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The map label for this gene is mtnN

Identifier: 138896112

GI number: 138896112

Start: 2579380

End: 2580090

Strand: Reverse

Name: mtnN

Synonym: GTNG_2475

Alternate gene names: 138896112

Gene position: 2580090-2579380 (Counterclockwise)

Preceding gene: 138896113

Following gene: 138896111

Centisome position: 72.67

GC content: 54.71

Gene sequence:

>711_bases
ATGAAAGCAGCTATTATTGGAGCAATGGAAGAAGAAGTAGCCATTTTGCGGTCGCGCATGGAAGAGCGCGAAGAGGTAGT
GATCGCCGGATGCGAATTTTCCACTGGACGCCTTGACGGTGTCGAAGCGGTGTTGTTGAAGTCTGGCATCGGCAAGGTGA
ACGCTGCGATGGGAACGACACTTTTGCTTGACCGATTCCGTCCTGATTTTGTGATCAACACTGGCTCAGCCGGCGGTTTT
TTGCCATCGCTGCGTGTTGGCGACCTTGTGATTTCTGATGAAGTCGTTCATCATGATGTTGATGTGACGGCGTTTGGCTA
TGCGTACGGGCAAGTGCCCGGCTTGCCGGCGCGTTATCGGGCCGATGAGGCGCTTGTCGAGGCAGCGAAGCAGGCCGCGG
CGCAGCTTGATGGCCTCCAAGCGGCCATCGGTTTGATCGCAACCGGCGATTCATTTATGAACGACCCGAAACGTGTTGAA
TTTGTGCGTGGACAGTTTCCGGAGTTGTGCGCCGTCGAAATGGAAGCGGCGGCAATCGCCCAAGTGTGCGTGCAGTTCGG
AACGCCGTTTGTCATCATCCGGGCGTTGTCTGATATTGCCGGTGAAGAGTCGAATGTGTCGTTTGAGCAGTTTTTGGAGA
CGGCGGCGAAACATTCGGCTGAGCTTGTGTTGTCGATGTTGACGGTGGTCCAAAGCAAGGCTAAACAGTGA

Upstream 100 bases:

>100_bases
TATTTGCCAACCACGGCTTTTCCGTCTCCTTTGCACAGCAAAACGCGTTTGTCTGGGTGATGGAGGCGGTGAAACAAACG
ACATAGAAAGAGGGAGAACG

Downstream 100 bases:

>100_bases
AAAGCGTAAAGGCGCCGCTGTCTCGCTGCCAAATGGACGTGAAGAAACGGAGTGACTCATATGCAGGTAGCAAAAAGCAT
CCATGAGCTGATCGGTCATA

Product: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKAAIIGAMEEEVAILRSRMEEREEVVIAGCEFSTGRLDGVEAVLLKSGIGKVNAAMGTTLLLDRFRPDFVINTGSAGGF
LPSLRVGDLVISDEVVHHDVDVTAFGYAYGQVPGLPARYRADEALVEAAKQAAAQLDGLQAAIGLIATGDSFMNDPKRVE
FVRGQFPELCAVEMEAAAIAQVCVQFGTPFVIIRALSDIAGEESNVSFEQFLETAAKHSAELVLSMLTVVQSKAKQ

Sequences:

>Translated_236_residues
MKAAIIGAMEEEVAILRSRMEEREEVVIAGCEFSTGRLDGVEAVLLKSGIGKVNAAMGTTLLLDRFRPDFVINTGSAGGF
LPSLRVGDLVISDEVVHHDVDVTAFGYAYGQVPGLPARYRADEALVEAAKQAAAQLDGLQAAIGLIATGDSFMNDPKRVE
FVRGQFPELCAVEMEAAAIAQVCVQFGTPFVIIRALSDIAGEESNVSFEQFLETAAKHSAELVLSMLTVVQSKAKQ
>Mature_236_residues
MKAAIIGAMEEEVAILRSRMEEREEVVIAGCEFSTGRLDGVEAVLLKSGIGKVNAAMGTTLLLDRFRPDFVINTGSAGGF
LPSLRVGDLVISDEVVHHDVDVTAFGYAYGQVPGLPARYRADEALVEAAKQAAAQLDGLQAAIGLIATGDSFMNDPKRVE
FVRGQFPELCAVEMEAAAIAQVCVQFGTPFVIIRALSDIAGEESNVSFEQFLETAAKHSAELVLSMLTVVQSKAKQ

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily

Homologues:

Organism=Escherichia coli, GI1786354, Length=227, Percent_Identity=54.625550660793, Blast_Score=234, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNN_GEOTN (A4IR66)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126565.1
- ProteinModelPortal:   A4IR66
- SMR:   A4IR66
- STRING:   A4IR66
- GeneID:   4967401
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2475
- NMPDR:   fig|420246.5.peg.2380
- eggNOG:   COG0775
- HOGENOM:   HBG367723
- OMA:   AMEQEVT
- PhylomeDB:   A4IR66
- ProtClustDB:   PRK05584
- BioCyc:   GTHE420246:GTNG_2475-MONOMER
- HAMAP:   MF_01684
- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845
- PANTHER:   PTHR21234
- TIGRFAMs:   TIGR01704

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =3.2.2.9

Molecular weight: Translated: 25177; Mature: 25177

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: ACT_SITE 12-12 BINDING 78-78 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAIIGAMEEEVAILRSRMEEREEVVIAGCEFSTGRLDGVEAVLLKSGIGKVNAAMGTT
CCCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
LLLDRFRPDFVINTGSAGGFLPSLRVGDLVISDEVVHHDVDVTAFGYAYGQVPGLPARYR
HHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCHHHHCCCCEEEECHHHCCCCCCCCHHH
ADEALVEAAKQAAAQLDGLQAAIGLIATGDSFMNDPKRVEFVRGQFPELCAVEMEAAAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHH
QVCVQFGTPFVIIRALSDIAGEESNVSFEQFLETAAKHSAELVLSMLTVVQSKAKQ
HHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAAIIGAMEEEVAILRSRMEEREEVVIAGCEFSTGRLDGVEAVLLKSGIGKVNAAMGTT
CCCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
LLLDRFRPDFVINTGSAGGFLPSLRVGDLVISDEVVHHDVDVTAFGYAYGQVPGLPARYR
HHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCHHHHCCCCEEEECHHHCCCCCCCCHHH
ADEALVEAAKQAAAQLDGLQAAIGLIATGDSFMNDPKRVEFVRGQFPELCAVEMEAAAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHH
QVCVQFGTPFVIIRALSDIAGEESNVSFEQFLETAAKHSAELVLSMLTVVQSKAKQ
HHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA