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The map label for this gene is csd [H]

Identifier: 138896581

GI number: 138896581

Start: 3044617

End: 3045837

Strand: Reverse

Name: csd [H]

Synonym: GTNG_2944

Alternate gene names: 138896581

Gene position: 3045837-3044617 (Counterclockwise)

Preceding gene: 138896582

Following gene: 138896580

Centisome position: 85.79

GC content: 53.89

Gene sequence:

>1221_bases
ATGAACGTGAAAGAAATTCGTTCGTTGTTTCCCATTTTGCATCAACAAGTGAACGGCCATCCGCTCATTTATTTTGATAG
TGCGGCGACATCGCAAAAACCGCTGCCGGTGATCGAAGCGCTCGACCGCTACTACCGCGAGTACAACTCGAACGTCCATC
GCGGCGTCCATACGCTCGGAACGAAGGCGACCGATGCGTATGAAGGAGCGCGCGAAAAAGTGCGTCGGTTTCTTAATGCC
AAATCGGCACAAGAGATCATCTTTACGCGCGGGACGACAACGGCGCTCAACTTGGTCGCTTCGAGTTATGCGCGCGCCAA
CGTCAAAGAAGGCGATGAAATCGTCATTACGTACATGGAGCACCATAGCAATTTAATTCCATGGCAACAAGCGGCGAAAC
AGACCGGAGCGACATTGAAATATATTTCGCTGCAAGAAGACGGAACGATCGATCTCAAGGATGTCGAGGCAACGGTGACG
CCGGCGACGAAAATCGTTGCCATCGCCCATGTATCGAACGTGCTCGGTACGATCAATCCGGTTCGGGAGATCGCCCGCAT
CGCTCACGATCGCGGCGCCGTTGTCGTTGTCGACGCGGCGCAAAGCGCTCCGCACATGAAAATTGATGTTCAAGAGCTCG
GCTGTGATTTTCTCGCGTTTTCCAGCCATAAAATGTGCGGACCGACCGGAGTTGGCGTATTATATGGAAAAAGAGAACTG
TTGGAGCAAATGGAGCCGATCGAGTTTGGCGGCGAAATGATCGATTTTGTCGAGCTGTATGACTCGACATGGAAAGAGCT
GCCGTGGAAGTTTGAGGGCGGCACGCCGATCATCGCCGGCGCGATTGGTCTCGGTGCGGCCATCGATTTCCTCGAACAAG
TCGGTTTGGACGCCATCGCTGCTCATGAACACGAGTTGGCGCAATATGCACTCGAACGGCTAGCTGACATCGAAGGCGTT
ACCGTCTACGGGCCGAAAGAACGGGCCGGGCTTGTGACGTTTAACATCGAAGGGGTGCACCCGCACGATGTGGCGACGGT
TCTTGACGCGGAAGGAATCGCCATCCGCGCCGGCCACCATTGCGCCCAGCCGTTGATGAAATGGCTTAACGTGACCGCAA
CCGCCCGGGCGAGCTTTTACCTGTACAATACGAAAGAGGAAATCGATACGTTTATCGCTGCATTACAGAAAGCGAAGGAG
TACTTCAGCCATGTCTTCTAA

Upstream 100 bases:

>100_bases
GGCTGATCATCCATGGCTTTTTGGCGCCAGTCGTTGAAGCGATTCCGCTTGAAGGTGTGAAAAAACAATTAATCGAAGTG
ATTGAAAGGAAAGTTCAATC

Downstream 100 bases:

>100_bases
TCATCCGTTAGACCAGCTTTACCGCCAAGTCATTATGGATCATTATAAAAACCCGCGCAACCGCGGCGTGCTTGAGGGGA
CGAACGTCGATATCAACATG

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNVKEIRSLFPILHQQVNGHPLIYFDSAATSQKPLPVIEALDRYYREYNSNVHRGVHTLGTKATDAYEGAREKVRRFLNA
KSAQEIIFTRGTTTALNLVASSYARANVKEGDEIVITYMEHHSNLIPWQQAAKQTGATLKYISLQEDGTIDLKDVEATVT
PATKIVAIAHVSNVLGTINPVREIARIAHDRGAVVVVDAAQSAPHMKIDVQELGCDFLAFSSHKMCGPTGVGVLYGKREL
LEQMEPIEFGGEMIDFVELYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLEQVGLDAIAAHEHELAQYALERLADIEGV
TVYGPKERAGLVTFNIEGVHPHDVATVLDAEGIAIRAGHHCAQPLMKWLNVTATARASFYLYNTKEEIDTFIAALQKAKE
YFSHVF

Sequences:

>Translated_406_residues
MNVKEIRSLFPILHQQVNGHPLIYFDSAATSQKPLPVIEALDRYYREYNSNVHRGVHTLGTKATDAYEGAREKVRRFLNA
KSAQEIIFTRGTTTALNLVASSYARANVKEGDEIVITYMEHHSNLIPWQQAAKQTGATLKYISLQEDGTIDLKDVEATVT
PATKIVAIAHVSNVLGTINPVREIARIAHDRGAVVVVDAAQSAPHMKIDVQELGCDFLAFSSHKMCGPTGVGVLYGKREL
LEQMEPIEFGGEMIDFVELYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLEQVGLDAIAAHEHELAQYALERLADIEGV
TVYGPKERAGLVTFNIEGVHPHDVATVLDAEGIAIRAGHHCAQPLMKWLNVTATARASFYLYNTKEEIDTFIAALQKAKE
YFSHVF
>Mature_406_residues
MNVKEIRSLFPILHQQVNGHPLIYFDSAATSQKPLPVIEALDRYYREYNSNVHRGVHTLGTKATDAYEGAREKVRRFLNA
KSAQEIIFTRGTTTALNLVASSYARANVKEGDEIVITYMEHHSNLIPWQQAAKQTGATLKYISLQEDGTIDLKDVEATVT
PATKIVAIAHVSNVLGTINPVREIARIAHDRGAVVVVDAAQSAPHMKIDVQELGCDFLAFSSHKMCGPTGVGVLYGKREL
LEQMEPIEFGGEMIDFVELYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLEQVGLDAIAAHEHELAQYALERLADIEGV
TVYGPKERAGLVTFNIEGVHPHDVATVLDAEGIAIRAGHHCAQPLMKWLNVTATARASFYLYNTKEEIDTFIAALQKAKE
YFSHVF

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=271, Percent_Identity=30.2583025830258, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI156713448, Length=331, Percent_Identity=29.607250755287, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1787970, Length=397, Percent_Identity=48.3627204030227, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1789175, Length=402, Percent_Identity=42.2885572139304, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI48994898, Length=393, Percent_Identity=26.4631043256997, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25143064, Length=341, Percent_Identity=26.099706744868, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193211090, Length=384, Percent_Identity=27.34375, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319831, Length=394, Percent_Identity=26.6497461928934, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20129463, Length=312, Percent_Identity=30.7692307692308, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44766; Mature: 44766

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVKEIRSLFPILHQQVNGHPLIYFDSAATSQKPLPVIEALDRYYREYNSNVHRGVHTLG
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHC
TKATDAYEGAREKVRRFLNAKSAQEIIFTRGTTTALNLVASSYARANVKEGDEIVITYME
CCCHHHHHHHHHHHHHHHCCCCCHHEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEEH
HHSNLIPWQQAAKQTGATLKYISLQEDGTIDLKDVEATVTPATKIVAIAHVSNVLGTINP
HCCCCCCHHHHHHHCCCEEEEEEECCCCCEEHCCCCEEECCHHHHHHHHHHHHHHHHHHH
VREIARIAHDRGAVVVVDAAQSAPHMKIDVQELGCDFLAFSSHKMCGPTGVGVLYGKREL
HHHHHHHHCCCCCEEEEECCCCCCCCEEEHHHCCCCCEEECCCCCCCCCCCHHEECHHHH
LEQMEPIEFGGEMIDFVELYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLEQVGLDAIA
HHHCCCHHHCCHHHHHHHHHHHHHHHCCEEECCCCEEEEHHHHHHHHHHHHHHHCCHHHH
AHEHELAQYALERLADIEGVTVYGPKERAGLVTFNIEGVHPHDVATVLDAEGIAIRAGHH
HHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHCCCCCEEEECCHH
CAQPLMKWLNVTATARASFYLYNTKEEIDTFIAALQKAKEYFSHVF
HHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVKEIRSLFPILHQQVNGHPLIYFDSAATSQKPLPVIEALDRYYREYNSNVHRGVHTLG
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHC
TKATDAYEGAREKVRRFLNAKSAQEIIFTRGTTTALNLVASSYARANVKEGDEIVITYME
CCCHHHHHHHHHHHHHHHCCCCCHHEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEEH
HHSNLIPWQQAAKQTGATLKYISLQEDGTIDLKDVEATVTPATKIVAIAHVSNVLGTINP
HCCCCCCHHHHHHHCCCEEEEEEECCCCCEEHCCCCEEECCHHHHHHHHHHHHHHHHHHH
VREIARIAHDRGAVVVVDAAQSAPHMKIDVQELGCDFLAFSSHKMCGPTGVGVLYGKREL
HHHHHHHHCCCCCEEEEECCCCCCCCEEEHHHCCCCCEEECCCCCCCCCCCHHEECHHHH
LEQMEPIEFGGEMIDFVELYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLEQVGLDAIA
HHHCCCHHHCCHHHHHHHHHHHHHHHCCEEECCCCEEEEHHHHHHHHHHHHHHHCCHHHH
AHEHELAQYALERLADIEGVTVYGPKERAGLVTFNIEGVHPHDVATVLDAEGIAIRAGHH
HHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHCCCCCEEEECCHH
CAQPLMKWLNVTATARASFYLYNTKEEIDTFIAALQKAKEYFSHVF
HHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]