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The map label for this gene is lonA [H]

Identifier: 138896216

GI number: 138896216

Start: 2683782

End: 2686124

Strand: Reverse

Name: lonA [H]

Synonym: GTNG_2579

Alternate gene names: 138896216

Gene position: 2686124-2683782 (Counterclockwise)

Preceding gene: 138896217

Following gene: 138896215

Centisome position: 75.66

GC content: 51.17

Gene sequence:

>2343_bases
ATGGAGGTGTTCGGCGTGAACGGAAAGAAAAAGGAGACGATCGTTCCGCTTTTGCCGCTGCGGGGGTTGCTTGTGTTTCC
GACGATGGTACTCCATTTGGACGTCGGGCGCGAGAAATCGGTGAAAGCACTCGAACAGGCGATGGTCGAGGACCATATCA
TTTTGCTGACATCGCAAAAAGATGTCGCCATCGACGAACCGGACATGGACGACTTATATAAAATGGGGACGATTGCGCGC
GTTAAGCAGTTGTTGAAATTGCCGAACGGCACGTTCCGTGTGCTTGTCGAAGGCATTGCCCGGGCGCTCATCACCGAAGT
CGTCAGCGAGGAGCCGTATTTTTCCGTCAAGGTGGAAAAATTCGCTGATCGGGCATCGAAAGACTTGGAAGATGAGGCGC
TCAAGCGGACGATGCTCGAATATTTTGAGCAATACATAAATTTATCCAAGCGGCTGTCGGCGGACATTTATGCCTCGATT
GTCGACATTGATGAGCCGGGGCGGATGGCCGATATTATCGCTTCGCATTTGCCGCTTAAGCTCGAAGAAAAACAGCGTAT
TTTAGAAACGATCGATGTGAAAGAACGGCTGAATAAAATTATTCAAATTTTGCACAACGAGAAAGAAGTGCTCCAGCTCG
AGAAAAAAATTAGCGCTCGCGTCAAACAGTCAATGGAGCGGACGCAAAAAGAGTATTATTTGCGCGAGCAAATGAAAGCC
ATTCAAAAAGAGCTCGGTGAAAAGGAAGGAAAAACGGGTGAAGTCGAGGCGCTCAAAGAGAAAATCGAGGCAGCCGGCAT
GCCAGAACATGTGAAAGAGACGGCCCTCAAGGAGCTCGACCGCTATGAAAAAATTCCGGCAACATCAGCGGAAAGTGCGG
TCATCCGCAACTACTTAGACTGGCTCATTGCTTTGCCATGGTCAAAAGAAACGAAAGACATCCACGATATTAAACGCGCG
GAAACGATTTTAAACGAGGAGCATTACGGGCTTGATAAGGTGAAAGAGCGGGTGCTTGAATTTTTGTCCGTGCAGCAGTT
GACCCAATCGTTAAAAGGACCGATTCTTTGCCTTGCCGGACCGCCGGGGGTCGGAAAAACATCGCTTGCCCGCTCGATTG
CCAAAGCACTCGGCCGTCGTTTCGTTCGCATGTCGCTTGGCGGCGTGCGCGACGAATCGGAAATTCGCGGCCATCGTCGC
ACGTACGTTGGAGCGATGCCGGGTCGCATCATTCAAGGCATGAAAAAAGCAGGCACGATCAATCCGGTCTTTTTGCTTGA
TGAGATCGACAAAATGTCAAGCGATTTCCGTGGCGACCCATCCGCGGCTATGCTTGAGGTGCTCGATCCGGAACAAAACC
ATACGTTCAGCGATCATTATATCGAAGAGCCGTACGATTTATCGAAAGTAATGTTTATCGCTACCGCTAACAATTTGGCG
ACGATTCCGCAGCCGTTGTTGGACCGGATGGAAATCATTCACATTCCAGGCTATACAGAGGTCGAAAAGCTGCATATCGC
CAAACGGCATTTGCTGCCGAAGCAGCTGGCGGAGCATGGACTGAAAAAGGCAGCGCTCCAGGTTCGGGATGATGCGATGT
TGGATATCATCCGTCATTATACGCGCGAAGCCGGCGTTCGGGAGCTTGAACGGCAACTTGCCGCCATTTGCCGGAAAGCG
GCTCGCCTCATCGTCTCTGGGGAGAAAAAACGGGTTGTGGTTACACAAAATAATATCGAAGAATTTTTAGGGAAACGAAA
ATACCGCTATGGTCAGGCGGAGGCAGAAGATCAAATTGGGGTAGCCACCGGTCTTGCGTATACCGCGTTTGGCGGTGATA
CGCTCGCCATCGAAGTGTCGCTTGCGAAAGGCAACGGCAAACTTGTCTTGACCGGAAAACTCGGAGATGTAATGAAAGAG
TCGGCACAAGCAGCGTTCAGCTATGTGCGTTCACGCGCCGAGGAGCTCGGCATTGACCCGAAATTTCATGAAACGTACGA
TATCCATATTCACGTTCCAGAAGGAGCGGTGCCAAAAGACGGACCGTCTGCTGGTATTACGATCGCGACTGCGCTCATTT
CCGCTTTAACAGGTAAGCCGGTCAGCCGGTTTGTCGGTATGACCGGGGAAATTACGCTGCGTGGCCGTGTGCTCCCGATC
GGCGGCTTAAAAGAGAAAACGCTAAGCGCCCACCGCGCCGGACTGAAAACGGTCATTTTACCGAAAGATAATGAAAAAGA
TTTGGCCGACATTCCGGATACAGTAAAGCGCGACTTGCGCTTTGTGCTCGTCTCCCATCTCGATGAGGTGCTGCCACATG
CGTTGGTGGGGTGGGAACGATGA

Upstream 100 bases:

>100_bases
ATTTTTCTTTGTCTGCAAATAAGATGCTGTTCTCTTTGGTATTCATCAAATTTTACAAATCTGGCTGTCGTACTATACAA
TAAACGAATAGAAGCGAGAT

Downstream 100 bases:

>100_bases
ACATCACAAAAGCAGAGCTCGTCATCAGTGCTGTCAAACCCGAGCAATATCCGGATAGTGGGCGGCCGGAAGTGGCGCTT
GCTGGTCGCTCAAACGTCGG

Product: class III heat-shock ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MEVFGVNGKKKETIVPLLPLRGLLVFPTMVLHLDVGREKSVKALEQAMVEDHIILLTSQKDVAIDEPDMDDLYKMGTIAR
VKQLLKLPNGTFRVLVEGIARALITEVVSEEPYFSVKVEKFADRASKDLEDEALKRTMLEYFEQYINLSKRLSADIYASI
VDIDEPGRMADIIASHLPLKLEEKQRILETIDVKERLNKIIQILHNEKEVLQLEKKISARVKQSMERTQKEYYLREQMKA
IQKELGEKEGKTGEVEALKEKIEAAGMPEHVKETALKELDRYEKIPATSAESAVIRNYLDWLIALPWSKETKDIHDIKRA
ETILNEEHYGLDKVKERVLEFLSVQQLTQSLKGPILCLAGPPGVGKTSLARSIAKALGRRFVRMSLGGVRDESEIRGHRR
TYVGAMPGRIIQGMKKAGTINPVFLLDEIDKMSSDFRGDPSAAMLEVLDPEQNHTFSDHYIEEPYDLSKVMFIATANNLA
TIPQPLLDRMEIIHIPGYTEVEKLHIAKRHLLPKQLAEHGLKKAALQVRDDAMLDIIRHYTREAGVRELERQLAAICRKA
ARLIVSGEKKRVVVTQNNIEEFLGKRKYRYGQAEAEDQIGVATGLAYTAFGGDTLAIEVSLAKGNGKLVLTGKLGDVMKE
SAQAAFSYVRSRAEELGIDPKFHETYDIHIHVPEGAVPKDGPSAGITIATALISALTGKPVSRFVGMTGEITLRGRVLPI
GGLKEKTLSAHRAGLKTVILPKDNEKDLADIPDTVKRDLRFVLVSHLDEVLPHALVGWER

Sequences:

>Translated_780_residues
MEVFGVNGKKKETIVPLLPLRGLLVFPTMVLHLDVGREKSVKALEQAMVEDHIILLTSQKDVAIDEPDMDDLYKMGTIAR
VKQLLKLPNGTFRVLVEGIARALITEVVSEEPYFSVKVEKFADRASKDLEDEALKRTMLEYFEQYINLSKRLSADIYASI
VDIDEPGRMADIIASHLPLKLEEKQRILETIDVKERLNKIIQILHNEKEVLQLEKKISARVKQSMERTQKEYYLREQMKA
IQKELGEKEGKTGEVEALKEKIEAAGMPEHVKETALKELDRYEKIPATSAESAVIRNYLDWLIALPWSKETKDIHDIKRA
ETILNEEHYGLDKVKERVLEFLSVQQLTQSLKGPILCLAGPPGVGKTSLARSIAKALGRRFVRMSLGGVRDESEIRGHRR
TYVGAMPGRIIQGMKKAGTINPVFLLDEIDKMSSDFRGDPSAAMLEVLDPEQNHTFSDHYIEEPYDLSKVMFIATANNLA
TIPQPLLDRMEIIHIPGYTEVEKLHIAKRHLLPKQLAEHGLKKAALQVRDDAMLDIIRHYTREAGVRELERQLAAICRKA
ARLIVSGEKKRVVVTQNNIEEFLGKRKYRYGQAEAEDQIGVATGLAYTAFGGDTLAIEVSLAKGNGKLVLTGKLGDVMKE
SAQAAFSYVRSRAEELGIDPKFHETYDIHIHVPEGAVPKDGPSAGITIATALISALTGKPVSRFVGMTGEITLRGRVLPI
GGLKEKTLSAHRAGLKTVILPKDNEKDLADIPDTVKRDLRFVLVSHLDEVLPHALVGWER
>Mature_780_residues
MEVFGVNGKKKETIVPLLPLRGLLVFPTMVLHLDVGREKSVKALEQAMVEDHIILLTSQKDVAIDEPDMDDLYKMGTIAR
VKQLLKLPNGTFRVLVEGIARALITEVVSEEPYFSVKVEKFADRASKDLEDEALKRTMLEYFEQYINLSKRLSADIYASI
VDIDEPGRMADIIASHLPLKLEEKQRILETIDVKERLNKIIQILHNEKEVLQLEKKISARVKQSMERTQKEYYLREQMKA
IQKELGEKEGKTGEVEALKEKIEAAGMPEHVKETALKELDRYEKIPATSAESAVIRNYLDWLIALPWSKETKDIHDIKRA
ETILNEEHYGLDKVKERVLEFLSVQQLTQSLKGPILCLAGPPGVGKTSLARSIAKALGRRFVRMSLGGVRDESEIRGHRR
TYVGAMPGRIIQGMKKAGTINPVFLLDEIDKMSSDFRGDPSAAMLEVLDPEQNHTFSDHYIEEPYDLSKVMFIATANNLA
TIPQPLLDRMEIIHIPGYTEVEKLHIAKRHLLPKQLAEHGLKKAALQVRDDAMLDIIRHYTREAGVRELERQLAAICRKA
ARLIVSGEKKRVVVTQNNIEEFLGKRKYRYGQAEAEDQIGVATGLAYTAFGGDTLAIEVSLAKGNGKLVLTGKLGDVMKE
SAQAAFSYVRSRAEELGIDPKFHETYDIHIHVPEGAVPKDGPSAGITIATALISALTGKPVSRFVGMTGEITLRGRVLPI
GGLKEKTLSAHRAGLKTVILPKDNEKDLADIPDTVKRDLRFVLVSHLDEVLPHALVGWER

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=781, Percent_Identity=42.8937259923175, Blast_Score=605, Evalue=1e-173,
Organism=Homo sapiens, GI21396489, Length=827, Percent_Identity=39.540507859734, Blast_Score=563, Evalue=1e-160,
Organism=Escherichia coli, GI1786643, Length=772, Percent_Identity=55.1813471502591, Blast_Score=870, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=679, Percent_Identity=40.500736377025, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17556486, Length=722, Percent_Identity=38.781163434903, Blast_Score=472, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319449, Length=681, Percent_Identity=40.2349486049927, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221513036, Length=679, Percent_Identity=42.5625920471281, Blast_Score=537, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24666867, Length=679, Percent_Identity=42.5625920471281, Blast_Score=537, Evalue=1e-152,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87403; Mature: 87403

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVFGVNGKKKETIVPLLPLRGLLVFPTMVLHLDVGREKSVKALEQAMVEDHIILLTSQK
CCEECCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCC
DVAIDEPDMDDLYKMGTIARVKQLLKLPNGTFRVLVEGIARALITEVVSEEPYFSVKVEK
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
FADRASKDLEDEALKRTMLEYFEQYINLSKRLSADIYASIVDIDEPGRMADIIASHLPLK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEECCCCCCHHHHHHHHHCCCC
LEEKQRILETIDVKERLNKIIQILHNEKEVLQLEKKISARVKQSMERTQKEYYLREQMKA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQKELGEKEGKTGEVEALKEKIEAAGMPEHVKETALKELDRYEKIPATSAESAVIRNYLD
HHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
WLIALPWSKETKDIHDIKRAETILNEEHYGLDKVKERVLEFLSVQQLTQSLKGPILCLAG
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PPGVGKTSLARSIAKALGRRFVRMSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAGTI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEECCCCHHHHHHHHHCCCC
NPVFLLDEIDKMSSDFRGDPSAAMLEVLDPEQNHTFSDHYIEEPYDLSKVMFIATANNLA
CHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
TIPQPLLDRMEIIHIPGYTEVEKLHIAKRHLLPKQLAEHGLKKAALQVRDDAMLDIIRHY
CCCHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TREAGVRELERQLAAICRKAARLIVSGEKKRVVVTQNNIEEFLGKRKYRYGQAEAEDQIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCH
VATGLAYTAFGGDTLAIEVSLAKGNGKLVLTGKLGDVMKESAQAAFSYVRSRAEELGIDP
HHHCCEEEEECCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
KFHETYDIHIHVPEGAVPKDGPSAGITIATALISALTGKPVSRFVGMTGEITLRGRVLPI
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEEEEEC
GGLKEKTLSAHRAGLKTVILPKDNEKDLADIPDTVKRDLRFVLVSHLDEVLPHALVGWER
CCCHHHHHHHHHCCCEEEEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEVFGVNGKKKETIVPLLPLRGLLVFPTMVLHLDVGREKSVKALEQAMVEDHIILLTSQK
CCEECCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCC
DVAIDEPDMDDLYKMGTIARVKQLLKLPNGTFRVLVEGIARALITEVVSEEPYFSVKVEK
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
FADRASKDLEDEALKRTMLEYFEQYINLSKRLSADIYASIVDIDEPGRMADIIASHLPLK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEECCCCCCHHHHHHHHHCCCC
LEEKQRILETIDVKERLNKIIQILHNEKEVLQLEKKISARVKQSMERTQKEYYLREQMKA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQKELGEKEGKTGEVEALKEKIEAAGMPEHVKETALKELDRYEKIPATSAESAVIRNYLD
HHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
WLIALPWSKETKDIHDIKRAETILNEEHYGLDKVKERVLEFLSVQQLTQSLKGPILCLAG
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PPGVGKTSLARSIAKALGRRFVRMSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAGTI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEECCCCHHHHHHHHHCCCC
NPVFLLDEIDKMSSDFRGDPSAAMLEVLDPEQNHTFSDHYIEEPYDLSKVMFIATANNLA
CHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
TIPQPLLDRMEIIHIPGYTEVEKLHIAKRHLLPKQLAEHGLKKAALQVRDDAMLDIIRHY
CCCHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TREAGVRELERQLAAICRKAARLIVSGEKKRVVVTQNNIEEFLGKRKYRYGQAEAEDQIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCH
VATGLAYTAFGGDTLAIEVSLAKGNGKLVLTGKLGDVMKESAQAAFSYVRSRAEELGIDP
HHHCCEEEEECCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
KFHETYDIHIHVPEGAVPKDGPSAGITIATALISALTGKPVSRFVGMTGEITLRGRVLPI
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEEEEEC
GGLKEKTLSAHRAGLKTVILPKDNEKDLADIPDTVKRDLRFVLVSHLDEVLPHALVGWER
CCCHHHHHHHHHCCCEEEEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961402; 8969504; 9384377 [H]