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The map label for this gene is yhxA [H]

Identifier: 138894948

GI number: 138894948

Start: 1365085

End: 1366437

Strand: Direct

Name: yhxA [H]

Synonym: GTNG_1286

Alternate gene names: 138894948

Gene position: 1365085-1366437 (Clockwise)

Preceding gene: 138894947

Following gene: 138894949

Centisome position: 38.45

GC content: 52.77

Gene sequence:

>1353_bases
ATGAAAACTGAACAAAGCCATCAATTATGGCTCGACAAAGACGATCGATACATTTGGCATTCGATGAAGCCGTACAATCC
AAATGCGACGGTTGTTGTGACCGAAGCCAAAGGATGCTGGGTGACCGATGTCGCTGGAAACAAATATTTGGACGCTATGG
CCGGGCTTTGGTGCGTCAATGTCGGCTACGGGCGCGAGGAGCTCGCTGAAGCGGCGTACGAGCAACTGAAAACGCTGCCA
TATTTCCCGCTGACGCAAAGTCACTTGCCTGCCATTCAGCTTGGGGAAAAACTCAATGAGCTGTTAGGCGATGAGTATGT
CATCTTCTTTTCCAACAGCGGGTCGGAGGCGAATGAAACAGCGTTTAAAATTGCCCGTCAATATCATCAGCAACGTGGCG
AACCCCACCGATACAAAATCATCTCCCGCTACCGGGCATATCACGGCAATTCGATGGGAGCGCTCGCGGCGACCGGACAG
GCACAACGAAAATACAAATATGAGCCGCTCGCTCCGGGCTTCATCCATGTGCCGCCGCCTGATCGATACCGCGATCCTGA
TGCAGCGGACGATCCGCGCCAGCTGCGAGCCGTGAAAGCTGTTGACGATGTGATGACGTGGGAACTGAGTGAGACGATCG
CCGCCATGATCATGGAGCCGATCATCACGGGCGGCGGAGTGCTCATGCCGCCAGATGGATACATGAAGGCGGTCAAGGAA
GTATGTGAAAAACACGGAGCACTACTCATTGTCGATGAAGTCATCTGCGGTTTCGGCCGAACAGGGAAGCCGTTTGGGTT
CATGCATGAGGGGATTAAGCCGGATATCATTACGATGGCGAAAGGCATTACAAGCGCCTACTTGCCGCTGGCAGCAACGG
CGGTGCGAAAGGAAATTTACGAGGCGTTTAAAGGAACGGATGAATACGACTATTTCCGTCATGTTAATACGTTTGGCGGC
CATCCGGCTTCGTGCGCTCTGGCGCTGAAAAATATTGAAATCATGGAGACAGAGCATCTGTTTGACCGTTCACGTGAGGC
GGGCGAATGGCTGCTTTCAGCACTGAAAACGAAACTGGCTGACCATCCGTATGTTGGCGATGTGCGCGGAAGAGGGCTGC
TTGTCGGCATTGAGCTTGTTGCTGACCAAACGACGAAAGAGCCGCTGGATGTATCGCTCGTCAATCAAGTAATCAGCCGC
TGCAAAGAGCATGGTGTCATTATCGGCAAAAACGGAGCGACGGTCGCCGGGTACAACAACGTGCTTACCTTATCGCCGCC
GCTGTGCATCAGTGATGATGAGCTTTCATTCCTTGTCCGTGTCTTGACGGAGGCATTAGCACAAATCAAATAG

Upstream 100 bases:

>100_bases
CAATGACTGTTTTTACATTGTGTCTAATGAACGGCGTAGGAAGTTGCGCGATAATGACTATAGCATGAGGCGATTCTAAA
TAGAGAGGAGCCAAGCGGTG

Downstream 100 bases:

>100_bases
AAAAGGAATGCCAGCCGGGTGGTTGCCTTGGCTGGCATTTTTATAGAGTTTTAGCTGCTGTATGGGAAAACGCGGCAGTG
AAGAGGGGGAAGCGAAGGAA

Product: aminotransferase

Products: S-adenosyl-4-methylthio-2-oxobutanoate; 7,8-diaminononanoate

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKTEQSHQLWLDKDDRYIWHSMKPYNPNATVVVTEAKGCWVTDVAGNKYLDAMAGLWCVNVGYGREELAEAAYEQLKTLP
YFPLTQSHLPAIQLGEKLNELLGDEYVIFFSNSGSEANETAFKIARQYHQQRGEPHRYKIISRYRAYHGNSMGALAATGQ
AQRKYKYEPLAPGFIHVPPPDRYRDPDAADDPRQLRAVKAVDDVMTWELSETIAAMIMEPIITGGGVLMPPDGYMKAVKE
VCEKHGALLIVDEVICGFGRTGKPFGFMHEGIKPDIITMAKGITSAYLPLAATAVRKEIYEAFKGTDEYDYFRHVNTFGG
HPASCALALKNIEIMETEHLFDRSREAGEWLLSALKTKLADHPYVGDVRGRGLLVGIELVADQTTKEPLDVSLVNQVISR
CKEHGVIIGKNGATVAGYNNVLTLSPPLCISDDELSFLVRVLTEALAQIK

Sequences:

>Translated_450_residues
MKTEQSHQLWLDKDDRYIWHSMKPYNPNATVVVTEAKGCWVTDVAGNKYLDAMAGLWCVNVGYGREELAEAAYEQLKTLP
YFPLTQSHLPAIQLGEKLNELLGDEYVIFFSNSGSEANETAFKIARQYHQQRGEPHRYKIISRYRAYHGNSMGALAATGQ
AQRKYKYEPLAPGFIHVPPPDRYRDPDAADDPRQLRAVKAVDDVMTWELSETIAAMIMEPIITGGGVLMPPDGYMKAVKE
VCEKHGALLIVDEVICGFGRTGKPFGFMHEGIKPDIITMAKGITSAYLPLAATAVRKEIYEAFKGTDEYDYFRHVNTFGG
HPASCALALKNIEIMETEHLFDRSREAGEWLLSALKTKLADHPYVGDVRGRGLLVGIELVADQTTKEPLDVSLVNQVISR
CKEHGVIIGKNGATVAGYNNVLTLSPPLCISDDELSFLVRVLTEALAQIK
>Mature_450_residues
MKTEQSHQLWLDKDDRYIWHSMKPYNPNATVVVTEAKGCWVTDVAGNKYLDAMAGLWCVNVGYGREELAEAAYEQLKTLP
YFPLTQSHLPAIQLGEKLNELLGDEYVIFFSNSGSEANETAFKIARQYHQQRGEPHRYKIISRYRAYHGNSMGALAATGQ
AQRKYKYEPLAPGFIHVPPPDRYRDPDAADDPRQLRAVKAVDDVMTWELSETIAAMIMEPIITGGGVLMPPDGYMKAVKE
VCEKHGALLIVDEVICGFGRTGKPFGFMHEGIKPDIITMAKGITSAYLPLAATAVRKEIYEAFKGTDEYDYFRHVNTFGG
HPASCALALKNIEIMETEHLFDRSREAGEWLLSALKTKLADHPYVGDVRGRGLLVGIELVADQTTKEPLDVSLVNQVISR
CKEHGVIIGKNGATVAGYNNVLTLSPPLCISDDELSFLVRVLTEALAQIK

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=433, Percent_Identity=33.4872979214781, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI24119277, Length=450, Percent_Identity=32.8888888888889, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI37574042, Length=448, Percent_Identity=32.1428571428571, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226442705, Length=445, Percent_Identity=32.3595505617978, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226442709, Length=403, Percent_Identity=33.2506203473945, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI4557809, Length=440, Percent_Identity=26.1363636363636, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI284507298, Length=337, Percent_Identity=27.0029673590504, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI188536080, Length=453, Percent_Identity=25.1655629139073, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI38679950, Length=453, Percent_Identity=25.1655629139073, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI38679946, Length=453, Percent_Identity=25.1655629139073, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI145693181, Length=418, Percent_Identity=31.5789473684211, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1789759, Length=426, Percent_Identity=30.9859154929577, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1789016, Length=424, Percent_Identity=29.0094339622642, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1788044, Length=417, Percent_Identity=29.0167865707434, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=28.6353467561521, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787560, Length=431, Percent_Identity=28.538283062645, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786349, Length=299, Percent_Identity=24.7491638795987, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=31.5436241610738, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71992977, Length=452, Percent_Identity=31.4159292035398, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=457, Percent_Identity=28.2275711159737, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI25144274, Length=448, Percent_Identity=25.2232142857143, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=394, Percent_Identity=22.5888324873096, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=445, Percent_Identity=28.0898876404494, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324432, Length=395, Percent_Identity=25.8227848101266, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6324386, Length=489, Percent_Identity=26.7893660531697, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321456, Length=454, Percent_Identity=24.2290748898678, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=32.4766355140187, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=32.5581395348837, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI21356575, Length=454, Percent_Identity=29.9559471365639, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21357415, Length=433, Percent_Identity=26.5588914549654, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI281366494, Length=412, Percent_Identity=24.7572815533981, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667139, Length=412, Percent_Identity=24.7572815533981, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667143, Length=412, Percent_Identity=24.7572815533981, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62

Molecular weight: Translated: 50052; Mature: 50052

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTEQSHQLWLDKDDRYIWHSMKPYNPNATVVVTEAKGCWVTDVAGNKYLDAMAGLWCVN
CCCCCCCCEEECCCCCEEEECCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHEEEE
VGYGREELAEAAYEQLKTLPYFPLTQSHLPAIQLGEKLNELLGDEYVIFFSNSGSEANET
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
AFKIARQYHQQRGEPHRYKIISRYRAYHGNSMGALAATGQAQRKYKYEPLAPGFIHVPPP
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCCCCCCEEECCCC
DRYRDPDAADDPRQLRAVKAVDDVMTWELSETIAAMIMEPIITGGGVLMPPDGYMKAVKE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHH
VCEKHGALLIVDEVICGFGRTGKPFGFMHEGIKPDIITMAKGITSAYLPLAATAVRKEIY
HHHHCCCEEEEHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAFKGTDEYDYFRHVNTFGGHPASCALALKNIEIMETEHLFDRSREAGEWLLSALKTKLA
HHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEHHHHHHHCCHHHHHHHHHHHHHHHC
DHPYVGDVRGRGLLVGIELVADQTTKEPLDVSLVNQVISRCKEHGVIIGKNGATVAGYNN
CCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEECCCC
VLTLSPPLCISDDELSFLVRVLTEALAQIK
EEEECCCCEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTEQSHQLWLDKDDRYIWHSMKPYNPNATVVVTEAKGCWVTDVAGNKYLDAMAGLWCVN
CCCCCCCCEEECCCCCEEEECCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHEEEE
VGYGREELAEAAYEQLKTLPYFPLTQSHLPAIQLGEKLNELLGDEYVIFFSNSGSEANET
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
AFKIARQYHQQRGEPHRYKIISRYRAYHGNSMGALAATGQAQRKYKYEPLAPGFIHVPPP
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCCCCCCEEECCCC
DRYRDPDAADDPRQLRAVKAVDDVMTWELSETIAAMIMEPIITGGGVLMPPDGYMKAVKE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHH
VCEKHGALLIVDEVICGFGRTGKPFGFMHEGIKPDIITMAKGITSAYLPLAATAVRKEIY
HHHHCCCEEEEHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAFKGTDEYDYFRHVNTFGGHPASCALALKNIEIMETEHLFDRSREAGEWLLSALKTKLA
HHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEHHHHHHHCCHHHHHHHHHHHHHHHC
DHPYVGDVRGRGLLVGIELVADQTTKEPLDVSLVNQVISRCKEHGVIIGKNGATVAGYNN
CCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEECCCC
VLTLSPPLCISDDELSFLVRVLTEALAQIK
EEEECCCCEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; 8-amino-7-oxononanoate

Specific reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]