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The map label for this gene is pepA

Identifier: 138896536

GI number: 138896536

Start: 3005826

End: 3007319

Strand: Reverse

Name: pepA

Synonym: GTNG_2899

Alternate gene names: 138896536

Gene position: 3007319-3005826 (Counterclockwise)

Preceding gene: 138896538

Following gene: 138896535

Centisome position: 84.71

GC content: 54.08

Gene sequence:

>1494_bases
ATGTTTACGGTAAAACCATGGTCATCGGCAGAAGTGGTGCACGAGGCGTTGGCTATCGGATTGTTTGAGGGGAAAGATTC
GTGGTCTGGGCTTGCCGGCGAGTACGATTCCCGTCTCGGTGGGCAGTTGTCCAACCTGCGGAAAGAAGGCGACATTTCCG
CCAAACGGGGGCGCATTGCCACCATTCATACGATGTTGCCGACCGGAGTTAAGCGGCTGTATTTTGTTGGTCTTGGCAAA
AAAGAAGAACTGACGTTTGAACGGCTTCGTGAAGTGTTCGGCAAGCTGTTTCGCACATGGAAGCAGGCGAAACGGACCGA
GGCCGCGATCGCTCTTGACACATTTACGACAGAAACGGTCGATTCGAACGAGGCGGCGCATGCGTTAGCTGAGGCGTACT
ATTTGGCGACATATGAATTCCCAGGCTATAAGCAGAAAAAGTCGGAACCAGACTATGCGCTTGAATCGCTCACCGTATAT
ACGGCGGCCGATGCGGCAGAAATCGAGGCAAGCTTATTTGTCGGCTCCGTGTACGGGAAGGCGACCAACTCAGCGCGCAC
GCTCGTCAATACGCCGGGCAATTTGCTGACGGCATCCGATTTGGCTGATTATGCCGTGGAGTTGGCGAAACGGTACGATT
TTGACTATGAAATTTTGGAAAAAGAAGAGATGGAGCGGCTCGGTATGGGCGCGCTATTGGCGGTCAATCAAGGGTCAAAG
CAGCCGCCCAAGCTGATCGTTCTAAAATACCAAGGAAAAGAGCAATGGGAGAACGTGATCGGCCTCGTCGGCAAAGGGGT
GACATTTGATACGGGAGGATATTGCCTGAAGCCGCGCGACAGCATGATCGACATGAAAACAGATATGGGCGGCGCCGCCG
CGGTGCTCGGTGCCATGGAAGCGATCGGCGAACTCCGTCCGGAGCAAAACGTGCTCGCCGTCATTCCGGCAACCGACAAC
ATGATTAGTGCTGAGGCGTTTAAGCCGGATGACGTCATTACATCGCTTTCCGGAAAAACGATTGAAGTGAGAAACACGGA
TGCCGAAGGACGGCTCATTTTGGCCGATGCGATCACCTACGCGAAACAGCATGGCGCTCGTTATTTGATTGATGTTGCTA
CGTTGACCGGCGGAGTGATCGTTGCGCTTGGCACGGATAAAACCGGTGCGATGACGAACAACGAAGCGCTGTTTGAGCAG
CTGCTGGAAGCATCCATGGAGACCGGGGAATTCATTTGGCGGCTGCCGATTACGGAAAAAGACCGCGAGCGGGTGCGAAG
CAGCAAAATTGCTGATTTAAACAATTCTCCAGGACGTGAAGGGCACGCGATTATGGGCGGGGCGTTCATCGGCGAATTTG
CTGAAGACACACCGTGGGTGCATTTAGATATTGCCGGCACGGCGACCACGAAGAAAGACGGTGATCTCGGCCCAGCCGGG
GCGACGGGTGTAATGGTGCGAACGCTGACGGCGTTTGTCGAACGATTTGAATAA

Upstream 100 bases:

>100_bases
TAGTAAAAGAAAAGAGGGAAAATCCATTAGACAATCGAAATAATCGCCATGTTTCGCTATAATGAGAAATGGAATGAATC
ACCATGAAAGGGATGAAAGA

Downstream 100 bases:

>100_bases
GCGGTTGAAGAGCTGGAGCGAAGTTGCATAGCTCCAGCTTTCTTTTGGCACGCTACATAGTACAAAGAGGCGAACAAAAC
GTAAAGGGAATGTAAATTTC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MFTVKPWSSAEVVHEALAIGLFEGKDSWSGLAGEYDSRLGGQLSNLRKEGDISAKRGRIATIHTMLPTGVKRLYFVGLGK
KEELTFERLREVFGKLFRTWKQAKRTEAAIALDTFTTETVDSNEAAHALAEAYYLATYEFPGYKQKKSEPDYALESLTVY
TAADAAEIEASLFVGSVYGKATNSARTLVNTPGNLLTASDLADYAVELAKRYDFDYEILEKEEMERLGMGALLAVNQGSK
QPPKLIVLKYQGKEQWENVIGLVGKGVTFDTGGYCLKPRDSMIDMKTDMGGAAAVLGAMEAIGELRPEQNVLAVIPATDN
MISAEAFKPDDVITSLSGKTIEVRNTDAEGRLILADAITYAKQHGARYLIDVATLTGGVIVALGTDKTGAMTNNEALFEQ
LLEASMETGEFIWRLPITEKDRERVRSSKIADLNNSPGREGHAIMGGAFIGEFAEDTPWVHLDIAGTATTKKDGDLGPAG
ATGVMVRTLTAFVERFE

Sequences:

>Translated_497_residues
MFTVKPWSSAEVVHEALAIGLFEGKDSWSGLAGEYDSRLGGQLSNLRKEGDISAKRGRIATIHTMLPTGVKRLYFVGLGK
KEELTFERLREVFGKLFRTWKQAKRTEAAIALDTFTTETVDSNEAAHALAEAYYLATYEFPGYKQKKSEPDYALESLTVY
TAADAAEIEASLFVGSVYGKATNSARTLVNTPGNLLTASDLADYAVELAKRYDFDYEILEKEEMERLGMGALLAVNQGSK
QPPKLIVLKYQGKEQWENVIGLVGKGVTFDTGGYCLKPRDSMIDMKTDMGGAAAVLGAMEAIGELRPEQNVLAVIPATDN
MISAEAFKPDDVITSLSGKTIEVRNTDAEGRLILADAITYAKQHGARYLIDVATLTGGVIVALGTDKTGAMTNNEALFEQ
LLEASMETGEFIWRLPITEKDRERVRSSKIADLNNSPGREGHAIMGGAFIGEFAEDTPWVHLDIAGTATTKKDGDLGPAG
ATGVMVRTLTAFVERFE
>Mature_497_residues
MFTVKPWSSAEVVHEALAIGLFEGKDSWSGLAGEYDSRLGGQLSNLRKEGDISAKRGRIATIHTMLPTGVKRLYFVGLGK
KEELTFERLREVFGKLFRTWKQAKRTEAAIALDTFTTETVDSNEAAHALAEAYYLATYEFPGYKQKKSEPDYALESLTVY
TAADAAEIEASLFVGSVYGKATNSARTLVNTPGNLLTASDLADYAVELAKRYDFDYEILEKEEMERLGMGALLAVNQGSK
QPPKLIVLKYQGKEQWENVIGLVGKGVTFDTGGYCLKPRDSMIDMKTDMGGAAAVLGAMEAIGELRPEQNVLAVIPATDN
MISAEAFKPDDVITSLSGKTIEVRNTDAEGRLILADAITYAKQHGARYLIDVATLTGGVIVALGTDKTGAMTNNEALFEQ
LLEASMETGEFIWRLPITEKDRERVRSSKIADLNNSPGREGHAIMGGAFIGEFAEDTPWVHLDIAGTATTKKDGDLGPAG
ATGVMVRTLTAFVERFE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=481, Percent_Identity=35.5509355509356, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI47155554, Length=350, Percent_Identity=32.8571428571429, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1790710, Length=497, Percent_Identity=35.010060362173, Blast_Score=273, Evalue=3e-74,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=37.8548895899054, Blast_Score=178, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=333, Percent_Identity=36.036036036036, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17565172, Length=157, Percent_Identity=41.4012738853503, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24661038, Length=463, Percent_Identity=32.829373650108, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI21355725, Length=457, Percent_Identity=32.1663019693654, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI20129969, Length=487, Percent_Identity=29.1581108829569, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI19922386, Length=474, Percent_Identity=30.168776371308, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662227, Length=468, Percent_Identity=28.6324786324786, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21355645, Length=492, Percent_Identity=28.4552845528455, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24662223, Length=492, Percent_Identity=28.4552845528455, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161077148, Length=449, Percent_Identity=28.5077951002227, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20130057, Length=449, Percent_Identity=28.5077951002227, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129963, Length=492, Percent_Identity=27.2357723577236, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21357381, Length=284, Percent_Identity=33.8028169014084, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI221379063, Length=284, Percent_Identity=33.8028169014084, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI221379062, Length=284, Percent_Identity=33.8028169014084, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24646701, Length=285, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646703, Length=285, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21358201, Length=285, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_GEOTN (A4ISE0)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126989.1
- ProteinModelPortal:   A4ISE0
- SMR:   A4ISE0
- STRING:   A4ISE0
- MEROPS:   M17.010
- GeneID:   4967825
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2899
- NMPDR:   fig|420246.5.peg.2778
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   ASMETGE
- PhylomeDB:   A4ISE0
- ProtClustDB:   PRK00913
- BioCyc:   GTHE420246:GTNG_2899-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54074; Mature: 54074

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 277-277 ACT_SITE 351-351

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTVKPWSSAEVVHEALAIGLFEGKDSWSGLAGEYDSRLGGQLSNLRKEGDISAKRGRIA
CEECCCCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCCCCEE
TIHTMLPTGVKRLYFVGLGKKEELTFERLREVFGKLFRTWKQAKRTEAAIALDTFTTETV
EEEHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCC
DSNEAAHALAEAYYLATYEFPGYKQKKSEPDYALESLTVYTAADAAEIEASLFVGSVYGK
CCCHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHEEEEEECCHHHHHHHEEEEHHHCC
ATNSARTLVNTPGNLLTASDLADYAVELAKRYDFDYEILEKEEMERLGMGALLAVNQGSK
CCCCCCEEEECCCCEEEHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCCEEEEECCCCC
QPPKLIVLKYQGKEQWENVIGLVGKGVTFDTGGYCLKPRDSMIDMKTDMGGAAAVLGAME
CCCEEEEEEECCHHHHHHHHHHHCCCEEECCCCEEECCCCCEEEECCCCCHHHHHHHHHH
AIGELRPEQNVLAVIPATDNMISAEAFKPDDVITSLSGKTIEVRNTDAEGRLILADAITY
HHHHCCCCCCEEEEEECCCCEEECCCCCCCHHHHHCCCCEEEEECCCCCCCEEEHHHHHH
AKQHGARYLIDVATLTGGVIVALGTDKTGAMTNNEALFEQLLEASMETGEFIWRLPITEK
HHHCCCEEEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCH
DRERVRSSKIADLNNSPGREGHAIMGGAFIGEFAEDTPWVHLDIAGTATTKKDGDLGPAG
HHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
ATGVMVRTLTAFVERFE
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFTVKPWSSAEVVHEALAIGLFEGKDSWSGLAGEYDSRLGGQLSNLRKEGDISAKRGRIA
CEECCCCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCCCCEE
TIHTMLPTGVKRLYFVGLGKKEELTFERLREVFGKLFRTWKQAKRTEAAIALDTFTTETV
EEEHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCC
DSNEAAHALAEAYYLATYEFPGYKQKKSEPDYALESLTVYTAADAAEIEASLFVGSVYGK
CCCHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHEEEEEECCHHHHHHHEEEEHHHCC
ATNSARTLVNTPGNLLTASDLADYAVELAKRYDFDYEILEKEEMERLGMGALLAVNQGSK
CCCCCCEEEECCCCEEEHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCCEEEEECCCCC
QPPKLIVLKYQGKEQWENVIGLVGKGVTFDTGGYCLKPRDSMIDMKTDMGGAAAVLGAME
CCCEEEEEEECCHHHHHHHHHHHCCCEEECCCCEEECCCCCEEEECCCCCHHHHHHHHHH
AIGELRPEQNVLAVIPATDNMISAEAFKPDDVITSLSGKTIEVRNTDAEGRLILADAITY
HHHHCCCCCCEEEEEECCCCEEECCCCCCCHHHHHCCCCEEEEECCCCCCCEEEHHHHHH
AKQHGARYLIDVATLTGGVIVALGTDKTGAMTNNEALFEQLLEASMETGEFIWRLPITEK
HHHCCCEEEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCH
DRERVRSSKIADLNNSPGREGHAIMGGAFIGEFAEDTPWVHLDIAGTATTKKDGDLGPAG
HHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
ATGVMVRTLTAFVERFE
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA