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The map label for this gene is pncB [H]

Identifier: 138895361

GI number: 138895361

Start: 1796654

End: 1798126

Strand: Reverse

Name: pncB [H]

Synonym: GTNG_1705

Alternate gene names: 138895361

Gene position: 1798126-1796654 (Counterclockwise)

Preceding gene: 138895362

Following gene: 138895359

Centisome position: 50.65

GC content: 48.61

Gene sequence:

>1473_bases
ATGGGTGGAACATATGCAGACGACAGTTTGATGCTCCATACGGACTTATATCAAATTAATATGGTTGAAACATATTGGGA
AGACGGGATACACGAGCGCCGGGCCGTGTTTGAGGTGTTTTTTCGCAAGTTGCCGTTTGGCAATGGCTATGCCGTCTTTG
CCGGGCTTGAGCGCGTGATACAGTTTTTGCAAGGATTCCGTTTTTCCGACAGCGATATCAATTATTTGCGCAATGAGCTT
GGTTACCGCGACGATTTTTTGGACTATTTGCGGACGCTTCGCTTTACTGGTACGGTTCGTTCGATGAAGGAAGGAGAAAT
CGTCTTTGCCAACGAGCCAATTATGCGCATTGAAGCACCGCTTGCGGAGGCGCAGCTCATTGAAACAGCCATTTTAAACA
TCATCAATTTCCAGACGCTCATCGCTACGAAAGCGTCGCGCATTAAGCATATTCTCGGGGACGAACCAGCATTGGAGTTT
GGCAGCCGCCGGGCGCAGGAGATGGACGCTGCTCTTTGGGGTGCGCGCGCGGCGTATATCGGCGGGATTGAAGCGACATC
GAACGTGCGGGCCGGGAAGCTGTTTGGCATTCCAGTCGCCGGGACGCACGCTCATTCCATGATTCAAGCGTATCAAGACG
AATACGTAGCATTTTACAAATATGCACGCCGCCATAAAGACTGCGTATTTCTTGTTGATACGTACGATACGTTAAAATCC
GGGGTGCCGAACGCCATTCGCGTCGCTAAAGAGCTTGGTGATAAGATCAATTTCATCGGCATTCGCATTGACAGCGGCGA
TTTGGCTTATTTATCAAAAGAAGCGCGGAAAATGCTTGATGAGGCCGGGTTCCCGAACGCGAAAATTTTTGCTTCGAACG
ATTTGGATGAAGATACGATTTTAAACTTGAAATCGCAAGGGGCGAAAATCGACGTGTGGGGGATCGGCACGAAGCTGATC
ACGGCATACGACCAGCCGGCGTTAGGTGCGGTATATAAAATCGTAGCGATTGAAAACGAAGCCGGTGAGATGGTCGATAC
GATCAAAATCAGCGGCAATCCAGAAAAAGTGACGACGCCGGGGCTGAAGCGGGTGTATCGCATCGTCAATAAAATCAATC
ATAAAGCAGAGGGCGATTACATTGCCTTAGAAAGCGAAAACCCGCAGCAAGAAGAGCGGTTGAAAATGTTCCATCCGGTG
TACACATTCATCAGCAAATTCGTCACGAATTTTGAAGCGCGCGACTTGCATGAAACGATTTTTGACAACGGCAAACTCGT
TTACACATCGCCGCCGCTTCCGGACATTCAGGCATATGCGAAGGAGAGTTTACGTTTATTTTGGGAGGAATACAAACGAA
CGCTCAACCCGGAGCAATATCCCGTCGATTTGAGCCAAGCGTGCTGGGACAATAAGATGGAAAACATTCGTAAAGTAAAA
GAAAAGATTGGGCACTCATCTGCAAACGAGTAA

Upstream 100 bases:

>100_bases
CGCAGAAATAGTGGAATAATGGTCGAAACATGGTAGAATAGACCGTGGACATTCTTTTTCATCCGGTGGCGTGTTCATTT
GGTTGTTGGAGGTTGCAAAA

Downstream 100 bases:

>100_bases
GCAACCACACCAGTTTCAAAGCTGTCAAAATAGAACAAGGTGTATGCTTACATAGTGCCAGGAGTGGAACGTGCCGACAA
CAAAGCGTTTGGCTGTCACT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MGGTYADDSLMLHTDLYQINMVETYWEDGIHERRAVFEVFFRKLPFGNGYAVFAGLERVIQFLQGFRFSDSDINYLRNEL
GYRDDFLDYLRTLRFTGTVRSMKEGEIVFANEPIMRIEAPLAEAQLIETAILNIINFQTLIATKASRIKHILGDEPALEF
GSRRAQEMDAALWGARAAYIGGIEATSNVRAGKLFGIPVAGTHAHSMIQAYQDEYVAFYKYARRHKDCVFLVDTYDTLKS
GVPNAIRVAKELGDKINFIGIRIDSGDLAYLSKEARKMLDEAGFPNAKIFASNDLDEDTILNLKSQGAKIDVWGIGTKLI
TAYDQPALGAVYKIVAIENEAGEMVDTIKISGNPEKVTTPGLKRVYRIVNKINHKAEGDYIALESENPQQEERLKMFHPV
YTFISKFVTNFEARDLHETIFDNGKLVYTSPPLPDIQAYAKESLRLFWEEYKRTLNPEQYPVDLSQACWDNKMENIRKVK
EKIGHSSANE

Sequences:

>Translated_490_residues
MGGTYADDSLMLHTDLYQINMVETYWEDGIHERRAVFEVFFRKLPFGNGYAVFAGLERVIQFLQGFRFSDSDINYLRNEL
GYRDDFLDYLRTLRFTGTVRSMKEGEIVFANEPIMRIEAPLAEAQLIETAILNIINFQTLIATKASRIKHILGDEPALEF
GSRRAQEMDAALWGARAAYIGGIEATSNVRAGKLFGIPVAGTHAHSMIQAYQDEYVAFYKYARRHKDCVFLVDTYDTLKS
GVPNAIRVAKELGDKINFIGIRIDSGDLAYLSKEARKMLDEAGFPNAKIFASNDLDEDTILNLKSQGAKIDVWGIGTKLI
TAYDQPALGAVYKIVAIENEAGEMVDTIKISGNPEKVTTPGLKRVYRIVNKINHKAEGDYIALESENPQQEERLKMFHPV
YTFISKFVTNFEARDLHETIFDNGKLVYTSPPLPDIQAYAKESLRLFWEEYKRTLNPEQYPVDLSQACWDNKMENIRKVK
EKIGHSSANE
>Mature_489_residues
GGTYADDSLMLHTDLYQINMVETYWEDGIHERRAVFEVFFRKLPFGNGYAVFAGLERVIQFLQGFRFSDSDINYLRNELG
YRDDFLDYLRTLRFTGTVRSMKEGEIVFANEPIMRIEAPLAEAQLIETAILNIINFQTLIATKASRIKHILGDEPALEFG
SRRAQEMDAALWGARAAYIGGIEATSNVRAGKLFGIPVAGTHAHSMIQAYQDEYVAFYKYARRHKDCVFLVDTYDTLKSG
VPNAIRVAKELGDKINFIGIRIDSGDLAYLSKEARKMLDEAGFPNAKIFASNDLDEDTILNLKSQGAKIDVWGIGTKLIT
AYDQPALGAVYKIVAIENEAGEMVDTIKISGNPEKVTTPGLKRVYRIVNKINHKAEGDYIALESENPQQEERLKMFHPVY
TFISKFVTNFEARDLHETIFDNGKLVYTSPPLPDIQAYAKESLRLFWEEYKRTLNPEQYPVDLSQACWDNKMENIRKVKE
KIGHSSANE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=515, Percent_Identity=32.8155339805825, Blast_Score=265, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI71997952, Length=527, Percent_Identity=37.7609108159393, Blast_Score=314, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI71997947, Length=527, Percent_Identity=37.7609108159393, Blast_Score=314, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI71997955, Length=214, Percent_Identity=47.196261682243, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24581587, Length=536, Percent_Identity=36.9402985074627, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI161076680, Length=222, Percent_Identity=42.7927927927928, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24581595, Length=222, Percent_Identity=42.7927927927928, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI28574709, Length=222, Percent_Identity=42.7927927927928, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24581593, Length=222, Percent_Identity=42.7927927927928, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24581591, Length=222, Percent_Identity=42.7927927927928, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55631; Mature: 55500

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGTYADDSLMLHTDLYQINMVETYWEDGIHERRAVFEVFFRKLPFGNGYAVFAGLERVI
CCCCCCCCCEEEEECCEEEEHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QFLQGFRFSDSDINYLRNELGYRDDFLDYLRTLRFTGTVRSMKEGEIVFANEPIMRIEAP
HHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECC
LAEAQLIETAILNIINFQTLIATKASRIKHILGDEPALEFGSRRAQEMDAALWGARAAYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHC
GGIEATSNVRAGKLFGIPVAGTHAHSMIQAYQDEYVAFYKYARRHKDCVFLVDTYDTLKS
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHH
GVPNAIRVAKELGDKINFIGIRIDSGDLAYLSKEARKMLDEAGFPNAKIFASNDLDEDTI
CCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHE
LNLKSQGAKIDVWGIGTKLITAYDQPALGAVYKIVAIENEAGEMVDTIKISGNPEKVTTP
EEHHCCCCEEEEEECCCEEEEECCCCHHHHEEEEEEEECCCCCEEEEEEECCCCCCCCCH
GLKRVYRIVNKINHKAEGDYIALESENPQQEERLKMFHPVYTFISKFVTNFEARDLHETI
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FDNGKLVYTSPPLPDIQAYAKESLRLFWEEYKRTLNPEQYPVDLSQACWDNKMENIRKVK
HCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
EKIGHSSANE
HHHCCCCCCC
>Mature Secondary Structure 
GGTYADDSLMLHTDLYQINMVETYWEDGIHERRAVFEVFFRKLPFGNGYAVFAGLERVI
CCCCCCCCEEEEECCEEEEHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QFLQGFRFSDSDINYLRNELGYRDDFLDYLRTLRFTGTVRSMKEGEIVFANEPIMRIEAP
HHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECC
LAEAQLIETAILNIINFQTLIATKASRIKHILGDEPALEFGSRRAQEMDAALWGARAAYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHC
GGIEATSNVRAGKLFGIPVAGTHAHSMIQAYQDEYVAFYKYARRHKDCVFLVDTYDTLKS
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHH
GVPNAIRVAKELGDKINFIGIRIDSGDLAYLSKEARKMLDEAGFPNAKIFASNDLDEDTI
CCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHE
LNLKSQGAKIDVWGIGTKLITAYDQPALGAVYKIVAIENEAGEMVDTIKISGNPEKVTTP
EEHHCCCCEEEEEECCCEEEEECCCCHHHHEEEEEEEECCCCCEEEEEEECCCCCCCCCH
GLKRVYRIVNKINHKAEGDYIALESENPQQEERLKMFHPVYTFISKFVTNFEARDLHETI
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FDNGKLVYTSPPLPDIQAYAKESLRLFWEEYKRTLNPEQYPVDLSQACWDNKMENIRKVK
HCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
EKIGHSSANE
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]