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The map label for this gene is ponA [H]

Identifier: 138895746

GI number: 138895746

Start: 2233977

End: 2236679

Strand: Direct

Name: ponA [H]

Synonym: GTNG_2102

Alternate gene names: 138895746

Gene position: 2233977-2236679 (Clockwise)

Preceding gene: 138895745

Following gene: 138895765

Centisome position: 62.92

GC content: 51.46

Gene sequence:

>2703_bases
ATGTCTGGTGAATATCGTTCTCGTGTGGAACGAAAGCAGGCAGAGAAACAGGCGAAACAAGCGAAACAAAAGAAGGCGAA
AAAGAAAAAAGGACTATCGTGGTTGAAGACGATCGCCATTGCCATATTGCTTGTGATTTTTATCGGAGCGGCAAGCGGCG
TGGCGGCGTTCGCCTATTTCGTCAAGGACGCTCCCCCGCTTGATGAGACGAAAATCAAAGACCCGCTCTCTTCAACCGTA
TACGATATGAACGGAAAAAAAGTCGCCGAACTTGGCGGCCACAAACGAACGTACATTTCGTATAAAGACGTGCCGAAAGT
GCTTGAAAATGCCGTGTTGGCAACCGAAGATGCCCGCTTTTATGAACATCACGGCATCGATGTTGTCCGCTTAGTCGGCG
CCGTCGTCGCCAATTTTCAAGAAGGATTCGGGGCAGAAGGCGGCAGTACAATCACCCAACAAGTAGTGAAATTGTCGTTC
CTGTCGCCGAAAAAAACGTTGGAGCGAAAGGCGCAAGAGGCGTGGCTCGCTCTGCAGCTTGAGCAAAAATATTCAAAGCA
AGAAATTTTAGAAATGTACTTGAACAAAATTTATTATTCAGACGGCATTTACGGCGTTGCCCGGGCGGCAGAATATTACT
TTGGCAAGACAAACTTAAAAGAGTTGACGCTTGTGGAAGCGGCGCTCTTAGCCGGTATGCCGCAAAGCCCGAACCGGTAC
AATCCATATGACCATCCGGAGGCGGCGAAAAAACGGCGCGATACTGTTTTGTCGCTCATGGCGAAACACGGCTTCATCAG
CCAAGAAGAGGCGGAAAAGGCGAAACAAGTGCCGATCCAATCGATGCTTACCGAACGGAAAAAACCGCAAAGCTCCGTGC
CGTATGATGCCTTCATTGACGAAGTGATCAAAGAAGTGACTGACAAAGCGAACGTTAACGTCTTTGAAGACGGACTGAAA
ATTTACACCACGCTTGATCAAGAAGCGCAGTCGCATGTCGAAAAACTATTAAACTCAGAGCAGTACTTCACCAATAAAAA
AGACTTACAATCGGCTATCGCCCTCGTCGATACGAAAACAGGCGCCATTCGCGCTTTAGGCGGCGGGCGAAACCGCGATC
ATGTCCAGTTCGGCTTTAACTACGCCATTCAGCCGGTCGGCCAGCCCGGTTCGGCGATTAAACCGATTTTAGACTACGGA
CCGGCCATTGAATATTTAAAATGGTCAACTGCACACATTATCGTTGATGAACCGTACACGTATTCAGACGGCACACCGAT
CCGCAACGCCGATCGGACATACAAAGGACCGGTGACGATGCGCTATGCGCTTACTTGGTCGCGTAACATCCCGGCGTTAA
AAGCGTTCCAAGCGGTCGGCAAAGAGCGGGCGCAAGAATTTGCCAATCGGCTTGGCATGGGCTTTGATAAGGTAGAGGAA
GCGTACTCGATCGGCGGTGTCGCACGCTATGTGTCGCCGCTGCAAATGGCCGGTGCCTACAGTGCCTTCGGCAACAACGG
TTTGTATACCAAACCGTACGCGGTGACAAAAATCGTCTTCCCGGACGGCACGGAAATGGATTTAAAACCGAAGCCGAAAC
GGGTTATGCAGGACTACACCGCTTACATGATCACAGATATGCTCAAATCGGTCGTCCGTTCTGGTACAGGGCAAAGCGCC
AACGTTCCGGGGGTTGAGGTGGCCGGCAAAACGGGGACGACAAACTATGGCCCGTCCGGCGCCAAGTTTAATTTACCGGA
GAGCGCTGTGCCGGACAGTTGGTTTGTCGGCTATACACCAAACTATACCGCCGCTGTTTGGACCGGTTTCAGCAAACGAA
GCAGCACCGCAAATCTCAGCAAGGCGGAACAAAGAATTTCGCGTTCGCTCTTTAAAGCGCTCATCTCTCACATCGACGAC
GGCAGTGGGAAATTCGAACAGCCGGACAGCGTGGTGAAAGTGCCGATTAAAAAAGGCACGAATCCACCGAAACTAGCAAG
TAAACATACGCCGGCAAGCGAGATTACGTATGAACTGTTCGTGCGAGGCTCCCAACCGACAGAAGTAGCGAAAGACGAAC
CAAAAGAGCTGCCATCGGTGAAAGGCTTAACCGCTTCGTATGACCAAGCTACCAATGCGATTTCTGTCACTTGGTCGTAC
GATAAACAAACCGACAATACGCTCTTTGAAGTGCGCATCAAAGACGACCAAGGCCATACGGAAACTGTGACAACGAAAGA
CCTGAAGATGACGATCGCGAACCCAACGCCAGGCGCTTCGTATACGATTGCCGTCTATGCGAAAGATGGCGAGCGGATGA
GCAAACCAGCCATCACGAACGTCCGCATCCCTGGCGGTGAGCAAGGTGAAGGCCCGACAACGCCGGATGATGAGGAAAAT
GGTGATGATGGCCGGAATGATGGACATAACGGGCAAGATGGCAACAGCGGAAATAACAACAATGGAAACAACGGCCAAGG
GCAACAGCCTGAGCAACAGCCTGGGCAACAGCCTGGGCAACAACCTGGACAACAACCTGGACAACAGCCTGGGCAACAGC
CTGGGCAACAACCTGGACAACAACCTGGACAACAACCTGGACAACAGCCTGGGCAACAACCTGGACAACAGCCTGGGCAA
CAACCTGGACAACGGCAAGGACAACAGCAAGGGCAGCAGCAAGGACAACAACTAGGGCAATAG

Upstream 100 bases:

>100_bases
CCCACTTGGCTATCAGCCGAGAATTGATTATATTAGTGTAGTAGAAAAAGTGTACTTCACCGTATGAGGTGAAAACTTGT
AAGAAAGGCAGGATTTGCTT

Downstream 100 bases:

>100_bases
CCAGGACAATAGTAGTGCCTCTGCACTGACGACACCAACAACGCTGCCGAATACGAACGTCTCTGGCGCGAACGGTGAAA
ACCGTCAATAACTCAACTAA

Product: penicillin-binding proteins 1A and 1B

Products: NA

Alternate protein names: PBP1; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 900; Mature: 899

Protein sequence:

>900_residues
MSGEYRSRVERKQAEKQAKQAKQKKAKKKKGLSWLKTIAIAILLVIFIGAASGVAAFAYFVKDAPPLDETKIKDPLSSTV
YDMNGKKVAELGGHKRTYISYKDVPKVLENAVLATEDARFYEHHGIDVVRLVGAVVANFQEGFGAEGGSTITQQVVKLSF
LSPKKTLERKAQEAWLALQLEQKYSKQEILEMYLNKIYYSDGIYGVARAAEYYFGKTNLKELTLVEAALLAGMPQSPNRY
NPYDHPEAAKKRRDTVLSLMAKHGFISQEEAEKAKQVPIQSMLTERKKPQSSVPYDAFIDEVIKEVTDKANVNVFEDGLK
IYTTLDQEAQSHVEKLLNSEQYFTNKKDLQSAIALVDTKTGAIRALGGGRNRDHVQFGFNYAIQPVGQPGSAIKPILDYG
PAIEYLKWSTAHIIVDEPYTYSDGTPIRNADRTYKGPVTMRYALTWSRNIPALKAFQAVGKERAQEFANRLGMGFDKVEE
AYSIGGVARYVSPLQMAGAYSAFGNNGLYTKPYAVTKIVFPDGTEMDLKPKPKRVMQDYTAYMITDMLKSVVRSGTGQSA
NVPGVEVAGKTGTTNYGPSGAKFNLPESAVPDSWFVGYTPNYTAAVWTGFSKRSSTANLSKAEQRISRSLFKALISHIDD
GSGKFEQPDSVVKVPIKKGTNPPKLASKHTPASEITYELFVRGSQPTEVAKDEPKELPSVKGLTASYDQATNAISVTWSY
DKQTDNTLFEVRIKDDQGHTETVTTKDLKMTIANPTPGASYTIAVYAKDGERMSKPAITNVRIPGGEQGEGPTTPDDEEN
GDDGRNDGHNGQDGNSGNNNNGNNGQGQQPEQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQ
QPGQRQGQQQGQQQGQQLGQ

Sequences:

>Translated_900_residues
MSGEYRSRVERKQAEKQAKQAKQKKAKKKKGLSWLKTIAIAILLVIFIGAASGVAAFAYFVKDAPPLDETKIKDPLSSTV
YDMNGKKVAELGGHKRTYISYKDVPKVLENAVLATEDARFYEHHGIDVVRLVGAVVANFQEGFGAEGGSTITQQVVKLSF
LSPKKTLERKAQEAWLALQLEQKYSKQEILEMYLNKIYYSDGIYGVARAAEYYFGKTNLKELTLVEAALLAGMPQSPNRY
NPYDHPEAAKKRRDTVLSLMAKHGFISQEEAEKAKQVPIQSMLTERKKPQSSVPYDAFIDEVIKEVTDKANVNVFEDGLK
IYTTLDQEAQSHVEKLLNSEQYFTNKKDLQSAIALVDTKTGAIRALGGGRNRDHVQFGFNYAIQPVGQPGSAIKPILDYG
PAIEYLKWSTAHIIVDEPYTYSDGTPIRNADRTYKGPVTMRYALTWSRNIPALKAFQAVGKERAQEFANRLGMGFDKVEE
AYSIGGVARYVSPLQMAGAYSAFGNNGLYTKPYAVTKIVFPDGTEMDLKPKPKRVMQDYTAYMITDMLKSVVRSGTGQSA
NVPGVEVAGKTGTTNYGPSGAKFNLPESAVPDSWFVGYTPNYTAAVWTGFSKRSSTANLSKAEQRISRSLFKALISHIDD
GSGKFEQPDSVVKVPIKKGTNPPKLASKHTPASEITYELFVRGSQPTEVAKDEPKELPSVKGLTASYDQATNAISVTWSY
DKQTDNTLFEVRIKDDQGHTETVTTKDLKMTIANPTPGASYTIAVYAKDGERMSKPAITNVRIPGGEQGEGPTTPDDEEN
GDDGRNDGHNGQDGNSGNNNNGNNGQGQQPEQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQ
QPGQRQGQQQGQQQGQQLGQ
>Mature_899_residues
SGEYRSRVERKQAEKQAKQAKQKKAKKKKGLSWLKTIAIAILLVIFIGAASGVAAFAYFVKDAPPLDETKIKDPLSSTVY
DMNGKKVAELGGHKRTYISYKDVPKVLENAVLATEDARFYEHHGIDVVRLVGAVVANFQEGFGAEGGSTITQQVVKLSFL
SPKKTLERKAQEAWLALQLEQKYSKQEILEMYLNKIYYSDGIYGVARAAEYYFGKTNLKELTLVEAALLAGMPQSPNRYN
PYDHPEAAKKRRDTVLSLMAKHGFISQEEAEKAKQVPIQSMLTERKKPQSSVPYDAFIDEVIKEVTDKANVNVFEDGLKI
YTTLDQEAQSHVEKLLNSEQYFTNKKDLQSAIALVDTKTGAIRALGGGRNRDHVQFGFNYAIQPVGQPGSAIKPILDYGP
AIEYLKWSTAHIIVDEPYTYSDGTPIRNADRTYKGPVTMRYALTWSRNIPALKAFQAVGKERAQEFANRLGMGFDKVEEA
YSIGGVARYVSPLQMAGAYSAFGNNGLYTKPYAVTKIVFPDGTEMDLKPKPKRVMQDYTAYMITDMLKSVVRSGTGQSAN
VPGVEVAGKTGTTNYGPSGAKFNLPESAVPDSWFVGYTPNYTAAVWTGFSKRSSTANLSKAEQRISRSLFKALISHIDDG
SGKFEQPDSVVKVPIKKGTNPPKLASKHTPASEITYELFVRGSQPTEVAKDEPKELPSVKGLTASYDQATNAISVTWSYD
KQTDNTLFEVRIKDDQGHTETVTTKDLKMTIANPTPGASYTIAVYAKDGERMSKPAITNVRIPGGEQGEGPTTPDDEENG
DDGRNDGHNGQDGNSGNNNNGNNGQGQQPEQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQ
PGQRQGQQQGQQQGQQLGQ

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=Probably found all over the whole cell at low concentrations. Also localizes to the division site in vegetative cells [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 fibronectin type-III domain [H]

Homologues:

Organism=Escherichia coli, GI1786343, Length=546, Percent_Identity=32.4175824175824, Blast_Score=207, Evalue=3e-54,
Organism=Escherichia coli, GI87082258, Length=302, Percent_Identity=35.0993377483444, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1788867, Length=538, Percent_Identity=29.368029739777, Blast_Score=166, Evalue=5e-42,
Organism=Escherichia coli, GI1789601, Length=245, Percent_Identity=30.6122448979592, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR008957
- InterPro:   IPR003961
- InterPro:   IPR001264
- InterPro:   IPR013783
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00041 fn3; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.1.129; 3.4.-.- [C]

Molecular weight: Translated: 98616; Mature: 98484

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS50853 FN3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGEYRSRVERKQAEKQAKQAKQKKAKKKKGLSWLKTIAIAILLVIFIGAASGVAAFAYF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKDAPPLDETKIKDPLSSTVYDMNGKKVAELGGHKRTYISYKDVPKVLENAVLATEDARF
HHCCCCCCHHHHCCCHHHHEECCCCCCHHHCCCCCEEEECHHHHHHHHHHHHHCCCCHHH
YEHHGIDVVRLVGAVVANFQEGFGAEGGSTITQQVVKLSFLSPKKTLERKAQEAWLALQL
HHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EQKYSKQEILEMYLNKIYYSDGIYGVARAAEYYFGKTNLKELTLVEAALLAGMPQSPNRY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
NPYDHPEAAKKRRDTVLSLMAKHGFISQEEAEKAKQVPIQSMLTERKKPQSSVPYDAFID
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHH
EVIKEVTDKANVNVFEDGLKIYTTLDQEAQSHVEKLLNSEQYFTNKKDLQSAIALVDTKT
HHHHHHHCCCCCEEECCCEEEEEHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCC
GAIRALGGGRNRDHVQFGFNYAIQPVGQPGSAIKPILDYGPAIEYLKWSTAHIIVDEPYT
CCEEECCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHCCCHHHHHCCCCEEEEECCCEE
YSDGTPIRNADRTYKGPVTMRYALTWSRNIPALKAFQAVGKERAQEFANRLGMGFDKVEE
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AYSIGGVARYVSPLQMAGAYSAFGNNGLYTKPYAVTKIVFPDGTEMDLKPKPKRVMQDYT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCEEEEEECCCCCCCCCCCCHHHHHHHHH
AYMITDMLKSVVRSGTGQSANVPGVEVAGKTGTTNYGPSGAKFNLPESAVPDSWFVGYTP
HHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCC
NYTAAVWTGFSKRSSTANLSKAEQRISRSLFKALISHIDDGSGKFEQPDSVVKVPIKKGT
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHCCC
NPPKLASKHTPASEITYELFVRGSQPTEVAKDEPKELPSVKGLTASYDQATNAISVTWSY
CCCCCCCCCCCHHHCEEEEEEECCCCCHHHCCCHHHCCCCCCCCCCHHHCCCEEEEEEEC
DKQTDNTLFEVRIKDDQGHTETVTTKDLKMTIANPTPGASYTIAVYAKDGERMSKPAITN
CCCCCCEEEEEEEECCCCCCCEEEECCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCE
VRIPGGEQGEGPTTPDDEENGDDGRNDGHNGQDGNSGNNNNGNNGQGQQPEQQPGQQPGQ
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQRQGQQQGQQQGQQLGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGEYRSRVERKQAEKQAKQAKQKKAKKKKGLSWLKTIAIAILLVIFIGAASGVAAFAYF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKDAPPLDETKIKDPLSSTVYDMNGKKVAELGGHKRTYISYKDVPKVLENAVLATEDARF
HHCCCCCCHHHHCCCHHHHEECCCCCCHHHCCCCCEEEECHHHHHHHHHHHHHCCCCHHH
YEHHGIDVVRLVGAVVANFQEGFGAEGGSTITQQVVKLSFLSPKKTLERKAQEAWLALQL
HHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EQKYSKQEILEMYLNKIYYSDGIYGVARAAEYYFGKTNLKELTLVEAALLAGMPQSPNRY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
NPYDHPEAAKKRRDTVLSLMAKHGFISQEEAEKAKQVPIQSMLTERKKPQSSVPYDAFID
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHH
EVIKEVTDKANVNVFEDGLKIYTTLDQEAQSHVEKLLNSEQYFTNKKDLQSAIALVDTKT
HHHHHHHCCCCCEEECCCEEEEEHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCC
GAIRALGGGRNRDHVQFGFNYAIQPVGQPGSAIKPILDYGPAIEYLKWSTAHIIVDEPYT
CCEEECCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHCCCHHHHHCCCCEEEEECCCEE
YSDGTPIRNADRTYKGPVTMRYALTWSRNIPALKAFQAVGKERAQEFANRLGMGFDKVEE
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AYSIGGVARYVSPLQMAGAYSAFGNNGLYTKPYAVTKIVFPDGTEMDLKPKPKRVMQDYT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCEEEEEECCCCCCCCCCCCHHHHHHHHH
AYMITDMLKSVVRSGTGQSANVPGVEVAGKTGTTNYGPSGAKFNLPESAVPDSWFVGYTP
HHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCC
NYTAAVWTGFSKRSSTANLSKAEQRISRSLFKALISHIDDGSGKFEQPDSVVKVPIKKGT
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHCCC
NPPKLASKHTPASEITYELFVRGSQPTEVAKDEPKELPSVKGLTASYDQATNAISVTWSY
CCCCCCCCCCCHHHCEEEEEEECCCCCHHHCCCHHHCCCCCCCCCCHHHCCCEEEEEEEC
DKQTDNTLFEVRIKDDQGHTETVTTKDLKMTIANPTPGASYTIAVYAKDGERMSKPAITN
CCCCCCEEEEEEEECCCCCCCEEEECCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCE
VRIPGGEQGEGPTTPDDEENGDDGRNDGHNGQDGNSGNNNNGNNGQGQQPEQQPGQQPGQ
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQQPGQRQGQQQGQQQGQQLGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7814321; 8760912; 9384377; 9721295; 10322023 [H]