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The map label for this gene is ywrK [H]

Identifier: 138895207

GI number: 138895207

Start: 1628594

End: 1629928

Strand: Reverse

Name: ywrK [H]

Synonym: GTNG_1547

Alternate gene names: 138895207

Gene position: 1629928-1628594 (Counterclockwise)

Preceding gene: 138895208

Following gene: 138895199

Centisome position: 45.91

GC content: 45.99

Gene sequence:

>1335_bases
GTGTTTACATTTTTCTTTACGATGATGCTCATTTATTGGCGCCCGAAAGGAATGCATGAAGCCATTCCGGCCGCGATCGG
TGCAGCGATCATCCTTGTCAGCGGAGCGGTCAGTTTTTCCAATCTCATCAACATTAGCGCCAAAGTGAGCGGCGCAGCGG
TCACCATCATCTCCACTTTTATCATGGCGCTTGTGCTCGAGAGCATCGGCTTTTTTCATTGGATCGCCGCTATATTGGCC
GAGCGAGCTAACGGTTCGGGTATTCGGCTGTTTTGGTATACGAATGCTCTTTGCTTTCTTATGACACTGTTTTTCAATAA
CGACGGCAGCATCATTATCACAACCCCGATTTTGCTGTTGCTCTTAAAAAGCTTTCAACTCAAAAAGCATCAGCAGCTTC
CGTACCTGATAAGCGGTGCGCTCGTCGCTACCGCCTCAAGCGCACCGATCGGTGTGAGCAACATGGTGAACTTAATTTCG
CTAAAGATTATTGATATGAGCCTGTACTTGCAAACGACGATGATGTTTGTTCCTTCCATGCTTGGATTGCTCTTTTTGGT
CGGAATGCTGTTTGCTGTTTTTTACAAAGATCTTCCTAGAACACTTCCTCCGCTGTCCGTCCCAATCACTCCTCTCTCGT
TTTATCAGCACCCCCTCCGCCATTCCGAGGGCTATGATTATTTAAAAATATCGGAACAAAAGATGAAGGGGATTCTTCTC
TTTGTGTTGGTCATGCGGGTTAGTTTATTTGTCGCTTCCTACTGGCATATCCCGGTGGAATGGGTAGCTGTTACGGGATC
CGTTTTGCTGCTCGGATGGCGGTGGTACGCGTTACAGATGAAACCTTTTGATGTGTTGCGGAAAGCGCCTTGGCATATTC
TCATCTTTGCTTTTGGGATGTATATTATTGTGTACGGGTTAAACGGTGCCGGCCTCGGACATTATTTGGTGCAACAATTG
CAGCCTTATGTGTCTAATTTATTTCACGCCATTTTCACCATGGGAAGCATGATGTCCATTTTGTCAAATGTGTTTAACAA
CCACCCTGCGCTCATGATCGGAACGTTGACATTGACCGAAATGCGTATCGACCCACTCATTTTAAAAGCAGCATATTTGG
CAATGATCATTGGGAGCGATATCGGCTCACTGCTTTTGCCAACAGGGACGCTCGCAACGTTGCTTTGGCTCCATATCTTA
CAAAAATACCGTTATCCGCTTCCTTGGTCCACGTATACAAAAATCTCGCTTTTGGTCATTCCACCGACGGTGTTGTTTAC
CCTTGCCATGCTGTATAGTTGGATTTTCTTTTTGTCTTTGGTCCACCTTCTATAA

Upstream 100 bases:

>100_bases
ATATATATGCAGTACAAATGAGCACTATAGACAGTTTACACATATGGCCTCAACGAAAAAAATATAAGAAAGGAGGCTGG
CCATCATCGAACTCCTCATC

Downstream 100 bases:

>100_bases
AAAAAGCCCTCCTCACGCGGTGAACGAAGGAGGGCTTTTTTATAAAATTTCCTTTGTTGCATCTAGCGCCGCCATTTATC
CAGCGTACATCAAGCGAGTT

Product: arsenical pump membrane protein

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MFTFFFTMMLIYWRPKGMHEAIPAAIGAAIILVSGAVSFSNLINISAKVSGAAVTIISTFIMALVLESIGFFHWIAAILA
ERANGSGIRLFWYTNALCFLMTLFFNNDGSIIITTPILLLLLKSFQLKKHQQLPYLISGALVATASSAPIGVSNMVNLIS
LKIIDMSLYLQTTMMFVPSMLGLLFLVGMLFAVFYKDLPRTLPPLSVPITPLSFYQHPLRHSEGYDYLKISEQKMKGILL
FVLVMRVSLFVASYWHIPVEWVAVTGSVLLLGWRWYALQMKPFDVLRKAPWHILIFAFGMYIIVYGLNGAGLGHYLVQQL
QPYVSNLFHAIFTMGSMMSILSNVFNNHPALMIGTLTLTEMRIDPLILKAAYLAMIIGSDIGSLLLPTGTLATLLWLHIL
QKYRYPLPWSTYTKISLLVIPPTVLFTLAMLYSWIFFLSLVHLL

Sequences:

>Translated_444_residues
MFTFFFTMMLIYWRPKGMHEAIPAAIGAAIILVSGAVSFSNLINISAKVSGAAVTIISTFIMALVLESIGFFHWIAAILA
ERANGSGIRLFWYTNALCFLMTLFFNNDGSIIITTPILLLLLKSFQLKKHQQLPYLISGALVATASSAPIGVSNMVNLIS
LKIIDMSLYLQTTMMFVPSMLGLLFLVGMLFAVFYKDLPRTLPPLSVPITPLSFYQHPLRHSEGYDYLKISEQKMKGILL
FVLVMRVSLFVASYWHIPVEWVAVTGSVLLLGWRWYALQMKPFDVLRKAPWHILIFAFGMYIIVYGLNGAGLGHYLVQQL
QPYVSNLFHAIFTMGSMMSILSNVFNNHPALMIGTLTLTEMRIDPLILKAAYLAMIIGSDIGSLLLPTGTLATLLWLHIL
QKYRYPLPWSTYTKISLLVIPPTVLFTLAMLYSWIFFLSLVHLL
>Mature_444_residues
MFTFFFTMMLIYWRPKGMHEAIPAAIGAAIILVSGAVSFSNLINISAKVSGAAVTIISTFIMALVLESIGFFHWIAAILA
ERANGSGIRLFWYTNALCFLMTLFFNNDGSIIITTPILLLLLKSFQLKKHQQLPYLISGALVATASSAPIGVSNMVNLIS
LKIIDMSLYLQTTMMFVPSMLGLLFLVGMLFAVFYKDLPRTLPPLSVPITPLSFYQHPLRHSEGYDYLKISEQKMKGILL
FVLVMRVSLFVASYWHIPVEWVAVTGSVLLLGWRWYALQMKPFDVLRKAPWHILIFAFGMYIIVYGLNGAGLGHYLVQQL
QPYVSNLFHAIFTMGSMMSILSNVFNNHPALMIGTLTLTEMRIDPLILKAAYLAMIIGSDIGSLLLPTGTLATLLWLHIL
QKYRYPLPWSTYTKISLLVIPPTVLFTLAMLYSWIFFLSLVHLL

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsB family [H]

Homologues:

Organism=Escherichia coli, GI87082277, Length=431, Percent_Identity=30.3944315545244, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802 [H]

Pfam domain/function: PF02040 ArsB [H]

EC number: NA

Molecular weight: Translated: 49855; Mature: 49855

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTFFFTMMLIYWRPKGMHEAIPAAIGAAIILVSGAVSFSNLINISAKVSGAAVTIISTF
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHH
IMALVLESIGFFHWIAAILAERANGSGIRLFWYTNALCFLMTLFFNNDGSIIITTPILLL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEHHHHHHH
LLKSFQLKKHQQLPYLISGALVATASSAPIGVSNMVNLISLKIIDMSLYLQTTMMFVPSM
HHHHHHHHHHCCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLLFLVGMLFAVFYKDLPRTLPPLSVPITPLSFYQHPLRHSEGYDYLKISEQKMKGILL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHH
FVLVMRVSLFVASYWHIPVEWVAVTGSVLLLGWRWYALQMKPFDVLRKAPWHILIFAFGM
HHHHHHHHHHHHHHHCCCHHHHHHHCHHHEEEEEEEEEEECHHHHHHCCCHHHHHHHHHH
YIIVYGLNGAGLGHYLVQQLQPYVSNLFHAIFTMGSMMSILSNVFNNHPALMIGTLTLTE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHH
MRIDPLILKAAYLAMIIGSDIGSLLLPTGTLATLLWLHILQKYRYPLPWSTYTKISLLVI
HHCCHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
PPTVLFTLAMLYSWIFFLSLVHLL
CHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFTFFFTMMLIYWRPKGMHEAIPAAIGAAIILVSGAVSFSNLINISAKVSGAAVTIISTF
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHH
IMALVLESIGFFHWIAAILAERANGSGIRLFWYTNALCFLMTLFFNNDGSIIITTPILLL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEHHHHHHH
LLKSFQLKKHQQLPYLISGALVATASSAPIGVSNMVNLISLKIIDMSLYLQTTMMFVPSM
HHHHHHHHHHCCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLLFLVGMLFAVFYKDLPRTLPPLSVPITPLSFYQHPLRHSEGYDYLKISEQKMKGILL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHH
FVLVMRVSLFVASYWHIPVEWVAVTGSVLLLGWRWYALQMKPFDVLRKAPWHILIFAFGM
HHHHHHHHHHHHHHHCCCHHHHHHHCHHHEEEEEEEEEEECHHHHHHCCCHHHHHHHHHH
YIIVYGLNGAGLGHYLVQQLQPYVSNLFHAIFTMGSMMSILSNVFNNHPALMIGTLTLTE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHH
MRIDPLILKAAYLAMIIGSDIGSLLLPTGTLATLLWLHILQKYRYPLPWSTYTKISLLVI
HHCCHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
PPTVLFTLAMLYSWIFFLSLVHLL
CHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]