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The map label for this gene is panE [H]

Identifier: 138894643

GI number: 138894643

Start: 1038150

End: 1039040

Strand: Direct

Name: panE [H]

Synonym: GTNG_0973

Alternate gene names: 138894643

Gene position: 1038150-1039040 (Clockwise)

Preceding gene: 138894642

Following gene: 138894644

Centisome position: 29.24

GC content: 54.66

Gene sequence:

>891_bases
ATGAACATTGGCATTGTCGGCGGCGGGGCGGTTGGACTGCTACTTGCCGCCTATCTCGGGCAGCGCCACGAGGTAACAGT
TTATACGAGACGCTTGTCCCAAGCTGAGCAGCTTGCCAAGTGTGGCGTTGCGCTGAAAAAAGATGGGAAAACAGAGGTTG
TAGCGGTTCGAGCGCAGCCGTTTGCTGGGGCGGAGCTCGTTGAGCCGCTTGTGTTCGTGACCGTCAAACAATATGATATC
GCAGCTGTTTGCGCACAACCCGATTCGTTTCGCTGCGTCCGCACGCTTGTGTTTTTGCAAAACGGCATGGGCCACATTGA
AAAGCTATCCGCTTTTGCTGATAAAAACGTCATCGTCGGTGTCGTAGAGCATGGCGCACTGAAGCTTGACGACCGGACGG
TAGTACATACAGGGGTTGGCAAGTTAACGCTCGCATCGTTGTACGGAGCTCTTGCTATGGCCGCCGAATTGTCTGGGGAC
AGTGATTTTCCAATTGAATGGGCGGATGATTGGGAGCGGGTTCTTGTCGACAAGCTCATCGTTAATGCGGTCATCAACCC
GCTTACGGCGCTCTTGCAGGTAAAAAACGGGGCACTCCTTGAGGTGGCGCCGTATCGGGACATGATGGCGCAGTTGTTTG
ATGAAGTGAGACAAGTGTTGCCGCTTCATAGTGCCGAGCAGGCGTGGCAACGCATTGTCCATATATGCCGAAGCACGGCG
GACAACTATTCGTCAATGTATATGGATGTGGCAAACGGGCGCCGAACGGAAGTCGATGCGATTTTAGGCTATGTGTTAAG
GCAAGGGGAAGCGCGCGGGGTGGCGTTGCCGCTCGTCCGTTTTGTCTTTTGCGCGTTGAAGGGGAAAGAAGGGGGGAACG
CGGATGGGTGA

Upstream 100 bases:

>100_bases
TAAAAAGCTGGCTTTTTAGCCGGCTTTTTTTCTTAACGGACTAAGAAGACATTTGCTAAAATAAGGCTAGCGTGACTGTG
CTAGAAAGCGGGGGAGAGGC

Downstream 100 bases:

>100_bases
TTGGCTCGCGTCGATACTGGCGACATTTGTGACGTTGCCGCTTTTCCTGTTTTTGCTCGTCTATTTGGGAGCGCGTTTGT
TTGGGGGGCGGAAGCGGGCG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNIGIVGGGAVGLLLAAYLGQRHEVTVYTRRLSQAEQLAKCGVALKKDGKTEVVAVRAQPFAGAELVEPLVFVTVKQYDI
AAVCAQPDSFRCVRTLVFLQNGMGHIEKLSAFADKNVIVGVVEHGALKLDDRTVVHTGVGKLTLASLYGALAMAAELSGD
SDFPIEWADDWERVLVDKLIVNAVINPLTALLQVKNGALLEVAPYRDMMAQLFDEVRQVLPLHSAEQAWQRIVHICRSTA
DNYSSMYMDVANGRRTEVDAILGYVLRQGEARGVALPLVRFVFCALKGKEGGNADG

Sequences:

>Translated_296_residues
MNIGIVGGGAVGLLLAAYLGQRHEVTVYTRRLSQAEQLAKCGVALKKDGKTEVVAVRAQPFAGAELVEPLVFVTVKQYDI
AAVCAQPDSFRCVRTLVFLQNGMGHIEKLSAFADKNVIVGVVEHGALKLDDRTVVHTGVGKLTLASLYGALAMAAELSGD
SDFPIEWADDWERVLVDKLIVNAVINPLTALLQVKNGALLEVAPYRDMMAQLFDEVRQVLPLHSAEQAWQRIVHICRSTA
DNYSSMYMDVANGRRTEVDAILGYVLRQGEARGVALPLVRFVFCALKGKEGGNADG
>Mature_296_residues
MNIGIVGGGAVGLLLAAYLGQRHEVTVYTRRLSQAEQLAKCGVALKKDGKTEVVAVRAQPFAGAELVEPLVFVTVKQYDI
AAVCAQPDSFRCVRTLVFLQNGMGHIEKLSAFADKNVIVGVVEHGALKLDDRTVVHTGVGKLTLASLYGALAMAAELSGD
SDFPIEWADDWERVLVDKLIVNAVINPLTALLQVKNGALLEVAPYRDMMAQLFDEVRQVLPLHSAEQAWQRIVHICRSTA
DNYSSMYMDVANGRRTEVDAILGYVLRQGEARGVALPLVRFVFCALKGKEGGNADG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=303, Percent_Identity=29.3729372937294, Blast_Score=95, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32063; Mature: 32063

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGIVGGGAVGLLLAAYLGQRHEVTVYTRRLSQAEQLAKCGVALKKDGKTEVVAVRAQP
CEEEEECCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
FAGAELVEPLVFVTVKQYDIAAVCAQPDSFRCVRTLVFLQNGMGHIEKLSAFADKNVIVG
CCCHHHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEE
VVEHGALKLDDRTVVHTGVGKLTLASLYGALAMAAELSGDSDFPIEWADDWERVLVDKLI
EECCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
VNAVINPLTALLQVKNGALLEVAPYRDMMAQLFDEVRQVLPLHSAEQAWQRIVHICRSTA
HHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
DNYSSMYMDVANGRRTEVDAILGYVLRQGEARGVALPLVRFVFCALKGKEGGNADG
CCHHHHEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNIGIVGGGAVGLLLAAYLGQRHEVTVYTRRLSQAEQLAKCGVALKKDGKTEVVAVRAQP
CEEEEECCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
FAGAELVEPLVFVTVKQYDIAAVCAQPDSFRCVRTLVFLQNGMGHIEKLSAFADKNVIVG
CCCHHHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEE
VVEHGALKLDDRTVVHTGVGKLTLASLYGALAMAAELSGDSDFPIEWADDWERVLVDKLI
EECCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
VNAVINPLTALLQVKNGALLEVAPYRDMMAQLFDEVRQVLPLHSAEQAWQRIVHICRSTA
HHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
DNYSSMYMDVANGRRTEVDAILGYVLRQGEARGVALPLVRFVFCALKGKEGGNADG
CCHHHHEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]