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The map label for this gene is thiD [H]

Identifier: 138895023

GI number: 138895023

Start: 1449427

End: 1450230

Strand: Direct

Name: thiD [H]

Synonym: GTNG_1361

Alternate gene names: 138895023

Gene position: 1449427-1450230 (Clockwise)

Preceding gene: 138895022

Following gene: 138895024

Centisome position: 40.83

GC content: 56.34

Gene sequence:

>804_bases
ATGACGGTGTATAAAGCGTTGACGATTGCTGGGTCGGACAGCGGCGGTGGCGCCGGCATTCAAGCGGATTTAAAAACATT
TCAAGAGCTTGGCGTCTTTGGCATGTCAGCGATTACGGCGGTGACAGCACAAAACACGCTCGGCGTGCAAGGCGTCTATC
CGCTTTCGGCCGAAGCGGTGGCTGCACAAATCGAATCGGTTGCGGTTGACTTGGGCGTGGATGCGCTCAAAACCGGGATG
TTGTTTAGCGCTGATATTATCCGCACCGTTGCAGAGCAAGTGAAAAAACATGGCTGGGAGCGGCTTGTCGTCGACCCGGT
GATGATTGCCAAAGGCGGTGCCCCGCTGTTGCAGGAAGAAGCGGTTGCGGCGTTGAAAGAAGCGCTGTTGCCGCTGGCGT
TTGTCATTACACCAAACATTCCGGAAGCGGAAGTATTGACTGGCATTGCCATTCGCACGATGGATGACCGCCGTGAAGCG
GCGCGCCTTCTCCATCGCATGGGCGCCCGCTATGTCGTCATTAAAGGCGGCCATGACGATGATGGCGAAGAAACAGTCGA
CTTATTGTATAACGGCAGCGAATTTTCTTACTTCAAAAGCAAGCGGATTGATACGCGTCATACGCATGGAACCGGCTGTA
CGTTCGCCGCAGCGGTTGCGGCCGAGCTCGCGAAAGGAAGACATCCGGTGGATGCTGTCGGGACGGCGAAATCGTTCGTA
CAGGCGGCGATCTCTCATTCGCTCGGCATCGGCCAAGGCCACGGGCCGACCAACCATTGGGCATACCGTCAATACGGGGA
GTGA

Upstream 100 bases:

>100_bases
CAGTTTTCAGGTGGCGTTTTTGGACGCCTTGGCTCGCATTGGCGTTGATGATGTGAAGCGTGAGGGACGGGTTGAACAAC
GGTAAAAGGGGAGGAGAACC

Downstream 100 bases:

>100_bases
GAACGATGGCACGCATTACGAGCGAAGAGATGAAAGAACGGCTTGCTGTTTACTTTATTATGGGAAGCCAAAACAGCGAA
CGGCCGGCAGAGGATGTGCT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTVYKALTIAGSDSGGGAGIQADLKTFQELGVFGMSAITAVTAQNTLGVQGVYPLSAEAVAAQIESVAVDLGVDALKTGM
LFSADIIRTVAEQVKKHGWERLVVDPVMIAKGGAPLLQEEAVAALKEALLPLAFVITPNIPEAEVLTGIAIRTMDDRREA
ARLLHRMGARYVVIKGGHDDDGEETVDLLYNGSEFSYFKSKRIDTRHTHGTGCTFAAAVAAELAKGRHPVDAVGTAKSFV
QAAISHSLGIGQGHGPTNHWAYRQYGE

Sequences:

>Translated_267_residues
MTVYKALTIAGSDSGGGAGIQADLKTFQELGVFGMSAITAVTAQNTLGVQGVYPLSAEAVAAQIESVAVDLGVDALKTGM
LFSADIIRTVAEQVKKHGWERLVVDPVMIAKGGAPLLQEEAVAALKEALLPLAFVITPNIPEAEVLTGIAIRTMDDRREA
ARLLHRMGARYVVIKGGHDDDGEETVDLLYNGSEFSYFKSKRIDTRHTHGTGCTFAAAVAAELAKGRHPVDAVGTAKSFV
QAAISHSLGIGQGHGPTNHWAYRQYGE
>Mature_266_residues
TVYKALTIAGSDSGGGAGIQADLKTFQELGVFGMSAITAVTAQNTLGVQGVYPLSAEAVAAQIESVAVDLGVDALKTGML
FSADIIRTVAEQVKKHGWERLVVDPVMIAKGGAPLLQEEAVAALKEALLPLAFVITPNIPEAEVLTGIAIRTMDDRREAA
RLLHRMGARYVVIKGGHDDDGEETVDLLYNGSEFSYFKSKRIDTRHTHGTGCTFAAAVAAELAKGRHPVDAVGTAKSFVQ
AAISHSLGIGQGHGPTNHWAYRQYGE

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=46.3878326996198, Blast_Score=215, Evalue=2e-57,
Organism=Escherichia coli, GI1788758, Length=167, Percent_Identity=30.5389221556886, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6325378, Length=267, Percent_Identity=34.4569288389513, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324997, Length=268, Percent_Identity=35.8208955223881, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324517, Length=268, Percent_Identity=35.8208955223881, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28225; Mature: 28094

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYKALTIAGSDSGGGAGIQADLKTFQELGVFGMSAITAVTAQNTLGVQGVYPLSAEAV
CCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
AAQIESVAVDLGVDALKTGMLFSADIIRTVAEQVKKHGWERLVVDPVMIAKGGAPLLQEE
HHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCCHHHHH
AVAALKEALLPLAFVITPNIPEAEVLTGIAIRTMDDRREAARLLHRMGARYVVIKGGHDD
HHHHHHHHHHHEEEEECCCCCHHHHHHHHHEEECHHHHHHHHHHHHCCCCEEEEECCCCC
DGEETVDLLYNGSEFSYFKSKRIDTRHTHGTGCTFAAAVAAELAKGRHPVDAVGTAKSFV
CCHHHHHHEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QAAISHSLGIGQGHGPTNHWAYRQYGE
HHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVYKALTIAGSDSGGGAGIQADLKTFQELGVFGMSAITAVTAQNTLGVQGVYPLSAEAV
CEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
AAQIESVAVDLGVDALKTGMLFSADIIRTVAEQVKKHGWERLVVDPVMIAKGGAPLLQEE
HHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCCHHHHH
AVAALKEALLPLAFVITPNIPEAEVLTGIAIRTMDDRREAARLLHRMGARYVVIKGGHDD
HHHHHHHHHHHEEEEECCCCCHHHHHHHHHEEECHHHHHHHHHHHHCCCCEEEEECCCCC
DGEETVDLLYNGSEFSYFKSKRIDTRHTHGTGCTFAAAVAAELAKGRHPVDAVGTAKSFV
CCHHHHHHEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QAAISHSLGIGQGHGPTNHWAYRQYGE
HHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]