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The map label for this gene is comEC [H]

Identifier: 138896088

GI number: 138896088

Start: 2559113

End: 2561359

Strand: Reverse

Name: comEC [H]

Synonym: GTNG_2451

Alternate gene names: 138896088

Gene position: 2561359-2559113 (Counterclockwise)

Preceding gene: 138896089

Following gene: 138896086

Centisome position: 72.14

GC content: 55.32

Gene sequence:

>2247_bases
ATGAAAGGGCAAGCCGTTTACATCGCCGTGGCGGCGCTCTTGGCCGCTGCGGCTGCCTCTTTGTCCAAACCTGCATTTTT
CCTCCTTGTCGGCTATCTCCTTCTCCTTTTCTTCCGCCGGAAGCATCTATTGGTGCCGGCTTTAGCTGCAGCCACCTTCT
TTTTCGCCTATGTTCTCATCGTTGACCACCATAACAAAACGACTCTTTCTGGCGGCCGCCACACGTTTTTCATTCGCTTT
TCCGCTCAGCCAACGATTGATGGCGACCGGCTGCAGGCTCCAGTCAAAGTGGGACGGGAACGGGTGCAGCTTCGTTATAT
GATTCGGACGCCGGCGGAAAAAGAGGCGCTGCAAACGCACCTTGTGCCCGGAACCGTTTGCCGCGTTGCAGGGACGCTTG
AGCGTCCGATGCCATCAAGCAATCCGTACGCGTTTGACTACCGCCGTTATTTACGTCTCCATCGCATCCACTGGCTGTTT
TTCCCCGAGGAGATCGATCTTTCTGCCTGCGCACGCGACCGCCCGACCATGATCGAGCAGCTTGTTTCACTTCGCGAAGC
GGGCGTTCGCCGCATAGAAGATCATCTTCCGCCGGAAGCAGCCGGCATTGCCGCTGCCCTGATTTATGGGGAACGCCGTC
AGCTCGATGATTCGGTGCTTGATGGCTATCAACAGCTTGGGCTCATCCATCTGTTGGCGATTTCTGGCGGCCATGTCACC
TTGCTTGTCAGCGCAGTATTTGCCATAGCCATCCGTTTGATGACGCGCGAGGCGGCTGTGCTAACTTTAATGGCCGCGCT
GCCTGTTTACGCGGTGCTTGCGGGCGCCTCACCGCCGGTGTTGCGCGCTTGTATGACGGGAATGATTGTGCTTGCTGTCG
GATGGAAAAAAGGGACGATCCATCCGCTTGACGCATTAAGTTGGACTGCGCTCGCGCTTTTCGCCTTTGATCCATACATG
TTGTGGGATGTTGGCTTTCAGCTGTCGTTTGCGGTGACGTTTGTTCTCCTTGTTCATTTTCCGGCGCTCGCCGCCCGTTC
GATGATCGGGCGGCTGTGCGAAACAGCGCTTGCCGCTCAGCTCGCCGCGTTGCCGATTTTGCTTTATCATTTTTATGAAA
TTTCCATTTGGAGTGTCGGGCTCAATGTCTTGTTTGTCCCTTTGTACTCATTTGTCATCTTGCCGTTGGCGTTTGTTGTT
GCTGCCCTTCCTTTCCCTCCGCTCGTTTGGTTGTTTAGCTGCCTCATTGAACTCACAAACAACGTTGTCCGTTTTTTCTC
CGTTGATCACCCATTGACGATTGTGCTCGGGCGTCCCGAGCCATGGTGCTTAGCTGTTTATGTCGCAGCGGTCGTCGTTG
CGTTGTTGCTTTGGGAACGTGGACAGCTGTTTCGTGGGTTGGCGGCGGTGGCCATGGCGATGGTGCTTCAGCTTGTCAGT
CCGTACGTTGATCCGAAAGGGGAGGTGACGGTGTTAGATGTGGGCCAAGGCGACTGCCTCTACATTGAGCTCCCTCACCG
GAAAGCCATTTACCTTATCGACACCGGCGGAACGCCGAAAATAAAGGGAGAACGATGGCGCGAGCGAAAACGGCCGTTTT
CGGTGGGCCGCGATGTCGTTGTCCCGTTTTTAAAAGCGCAAGGGGTAAGGACGATCGACAAGCTCATTCTCACGCATGAT
GACGCTGACCATATCGGGGCGGCTCCTGAGGTGCTAAAAGCGGTGCGCGTCAAAGAAATCATCACAAGCCCAAAAGCGTT
GCCGGCCATTCAGGCGATGGCGCGCCCGTTTTCCGTACCGGTTGCCGCTGCGTCGCAAGGGAAACGGTGGGAGGAAGACG
GCATGACATTTGCCGTGATTCACCCGGAAGCGGGCAATCAGGACGACAATAACGGCTCGCTCGTTTTGTTCACCCGTCTT
GGCGGCTTGACGTGGCTGTTTGCCGGGGACATTGAGAAGGAAGCGGAACAGGCGCTCATTGGCATATATCCGCATTTGCG
CGCCGATGTGCTAAAAGTTGCCCACCATGGCAGTAAAACATCGACAACAGAGATGTTTTTGCAGGCGGTGAAACCGCGGG
TGGCCATTATTTCTGTCGGCCGCTCCAACCGTTACGGCCATCCGTCTCCGGATGTGCTGGCACGTCTGAAGCAACAGGGG
GCGGTCATTTGGCGGACAGATGAAAATGGCGCCATTCGTTATCTTTACGATAGAACAAGCGGAACCTTTCAAGTGATGAA
ACCATAG

Upstream 100 bases:

>100_bases
ATCCGTATGCCCTTGAACTGTTTGCCCAAGCCGGCGTCCGCCTCGTGCAAGTGCCGTTGAAGATGGATGTGTTTGCCCAA
CTTTCCGGCGGAGGGGAAAC

Downstream 100 bases:

>100_bases
TATATAGTGCGTAAAAAAAGTGGAACCTTTCGGTCGATCAAACCATAGCATATCATACAAAAAGAAAAAAGGATTGCTTA
TGTAAGCAATCCTTTACCGG

Product: DNA internalization-related competence protein ComEC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 748; Mature: 748

Protein sequence:

>748_residues
MKGQAVYIAVAALLAAAAASLSKPAFFLLVGYLLLLFFRRKHLLVPALAAATFFFAYVLIVDHHNKTTLSGGRHTFFIRF
SAQPTIDGDRLQAPVKVGRERVQLRYMIRTPAEKEALQTHLVPGTVCRVAGTLERPMPSSNPYAFDYRRYLRLHRIHWLF
FPEEIDLSACARDRPTMIEQLVSLREAGVRRIEDHLPPEAAGIAAALIYGERRQLDDSVLDGYQQLGLIHLLAISGGHVT
LLVSAVFAIAIRLMTREAAVLTLMAALPVYAVLAGASPPVLRACMTGMIVLAVGWKKGTIHPLDALSWTALALFAFDPYM
LWDVGFQLSFAVTFVLLVHFPALAARSMIGRLCETALAAQLAALPILLYHFYEISIWSVGLNVLFVPLYSFVILPLAFVV
AALPFPPLVWLFSCLIELTNNVVRFFSVDHPLTIVLGRPEPWCLAVYVAAVVVALLLWERGQLFRGLAAVAMAMVLQLVS
PYVDPKGEVTVLDVGQGDCLYIELPHRKAIYLIDTGGTPKIKGERWRERKRPFSVGRDVVVPFLKAQGVRTIDKLILTHD
DADHIGAAPEVLKAVRVKEIITSPKALPAIQAMARPFSVPVAAASQGKRWEEDGMTFAVIHPEAGNQDDNNGSLVLFTRL
GGLTWLFAGDIEKEAEQALIGIYPHLRADVLKVAHHGSKTSTTEMFLQAVKPRVAIISVGRSNRYGHPSPDVLARLKQQG
AVIWRTDENGAIRYLYDRTSGTFQVMKP

Sequences:

>Translated_748_residues
MKGQAVYIAVAALLAAAAASLSKPAFFLLVGYLLLLFFRRKHLLVPALAAATFFFAYVLIVDHHNKTTLSGGRHTFFIRF
SAQPTIDGDRLQAPVKVGRERVQLRYMIRTPAEKEALQTHLVPGTVCRVAGTLERPMPSSNPYAFDYRRYLRLHRIHWLF
FPEEIDLSACARDRPTMIEQLVSLREAGVRRIEDHLPPEAAGIAAALIYGERRQLDDSVLDGYQQLGLIHLLAISGGHVT
LLVSAVFAIAIRLMTREAAVLTLMAALPVYAVLAGASPPVLRACMTGMIVLAVGWKKGTIHPLDALSWTALALFAFDPYM
LWDVGFQLSFAVTFVLLVHFPALAARSMIGRLCETALAAQLAALPILLYHFYEISIWSVGLNVLFVPLYSFVILPLAFVV
AALPFPPLVWLFSCLIELTNNVVRFFSVDHPLTIVLGRPEPWCLAVYVAAVVVALLLWERGQLFRGLAAVAMAMVLQLVS
PYVDPKGEVTVLDVGQGDCLYIELPHRKAIYLIDTGGTPKIKGERWRERKRPFSVGRDVVVPFLKAQGVRTIDKLILTHD
DADHIGAAPEVLKAVRVKEIITSPKALPAIQAMARPFSVPVAAASQGKRWEEDGMTFAVIHPEAGNQDDNNGSLVLFTRL
GGLTWLFAGDIEKEAEQALIGIYPHLRADVLKVAHHGSKTSTTEMFLQAVKPRVAIISVGRSNRYGHPSPDVLARLKQQG
AVIWRTDENGAIRYLYDRTSGTFQVMKP
>Mature_748_residues
MKGQAVYIAVAALLAAAAASLSKPAFFLLVGYLLLLFFRRKHLLVPALAAATFFFAYVLIVDHHNKTTLSGGRHTFFIRF
SAQPTIDGDRLQAPVKVGRERVQLRYMIRTPAEKEALQTHLVPGTVCRVAGTLERPMPSSNPYAFDYRRYLRLHRIHWLF
FPEEIDLSACARDRPTMIEQLVSLREAGVRRIEDHLPPEAAGIAAALIYGERRQLDDSVLDGYQQLGLIHLLAISGGHVT
LLVSAVFAIAIRLMTREAAVLTLMAALPVYAVLAGASPPVLRACMTGMIVLAVGWKKGTIHPLDALSWTALALFAFDPYM
LWDVGFQLSFAVTFVLLVHFPALAARSMIGRLCETALAAQLAALPILLYHFYEISIWSVGLNVLFVPLYSFVILPLAFVV
AALPFPPLVWLFSCLIELTNNVVRFFSVDHPLTIVLGRPEPWCLAVYVAAVVVALLLWERGQLFRGLAAVAMAMVLQLVS
PYVDPKGEVTVLDVGQGDCLYIELPHRKAIYLIDTGGTPKIKGERWRERKRPFSVGRDVVVPFLKAQGVRTIDKLILTHD
DADHIGAAPEVLKAVRVKEIITSPKALPAIQAMARPFSVPVAAASQGKRWEEDGMTFAVIHPEAGNQDDNNGSLVLFTRL
GGLTWLFAGDIEKEAEQALIGIYPHLRADVLKVAHHGSKTSTTEMFLQAVKPRVAIISVGRSNRYGHPSPDVLARLKQQG
AVIWRTDENGAIRYLYDRTSGTFQVMKP

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=594, Percent_Identity=25.4208754208754, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 82582; Mature: 82582

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGQAVYIAVAALLAAAAASLSKPAFFLLVGYLLLLFFRRKHLLVPALAAATFFFAYVLI
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDHHNKTTLSGGRHTFFIRFSAQPTIDGDRLQAPVKVGRERVQLRYMIRTPAEKEALQTH
EECCCCCEECCCCEEEEEEEECCCCCCHHHHHCHHHHCHHHEEEEEEECCCCHHHHHHHH
LVPGTVCRVAGTLERPMPSSNPYAFDYRRYLRLHRIHWLFFPEEIDLSACARDRPTMIEQ
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCHHHHCCCCHHHHHH
LVSLREAGVRRIEDHLPPEAAGIAAALIYGERRQLDDSVLDGYQQLGLIHLLAISGGHVT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHCHHEEEEECCCHHH
LLVSAVFAIAIRLMTREAAVLTLMAALPVYAVLAGASPPVLRACMTGMIVLAVGWKKGTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEECCCCCCC
HPLDALSWTALALFAFDPYMLWDVGFQLSFAVTFVLLVHFPALAARSMIGRLCETALAAQ
CCHHHHHHHHHHHHHCCCHHEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAALPILLYHFYEISIWSVGLNVLFVPLYSFVILPLAFVVAALPFPPLVWLFSCLIELTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
NVVRFFSVDHPLTIVLGRPEPWCLAVYVAAVVVALLLWERGQLFRGLAAVAMAMVLQLVS
HHEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
PYVDPKGEVTVLDVGQGDCLYIELPHRKAIYLIDTGGTPKIKGERWRERKRPFSVGRDVV
CCCCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCHHH
VPFLKAQGVRTIDKLILTHDDADHIGAAPEVLKAVRVKEIITSPKALPAIQAMARPFSVP
HHHHHCCCHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
VAAASQGKRWEEDGMTFAVIHPEAGNQDDNNGSLVLFTRLGGLTWLFAGDIEKEAEQALI
CHHCCCCCCCHHCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHH
GIYPHLRADVLKVAHHGSKTSTTEMFLQAVKPRVAIISVGRSNRYGHPSPDVLARLKQQG
HHCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
AVIWRTDENGAIRYLYDRTSGTFQVMKP
CEEEEECCCCCEEEEEECCCCEEEEECC
>Mature Secondary Structure
MKGQAVYIAVAALLAAAAASLSKPAFFLLVGYLLLLFFRRKHLLVPALAAATFFFAYVLI
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDHHNKTTLSGGRHTFFIRFSAQPTIDGDRLQAPVKVGRERVQLRYMIRTPAEKEALQTH
EECCCCCEECCCCEEEEEEEECCCCCCHHHHHCHHHHCHHHEEEEEEECCCCHHHHHHHH
LVPGTVCRVAGTLERPMPSSNPYAFDYRRYLRLHRIHWLFFPEEIDLSACARDRPTMIEQ
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCHHHHCCCCHHHHHH
LVSLREAGVRRIEDHLPPEAAGIAAALIYGERRQLDDSVLDGYQQLGLIHLLAISGGHVT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHCHHEEEEECCCHHH
LLVSAVFAIAIRLMTREAAVLTLMAALPVYAVLAGASPPVLRACMTGMIVLAVGWKKGTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEECCCCCCC
HPLDALSWTALALFAFDPYMLWDVGFQLSFAVTFVLLVHFPALAARSMIGRLCETALAAQ
CCHHHHHHHHHHHHHCCCHHEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAALPILLYHFYEISIWSVGLNVLFVPLYSFVILPLAFVVAALPFPPLVWLFSCLIELTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
NVVRFFSVDHPLTIVLGRPEPWCLAVYVAAVVVALLLWERGQLFRGLAAVAMAMVLQLVS
HHEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
PYVDPKGEVTVLDVGQGDCLYIELPHRKAIYLIDTGGTPKIKGERWRERKRPFSVGRDVV
CCCCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCHHH
VPFLKAQGVRTIDKLILTHDDADHIGAAPEVLKAVRVKEIITSPKALPAIQAMARPFSVP
HHHHHCCCHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
VAAASQGKRWEEDGMTFAVIHPEAGNQDDNNGSLVLFTRLGGLTWLFAGDIEKEAEQALI
CHHCCCCCCCHHCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHH
GIYPHLRADVLKVAHHGSKTSTTEMFLQAVKPRVAIISVGRSNRYGHPSPDVLARLKQQG
HHCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
AVIWRTDENGAIRYLYDRTSGTFQVMKP
CEEEEECCCCCEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]