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The map label for this gene is srrA [H]

Identifier: 138895267

GI number: 138895267

Start: 1696321

End: 1696992

Strand: Direct

Name: srrA [H]

Synonym: GTNG_1609

Alternate gene names: 138895267

Gene position: 1696321-1696992 (Clockwise)

Preceding gene: 138895266

Following gene: 138895268

Centisome position: 47.78

GC content: 41.82

Gene sequence:

>672_bases
TTGTACACGATTTTACTGGTTGACGATGAAAAACGAATGTTAGATTTACTTGATCTTTATCTTTCGCCTAAAGGATATCA
TTGCGTAAAGTGTGAGTCCGGTTTAGCAGCGATACAGTACCTAGAAAATAACAAAGTGGATTTAGTTTTGCTGGATATTA
TGATGCCGGAACTGGATGGTTGGGAAACGTGCAAGCGAATTCGGGAATTTTCTAACGTCCCGATCATCATGGTAACGGCC
CGAGATCAAACAACGGATATCGTCCAAGGACTGAAAATCGGAGCGGATGACTATATTACGAAGCCGTTTGACGAATCCGA
ACTGCTAGCGCGCATCGAGGCTGTACTACGCCGTTCAGTAGGAAAACATTCGAAAATGGAGTTTCAAGGTTTAGTGTGGG
ATGAAGACGAATATAAAGTCCACTATCAAAACAAACCGATTTTTCTAACGCCGAAAGAGTTTGCTATATTGGGTCTGTTT
TTGAAGCACCCAAACAGAGTGTTCAGCAGAGAACAAATCATCGTGTCCTTATGGGGTTATAACGCAAACACAGAAGAGCG
TACAATAGACTCTCATGTCAAAAATATTAGAGAAAAGCTTAGACAAGCCGGTTTTCCGATCGATCAATTTCTGCAAACCG
TTTGGGGGGTAGGATATAAATGGGAGGCATAA

Upstream 100 bases:

>100_bases
TCGCCAAGGAAATTGTGGAAGCGCACGGAGGGTCGATTTACGCCGCAAGTGAATATGGAAAAGGAACAAACATGATCATT
ACATTGCCGGAGGGATAAGC

Downstream 100 bases:

>100_bases
GGCAAGAAGAGGATGAGAGAACAAATCATTGCACTACTCAACACCTATGAAAATGCTGCTTATCTCATCAGCATTGTGAT
AAATATTATAATTAGTATTT

Product: two-component response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MYTILLVDDEKRMLDLLDLYLSPKGYHCVKCESGLAAIQYLENNKVDLVLLDIMMPELDGWETCKRIREFSNVPIIMVTA
RDQTTDIVQGLKIGADDYITKPFDESELLARIEAVLRRSVGKHSKMEFQGLVWDEDEYKVHYQNKPIFLTPKEFAILGLF
LKHPNRVFSREQIIVSLWGYNANTEERTIDSHVKNIREKLRQAGFPIDQFLQTVWGVGYKWEA

Sequences:

>Translated_223_residues
MYTILLVDDEKRMLDLLDLYLSPKGYHCVKCESGLAAIQYLENNKVDLVLLDIMMPELDGWETCKRIREFSNVPIIMVTA
RDQTTDIVQGLKIGADDYITKPFDESELLARIEAVLRRSVGKHSKMEFQGLVWDEDEYKVHYQNKPIFLTPKEFAILGLF
LKHPNRVFSREQIIVSLWGYNANTEERTIDSHVKNIREKLRQAGFPIDQFLQTVWGVGYKWEA
>Mature_223_residues
MYTILLVDDEKRMLDLLDLYLSPKGYHCVKCESGLAAIQYLENNKVDLVLLDIMMPELDGWETCKRIREFSNVPIIMVTA
RDQTTDIVQGLKIGADDYITKPFDESELLARIEAVLRRSVGKHSKMEFQGLVWDEDEYKVHYQNKPIFLTPKEFAILGLF
LKHPNRVFSREQIIVSLWGYNANTEERTIDSHVKNIREKLRQAGFPIDQFLQTVWGVGYKWEA

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=39.4618834080717, Blast_Score=166, Evalue=8e-43,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=39.0134529147982, Blast_Score=166, Evalue=9e-43,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=37.280701754386, Blast_Score=146, Evalue=9e-37,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=35.5855855855856, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=34.5291479820628, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=35.2173913043478, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=32.5688073394495, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=29.9107142857143, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=33.4862385321101, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=31.6017316017316, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.0701754385965, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693140, Length=213, Percent_Identity=25.3521126760563, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=35.8490566037736, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.9649122807018, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788905, Length=118, Percent_Identity=36.4406779661017, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=109, Percent_Identity=33.0275229357798, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=36, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790299, Length=109, Percent_Identity=33.0275229357798, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=31.0679611650485, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=108, Percent_Identity=36.1111111111111, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25987; Mature: 25987

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTILLVDDEKRMLDLLDLYLSPKGYHCVKCESGLAAIQYLENNKVDLVLLDIMMPELDG
CEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCEEEEEEEECCCCCCC
WETCKRIREFSNVPIIMVTARDQTTDIVQGLKIGADDYITKPFDESELLARIEAVLRRSV
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GKHSKMEFQGLVWDEDEYKVHYQNKPIFLTPKEFAILGLFLKHPNRVFSREQIIVSLWGY
CCCCCEEECCEEECCCCEEEEECCCCEEECCHHHHHHHHHHHCCCHHHCHHEEEEEEECC
NANTEERTIDSHVKNIREKLRQAGFPIDQFLQTVWGVGYKWEA
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECC
>Mature Secondary Structure
MYTILLVDDEKRMLDLLDLYLSPKGYHCVKCESGLAAIQYLENNKVDLVLLDIMMPELDG
CEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCEEEEEEEECCCCCCC
WETCKRIREFSNVPIIMVTARDQTTDIVQGLKIGADDYITKPFDESELLARIEAVLRRSV
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GKHSKMEFQGLVWDEDEYKVHYQNKPIFLTPKEFAILGLFLKHPNRVFSREQIIVSLWGY
CCCCCEEECCEEECCCCEEEEECCCCEEECCHHHHHHHHHHHCCCHHHCHHEEEEEEECC
NANTEERTIDSHVKNIREKLRQAGFPIDQFLQTVWGVGYKWEA
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA