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The map label for this gene is ctaB

Identifier: 138894616

GI number: 138894616

Start: 1017867

End: 1018790

Strand: Direct

Name: ctaB

Synonym: GTNG_0946

Alternate gene names: 138894616

Gene position: 1017867-1018790 (Clockwise)

Preceding gene: 138894614

Following gene: 138894617

Centisome position: 28.67

GC content: 51.19

Gene sequence:

>924_bases
ATGGCCGATTTGAAAGCGGTGCAAGAAGCCGATGTTCGGCAGCGCCCGCAGGCAAGCATAAAGCTGTTTTGGAAAGAGTT
ATCGGCAGTTGTGAAAATCGGAATCGTTAATTCCAACTTGATCACGACATTTGCCGGAATGTGGTTGGCGTTTTATTTTA
CTGGAGAGCGATTTTTAGAAAACTTGCATATCGTCTTTTTCACGCTGTTCGGGGCGGCGCTTGTCATCGCCGGATCGTGC
AGCATTAACAATTTTATAGACCGCGATATTGACCAGCATATGGAGCGGACGAAAACGCGGCCGACGGTGACGGGGACGAT
GGAGCCGCGGCGGGTGCTTTGGCTTGGGGTGACGCTTGTTGCCATCGGGACGATGAGCCTGCTCATGACAACGGTTACGG
CTGCAATTGTCGGGCTGATCGGCGTGGTGACTTACGTTTTCCTGTATACGCTTTGGACGAAGCGCAACTATACGCTTAAC
ACCGTTGTCGGCAGCATCTCTGGTGCTGTACCCCCGGTGATCGGCTGGACAGCGGTCGATTCGGATTTCCATATCGTTCC
GCTCATCTTGTTTTTAATCATGTTTTTATGGCAGCCGCCTCACTTTTTGGCTCTAGCGATGAAGCGGTGTGAAGAATACC
GGGCTGCCGGCATCCCGATGTTGCCGGTCGTTCATGGCTTTGAGATGACGAAGCGGCAAATCATCGTCTGGGTGGCATGT
TTGTTGCCGCTGCCGTTTTATTTGTTTTCGCTCGGCATCCCGTTTTTAATAGTCGCAACGGTGCTGAATGTCGGGTGGTT
GTTGTTAGGCCTATGGGGCTTGAAAATGAAAGACGACATCAAGTGGGCCAAGTTGATGTTTGTCTACTCGCTCAACTATT
TGACGATTTTGTTCGTGGCGATGGTCATCGCCACGATTTGGTGA

Upstream 100 bases:

>100_bases
ATCTTTTTGTTCTTTTTTCGTATTGGATAGAATGTTAAGCAATAAGCAATATGATGGCGCTGTTCTCATCACGGATGGCG
CAGCGAGGAGGAACAGGAGA

Downstream 100 bases:

>100_bases
ACAGGTTAAAATTCTTTCTTCGTGAAAGAATTTATATACATTTATCCATCAAAGAAAGAGGGGTTTGATTAGGCTATGAA
GAAAGGGCTACGGAACTGGC

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MADLKAVQEADVRQRPQASIKLFWKELSAVVKIGIVNSNLITTFAGMWLAFYFTGERFLENLHIVFFTLFGAALVIAGSC
SINNFIDRDIDQHMERTKTRPTVTGTMEPRRVLWLGVTLVAIGTMSLLMTTVTAAIVGLIGVVTYVFLYTLWTKRNYTLN
TVVGSISGAVPPVIGWTAVDSDFHIVPLILFLIMFLWQPPHFLALAMKRCEEYRAAGIPMLPVVHGFEMTKRQIIVWVAC
LLPLPFYLFSLGIPFLIVATVLNVGWLLLGLWGLKMKDDIKWAKLMFVYSLNYLTILFVAMVIATIW

Sequences:

>Translated_307_residues
MADLKAVQEADVRQRPQASIKLFWKELSAVVKIGIVNSNLITTFAGMWLAFYFTGERFLENLHIVFFTLFGAALVIAGSC
SINNFIDRDIDQHMERTKTRPTVTGTMEPRRVLWLGVTLVAIGTMSLLMTTVTAAIVGLIGVVTYVFLYTLWTKRNYTLN
TVVGSISGAVPPVIGWTAVDSDFHIVPLILFLIMFLWQPPHFLALAMKRCEEYRAAGIPMLPVVHGFEMTKRQIIVWVAC
LLPLPFYLFSLGIPFLIVATVLNVGWLLLGLWGLKMKDDIKWAKLMFVYSLNYLTILFVAMVIATIW
>Mature_306_residues
ADLKAVQEADVRQRPQASIKLFWKELSAVVKIGIVNSNLITTFAGMWLAFYFTGERFLENLHIVFFTLFGAALVIAGSCS
INNFIDRDIDQHMERTKTRPTVTGTMEPRRVLWLGVTLVAIGTMSLLMTTVTAAIVGLIGVVTYVFLYTLWTKRNYTLNT
VVGSISGAVPPVIGWTAVDSDFHIVPLILFLIMFLWQPPHFLALAMKRCEEYRAAGIPMLPVVHGFEMTKRQIIVWVACL
LPLPFYLFSLGIPFLIVATVLNVGWLLLGLWGLKMKDDIKWAKLMFVYSLNYLTILFVAMVIATIW

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=160, Percent_Identity=35, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786631, Length=290, Percent_Identity=38.2758620689655, Blast_Score=173, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325085, Length=251, Percent_Identity=28.2868525896414, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921064, Length=156, Percent_Identity=34.6153846153846, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_GEOTN (A4ILX0)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125069.1
- STRING:   A4ILX0
- GeneID:   4965889
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0946
- NMPDR:   fig|420246.5.peg.913
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   VGYCAVT
- PhylomeDB:   A4ILX0
- ProtClustDB:   PRK04375
- BioCyc:   GTHE420246:GTNG_0946-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 34613; Mature: 34482

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd3b2ab4)-; HASH(0xe05c38c)-; HASH(0xe07680c)-; HASH(0xe07e264)-; HASH(0xdf985b0)-; HASH(0xe05c5a8)-; HASH(0xe05c338)-; HASH(0xdd4ec7c)-; HASH(0xe069b08)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLKAVQEADVRQRPQASIKLFWKELSAVVKIGIVNSNLITTFAGMWLAFYFTGERFLE
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
NLHIVFFTLFGAALVIAGSCSINNFIDRDIDQHMERTKTRPTVTGTMEPRRVLWLGVTLV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHH
AIGTMSLLMTTVTAAIVGLIGVVTYVFLYTLWTKRNYTLNTVVGSISGAVPPVIGWTAVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEECC
SDFHIVPLILFLIMFLWQPPHFLALAMKRCEEYRAAGIPMLPVVHGFEMTKRQIIVWVAC
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LLPLPFYLFSLGIPFLIVATVLNVGWLLLGLWGLKMKDDIKWAKLMFVYSLNYLTILFVA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MVIATIW
HHHHHCH
>Mature Secondary Structure 
ADLKAVQEADVRQRPQASIKLFWKELSAVVKIGIVNSNLITTFAGMWLAFYFTGERFLE
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH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HHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA