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The map label for this gene is mdh [H]

Identifier: 138895410

GI number: 138895410

Start: 1852842

End: 1854029

Strand: Reverse

Name: mdh [H]

Synonym: GTNG_1754

Alternate gene names: 138895410

Gene position: 1854029-1852842 (Counterclockwise)

Preceding gene: 138895411

Following gene: 138895409

Centisome position: 52.22

GC content: 54.63

Gene sequence:

>1188_bases
ATGAGTGTAGCCCGCATTGTCTTTCCGCCGCTCAGCCATGTCGGCTGGGGAGCGCTTGACCAGTTAGTTCCTGAAGTGAA
GCGGTTGGGAGCAAAACATATTTTGGTGATTACCGACCCGATGCTTGTGAAGATCGGCCTAGTCGATCAAGTGACGTCCC
CGCTCCGTCAAGAAGGGTATAGCGTGCATGTGTATACGGATGTTGTGCCAGAGCCGCCGCTTGAGACAGGGGAAAAGGCA
GTGGCGTTTGCCCGCGACGGAAAGTTTGACCTTGTCATCGGTGTTGGTGGTGGCAGCGCGCTGGATTTGGCGAAACTGGC
GGCTGTTTTGGCGGTGCATGATGGCTCGGTCGCTGACTATTTAAATTTGACAGGAACGCGAACACTTGAGAAAAAAGGGT
TGCCGAAAATTTTGATTCCCACGACATCGGGCACCGGGTCGGAAGTGACAAACATCTCTGTCTTGTCTTTGGAAACGACG
AAAGATGTCGTGACGCACGATTACTTATTGGCCGACGTCGCGATCGTTGATCCGCAGCTGACCGTTTCCGTTCCACCGCG
GGTAACGGCCGCAACGGGAATTGATGCACTCACCCATGCAGTTGAGGCGTATGTGTCGGTCAATGCGAGCCCAACATCGG
ATGGATTGGCCGTTGCCGCTATTCGGCTGATTTCACGCTCACTGCGCAAAGCGGTGGCCAACGGTTCGGACAAACAGGCG
CGCATTGATATGGCGAACGGCAGTTATTTGGCCGGCTTGGCATTTTTCAACGCCGGGGTAGCCGGTGTGCATGCGCTCGC
TTATCCGCTCGGTGGTCAGTTTCATATCGCTCATGGTGAATCGAATGCTGTGCTGTTGCCGTATGTGATGGGCTACATCC
GTCAAAGCTGTACGAAGAGAATGGCCGATATTTTCAACGCGCTTGGCGGCAACTCAAGTTTTTTGTCCGAAGTGGAAGCG
TCTTATCGGTGCGTCGAGGAACTAGAACGGTTCGTCGCCGATGTCGGCATTCCGAAAACATTGGGGGGATTTGGCATCCC
CGAAAGCGCGCTAGAAAGCTTGACGAAAGATGCTGTCCAACAGAAACGTTTGCTTGCCCGCAGTCCGTTGCCGCTGTTGG
AAGCCGACATCCGTGCGATTTACGAAGCCGCGTTTGCCGGGACGATCGTAGAGCCGCACAAGGCGTAA

Upstream 100 bases:

>100_bases
AATCTTTGCATTCGGCTCTAGAAGAAGAGAAGCGCATTGTGTTGAGCGAGTTTTGGAATGACGCTGTTTAATCAACCAAA
TAGGAAGGGAGAGGAGAACC

Downstream 100 bases:

>100_bases
ACCGTTGGGAAACAGGCGCTGCAAACGGCGCCTGTTTGTTATGTAGATTGAATATATCCTTGCACATTGGGGCCTTCGTT
CTGTATGATCTGTTAAACCC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSVARIVFPPLSHVGWGALDQLVPEVKRLGAKHILVITDPMLVKIGLVDQVTSPLRQEGYSVHVYTDVVPEPPLETGEKA
VAFARDGKFDLVIGVGGGSALDLAKLAAVLAVHDGSVADYLNLTGTRTLEKKGLPKILIPTTSGTGSEVTNISVLSLETT
KDVVTHDYLLADVAIVDPQLTVSVPPRVTAATGIDALTHAVEAYVSVNASPTSDGLAVAAIRLISRSLRKAVANGSDKQA
RIDMANGSYLAGLAFFNAGVAGVHALAYPLGGQFHIAHGESNAVLLPYVMGYIRQSCTKRMADIFNALGGNSSFLSEVEA
SYRCVEELERFVADVGIPKTLGGFGIPESALESLTKDAVQQKRLLARSPLPLLEADIRAIYEAAFAGTIVEPHKA

Sequences:

>Translated_395_residues
MSVARIVFPPLSHVGWGALDQLVPEVKRLGAKHILVITDPMLVKIGLVDQVTSPLRQEGYSVHVYTDVVPEPPLETGEKA
VAFARDGKFDLVIGVGGGSALDLAKLAAVLAVHDGSVADYLNLTGTRTLEKKGLPKILIPTTSGTGSEVTNISVLSLETT
KDVVTHDYLLADVAIVDPQLTVSVPPRVTAATGIDALTHAVEAYVSVNASPTSDGLAVAAIRLISRSLRKAVANGSDKQA
RIDMANGSYLAGLAFFNAGVAGVHALAYPLGGQFHIAHGESNAVLLPYVMGYIRQSCTKRMADIFNALGGNSSFLSEVEA
SYRCVEELERFVADVGIPKTLGGFGIPESALESLTKDAVQQKRLLARSPLPLLEADIRAIYEAAFAGTIVEPHKA
>Mature_394_residues
SVARIVFPPLSHVGWGALDQLVPEVKRLGAKHILVITDPMLVKIGLVDQVTSPLRQEGYSVHVYTDVVPEPPLETGEKAV
AFARDGKFDLVIGVGGGSALDLAKLAAVLAVHDGSVADYLNLTGTRTLEKKGLPKILIPTTSGTGSEVTNISVLSLETTK
DVVTHDYLLADVAIVDPQLTVSVPPRVTAATGIDALTHAVEAYVSVNASPTSDGLAVAAIRLISRSLRKAVANGSDKQAR
IDMANGSYLAGLAFFNAGVAGVHALAYPLGGQFHIAHGESNAVLLPYVMGYIRQSCTKRMADIFNALGGNSSFLSEVEAS
YRCVEELERFVADVGIPKTLGGFGIPESALESLTKDAVQQKRLLARSPLPLLEADIRAIYEAAFAGTIVEPHKA

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=400, Percent_Identity=29, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI87082107, Length=379, Percent_Identity=38.7862796833773, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI48994951, Length=387, Percent_Identity=32.5581395348837, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789163, Length=387, Percent_Identity=33.5917312661499, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1787493, Length=386, Percent_Identity=33.419689119171, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789386, Length=357, Percent_Identity=27.1708683473389, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=411, Percent_Identity=28.9537712895377, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6321181, Length=388, Percent_Identity=35.3092783505155, Blast_Score=219, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24657991, Length=419, Percent_Identity=27.2076372315036, Blast_Score=131, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41664; Mature: 41533

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVARIVFPPLSHVGWGALDQLVPEVKRLGAKHILVITDPMLVKIGLVDQVTSPLRQEGY
CCCCEEECCCHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHHHHHHCCC
SVHVYTDVVPEPPLETGEKAVAFARDGKFDLVIGVGGGSALDLAKLAAVLAVHDGSVADY
EEEEEECCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHH
LNLTGTRTLEKKGLPKILIPTTSGTGSEVTNISVLSLETTKDVVTHDYLLADVAIVDPQL
HCCCCCCCHHHCCCCEEEEECCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHEEEECCEE
TVSVPPRVTAATGIDALTHAVEAYVSVNASPTSDGLAVAAIRLISRSLRKAVANGSDKQA
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
RIDMANGSYLAGLAFFNAGVAGVHALAYPLGGQFHIAHGESNAVLLPYVMGYIRQSCTKR
EEEECCCCEEHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHH
MADIFNALGGNSSFLSEVEASYRCVEELERFVADVGIPKTLGGFGIPESALESLTKDAVQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHH
QKRLLARSPLPLLEADIRAIYEAAFAGTIVEPHKA
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SVARIVFPPLSHVGWGALDQLVPEVKRLGAKHILVITDPMLVKIGLVDQVTSPLRQEGY
CCCEEECCCHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHHHHHHCCC
SVHVYTDVVPEPPLETGEKAVAFARDGKFDLVIGVGGGSALDLAKLAAVLAVHDGSVADY
EEEEEECCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHH
LNLTGTRTLEKKGLPKILIPTTSGTGSEVTNISVLSLETTKDVVTHDYLLADVAIVDPQL
HCCCCCCCHHHCCCCEEEEECCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHEEEECCEE
TVSVPPRVTAATGIDALTHAVEAYVSVNASPTSDGLAVAAIRLISRSLRKAVANGSDKQA
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
RIDMANGSYLAGLAFFNAGVAGVHALAYPLGGQFHIAHGESNAVLLPYVMGYIRQSCTKR
EEEECCCCEEHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHH
MADIFNALGGNSSFLSEVEASYRCVEELERFVADVGIPKTLGGFGIPESALESLTKDAVQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHH
QKRLLARSPLPLLEADIRAIYEAAFAGTIVEPHKA
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]