCATCGCCGGCTCGGGCCCAGAGGGCTTGACCT
ATGAGCGCGCCTTGCCGCTGCTTGGTGTCACAAGCTTCACGCTTATCGACGATTCGATCCATGCCCTTGCATCTAAAGAC
AACGCAAGCATGTTCACCACGATCGATAACGTCATAGAAGAAGGCCTCGAACCGCGACGTTTCACCATCGACCTCCTCGA
CCGCCTCCGTGATTTGATGGTCCTCCAAGCCGTCCCAGAAGCCTTAAACCTCGGGCTTGTCGACGCCCCCACCGACCGCG
CCGACGTCCTCATCGAACAATCCACCCTGTTCAAAGGCAACGAGCTCGCCAACCTAGCCTCCATGGTGAACTCCGGCCTC
GACGACATGCGCGGCGCCACCTCACCACGACTGCTGTTGGAAATCCTCTGCGCCCGACTGCTCCTAGCCAGCAACACAGT
CGCAGTTCCAGTGGCCAGCAGTTCGTCTGAAGCTACACCCGCGGCGTCTCCTGGTGGTCTCACTGGTATTGCTGCTGCCC
GCGCGAAAGCACGGGAGTATGGACAGAAGAAGGCAGCTCCAACTCCAGCGCCGGCACCTGAGCCAACACCAGCGCCTGAA
CCTACACCTCAGCCCGCGCCGGAACCGGAACCCGCCAGGGAACCAGTGGTGGAAGTGCGGGAGGCGAGCGTCGAAAAGCA
GCCTGCAAGCAGTGATCCCCTCGAAACCATTCGAAGCCACTGGTCAGAGCTGCGCAGCATTGTGGAAAAACAAAGTGTGC
GCACCTCAATCATGCTGACCGAAGCGCGAGTTTTAGGACTGCGTGGCGATACTCTCGTGCTCGGTCACAGCACCGGGGCG
TTGGCTGCGCGTTTGAACGCTGCTGATCACAACGGAATTTTGGTCAAGGTGTTGGCTGAGGAAACTGGTCTGCAGCTCAA
GGTCGAATGCATTGTGGGCACGAACCCAGCCGAAGCTGGATTTACCGCCCAGCCTGCTGTGCAAAAGAGCTCGTGGAACC
CCAACCACGACTCCAAACCAGCCACTCCAAGTGCGCCTGCGCAGCCTCAGACGCCTAAGCAAGAATCCGTGCCCACCGAG
CCAGAGGAGCCTGAGAGTTCGGCTGAAACTTCGGGATGGGGGCAACCGGTAAAAATCGGTGGGCCGGAACCTGAGGCACA
GACTCCAACGCCTCCCCCTGCTCCGGTGGTTCCGGCTACTCCTGCTGCTCCGGCTGCGGGTTCTGCGAAACCAGCGTGGA
AGGAACGCGTCGAACAAGCCGCGGCAAATGCAGCGCAACAACGTCAGCATCGCCAGGGCAGCTCCGAGCCCTTCGAGCGG
GGTGTTCCGCTGCCACCAGAACCTGACCTGCCACCGGACCCCTATGGATACCCAGCTGACGAGGGTTTCCCCGAACGAAA
CCAAGGGTTCCAGCAACAGCCAGCGCCTCCCGTTGAGCAACCAGCTCCTGCACCTGTGGTGGAGCCAGTTCCAGCAGTTG
CGCCTGAGCCGGAGGTCAGCCAGCTATCTGAAGAAGAGCAGCTGATCCGCGAAGCAGACGAAGAGCCAGGTGAAATGGAT
CGTCGTGATGCGAAAACCATCGCGATGGAACTGCTTGCTCAGGAACTCGGCGCGAAACCTTTGTAA

Upstream 100 bases:

>100_bases
TCTTCTGGATCTGAAACGTTAAGACGGTAGGCTCAATTCCGTGGCTTTGTATAGCAAGTATCGACCGGCAAGTTTTGGTG
AACTAGTTGGGCAGTCGCAA

Downstream 100 bases:

>100_bases
GACTCGTTTGTAAGCCGAGAGCGAACCTGCCAAAAGTAAGGGGCGGGTTCGCGGTGACGTCGGTAGGATCGAGCGAAGAA
ACCAACAAACTTCTTAGGAG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 741; Mature: 740

Protein sequence:

>741_residues
MTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALAPGGPGTLDVTELDAASNNGV
DDMRELRERANYAPAESRYRVFIIDEAHMISTQGFNALLKIVEEPPAHLIFIFATTEPDKMIGTIRSRTHNYPFRLLTPG
DMRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPLLGVTSFTLIDDSIHALASKD
NASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEALNLGLVDAPTDRADVLIEQSTLFKGNELANLASMVNSGL
DDMRGATSPRLLLEILCARLLLASNTVAVPVASSSSEATPAASPGGLTGIAAARAKAREYGQKKAAPTPAPAPEPTPAPE
PTPQPAPEPEPAREPVVEVREASVEKQPASSDPLETIRSHWSELRSIVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGA
LAARLNAADHNGILVKVLAEETGLQLKVECIVGTNPAEAGFTAQPAVQKSSWNPNHDSKPATPSAPAQPQTPKQESVPTE
PEEPESSAETSGWGQPVKIGGPEPEAQTPTPPPAPVVPATPAAPAAGSAKPAWKERVEQAAANAAQQRQHRQGSSEPFER
GVPLPPEPDLPPDPYGYPADEGFPERNQGFQQQPAPPVEQPAPAPVVEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMD
RRDAKTIAMELLAQELGAKPL

Sequences:

>Translated_741_residues
MTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALAPGGPGTLDVTELDAASNNGV
DDMRELRERANYAPAESRYRVFIIDEAHMISTQGFNALLKIVEEPPAHLIFIFATTEPDKMIGTIRSRTHNYPFRLLTPG
DMRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPLLGVTSFTLIDDSIHALASKD
NASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEALNLGLVDAPTDRADVLIEQSTLFKGNELANLASMVNSGL
DDMRGATSPRLLLEILCARLLLASNTVAVPVASSSSEATPAASPGGLTGIAAARAKAREYGQKKAAPTPAPAPEPTPAPE
PTPQPAPEPEPAREPVVEVREASVEKQPASSDPLETIRSHWSELRSIVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGA
LAARLNAADHNGILVKVLAEETGLQLKVECIVGTNPAEAGFTAQPAVQKSSWNPNHDSKPATPSAPAQPQTPKQESVPTE
PEEPESSAETSGWGQPVKIGGPEPEAQTPTPPPAPVVPATPAAPAAGSAKPAWKERVEQAAANAAQQRQHRQGSSEPFER
GVPLPPEPDLPPDPYGYPADEGFPERNQGFQQQPAPPVEQPAPAPVVEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMD
RRDAKTIAMELLAQELGAKPL
>Mature_740_residues
TDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALAPGGPGTLDVTELDAASNNGVD
DMRELRERANYAPAESRYRVFIIDEAHMISTQGFNALLKIVEEPPAHLIFIFATTEPDKMIGTIRSRTHNYPFRLLTPGD
MRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPLLGVTSFTLIDDSIHALASKDN
ASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEALNLGLVDAPTDRADVLIEQSTLFKGNELANLASMVNSGLD
DMRGATSPRLLLEILCARLLLASNTVAVPVASSSSEATPAASPGGLTGIAAARAKAREYGQKKAAPTPAPAPEPTPAPEP
TPQPAPEPEPAREPVVEVREASVEKQPASSDPLETIRSHWSELRSIVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGAL
AARLNAADHNGILVKVLAEETGLQLKVECIVGTNPAEAGFTAQPAVQKSSWNPNHDSKPATPSAPAQPQTPKQESVPTEP
EEPESSAETSGWGQPVKIGGPEPEAQTPTPPPAPVVPATPAAPAAGSAKPAWKERVEQAAANAAQQRQHRQGSSEPFERG
VPLPPEPDLPPDPYGYPADEGFPERNQGFQQQPAPPVEQPAPAPVVEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMDR
RDAKTIAMELLAQELGAKPL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=282, Percent_Identity=40.0709219858156, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787341, Length=148, Percent_Identity=31.7567567567568, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 78586; Mature: 78455

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALA
CCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEC
PGGPGTLDVTELDAASNNGVDDMRELRERANYAPAESRYRVFIIDEAHMISTQGFNALLK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCEECCCCHHHHHH
IVEEPPAHLIFIFATTEPDKMIGTIRSRTHNYPFRLLTPGDMRKVLKNAVDGEGVHVDDS
HHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCEEECCC
VYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPLLGVTSFTLIDDSIHALASKD
CEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCHHCCCEEEEEHHHHHHHHCCC
NASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEALNLGLVDAPTDRADVLIEQ
CCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEH
STLFKGNELANLASMVNSGLDDMRGATSPRLLLEILCARLLLASNTVAVPVASSSSEATP
HHCCCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
AASPGGLTGIAAARAKAREYGQKKAAPTPAPAPEPTPAPEPTPQPAPEPEPAREPVVEVR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
EASVEKQPASSDPLETIRSHWSELRSIVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHEEECCCCEEEEECCCCC
LAARLNAADHNGILVKVLAEETGLQLKVECIVGTNPAEAGFTAQPAVQKSSWNPNHDSKP
HHHEECCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
ATPSAPAQPQTPKQESVPTEPEEPESSAETSGWGQPVKIGGPEPEAQTPTPPPAPVVPAT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCC
PAAPAAGSAKPAWKERVEQAAANAAQQRQHRQGSSEPFERGVPLPPEPDLPPDPYGYPAD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCC
EGFPERNQGFQQQPAPPVEQPAPAPVVEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
RRDAKTIAMELLAQELGAKPL
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALA
CCHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEC
PGGPGTLDVTELDAASNNGVDDMRELRERANYAPAESRYRVFIIDEAHMISTQGFNALLK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCEECCCCHHHHHH
IVEEPPAHLIFIFATTEPDKMIGTIRSRTHNYPFRLLTPGDMRKVLKNAVDGEGVHVDDS
HHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCEEECCC
VYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPLLGVTSFTLIDDSIHALASKD
CEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCHHCCCEEEEEHHHHHHHHCCC
NASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEALNLGLVDAPTDRADVLIEQ
CCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEH
STLFKGNELANLASMVNSGLDDMRGATSPRLLLEILCARLLLASNTVAVPVASSSSEATP
HHCCCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
AASPGGLTGIAAARAKAREYGQKKAAPTPAPAPEPTPAPEPTPQPAPEPEPAREPVVEVR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
EASVEKQPASSDPLETIRSHWSELRSIVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHEEECCCCEEEEECCCCC
LAARLNAADHNGILVKVLAEETGLQLKVECIVGTNPAEAGFTAQPAVQKSSWNPNHDSKP
HHHEECCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
ATPSAPAQPQTPKQESVPTEPEEPESSAETSGWGQPVKIGGPEPEAQTPTPPPAPVVPAT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCC
PAAPAAGSAKPAWKERVEQAAANAAQQRQHRQGSSEPFERGVPLPPEPDLPPDPYGYPAD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCC
EGFPERNQGFQQQPAPPVEQPAPAPVVEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
RRDAKTIAMELLAQELGAKPL
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]