BacMap

Definition	Geobacillus thermodenitrificans NG80-2 chromosome, complete genome.
Accession	NC_009328
Length	3,550,319

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The map label for this gene is gmk [H]

Identifier: 138894688

GI number: 138894688

Start: 1089101

End: 1089718

Strand: Direct

Name: gmk [H]

Synonym: GTNG_1020

Alternate gene names: 138894688

Gene position: 1089101-1089718 (Clockwise)

Preceding gene: 138894687

Following gene: 138894689

Centisome position: 30.68

GC content: 52.75

Gene sequence:

>618_bases
TTGAGGAACGAACGAGGGTTGTTAATCGTCATGTCAGGGCCGTCCGGTGTCGGCAAGGGAACGGTGCGCAAAGCGCTGTT
TTCGCGACCAGACATCGAGCTTCATTATTCGGTGTCAGTTACGACGCGCAAGCCGCGGGAAGGTGAAGTGGAAGGCGTTG
ATTATTTCTTCCGGACCCGCGAGCAGTTTGAGCAAATGATCCGTGAAAATAAGCTGCTTGAATGGGCGGAATACGTCGGC
AACTATTACGGGACGCCGATCGACTATGTGGAAAAAACGCTCGCGGAAGGGAAAGACGTATTTTTGGAAATCGAGGTGCA
AGGCGCGATGAAAGTGCGCCAAGCGTTCCCGGAAGCGCTCTTTATTTTCCTTGCCCCACCAAGCTTATCGGAGCTTGAGA
AGCGGATCATCGGGCGCGGCACCGAATCGAAAGATTTGATCGAAAATCGGCTGCAAGCAGCCAAAGAGGAATTGGAAATG
ATGGACGCATACGACTATGTCGTTGAAAATGATGAGATCGAGCTCGCATGCGAGCGAATCAAGGCGATCGTCATGGCCGA
ACATTGTCGGCGTGAGCGCGTCGCCGAGCGATATAAACGGATGTTGGAGGTGGAATGA

Upstream 100 bases:

>100_bases
ATAGTGATCATGTCATTTTATCATCCGTGCAACCGGAAACGGTGGCGAACCGCTTGTACGGAAGCGATGATTTCTCCGAG
GAAGGGTAGGGTTTTCAACG

Downstream 100 bases:

>100_bases
CGATGTTGTATCCTTCCATCGATTTGCTTATGAAAAAAGTGGATTCGAAATATAAGCTTGTTACGGTTGTCGCGAAACGG
GCGCGTCAGCTTCAAGACGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRNERGLLIVMSGPSGVGKGTVRKALFSRPDIELHYSVSVTTRKPREGEVEGVDYFFRTREQFEQMIRENKLLEWAEYVG
NYYGTPIDYVEKTLAEGKDVFLEIEVQGAMKVRQAFPEALFIFLAPPSLSELEKRIIGRGTESKDLIENRLQAAKEELEM
MDAYDYVVENDEIELACERIKAIVMAEHCRRERVAERYKRMLEVE

Sequences:

>Translated_205_residues
MRNERGLLIVMSGPSGVGKGTVRKALFSRPDIELHYSVSVTTRKPREGEVEGVDYFFRTREQFEQMIRENKLLEWAEYVG
NYYGTPIDYVEKTLAEGKDVFLEIEVQGAMKVRQAFPEALFIFLAPPSLSELEKRIIGRGTESKDLIENRLQAAKEELEM
MDAYDYVVENDEIELACERIKAIVMAEHCRRERVAERYKRMLEVE
>Mature_205_residues
MRNERGLLIVMSGPSGVGKGTVRKALFSRPDIELHYSVSVTTRKPREGEVEGVDYFFRTREQFEQMIRENKLLEWAEYVG
NYYGTPIDYVEKTLAEGKDVFLEIEVQGAMKVRQAFPEALFIFLAPPSLSELEKRIIGRGTESKDLIENRLQAAKEELEM
MDAYDYVVENDEIELACERIKAIVMAEHCRRERVAERYKRMLEVE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=190, Percent_Identity=34.7368421052632, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI226874833, Length=190, Percent_Identity=34.7368421052632, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4504221, Length=190, Percent_Identity=34.7368421052632, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI14780902, Length=187, Percent_Identity=28.8770053475936, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI38570142, Length=136, Percent_Identity=33.0882352941176, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI21361598, Length=184, Percent_Identity=28.804347826087, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI111154074, Length=163, Percent_Identity=31.2883435582822, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4505237, Length=118, Percent_Identity=35.5932203389831, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI262118259, Length=118, Percent_Identity=35.5932203389831, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI262118255, Length=118, Percent_Identity=35.5932203389831, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI262118263, Length=118, Percent_Identity=35.5932203389831, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI52630447, Length=152, Percent_Identity=30.2631578947368, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI119943106, Length=177, Percent_Identity=29.9435028248588, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI261862237, Length=177, Percent_Identity=29.9435028248588, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI119943108, Length=177, Percent_Identity=29.9435028248588, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI186700627, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI186972120, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI186700629, Length=168, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI192447426, Length=180, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4557529, Length=180, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=199, Percent_Identity=42.2110552763819, Blast_Score=169, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17508835, Length=173, Percent_Identity=39.3063583815029, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193203132, Length=173, Percent_Identity=39.3063583815029, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71988048, Length=177, Percent_Identity=28.2485875706215, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988041, Length=177, Percent_Identity=28.2485875706215, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=180, Percent_Identity=28.3333333333333, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=44.8087431693989, Blast_Score=160, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=37.3626373626374, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI161077626, Length=179, Percent_Identity=31.2849162011173, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640542, Length=179, Percent_Identity=31.2849162011173, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45554489, Length=179, Percent_Identity=31.2849162011173, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45554481, Length=179, Percent_Identity=31.2849162011173, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI116007136, Length=179, Percent_Identity=31.2849162011173, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI85724806, Length=179, Percent_Identity=31.2849162011173, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221330166, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330162, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330164, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85816281, Length=127, Percent_Identity=29.9212598425197, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551002, Length=127, Percent_Identity=29.9212598425197, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85816106, Length=127, Percent_Identity=29.9212598425197, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554804, Length=153, Percent_Identity=31.3725490196078, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641280, Length=153, Percent_Identity=31.3725490196078, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281360700, Length=153, Percent_Identity=31.3725490196078, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641282, Length=153, Percent_Identity=31.3725490196078, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45554818, Length=153, Percent_Identity=31.3725490196078, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161077752, Length=153, Percent_Identity=31.3725490196078, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24648808, Length=124, Percent_Identity=29.0322580645161, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281362230, Length=124, Percent_Identity=29.0322580645161, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23809; Mature: 23809

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNERGLLIVMSGPSGVGKGTVRKALFSRPDIELHYSVSVTTRKPREGEVEGVDYFFRTR
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHH
EQFEQMIRENKLLEWAEYVGNYYGTPIDYVEKTLAEGKDVFLEIEVQGAMKVRQAFPEAL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEEHHHHHHHHHCHHHE
FIFLAPPSLSELEKRIIGRGTESKDLIENRLQAAKEELEMMDAYDYVVENDEIELACERI
EEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KAIVMAEHCRRERVAERYKRMLEVE
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNERGLLIVMSGPSGVGKGTVRKALFSRPDIELHYSVSVTTRKPREGEVEGVDYFFRTR
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHH
EQFEQMIRENKLLEWAEYVGNYYGTPIDYVEKTLAEGKDVFLEIEVQGAMKVRQAFPEAL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEEHHHHHHHHHCHHHE
FIFLAPPSLSELEKRIIGRGTESKDLIENRLQAAKEELEMMDAYDYVVENDEIELACERI
EEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KAIVMAEHCRRERVAERYKRMLEVE
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA