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The map label for this gene is map [H]

Identifier: 138895379

GI number: 138895379

Start: 1822786

End: 1823535

Strand: Direct

Name: map [H]

Synonym: GTNG_1723

Alternate gene names: 138895379

Gene position: 1822786-1823535 (Clockwise)

Preceding gene: 138895378

Following gene: 138895381

Centisome position: 51.34

GC content: 52.27

Gene sequence:

>750_bases
ATGATTCACGTCAAAACAGAACGGGAAATTCAATTGATGCGCGAGGCAGGGAAGCTGCTCGCTGCCTGCCATCAAGAAAT
CGCCAAACGCATCGGACCGGGGGTAACTACTATGGAGATCGACCGGTTCGTGGAAACGTTTTTGGCCAAATACGGCGCCA
AGCCGGAACAAAAAGGATACCGCGGCTATCCATATGCCACATGTGCTTCGGTAAACGATGAAATTTGCCACGGGTTTCCG
CGCAAAGAACCGCTTAAGGAAGGGGATATCGTCACCATCGATTTTGTCGTCAATTGGCGCGGAGCGCTCGCCGATTCCGC
TTGGACGTACGCCATCGGCGATATCGACGAAGACGTGCAAACTTTGCTTCATGTCACCGAGCAGTCGCTATATAAAGGGA
TTGAACAAGCGGTTCTTGGCAACCGGATCGGCGATATCGGCCATGCCATTCAAACGTACGTCGAATCGCACGGGTTTTCC
GTCGTCCGCGATTTCACCGGGCACGGCATCGGGCCGAAAATTCATGAAGAGCCGTACATTCCCCATTTTGGCGAAAAAGG
AAAAGGGATGCGCTTAAAAGAAGGAATGGTCATTACGATCGAACCGATGGTCAACATGGGGGCTTGGCAAAGCAAAATGG
ACGCGAACGGTTGGACGGCGCGAACCATTGACGGCTCGTACTCAGCGCAATATGAACATACGATCGCCATTACGAAAGAC
GGGCCGCTCATTTTAACAACGCTGGCATGA

Upstream 100 bases:

>100_bases
CATCTATTCTCTGTTCATTTCATCGTGGTTTATCACCGCCGTTGTTTTTGTTACAATACTATAGGAGTGGAAACACATCG
AGAGAAAAGGAGACGTTGGG

Downstream 100 bases:

>100_bases
GCACGCCAATGGCTTCCTAGCGGCTAACTTCGATGAGAAAAACCCGGGAGACGTTCACCCGGGTTTTTCATCCTCTTCTG
ATGATTTCTGTTATGCGGTG

Product: methionyl aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MIHVKTEREIQLMREAGKLLAACHQEIAKRIGPGVTTMEIDRFVETFLAKYGAKPEQKGYRGYPYATCASVNDEICHGFP
RKEPLKEGDIVTIDFVVNWRGALADSAWTYAIGDIDEDVQTLLHVTEQSLYKGIEQAVLGNRIGDIGHAIQTYVESHGFS
VVRDFTGHGIGPKIHEEPYIPHFGEKGKGMRLKEGMVITIEPMVNMGAWQSKMDANGWTARTIDGSYSAQYEHTIAITKD
GPLILTTLA

Sequences:

>Translated_249_residues
MIHVKTEREIQLMREAGKLLAACHQEIAKRIGPGVTTMEIDRFVETFLAKYGAKPEQKGYRGYPYATCASVNDEICHGFP
RKEPLKEGDIVTIDFVVNWRGALADSAWTYAIGDIDEDVQTLLHVTEQSLYKGIEQAVLGNRIGDIGHAIQTYVESHGFS
VVRDFTGHGIGPKIHEEPYIPHFGEKGKGMRLKEGMVITIEPMVNMGAWQSKMDANGWTARTIDGSYSAQYEHTIAITKD
GPLILTTLA
>Mature_249_residues
MIHVKTEREIQLMREAGKLLAACHQEIAKRIGPGVTTMEIDRFVETFLAKYGAKPEQKGYRGYPYATCASVNDEICHGFP
RKEPLKEGDIVTIDFVVNWRGALADSAWTYAIGDIDEDVQTLLHVTEQSLYKGIEQAVLGNRIGDIGHAIQTYVESHGFS
VVRDFTGHGIGPKIHEEPYIPHFGEKGKGMRLKEGMVITIEPMVNMGAWQSKMDANGWTARTIDGSYSAQYEHTIAITKD
GPLILTTLA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=245, Percent_Identity=37.9591836734694, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=35.6275303643725, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=41.7004048582996, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=38.8663967611336, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=36.5853658536585, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319380, Length=213, Percent_Identity=28.6384976525822, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=40, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24583427, Length=243, Percent_Identity=35.8024691358025, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27665; Mature: 27665

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHVKTEREIQLMREAGKLLAACHQEIAKRIGPGVTTMEIDRFVETFLAKYGAKPEQKGY
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
RGYPYATCASVNDEICHGFPRKEPLKEGDIVTIDFVVNWRGALADSAWTYAIGDIDEDVQ
CCCCCEEECCCCHHHHCCCCCCCCCCCCCEEEEEEEEECCCHHCCCCEEEEECCCCHHHH
TLLHVTEQSLYKGIEQAVLGNRIGDIGHAIQTYVESHGFSVVRDFTGHGIGPKIHEEPYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCCCCCCCC
PHFGEKGKGMRLKEGMVITIEPMVNMGAWQSKMDANGWTARTIDGSYSAQYEHTIAITKD
CCCCCCCCCCEECCCEEEEEECCCCCCCCHHCCCCCCCEEEEECCCCCCCEEEEEEEECC
GPLILTTLA
CCEEEEECC
>Mature Secondary Structure
MIHVKTEREIQLMREAGKLLAACHQEIAKRIGPGVTTMEIDRFVETFLAKYGAKPEQKGY
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
RGYPYATCASVNDEICHGFPRKEPLKEGDIVTIDFVVNWRGALADSAWTYAIGDIDEDVQ
CCCCCEEECCCCHHHHCCCCCCCCCCCCCEEEEEEEEECCCHHCCCCEEEEECCCCHHHH
TLLHVTEQSLYKGIEQAVLGNRIGDIGHAIQTYVESHGFSVVRDFTGHGIGPKIHEEPYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCCCCCCCC
PHFGEKGKGMRLKEGMVITIEPMVNMGAWQSKMDANGWTARTIDGSYSAQYEHTIAITKD
CCCCCCCCCCEECCCEEEEEECCCCCCCCHHCCCCCCCEEEEECCCCCCCEEEEEEEECC
GPLILTTLA
CCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]