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The map label for this gene is pyrD [H]

Identifier: 138894681

GI number: 138894681

Start: 1079102

End: 1080043

Strand: Direct

Name: pyrD [H]

Synonym: GTNG_1011

Alternate gene names: 138894681

Gene position: 1079102-1080043 (Clockwise)

Preceding gene: 138894680

Following gene: 138894682

Centisome position: 30.39

GC content: 55.63

Gene sequence:

>942_bases
ATGAACCGGCTTGCGGTCGAACTGCCAGGTCTTTCGCTCAAAAACCCGATCATGCCGGCGTCCGGATGTTTCGGGTTTGG
CCGCGAGTACGCCCAGTTTTACGATTTAAGCGTGTTAGGGGCCATAATGATTAAAGCGACGACAAAAGAGCCTCGCTTCG
GCAATTCGACGCCACGGGTGGCGGAAACGCCTAGCGGGATGTTAAACGCTATTGGCTTGCAAAATCCAGGGCTTGATAAG
GTGCTTGCGGAAGAATTGCCGTGGCTTGAACAGTTTGATGTGCCGATCATCGCGAACATCGCCGGCTCAACGATGGAAGA
ATACGTCGAGGTAGCCGCCGCGATTTCCAAAGCACCGAACGTCCATGCCTTGGAGCTCAACATTTCCTGCCCGAACGTGA
AAAAAGGAGGCATTGCGTTCGGCACCGTGCCGGAGGTGGCCGCCGAGCTGACGCGGCTTGTCAAGGAAGTGTCGGCTGTT
CCGGTGTATGTGAAGCTATCGCCTAACGTTACGGACATCGTCGCGATGGCGAAAGCAATTGAACAAGCGGGCGCCGACGG
CTTGACAATGATCAATACGCTCGTCGGTATGCGCATCGATGTGAAAACAGGCCGGCCGATTTTAGCAAATGGCACCGGCG
GTTTATCCGGCCCGGCAGTGAAACCGATCGCTGTCCGCATGATTTATGAAGTGAGCCAAGCGGTATCCATTCCGATTATC
GGCATGGGCGGCGTGCAAACAGCGGAAGATGTGCTCGAATTTTTCTACGCCGGCGCGAGCGCGGTCGCCGTTGGGACGGC
CAATTTCATCGACCCGTTTGTCTGCCCGACGATCATCAATGAACTGCCGGTGCTGCTTGACGAGCTTGGGATTCGACATA
TCTCGGAATGTACGGGAAGGAGCTGGAAAACCGGTGCACACGCCGTTCATTGTCGCTCTTGA

Upstream 100 bases:

>100_bases
GAGCGTGTTTTGCCTGCGTCTGCCATGTGCCGGGGAGCGAGACGGCGTATAAAAAAGTATGCAGCGACGGTCCGGTATTT
CGGGCCGGGGAGGTGGTGTT

Downstream 100 bases:

>100_bases
TTTTCCATCTAAACATGACGTACAGCAGTTTTTACGCCCGTTTAGCGGCACGCCGCTGTTTGTGAAAGTCGGCATGGAGC
TGTATTATCAGGAGGGTCCA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNRLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRVAETPSGMLNAIGLQNPGLDK
VLAEELPWLEQFDVPIIANIAGSTMEEYVEVAAAISKAPNVHALELNISCPNVKKGGIAFGTVPEVAAELTRLVKEVSAV
PVYVKLSPNVTDIVAMAKAIEQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKPIAVRMIYEVSQAVSIPII
GMGGVQTAEDVLEFFYAGASAVAVGTANFIDPFVCPTIINELPVLLDELGIRHISECTGRSWKTGAHAVHCRS

Sequences:

>Translated_313_residues
MNRLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRVAETPSGMLNAIGLQNPGLDK
VLAEELPWLEQFDVPIIANIAGSTMEEYVEVAAAISKAPNVHALELNISCPNVKKGGIAFGTVPEVAAELTRLVKEVSAV
PVYVKLSPNVTDIVAMAKAIEQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKPIAVRMIYEVSQAVSIPII
GMGGVQTAEDVLEFFYAGASAVAVGTANFIDPFVCPTIINELPVLLDELGIRHISECTGRSWKTGAHAVHCRS
>Mature_313_residues
MNRLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRVAETPSGMLNAIGLQNPGLDK
VLAEELPWLEQFDVPIIANIAGSTMEEYVEVAAAISKAPNVHALELNISCPNVKKGGIAFGTVPEVAAELTRLVKEVSAV
PVYVKLSPNVTDIVAMAKAIEQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKPIAVRMIYEVSQAVSIPII
GMGGVQTAEDVLEFFYAGASAVAVGTANFIDPFVCPTIINELPVLLDELGIRHISECTGRSWKTGAHAVHCRS

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=333, Percent_Identity=30.9309309309309, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI45006951, Length=321, Percent_Identity=28.3489096573209, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI87082059, Length=290, Percent_Identity=30.6896551724138, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71984108, Length=171, Percent_Identity=33.9181286549708, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17509475, Length=325, Percent_Identity=29.8461538461538, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322633, Length=266, Percent_Identity=31.203007518797, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24640763, Length=199, Percent_Identity=34.6733668341709, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18858217, Length=199, Percent_Identity=34.6733668341709, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281361352, Length=325, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17137316, Length=325, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33012; Mature: 33012

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRV
CCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
AETPSGMLNAIGLQNPGLDKVLAEELPWLEQFDVPIIANIAGSTMEEYVEVAAAISKAPN
CCCCCHHHHHHCCCCCCHHHHHHHHCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCC
VHALELNISCPNVKKGGIAFGTVPEVAAELTRLVKEVSAVPVYVKLSPNVTDIVAMAKAI
EEEEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHH
EQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKPIAVRMIYEVSQAVSIPII
HHHCCCCHHHHHHHHCCEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
GMGGVQTAEDVLEFFYAGASAVAVGTANFIDPFVCPTIINELPVLLDELGIRHISECTGR
ECCCCCHHHHHHHHHHCCCHHEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SWKTGAHAVHCRS
CCCCCCCEEEECC
>Mature Secondary Structure
MNRLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRV
CCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
AETPSGMLNAIGLQNPGLDKVLAEELPWLEQFDVPIIANIAGSTMEEYVEVAAAISKAPN
CCCCCHHHHHHCCCCCCHHHHHHHHCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCC
VHALELNISCPNVKKGGIAFGTVPEVAAELTRLVKEVSAVPVYVKLSPNVTDIVAMAKAI
EEEEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHH
EQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKPIAVRMIYEVSQAVSIPII
HHHCCCCHHHHHHHHCCEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
GMGGVQTAEDVLEFFYAGASAVAVGTANFIDPFVCPTIINELPVLLDELGIRHISECTGR
ECCCCCHHHHHHHHHHCCCHHEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SWKTGAHAVHCRS
CCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7516791 [H]