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The map label for this gene is lonB [H]

Identifier: 138896217

GI number: 138896217

Start: 2686394

End: 2688070

Strand: Reverse

Name: lonB [H]

Synonym: GTNG_2580

Alternate gene names: 138896217

Gene position: 2688070-2686394 (Counterclockwise)

Preceding gene: 138896218

Following gene: 138896216

Centisome position: 75.71

GC content: 51.52

Gene sequence:

>1677_bases
ATGAATTGGACGAATATCGTGCTTGTAATTCAGTTGTTTTTTGGGGTCGTCATCGGCCTTTATTTTTGGAATTTGTTAAA
AGGACAGCGTGTGCAAAAAGTATCGATTGATAAAGAATCGCGCAAAGAGATGGAGCAGCTCCGCAAGCTGCGCTCTATTT
CACTCACTGAGCCGCTTGCCGAAAAAGTACGCCCGAAAAGTTTTGACGATATCGTAGGTCAGGAAGACGGCATCAAGGCA
TTGAAAGCAGCACTGTGCGGGCCGAACCCGCAACATGTCATCATTTATGGACCACCTGGCGTCGGCAAAACAGCCGCAGC
CCGGTTGGTACTTGAAGAAGCGAAGAAAAATCCGCTCTCCCCGTTTAAGAAAAATGCTGTATTTGTTGAGCTCGATGCGA
CGACGGCGCGCTTTGACGAGCGCGGCATCGCCGATCCGCTCATTGGCTCGGTGCATGACCCGATTTACCAAGGGGCCGGG
GCGATGGGACAAGCCGGTATCCCCCAGCCGAAACAAGGGGCGGTGACGAACGCTCATGGCGGCGTTTTGTTTATTGATGA
AATTGGCGAACTCCATCCCATCCAAATGAACAAGCTGCTCAAAGTGCTTGAGGATCGGAAAGTGTTTTTTGAAAGCGCCT
ATTACAGCAAAGAAAACCCACAAATTCCAAGCCATATCCATGACATTTTCCAAAACGGGCTGCCGGCCGATTTTCGCCTT
GTCGGTGCAACGACACGAACGCCAAACGAGATTCCTCCGGCCATTCGTTCCCGTTGTTTAGAAGTGTTTTTCCGCGAATT
GGATCAAGACGAAATCGCCTTGATCGCCAAAAAAGCAGCGGAAAAAATCCGCTTGAATGTTTCCGAAAGCGGCATTCGTC
TCCTTGCCGCTTATGCGCGCAACGGTCGGGAAGCGGTGAACATGATGCAAATTGCGGCCGGGCTTGCCATTACGGAAAAC
CGGGAGAAAATTTTGGATAAAGATATTGAATGGGTCATTCACTCAAGCCAAATGGCTCCGCGCTATGAAAAGAAAATTGG
ATCCGCTCCGGCAGTCGGTGTTGTCAATGGGCTGGCGGTATACGGACCGAACACCGGCGCGCTTCTCGAAATTGAAGTGA
CTGCCTTGCCAGCGAAAGGAAAAGGATCAATCAATGTGACCGGCATTGTCGAGGAAGAAAGCATTGGTAGTCCGGAAAAA
TCGGTGCGCCGCAAAAGTATGGCGCGCGGCTCGGCGGAAAACGTGATTACCGTGCTTCGTGCGATGGGGGTACCGGCGGA
CCGTTACGATATTCACGTCAATTTTCCAGGCGGTGTGCCAGTCGACGGTCCTTCAGCCGGGGTGGCGATCGCGGTTGGGA
TTTATTCGGCCATTTATCAGCTGCCGGTCGATCATACCGTCGCAATGACTGGAGAAATTAGCATCCACGGCTACGTCAAA
CCGGTCGGTGGCGTGTTTGCTAAAATTAAAGCGGCCAAGCAAGCCGGAGCGAAAAAAGTCATTATTCCGATTGAAAACAT
GCAATCGCTGTTGCGGGAAGTGAGCGGTATTCAAATTATCGCTGTCCGCCGCCTTGAAGAAGCGCTCATCCACGTGTTCG
GTGAAGAAACACTCCGTCGAGGCACTGCATTTTTGCCGGCTGCTGCCGCCGATCGTTCAGGGAAAAAGCTCGTGTAA

Upstream 100 bases:

>100_bases
ATGCCCTAGGCGCCAGTCGGCGCTTTTTTTGTTTATTCCCGCCAATTCGCGGAGATACTATTATACTACATACTACTTGA
AGGCAGGAGGATATCGGGGC

Downstream 100 bases:

>100_bases
CAAAGGGGGAGCGATGGTAAAGAGGAGCGCAGCCGCCCGTTTTTGCCGCTGTGGAATATACCGTTTCGTGTACGGCTCGC
TGCATTGTGCGGCCGACTAT

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MNWTNIVLVIQLFFGVVIGLYFWNLLKGQRVQKVSIDKESRKEMEQLRKLRSISLTEPLAEKVRPKSFDDIVGQEDGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNPLSPFKKNAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKQGAVTNAHGGVLFIDEIGELHPIQMNKLLKVLEDRKVFFESAYYSKENPQIPSHIHDIFQNGLPADFRL
VGATTRTPNEIPPAIRSRCLEVFFRELDQDEIALIAKKAAEKIRLNVSESGIRLLAAYARNGREAVNMMQIAAGLAITEN
REKILDKDIEWVIHSSQMAPRYEKKIGSAPAVGVVNGLAVYGPNTGALLEIEVTALPAKGKGSINVTGIVEEESIGSPEK
SVRRKSMARGSAENVITVLRAMGVPADRYDIHVNFPGGVPVDGPSAGVAIAVGIYSAIYQLPVDHTVAMTGEISIHGYVK
PVGGVFAKIKAAKQAGAKKVIIPIENMQSLLREVSGIQIIAVRRLEEALIHVFGEETLRRGTAFLPAAAADRSGKKLV

Sequences:

>Translated_558_residues
MNWTNIVLVIQLFFGVVIGLYFWNLLKGQRVQKVSIDKESRKEMEQLRKLRSISLTEPLAEKVRPKSFDDIVGQEDGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNPLSPFKKNAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKQGAVTNAHGGVLFIDEIGELHPIQMNKLLKVLEDRKVFFESAYYSKENPQIPSHIHDIFQNGLPADFRL
VGATTRTPNEIPPAIRSRCLEVFFRELDQDEIALIAKKAAEKIRLNVSESGIRLLAAYARNGREAVNMMQIAAGLAITEN
REKILDKDIEWVIHSSQMAPRYEKKIGSAPAVGVVNGLAVYGPNTGALLEIEVTALPAKGKGSINVTGIVEEESIGSPEK
SVRRKSMARGSAENVITVLRAMGVPADRYDIHVNFPGGVPVDGPSAGVAIAVGIYSAIYQLPVDHTVAMTGEISIHGYVK
PVGGVFAKIKAAKQAGAKKVIIPIENMQSLLREVSGIQIIAVRRLEEALIHVFGEETLRRGTAFLPAAAADRSGKKLV
>Mature_558_residues
MNWTNIVLVIQLFFGVVIGLYFWNLLKGQRVQKVSIDKESRKEMEQLRKLRSISLTEPLAEKVRPKSFDDIVGQEDGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNPLSPFKKNAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKQGAVTNAHGGVLFIDEIGELHPIQMNKLLKVLEDRKVFFESAYYSKENPQIPSHIHDIFQNGLPADFRL
VGATTRTPNEIPPAIRSRCLEVFFRELDQDEIALIAKKAAEKIRLNVSESGIRLLAAYARNGREAVNMMQIAAGLAITEN
REKILDKDIEWVIHSSQMAPRYEKKIGSAPAVGVVNGLAVYGPNTGALLEIEVTALPAKGKGSINVTGIVEEESIGSPEK
SVRRKSMARGSAENVITVLRAMGVPADRYDIHVNFPGGVPVDGPSAGVAIAVGIYSAIYQLPVDHTVAMTGEISIHGYVK
PVGGVFAKIKAAKQAGAKKVIIPIENMQSLLREVSGIQIIAVRRLEEALIHVFGEETLRRGTAFLPAAAADRSGKKLV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=177, Percent_Identity=36.7231638418079, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI21396489, Length=461, Percent_Identity=25.5965292841649, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1786643, Length=478, Percent_Identity=26.7782426778243, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17556486, Length=481, Percent_Identity=27.4428274428274, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17505831, Length=502, Percent_Identity=26.6932270916335, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319449, Length=92, Percent_Identity=42.3913043478261, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221513036, Length=497, Percent_Identity=24.9496981891348, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666867, Length=495, Percent_Identity=25.2525252525253, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 60516; Mature: 60516

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWTNIVLVIQLFFGVVIGLYFWNLLKGQRVQKVSIDKESRKEMEQLRKLRSISLTEPLA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHH
EKVRPKSFDDIVGQEDGIKALKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNPLS
HHCCCCCHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCC
PFKKNAVFVELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKQGAVTNAHG
CHHCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCC
GVLFIDEIGELHPIQMNKLLKVLEDRKVFFESAYYSKENPQIPSHIHDIFQNGLPADFRL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEE
VGATTRTPNEIPPAIRSRCLEVFFRELDQDEIALIAKKAAEKIRLNVSESGIRLLAAYAR
EECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHH
NGREAVNMMQIAAGLAITENREKILDKDIEWVIHSSQMAPRYEKKIGSAPAVGVVNGLAV
CCHHHHHHHHHHHCCEEECCHHHHHHCHHHHEEECCCCCCHHHHHCCCCCCHHHHCCEEE
YGPNTGALLEIEVTALPAKGKGSINVTGIVEEESIGSPEKSVRRKSMARGSAENVITVLR
ECCCCCCEEEEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHH
AMGVPADRYDIHVNFPGGVPVDGPSAGVAIAVGIYSAIYQLPVDHTVAMTGEISIHGYVK
HHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEC
PVGGVFAKIKAAKQAGAKKVIIPIENMQSLLREVSGIQIIAVRRLEEALIHVFGEETLRR
CHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHC
GTAFLPAAAADRSGKKLV
CCCCCCCHHCCCCCCCCC
>Mature Secondary Structure
MNWTNIVLVIQLFFGVVIGLYFWNLLKGQRVQKVSIDKESRKEMEQLRKLRSISLTEPLA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHH
EKVRPKSFDDIVGQEDGIKALKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNPLS
HHCCCCCHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCC
PFKKNAVFVELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKQGAVTNAHG
CHHCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCC
GVLFIDEIGELHPIQMNKLLKVLEDRKVFFESAYYSKENPQIPSHIHDIFQNGLPADFRL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEE
VGATTRTPNEIPPAIRSRCLEVFFRELDQDEIALIAKKAAEKIRLNVSESGIRLLAAYAR
EECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHH
NGREAVNMMQIAAGLAITENREKILDKDIEWVIHSSQMAPRYEKKIGSAPAVGVVNGLAV
CCHHHHHHHHHHHCCEEECCHHHHHHCHHHHEEECCCCCCHHHHHCCCCCCHHHHCCEEE
YGPNTGALLEIEVTALPAKGKGSINVTGIVEEESIGSPEKSVRRKSMARGSAENVITVLR
ECCCCCCEEEEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHH
AMGVPADRYDIHVNFPGGVPVDGPSAGVAIAVGIYSAIYQLPVDHTVAMTGEISIHGYVK
HHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEC
PVGGVFAKIKAAKQAGAKKVIIPIENMQSLLREVSGIQIIAVRRLEEALIHVFGEETLRR
CHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHC
GTAFLPAAAADRSGKKLV
CCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]