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The map label for this gene is gyaR [H]

Identifier: 138896552

GI number: 138896552

Start: 3020365

End: 3021354

Strand: Reverse

Name: gyaR [H]

Synonym: GTNG_2915

Alternate gene names: 138896552

Gene position: 3021354-3020365 (Counterclockwise)

Preceding gene: 138896553

Following gene: 138896551

Centisome position: 85.1

GC content: 55.15

Gene sequence:

>990_bases
ATGGGGGGCTGCTTGATGACAAAACCGTACGTCTTTATTACGCGAAAACTGCCAAAAAACGTTGTTGCACCGCTTTTGGC
CATCGCAAAAGTAAAGATGTGGCCGCATGAAAACGTGGCTGTGCCGCGCGACGTGCTCGTGGAAAAAACGAAACGGGCGA
CGGCCATCTTGCCGATGGTGTCCGATCCGATCGACAAAGGTGTGTTGTCTGCTGGCTCGGCGCTCAAAGTGGTCGCCAAT
ATGGGGGTCGGCTATGACAATATTGACGTGCCAGCGGCCACCCAGCGCGGCATTGTCGTTTGCAATACACCCGATGTGTT
AACCGATACCACAGCAGATTTGACGTTTGCGCTGTTATTGGCGACCGCCCGGCGGCTTGTAGAAGCAGCTGATTTTTTGA
AAGAAGGAAAATGGAAAAGCTGGAGTCCGTTTTTGCTTGCTGGCGCCGATGTTCATCATAAAACGATCGGCATTGTCGGC
ATGGGGAACATCGGACAAGCGGTGGCCAAGCGGGCGAAAGGGTTTGATATGAACGTGCTTTATCACAATCGTTCCCGCCG
TCCGGAGGCGGAAGAGAAGCTTGGCGCGGTCTACCGCCCGTTTTTCGATTTGTTGACGGAAAGTGATTTTGTCGTCTGCT
TGACGCCGCTCACCCCGGAGACGCGTCATTTGTTTAACCGCGAGGCGTTTCGGCAAATGAAACCGTCGGCCATTTTCATT
AACGCGGCGCGCGGCGCGGTCGTCGATGAACAAGCGCTGTATGAGGCGCTCGTTCGTGGGGAGATCGCCGCGGCCGGATT
GGACGTATTTGAAAAAGAACCGGTTGCGGCCGATCATCCGCTCGTTTCGCTTCCAAACGTCGTCGCTTTGCCGCATATTG
GCAGCGCGACGTACGAAACGCGACGCGCTATGATGACGCTGGCGCGCGACAACATCATTGCCGTTCTTGAAGGACGGTCG
CCATTGACGCCGGTGAATCAGCCATCGTAA

Upstream 100 bases:

>100_bases
TTGAGCCAAAGCGAACCGCGATGCTTTCCTGCCGGTCGCAGCCGGGACAACTTCTCATTTTTTTTTGGTAGAAGTTGTGA
TAAGATTTAAAAAAAATCAT

Downstream 100 bases:

>100_bases
AAATTTTCATTGCCAAATGGCAGATCGTCTTTTATAATGTCTACTATAAAAATACAGATGTCTACTGTACGTAAACAGAA
GGGGCGGTAAGGATGGAAAA

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MGGCLMTKPYVFITRKLPKNVVAPLLAIAKVKMWPHENVAVPRDVLVEKTKRATAILPMVSDPIDKGVLSAGSALKVVAN
MGVGYDNIDVPAATQRGIVVCNTPDVLTDTTADLTFALLLATARRLVEAADFLKEGKWKSWSPFLLAGADVHHKTIGIVG
MGNIGQAVAKRAKGFDMNVLYHNRSRRPEAEEKLGAVYRPFFDLLTESDFVVCLTPLTPETRHLFNREAFRQMKPSAIFI
NAARGAVVDEQALYEALVRGEIAAAGLDVFEKEPVAADHPLVSLPNVVALPHIGSATYETRRAMMTLARDNIIAVLEGRS
PLTPVNQPS

Sequences:

>Translated_329_residues
MGGCLMTKPYVFITRKLPKNVVAPLLAIAKVKMWPHENVAVPRDVLVEKTKRATAILPMVSDPIDKGVLSAGSALKVVAN
MGVGYDNIDVPAATQRGIVVCNTPDVLTDTTADLTFALLLATARRLVEAADFLKEGKWKSWSPFLLAGADVHHKTIGIVG
MGNIGQAVAKRAKGFDMNVLYHNRSRRPEAEEKLGAVYRPFFDLLTESDFVVCLTPLTPETRHLFNREAFRQMKPSAIFI
NAARGAVVDEQALYEALVRGEIAAAGLDVFEKEPVAADHPLVSLPNVVALPHIGSATYETRRAMMTLARDNIIAVLEGRS
PLTPVNQPS
>Mature_328_residues
GGCLMTKPYVFITRKLPKNVVAPLLAIAKVKMWPHENVAVPRDVLVEKTKRATAILPMVSDPIDKGVLSAGSALKVVANM
GVGYDNIDVPAATQRGIVVCNTPDVLTDTTADLTFALLLATARRLVEAADFLKEGKWKSWSPFLLAGADVHHKTIGIVGM
GNIGQAVAKRAKGFDMNVLYHNRSRRPEAEEKLGAVYRPFFDLLTESDFVVCLTPLTPETRHLFNREAFRQMKPSAIFIN
AARGAVVDEQALYEALVRGEIAAAGLDVFEKEPVAADHPLVSLPNVVALPHIGSATYETRRAMMTLARDNIIAVLEGRSP
LTPVNQPS

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=312, Percent_Identity=44.5512820512821, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=33.1034482758621, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI145580578, Length=255, Percent_Identity=36.8627450980392, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4557499, Length=255, Percent_Identity=36.8627450980392, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI145580575, Length=255, Percent_Identity=36.8627450980392, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=35.8267716535433, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=35.8267716535433, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI87082289, Length=326, Percent_Identity=46.0122699386503, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1789279, Length=270, Percent_Identity=31.8518518518519, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787645, Length=235, Percent_Identity=32.3404255319149, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI87081824, Length=235, Percent_Identity=26.8085106382979, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788660, Length=243, Percent_Identity=29.2181069958848, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=253, Percent_Identity=35.1778656126482, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=278, Percent_Identity=30.5755395683453, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=250, Percent_Identity=41.2, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320925, Length=284, Percent_Identity=31.6901408450704, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=309, Percent_Identity=30.42071197411, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=28.8537549407115, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=169, Percent_Identity=33.1360946745562, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=291, Percent_Identity=24.3986254295533, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=162, Percent_Identity=32.0987654320988, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571528, Length=317, Percent_Identity=45.4258675078864, Blast_Score=231, Evalue=3e-61,
Organism=Drosophila melanogaster, GI45552429, Length=291, Percent_Identity=41.9243986254296, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI45551003, Length=291, Percent_Identity=41.9243986254296, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28574284, Length=291, Percent_Identity=41.9243986254296, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24585514, Length=291, Percent_Identity=41.9243986254296, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28574282, Length=291, Percent_Identity=41.9243986254296, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24585516, Length=290, Percent_Identity=38.2758620689655, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI28574286, Length=285, Percent_Identity=41.4035087719298, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI19921140, Length=285, Percent_Identity=36.140350877193, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24646446, Length=232, Percent_Identity=38.3620689655172, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646448, Length=232, Percent_Identity=38.3620689655172, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646452, Length=232, Percent_Identity=38.3620689655172, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646450, Length=232, Percent_Identity=38.3620689655172, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI62472511, Length=227, Percent_Identity=39.2070484581498, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35770; Mature: 35639

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGCLMTKPYVFITRKLPKNVVAPLLAIAKVKMWPHENVAVPRDVLVEKTKRATAILPMV
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEEECHH
SDPIDKGVLSAGSALKVVANMGVGYDNIDVPAATQRGIVVCNTPDVLTDTTADLTFALLL
CCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHH
ATARRLVEAADFLKEGKWKSWSPFLLAGADVHHKTIGIVGMGNIGQAVAKRAKGFDMNVL
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEE
YHNRSRRPEAEEKLGAVYRPFFDLLTESDFVVCLTPLTPETRHLFNREAFRQMKPSAIFI
EECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEE
NAARGAVVDEQALYEALVRGEIAAAGLDVFEKEPVAADHPLVSLPNVVALPHIGSATYET
ECCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEECCCCCCHHHHH
RRAMMTLARDNIIAVLEGRSPLTPVNQPS
HHHHHHHHCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
GGCLMTKPYVFITRKLPKNVVAPLLAIAKVKMWPHENVAVPRDVLVEKTKRATAILPMV
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEEECHH
SDPIDKGVLSAGSALKVVANMGVGYDNIDVPAATQRGIVVCNTPDVLTDTTADLTFALLL
CCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHH
ATARRLVEAADFLKEGKWKSWSPFLLAGADVHHKTIGIVGMGNIGQAVAKRAKGFDMNVL
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEE
YHNRSRRPEAEEKLGAVYRPFFDLLTESDFVVCLTPLTPETRHLFNREAFRQMKPSAIFI
EECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEE
NAARGAVVDEQALYEALVRGEIAAAGLDVFEKEPVAADHPLVSLPNVVALPHIGSATYET
ECCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEECCCCCCHHHHH
RRAMMTLARDNIIAVLEGRSPLTPVNQPS
HHHHHHHHCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA