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The map label for this gene is pyrE [H]

Identifier: 138894683

GI number: 138894683

Start: 1080731

End: 1081354

Strand: Direct

Name: pyrE [H]

Synonym: GTNG_1013

Alternate gene names: 138894683

Gene position: 1080731-1081354 (Clockwise)

Preceding gene: 138894682

Following gene: 138894685

Centisome position: 30.44

GC content: 58.97

Gene sequence:

>624_bases
ATGAAACACGACATCGCTGCCAAACTGCTTCAGATCGGGGCCGTCGCCCTGCAGCCAAGCGAACCGTTTACGTGGTCGTC
TGGCTTGAAATCGCCCATTTATTGTGACAATCGCCTAACGCTTGCCTATCCAGAAGTGCGCCGCATGATCGCTGACGGTC
TCGCGGACCTCATCCGCACCCATTTCCCGGAAGCAGTTCTCATCGCTGGCACAGCGACCGCCGGCATCCCACACGCCGCC
TGGGTAAGCGAACGGCTTGACCTGCCGATGTGCTATGTCCGCAGCCAAGCGAAAGCGCACGGAAAAGGGAAACAAATTGA
AGGAAAAGCCGAAGCGGGCCAACGCGTTGTCGTCATCGAGGATTTAATCTCCACCGGCGGCAGCTCGCTCAATGCCGTTC
GCGCCTTGAAAGAGGCGGGCTGCGACGTGCTTGGCGTCGCCGCCATCTTCACGTACGGACTTGAAAAAGCGAAGCAGGCG
TTTGCCGAAGCGAATGTGCCTGCCTACACCCTCACCGACTACGACACACTCATCGAAACGGCCGTCCGCCTTGGCGCCGT
CAGCGAACACGACCTGGCGACATTGCGGCAATGGCGGGAAAATCCGGAAGAGTGGGGAAAATAG

Upstream 100 bases:

>100_bases
GCGCCGACTACATCGTCATCGGCCGCAGCATCACCCGCGCCGCTGACCCGCTCGCGGCCTACTCCCGCTTGCAACACGAA
TGGAACGGAGGAGAAACAGA

Downstream 100 bases:

>100_bases
ATAGAGAAGAGAGAAGCGCGGACCAAAGGATGGTTCGCGCTTTTGTCATGTGTTGTTAGCGAACGGGACTTCCGTCGCCT
CCGATGATGACGGAAATGGC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MKHDIAAKLLQIGAVALQPSEPFTWSSGLKSPIYCDNRLTLAYPEVRRMIADGLADLIRTHFPEAVLIAGTATAGIPHAA
WVSERLDLPMCYVRSQAKAHGKGKQIEGKAEAGQRVVVIEDLISTGGSSLNAVRALKEAGCDVLGVAAIFTYGLEKAKQA
FAEANVPAYTLTDYDTLIETAVRLGAVSEHDLATLRQWRENPEEWGK

Sequences:

>Translated_207_residues
MKHDIAAKLLQIGAVALQPSEPFTWSSGLKSPIYCDNRLTLAYPEVRRMIADGLADLIRTHFPEAVLIAGTATAGIPHAA
WVSERLDLPMCYVRSQAKAHGKGKQIEGKAEAGQRVVVIEDLISTGGSSLNAVRALKEAGCDVLGVAAIFTYGLEKAKQA
FAEANVPAYTLTDYDTLIETAVRLGAVSEHDLATLRQWRENPEEWGK
>Mature_207_residues
MKHDIAAKLLQIGAVALQPSEPFTWSSGLKSPIYCDNRLTLAYPEVRRMIADGLADLIRTHFPEAVLIAGTATAGIPHAA
WVSERLDLPMCYVRSQAKAHGKGKQIEGKAEAGQRVVVIEDLISTGGSSLNAVRALKEAGCDVLGVAAIFTYGLEKAKQA
FAEANVPAYTLTDYDTLIETAVRLGAVSEHDLATLRQWRENPEEWGK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI17554964, Length=169, Percent_Identity=27.810650887574, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508631, Length=175, Percent_Identity=27.4285714285714, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17933654, Length=136, Percent_Identity=33.0882352941176, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22414; Mature: 22414

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00626 RCC1_2 ; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHDIAAKLLQIGAVALQPSEPFTWSSGLKSPIYCDNRLTLAYPEVRRMIADGLADLIRT
CCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEECCCEEEECHHHHHHHHHHHHHHHHH
HFPEAVLIAGTATAGIPHAAWVSERLDLPMCYVRSQAKAHGKGKQIEGKAEAGQRVVVIE
HCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHCCCEEEEHH
DLISTGGSSLNAVRALKEAGCDVLGVAAIFTYGLEKAKQAFAEANVPAYTLTDYDTLIET
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHH
AVRLGAVSEHDLATLRQWRENPEEWGK
HHHHCCCCHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MKHDIAAKLLQIGAVALQPSEPFTWSSGLKSPIYCDNRLTLAYPEVRRMIADGLADLIRT
CCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEECCCEEEECHHHHHHHHHHHHHHHHH
HFPEAVLIAGTATAGIPHAAWVSERLDLPMCYVRSQAKAHGKGKQIEGKAEAGQRVVVIE
HCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHCCCEEEEHH
DLISTGGSSLNAVRALKEAGCDVLGVAAIFTYGLEKAKQAFAEANVPAYTLTDYDTLIET
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHH
AVRLGAVSEHDLATLRQWRENPEEWGK
HHHHCCCCHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7516791 [H]